Fabrizio Spinozzi

Summary

Affiliation: University of Perugia
Country: Italy

Publications

  1. ncbi Recognition of lipids from pollens by CD1-restricted T cells
    Fabrizio Spinozzi
    Experimental Immunology and Allergy, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce, Via Brunamonti 51, I 06122 Perugia, Italy
    Immunol Allergy Clin North Am 27:79-92. 2007
  2. ncbi Role of T-helper type 2 cytokines in down-modulation of fas mRNA and receptor on the surface of activated CD4(+) T cells: molecular basis for the persistence of the allergic immune response
    F Spinozzi
    Laboratory of Allergology and Clinical Immunology, Department of Clinical and Experimental Medicine, Perugia, Italy
    FASEB J 12:1747-53. 1998
  3. ncbi CD4+IL13+ T lymphocytes at birth and the development of wheezing and/or asthma during the 1st year of life
    F Spinozzi
    Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Int Arch Allergy Immunol 124:497-501. 2001
  4. ncbi The biology of cypress allergy
    E Agea
    Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce, I-06122 Perugia, Italy
    Allergy 57:959-60. 2002
  5. ncbi Biological effects of montelukast, a cysteinyl-leukotriene receptor-antagonist, on T lymphocytes
    F Spinozzi
    Laboratory of Experimental Immunology and Allergy, Department of Clinical and Experimental Medicine, University of Perugia, I 06122 Perugia, Italy
    Clin Exp Allergy 34:1876-82. 2004
  6. ncbi Human CD1-restricted T cell recognition of lipids from pollens
    Elisabetta Agea
    Experimental Immunology and Allergy, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    J Exp Med 202:295-308. 2005
  7. ncbi CD1-restricted recognition of exogenous and self-lipid antigens by duodenal gammadelta+ T lymphocytes
    Anna M Russano
    Laboratory of Experimental Immunology and Allergy, Section of Internal Medicine and Oncological Sciences, Department of Clinical and Experimental Medicine, University of Perugia Medical School, Perugia, Italy
    J Immunol 178:3620-6. 2007
  8. ncbi Recognition of pollen-derived phosphatidyl-ethanolamine by human CD1d-restricted gamma delta T cells
    Anna M Russano
    Experimental Immunology and Allergy, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    J Allergy Clin Immunol 117:1178-84. 2006
  9. ncbi Biochemical and immunological characterization of pollen-derived beta-galactosidase reveals a new cross-reactive class of allergens among Mediterranean trees
    Onelia Bistoni
    Laboratory of Experimental Immunology and Allergy, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Int Arch Allergy Immunol 136:123-33. 2005
  10. ncbi Apoptosis, airway inflammation and anti-asthma therapy: from immunobiology to clinical application
    Fabrizio Spinozzi
    Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Pediatr Allergy Immunol 19:287-95. 2008

Collaborators

  • Gennaro De Libero
  • G Bassotti
  • Liliana Minelli
  • Anthony D Postle
  • Steven Porcelli
  • Claude Bagnis
  • Mauro Di Ianni
  • Roberto Gerli
  • A Siracusa
  • Anna M Russano
  • Onelia Bistoni
  • Elisabetta Agea
  • Lanfranco Corazzi
  • Anna M Iorio
  • E Agea
  • A M Russano
  • Morena Buratta
  • F M de Benedictis
  • E Fringuelli
  • A Russano
  • Barbara Camilloni
  • Mariella Neri
  • Michela Basileo
  • Massimiliano Galdiero
  • Enrica Lepri
  • Roberto Maria Pellegrino
  • Rita Roberti
  • Emilia Castigli
  • Miriam Sciaccaluga
  • C Casciari
  • Antonio Morelli
  • Alessandro Mazzocchi
  • Fernando M de Benedictis
  • Roberta Mannucci
  • Aldo Orlacchio
  • Ildo Nicoletti
  • Carla Emiliani
  • Simona Mencarelli
  • Anna Russano
  • A M Iorio
  • E Lepri
  • B Camilloni
  • M Neri
  • L Corazzi
  • O Bistoni

Detail Information

Publications17

  1. ncbi Recognition of lipids from pollens by CD1-restricted T cells
    Fabrizio Spinozzi
    Experimental Immunology and Allergy, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce, Via Brunamonti 51, I 06122 Perugia, Italy
    Immunol Allergy Clin North Am 27:79-92. 2007
    ....
  2. ncbi Role of T-helper type 2 cytokines in down-modulation of fas mRNA and receptor on the surface of activated CD4(+) T cells: molecular basis for the persistence of the allergic immune response
    F Spinozzi
    Laboratory of Allergology and Clinical Immunology, Department of Clinical and Experimental Medicine, Perugia, Italy
    FASEB J 12:1747-53. 1998
    ..T-helper type 2 cytokines (IL-4, IL-5, and GM-CSF) had a dose-dependent and specific inhibitory effect on Fas mRNA, suggesting a new fundamental biological role in the survival of inflammatory cells during allergen exposure...
  3. ncbi CD4+IL13+ T lymphocytes at birth and the development of wheezing and/or asthma during the 1st year of life
    F Spinozzi
    Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Int Arch Allergy Immunol 124:497-501. 2001
    ..The prognostic significance of these cells for asthma development later in life remains to be determined...
  4. ncbi The biology of cypress allergy
    E Agea
    Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce, I-06122 Perugia, Italy
    Allergy 57:959-60. 2002
  5. ncbi Biological effects of montelukast, a cysteinyl-leukotriene receptor-antagonist, on T lymphocytes
    F Spinozzi
    Laboratory of Experimental Immunology and Allergy, Department of Clinical and Experimental Medicine, University of Perugia, I 06122 Perugia, Italy
    Clin Exp Allergy 34:1876-82. 2004
    ..If this effect is due only to blocking leukotrienes or also owing to inhibiting proliferation and survival of inflammatory cells, is actually unknown...
  6. ncbi Human CD1-restricted T cell recognition of lipids from pollens
    Elisabetta Agea
    Experimental Immunology and Allergy, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    J Exp Med 202:295-308. 2005
    ..Finally, allergic, but not normal subjects, displayed circulating specific IgE and cutaneous weal and flare reactions to phospholipids...
  7. ncbi CD1-restricted recognition of exogenous and self-lipid antigens by duodenal gammadelta+ T lymphocytes
    Anna M Russano
    Laboratory of Experimental Immunology and Allergy, Section of Internal Medicine and Oncological Sciences, Department of Clinical and Experimental Medicine, University of Perugia Medical School, Perugia, Italy
    J Immunol 178:3620-6. 2007
    ..This adaptive response could contribute to mucosal homeostasis, but could also favor the emergence of inflammatory or allergic intestinal diseases...
  8. ncbi Recognition of pollen-derived phosphatidyl-ethanolamine by human CD1d-restricted gamma delta T cells
    Anna M Russano
    Experimental Immunology and Allergy, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    J Allergy Clin Immunol 117:1178-84. 2006
    ....
  9. ncbi Biochemical and immunological characterization of pollen-derived beta-galactosidase reveals a new cross-reactive class of allergens among Mediterranean trees
    Onelia Bistoni
    Laboratory of Experimental Immunology and Allergy, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Int Arch Allergy Immunol 136:123-33. 2005
    ..CONCLUSIONS: Despite different isoenzymatic patterns, Olea-derived beta-GAL cross-reacted with that from cypress pollen, suggesting that these enzymatic glycoproteins may represent major native allergens among these Mediterranean trees...
  10. ncbi Apoptosis, airway inflammation and anti-asthma therapy: from immunobiology to clinical application
    Fabrizio Spinozzi
    Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Pediatr Allergy Immunol 19:287-95. 2008
    ..Finally, the paper presents an update on pharmacological targeting of apoptosis to control airway inflammation in patients with allergic asthma...
  11. ncbi Prevalence of occupational allergy due to live fish bait
    A Siracusa
    Occupational Medicine, Terni Hospital, University of Perugia, Italy
    Clin Exp Allergy 33:507-10. 2003
    ..Larvae of insects and worms, used as live fish bait (LFB), are a common source of allergy in anglers and occupationally exposed workers, but the prevalence and predictors have not yet been investigated...
  12. ncbi Influenza viruses and cross-reactivity in healthy adults: Humoral and cellular immunity induced by seasonal 2007/2008 influenza vaccination against vaccine antigens and 2009 A(H1N1) pandemic influenza virus
    Anna M Iorio
    Department of Medical and Surgical Specialties and Public Health, University of Perugia, Via del Giochetto, 06123 Perugia, Italy
    Vaccine 30:1617-23. 2012
    ....
  13. ncbi Interleukin 7-engineered stromal cells: a new approach for hastening naive T cell recruitment
    Mauro Di Ianni
    University of Perugia, 06123 Perugia, Italy
    Hum Gene Ther 16:752-64. 2005
    ..Because of their efficient cytokine production and homing, IL-7-engineered stromal cells might be an ideal vehicle to hasten immunological reconstitution in T cell-depleted hosts...
  14. ncbi Loss of cardiolipin in palmitate-treated GL15 glioblastoma cells favors cytochrome c release from mitochondria leading to apoptosis
    Morena Buratta
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    J Neurochem 105:1019-31. 2008
    ..Fused CL moved to mitochondria, as detected by nonylacridine orange probe. Enrichment of mitochondrial membranes with CL prior to palmitate treatment of cells caused decreased cyt c release and caspase 3 activity...
  15. ncbi Complementary roles for lipid and protein allergens in triggering innate and adaptive immune systems
    A M Russano
    Laboratory of Experimental Immunology and Allergy, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Allergy 63:1428-37. 2008
    ..These advancements could appear to be in conflict each other, as innate T cells have a poorly-defined antigen specificity that is often directed toward nonprotein substances, such as lipids...
  16. ncbi Ethanol-induced CD3 and CD2 hyporesponsiveness of peripheral blood T lymphocytes
    F Spinozzi
    Department of Internal Medicine, University of Perugia, Italy
    Immunopharmacol Immunotoxicol 14:939-53. 1992
    ..These data clearly indicate that a membrane-specific ethanol interaction both modifies surface glycoproteic and/or glycolipidic structures and alters transmembrane transduction of the activation signals...
  17. ncbi Flow cytometric measurement of intracellular IFN-gamma induction in aged subjects before and after parenteral influenza vaccination
    E Fringuelli
    Department of Hygiene and Public Health, University of Perugia, Italy
    Dev Biol (Basel) 115:55-9. 2003
    ..Although the vaccine was capable of generating a satisfactory antibody response, it did not stimulate an increase in the percentage of IFN-gamma positive cells...