Anna Scotto d'Abusco

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. ncbi A peptidyl-glucosamine derivative affects IKKalpha kinase activity in human chondrocytes
    Anna Scotto d'Abusco
    Department of Biochemical Sciences, Sapienza University of Roma, P, le Aldo Moro, 5, 00185 Roma, Italy
    Arthritis Res Ther 12:R18. 2010
  2. ncbi Beta-peptido sulfonamides: for-Met-Leu-Phe-OMe analogues containing taurine and chiral beta-amino-ethanesulfonic acid residues
    Cesare Giordano
    Istituto di Chimica Biomolecolare del CNR, Sezione di Roma c/o Dipartimento di Studi Farmaceutici, , Piazzale A. Moro 5, 00185 Rome, Italy
    Farmaco 59:953-63. 2004
  3. ncbi Alpha-peptide/beta-sulfonamidopeptide hybrids: analogs of the chemotactic agent for-Met-Leu-Phe-OMe
    Cesare Giordano
    Dipartimento di Studi Farmaceutici, Università di Roma La Sapienza and istituto di Chimica Biomolecolare del CNR, Sezione di Roma, P le A Moro 5, 00185 Roma, Italy
    Bioorg Med Chem 14:2642-52. 2006
  4. ncbi Effects of intra-articular administration of glucosamine and a peptidyl-glucosamine derivative in a rabbit model of experimental osteoarthritis: a pilot study
    Anna Scotto d'Abusco
    Dipartimento di Scienze Biochimiche, Sapienza Universita di Roma, P le Aldo Moro, 5, 00185 Rome, Italy
    Rheumatol Int 28:437-43. 2008
  5. ncbi Glucosamine affects intracellular signalling through inhibition of mitogen-activated protein kinase phosphorylation in human chondrocytes
    Anna Scotto d'Abusco
    Department of Biochemical Sciences, Sapienza University of Roma, P le Aldo Moro 5, 00185 Roma, Italy
    Arthritis Res Ther 9:R104. 2007
  6. ncbi Synthesis and activity of fibrillogenesis peptide inhibitors related to the 17-21 beta-amyloid sequence
    Cesare Giordano
    Istituto di Chimica Biomolecolare del CNR, Universita La Sapienza, P le A Moro 5, 00185 Roma, Italy
    Eur J Med Chem 44:179-89. 2009
  7. ncbi Synthesis and bioactivity of chemotactic tetrapeptides: fMLF-OMe analogues incorporating spacer aminoacids at the lateral positions
    Gino Lucente
    Dipartimento di Studi Farmaceutici, Universita degli Studi di Roma La Sapienza, P le A Moro 5, 00185 Rome, Italy
    Amino Acids 37:285-95. 2009
  8. ncbi Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2
    Cesare Giordano
    Istituto di Chimica Biomolecolare del CNR, c o Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Universita di Roma, P le A Moro 5, 00185 Roma, Italy
    Eur J Med Chem 45:4594-600. 2010

Collaborators

Detail Information

Publications8

  1. ncbi A peptidyl-glucosamine derivative affects IKKalpha kinase activity in human chondrocytes
    Anna Scotto d'Abusco
    Department of Biochemical Sciences, Sapienza University of Roma, P, le Aldo Moro, 5, 00185 Roma, Italy
    Arthritis Res Ther 12:R18. 2010
    ....
  2. ncbi Beta-peptido sulfonamides: for-Met-Leu-Phe-OMe analogues containing taurine and chiral beta-amino-ethanesulfonic acid residues
    Cesare Giordano
    Istituto di Chimica Biomolecolare del CNR, Sezione di Roma c/o Dipartimento di Studi Farmaceutici, , Piazzale A. Moro 5, 00185 Rome, Italy
    Farmaco 59:953-63. 2004
    ..The results are analyzed in terms of structure-activity relationships. The conformational preferences of the new tripeptides 1b and 2b, containing a central chiral beta-amino-ethanesulfonic acid residue, have also been discussed...
  3. ncbi Alpha-peptide/beta-sulfonamidopeptide hybrids: analogs of the chemotactic agent for-Met-Leu-Phe-OMe
    Cesare Giordano
    Dipartimento di Studi Farmaceutici, Università di Roma La Sapienza and istituto di Chimica Biomolecolare del CNR, Sezione di Roma, P le A Moro 5, 00185 Roma, Italy
    Bioorg Med Chem 14:2642-52. 2006
    ..The biochemical functions and the conformational properties of the new compounds are discussed and related to previously studied models containing beta-residues...
  4. ncbi Effects of intra-articular administration of glucosamine and a peptidyl-glucosamine derivative in a rabbit model of experimental osteoarthritis: a pilot study
    Anna Scotto d'Abusco
    Dipartimento di Scienze Biochimiche, Sapienza Universita di Roma, P le Aldo Moro, 5, 00185 Rome, Italy
    Rheumatol Int 28:437-43. 2008
    ..Our preliminary in vivo and in vitro studies suggest that GlcN and NAPA could play a disease-modifying protective role in OA by an anti-catabolic effect and an anti-inflammatory activity on chondrocytes...
  5. ncbi Glucosamine affects intracellular signalling through inhibition of mitogen-activated protein kinase phosphorylation in human chondrocytes
    Anna Scotto d'Abusco
    Department of Biochemical Sciences, Sapienza University of Roma, P le Aldo Moro 5, 00185 Roma, Italy
    Arthritis Res Ther 9:R104. 2007
    ..These findings demonstrate, for the first time, that glucosamine inhibits IL-1beta-stimulated MMP production in human chondrocytes by affecting MAPK phosphorylation...
  6. ncbi Synthesis and activity of fibrillogenesis peptide inhibitors related to the 17-21 beta-amyloid sequence
    Cesare Giordano
    Istituto di Chimica Biomolecolare del CNR, Universita La Sapienza, P le A Moro 5, 00185 Roma, Italy
    Eur J Med Chem 44:179-89. 2009
    ..Conformational properties of the new compounds have been determined by CD and FT-IR spectroscopies...
  7. ncbi Synthesis and bioactivity of chemotactic tetrapeptides: fMLF-OMe analogues incorporating spacer aminoacids at the lateral positions
    Gino Lucente
    Dipartimento di Studi Farmaceutici, Universita degli Studi di Roma La Sapienza, P le A Moro 5, 00185 Rome, Italy
    Amino Acids 37:285-95. 2009
    ....
  8. ncbi Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2
    Cesare Giordano
    Istituto di Chimica Biomolecolare del CNR, c o Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Universita di Roma, P le A Moro 5, 00185 Roma, Italy
    Eur J Med Chem 45:4594-600. 2010
    ..The highest micro-receptor affinity is shown by [(S)betaPrs(2)]EM2 analogue (6e) which represents the first example of a beta-sulphonamido analogue in the field of opioid peptides...