M Gabriella Santoro

Summary

Affiliation: University of Rome Tor Vergata
Country: Italy

Publications

  1. ncbi Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway
    Alessandra Ciucci
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    Mol Pharmacol 70:1812-21. 2006
  2. ncbi Heat shock factors and the control of the stress response
    M G Santoro
    Department of Biology, University of Rome Tor Vergata, Italy
    Biochem Pharmacol 59:55-63. 2000
  3. ncbi NF-kappaB and virus infection: who controls whom
    M Gabriella Santoro
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica and INeMM, CNR, 00133 Rome, Italy
    EMBO J 22:2552-60. 2003
  4. ncbi Antiviral activity of proteasome inhibitors in herpes simplex virus-1 infection: role of nuclear factor-kappaB
    Simone La Frazia
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Antivir Ther 11:995-1004. 2006
  5. ncbi Herpes simplex virus disrupts NF-kappaB regulation by blocking its recruitment on the IkappaBalpha promoter and directing the factor on viral genes
    Carla Amici
    Department of Biology and Dermatology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    J Biol Chem 281:7110-7. 2006
  6. ncbi Indomethacin has a potent antiviral activity against SARS coronavirus
    Carla Amici
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Antivir Ther 11:1021-30. 2006
  7. ncbi AIRAP, a new human heat shock gene regulated by heat shock factor 1
    Antonio Rossi
    Institute of Neurobiology and Molecular Medicine, CNR, 00133 Rome, Italy
    J Biol Chem 285:13607-15. 2010
  8. ncbi The IkappaB kinase is a key factor in triggering influenza A virus-induced inflammatory cytokine production in airway epithelial cells
    Daniela Bernasconi
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, Rome 00133, Italy
    J Biol Chem 280:24127-34. 2005
  9. ncbi 15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-kappa B activity and down-regulation of antiapoptotic proteins
    Roberto Piva
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    Blood 105:1750-8. 2005
  10. ncbi Antiviral activity of cyclopentenone prostanoids
    M G Santoro
    Institute of Experimental Medicine, CNR, Rome, Italy
    Trends Microbiol 5:276-81. 1997

Collaborators

  • Antonio Rossi
  • Roberto Piva
  • Maria R Capobianchi
  • Nicola Decaro
  • Canio Buonavoglia
  • Massimo Levrero
  • Carla Amici
  • G Belardo
  • Alessandra Ciucci
  • Simone La Frazia
  • Daniela Bernasconi
  • Elisabetta Caselli
  • C Amici
  • G Elia
  • Arnaldo Caruso
  • Simona Fiorentini
  • Dario Di Luca
  • Timothy J Snape
  • Antonino Di Coro
  • Barbara Marinari
  • Thierry Guyot
  • Antonio Costanzo
  • Patrizia Gianferretti
  • Concetta Castilletti
  • Vito Martella
  • Stefania Ciafrè
  • Mirna Balsamo
  • Stanley M Roberts
  • Lucia Chiappa
  • Angela Ianaro
  • Carmela Rozera
  • Giuseppe Belardo
  • B Polla

Detail Information

Publications16

  1. ncbi Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway
    Alessandra Ciucci
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    Mol Pharmacol 70:1812-21. 2006
    ..The results open new perspectives in the search for novel proapoptotic molecules effective in the treatment of cancers presenting aberrant NF-kappaB regulation...
  2. ncbi Heat shock factors and the control of the stress response
    M G Santoro
    Department of Biology, University of Rome Tor Vergata, Italy
    Biochem Pharmacol 59:55-63. 2000
    ....
  3. ncbi NF-kappaB and virus infection: who controls whom
    M Gabriella Santoro
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica and INeMM, CNR, 00133 Rome, Italy
    EMBO J 22:2552-60. 2003
    ..This review summarizes what is known about the control of NF-kappaB by viruses, and discusses the possible outcome of NF-kappaB activation during viral infection, which may benefit either the host or the pathogen...
  4. ncbi Antiviral activity of proteasome inhibitors in herpes simplex virus-1 infection: role of nuclear factor-kappaB
    Simone La Frazia
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Antivir Ther 11:995-1004. 2006
    ..CONCLUSIONS: Proteasome inhibitors possess NF-kappaB-dependent antiherpetic activity. The results described further identify the IKK/NF-kappaB pathway as a suitable target for novel antiherpetic drugs...
  5. ncbi Herpes simplex virus disrupts NF-kappaB regulation by blocking its recruitment on the IkappaBalpha promoter and directing the factor on viral genes
    Carla Amici
    Department of Biology and Dermatology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    J Biol Chem 281:7110-7. 2006
    ....
  6. ncbi Indomethacin has a potent antiviral activity against SARS coronavirus
    Carla Amici
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Antivir Ther 11:1021-30. 2006
    ..CONCLUSIONS: The results identify INDO as a potent inhibitor of coronavirus replication and suggest that, having both anti-inflammatory and antiviral activity, INDO could be beneficial in SARS therapy...
  7. ncbi AIRAP, a new human heat shock gene regulated by heat shock factor 1
    Antonio Rossi
    Institute of Neurobiology and Molecular Medicine, CNR, 00133 Rome, Italy
    J Biol Chem 285:13607-15. 2010
    ..Because its expression is induced at febrile temperatures in human cells, AIRAP may represent a new potential component of the protective response during fever in humans...
  8. ncbi The IkappaB kinase is a key factor in triggering influenza A virus-induced inflammatory cytokine production in airway epithelial cells
    Daniela Bernasconi
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, Rome 00133, Italy
    J Biol Chem 280:24127-34. 2005
    ..The results identify IKK as an important factor in triggering influenza virus-induced inflammatory reactions in pulmonary epithelium, suggesting novel therapeutic approaches in the treatment of influenza...
  9. ncbi 15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-kappa B activity and down-regulation of antiapoptotic proteins
    Roberto Piva
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    Blood 105:1750-8. 2005
    ..The results indicate that inhibition of NF-kappa B plays a major role in the proapoptotic activity of 15d-PGJ(2) in aggressive B-cell malignancies characterized by aberrant regulation of NF-kappa B...
  10. ncbi Antiviral activity of cyclopentenone prostanoids
    M G Santoro
    Institute of Experimental Medicine, CNR, Rome, Italy
    Trends Microbiol 5:276-81. 1997
    ..These molecules represent an interesting model for the development of novel antiviral drugs that can affect different targets during the virus life cycle...
  11. ncbi Inhibition of herpesvirus-induced HIV-1 replication by cyclopentenone prostaglandins: role of IkappaB kinase (IKK)
    Carla Amici
    Department of Biology, University of Rome Tor Vergata, 00133 Rome
    AIDS 18:1271-80. 2004
    ..CONCLUSIONS: The results indicate that IKK is a key factor in triggering HSV-1-induced HIV-1 transcription in chronically-infected cells and identify cyclopentenone prostanoids as potent inhibitors of HSV-1-induced HIV-1 reactivation...
  12. ncbi Heat stress triggers apoptosis by impairing NF-kappaB survival signaling in malignant B cells
    G Belardo
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, Rome 00133, Italy
    Leukemia 24:187-96. 2010
    ....
  13. ncbi Activation of I kappa b kinase by herpes simplex virus type 1. A novel target for anti-herpetic therapy
    C Amici
    Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy
    J Biol Chem 276:28759-66. 2001
    ..The results identify IKK as a potential target for anti-herpetic drugs and suggest that cyclopentenone prostaglandins or their derivatives could be used in the treatment of HSV infection...
  14. ncbi Induction of ferritin and heat shock proteins by prostaglandin A1 in human monocytes. Evidence for transcriptional and post-transcriptional regulation
    G Elia
    Institute of Experimental Medicine, CNR, Roma, Italy
    Eur J Biochem 264:736-45. 1999
    ..As ferritin, together with hsp70 and HO, plays a key role in protection from oxidant damage, these results suggest that PGA1 may have cytoprotective activity also during oxidative injury...
  15. ncbi NF-kappaB: a stress-regulated switch for cell survival
    Roberto Piva
    Department of Pathology and Center for Experimental Research and Medical Studies (CERMS, University of Turin, Turin, Italy
    Antioxid Redox Signal 8:478-86. 2006
    ....
  16. ncbi Human herpesvirus 8 acute infection of endothelial cells induces monocyte chemoattractant protein 1-dependent capillary-like structure formation: role of the IKK/NF-kappaB pathway
    Elisabetta Caselli
    Section of Microbiology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Italy
    Blood 109:2718-26. 2007
    ..The results suggest that HHV-8-induced MCP-1 may play an important role in promoting inflammation and pathogenic angiogenesis typical of HHV-8-associated lesions...