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Genomes and Genes | F SantiniSummaryAffiliation: University of Pisa Country: Italy Publications
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Publications
The obesity and inflammatory marker haptoglobin attracts monocytes via interaction with chemokine (C-C motif) receptor 2 (CCR2)Margherita Maffei
Dulbecco Telethon Institute, CNR, Area della Ricerca di Pisa, Pisa, Italy
BMC Biol 7:87. 2009..In an effort to elucidate the biological significance of Hp presence in the WAT and of its upregulation in obesity we formulated the hypothesis that Hp may serve as a macrophage chemoattractant...- Serum iodothyronines in the human fetus and the newborn: evidence for an important role of placenta in fetal thyroid hormone homeostasisF Santini
Department of Endocrinology and Metabolism, University of Pisa, Italy
J Clin Endocrinol Metab 84:493-8. 1999.... - Thyroid function and exposure to styreneFerruccio Santini
Department of Endocrinology and Kidney, University Hospital of Pisa, Pisa, Italy
Thyroid 18:1065-9. 2008..The aim of this study was to evaluate the effects of styrene on the thyroid axis in occupationally exposed workers... - Acute exogenous TSH administration stimulates leptin secretion in vivoFerruccio Santini
Department of Endocrinology and Kidney Dulbecco Telethon Institute at Department of Endocrinology and Kidney University Hospital of Pisa, Via Paradisa, 2, 56124 Pisa, Italy
Eur J Endocrinol 163:63-7. 2010..The role that TSHR activation in adipocytes might play in physiological and pathological conditions remains a matter of investigation... - Melanocortin-4 receptor mutations in obesityFerruccio Santini
Department of Endocrinology and Kidney, University Hospital of Pisa, 56124 Pisa, Italy
Adv Clin Chem 48:95-109. 2009.... - Ultrasonographic evaluation of liver volume and the metabolic syndrome in obese womenF Santini
Department of Endocrinology and Metabolic Diseases, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, Italy
J Endocrinol Invest 30:104-10. 2007.... - Serum concentrations of adiponectin and leptin in patients with thyroid dysfunctionsF Santini
Department of Endocrinology, University of Pisa, Pisa, Italy
J Endocrinol Invest 27:RC5-7. 2004..We conclude that metabolic changes associated with thyroid dysfunction are not related to variations in serum levels of adiponectin or leptin... - Genetic screening for melanocortin-4 receptor mutations in a cohort of Italian obese patients: description and functional characterization of a novel mutationFerruccio Santini
Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
J Clin Endocrinol Metab 89:904-8. 2004..7% prevalence of potentially pathogenic mutations. A novel heterozygous missense mutation (Glu(308)Lys) that impairs MC4-R functional activity in vitro was characterized... - In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activityF Santini
Department of Endocrinology, Centro di Eccellenza AmbiSEN, University of Pisa, Pisa, Italy
J Endocrinol Invest 26:950-5. 2003..These assays may be useful to identify the mechanism of action of thyroid disruptors, coming beside and supporting animal studies or epidemiological surveys... - Lean body mass is a major determinant of levothyroxine dosage in the treatment of thyroid diseasesFerruccio Santini
Department of Endocrinology, University of Pisa, 56124, Pisa, Italy
J Clin Endocrinol Metab 90:124-7. 2005..An estimate of lean mass may be helpful to shorten the time required to attain a stable dose of l-T(4), particularly in subjects with high body mass index values that may be due either to increased muscular mass or to obesity... - Evidence for a role of the type III-iodothyronine deiodinase in the regulation of 3,5,3'-triiodothyronine content in the human central nervous systemF Santini
Department of Endocrinology and Metabolism, University of Pisa, Italy
Eur J Endocrinol 144:577-83. 2001..A regional expression of D3 activity has been observed in the human central nervous system (CNS), and a critical role for D3 has been suggested in the regulation of local T3 content in concert with other enzymes... - Male sex, single nodularity, and young age are associated with the risk of finding a papillary thyroid cancer on fine-needle aspiration cytology in a large series of patients with nodular thyroid diseaseT Rago
Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
Eur J Endocrinol 162:763-70. 2010..To evaluate the risk of papillary thyroid carcinoma (PTC) at fine-needle aspiration (FNA) cytology in 34 120 patients... - Real-time elastosonography: useful tool for refining the presurgical diagnosis in thyroid nodules with indeterminate or nondiagnostic cytologyT Rago
Department of Endocrinology, University of Pisa, Via Paradisa, 2, 56124 Pisa, Italy
J Clin Endocrinol Metab 95:5274-80. 2010..The aim of this study was to get further insights into the role of USE in the presurgical diagnosis of nodules with indeterminate or nondiagnostic cytology... - Pattern of expression of adiponectin receptors in human liver and its relation to nonalcoholic steatohepatitisM Nannipieri
Department of Internal Medicine, University of Pisa, Pisa, Italy
Obes Surg 19:467-74. 2009..Adiponectin has antisteatosis-anti-inflammatory properties and its circulating levels are reduced in nonalcoholic steatohepatitis (NASH)... - Study of potential inhibitors of thyroid iodide uptake by using CHO cells stably expressing the human sodium/iodide symporter (hNIS) proteinP Agretti
Department of Endocrinology and Metabolism, Centro Eccellenza AmbiSEN, University of Pisa, Pisa, Italy
J Endocrinol Invest 34:170-4. 2011..Beyond to perchlorate and thyocianate ions a few other inhibitors of iodide uptake have been described... - Autoantibodies from patients with autoimmune thyroid disease do not interfere with the activity of the human iodide symporter gene stably transfected in CHO cellsM Tonacchera
Dipartimento di Endocrinologia e Metabolismo, Medicina del Lavoro, Universita di Pisa, Pisa, Italy
Eur J Endocrinol 144:611-8. 2001..To investigate the possible existence of autoantibodies able to interfere with the biological activity of hNIS, an assay was developed using a cell line stably expressing hNIS... - Serum haptoglobin: a novel marker of adiposity in humansC Chiellini
Dulbecco Telethon Institute, University of Pisa, 56126 Pisa, Italy
J Clin Endocrinol Metab 89:2678-83. 2004..In conclusion, serum Hp constitutes a novel marker of adiposity in humans, and the adipose tissue likely contributes to determine its levels... - Hepatic left lobe volume is a sensitive index of metabolic improvement in obese women after gastric bandingM Giannetti
Department of Endocrinology and Kidney, University Hospital of Pisa, Pisa, Italy
Int J Obes (Lond) 36:336-41. 2012..Nonalcoholic fatty liver disease is a common finding in obese subjects. Increasing evidence has been provided suggesting that it represents the hepatic component of the metabolic syndrome... - Relationship between preclinical abnormalities of global and regional left ventricular function and insulin resistance in severe obesity: a Color Doppler Imaging StudyV Di Bello
Cardiac and Thoracic Department, University of Pisa, Pisa, Italy
Int J Obes (Lond) 30:948-56. 2006..Furthermore, another main finding of the study was that myocardial deformation (systolic strain) could have a correlation with insulin resistance level... - Elastography: new developments in ultrasound for predicting malignancy in thyroid nodulesT Rago
Department of Endocrinology, University of Pisa, Via Paradisa, 2, 56124 Pisa, Italy
J Clin Endocrinol Metab 92:2917-22. 2007..US elastography has been applied to differentiate malignant from benign lesions... - Pattern of expression of adiponectin receptors in human adipose tissue depots and its relation to the metabolic stateM Nannipieri
Department of Internal Medicine and C N R Institute of Clinical Physiology, University of Pisa, Pisa, Italy
Int J Obes (Lond) 31:1843-8. 2007.... - Genetic analysis of metamorphic and premetamorphic Xenopus ciliary marginal zoneS Casarosa
Laboratorio di Biologia Cellulare e dello Sviluppo, Dipartimento di Fisiologia e Biochimica, Universita di Pisa, Ghezzano Pisa, Italy
Dev Dyn 233:646-51. 2005.... - Serotonin transporter (SERT) and translocator protein (TSPO) expression in the obese ob/ob mouseGino Giannaccini
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy
BMC Neurosci 12:18. 2011.... - Effects of bariatric surgery on early myocardial alterations in adult severely obese subjectsVitantonio Di Bello
Cardiac Thoracic and Vascular Department, University of Pisa, Pisa, Italy
Cardiology 109:241-8. 2008..Aim of this study was to investigate the effect of weight loss on structural and functional myocardial alterations in severely obese subjects treated with bariatric surgery... - Human serotonin transporter expression during megakaryocytic differentiation of MEG-01 cellsGino Giannaccini
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy
Neurochem Res 35:628-35. 2010..Differentiation of MEG-01 cells can provide considerable insight into interactions between SERT genetics, transmitter-hormonal/homeostatic mechanisms and signaling pathways... - Abnormal expression of PPAR gamma isoforms in the subcutaneous adipose tissue of patients with Cushing's diseaseFausto Bogazzi
Department of Endocrinology, University of Pisa, Italy
Clin Endocrinol (Oxf) 66:7-12. 2007..Peroxisome proliferators-activated receptor (PPAR)gamma is the master regulator of adipogenesis; however, the expression of PPARgamma isoforms in the subcutaneous adipose tissue (SAT) of patients with Cushing's disease is unknown... - Treatment with drugs able to reduce iodine efflux significantly increases the intracellular retention time in thyroid cancer cells stably transfected with sodium iodide symporter complementary deoxyribonucleic acidRossella Elisei
Department of Endocrinology and Metabolism, Via Paradisa 2, University of Pisa, 56124 Pisa, Italy
J Clin Endocrinol Metab 91:2389-95. 2006..One of the major limits of gene therapy with sodium iodide symporter (NIS), which enables cells to be subjected to radioiodine therapy, is that NIS-transfected cells rapidly release the intracellular iodine... - Axis I and II disorders and quality of life in bariatric surgery candidatesMauro Mauri
Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnology, University of Pisa, Pisa, Italy
J Clin Psychiatry 69:295-301. 2008..This study examined the prevalence of Axis I and II psychopathology and its relationship with quality of life in candidates for bariatric surgery... - Sleep apnea in morbidly obese patients: prevalence and clinical predictivityAntonio Palla
Cardiac and Thoracic Department, Section of Respiratory Disease, University and Hospital of Pisa, IT 56124 Pisa, Italy
Respiration 78:134-40. 2009..Little is known about the prevalence of obstructive sleep apnea-hypopnea syndrome (OSAHS) in morbidly obese patients and whether such patients show peculiar clinical findings that may make it easier to suspect and diagnose OSAHS... - Is combined therapy with levothyroxine and liothyronine effective in patients with primary hypothyroidism?Aldo Pinchera
Department of Endocrinology and Metabolism, University Hospital of Pisa, Italy
Nat Clin Pract Endocrinol Metab 1:18-9. 2005 - Obesity cardiomyopathy: is it a reality? An ultrasonic tissue characterization studyVitantonio Di Bello
Cardiac and Thoracic Department, University of Pisa, Pisa, Italy
J Am Soc Echocardiogr 19:1063-71. 2006.... - Tubby protein in human lymphocytes from normal weight and obese subjectsGino Giannaccini
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, Environment and Endocrine and Nervous Systems High Technology Center for the Study of the Effects of Harmful Agents, University of Pisa, Via Bonanno 6, Pisa, Italy
Clin Biochem 40:806-9. 2007..The presence of tubby protein in human lymphocytes was investigated and their electrophoretic mobility property between normal weight and obese subjects was compared... - Lopanoic acid rapidly controls type I amiodarone-induced thyrotoxicosis prior to thyroidectomyF Bogazzi
Department of Endocrinology and Metabolism, University of Pisa, Italy
J Endocrinol Invest 25:176-80. 2002..We suggest that IOP is the drug of choice in the rapid restoration of euthyroidism prior to definitive thyroidectomy in patients with drug resistant Type I AIT... - Role for inner ring deiodination preventing transcutaneous passage of thyroxineFerruccio Santini
Department of Endocrinology, University of Pisa, 56124 Pisa, Italy
J Clin Endocrinol Metab 88:2825-30. 2003..In conclusion, our study indicates that normal human skin serves as a substantial, but incomplete, barrier to T(4) passage. D3 plays an important role in augmenting T(4) blockade by inactivating T(4) to rT(3)... - Influence of human body composition on serum peak thyrotropin (TSH) after recombinant human TSH administration in patients with differentiated thyroid carcinomaMaria Grazia Castagna
Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
J Clin Endocrinol Metab 90:4047-50. 2005..CONCLUSIONS: With this study we demonstrated that LBM is the only parameter independently associated with serum peak TSH after rhTSH administration. However, the serum peak TSH does not influence the rate of (131)I remnant ablation... - Genetic analysis of the PAX8 gene in children with congenital hypothyroidism and dysgenetic or eutopic thyroid glands: identification of a novel sequence variantMassimo Tonacchera
Dipartimento di Endocrinologia e Metabolismo, Centro di Eccellenza AmbiSEN, Universita di Pisa, Pisa, Italy
Clin Endocrinol (Oxf) 67:34-40. 2007..To analyse the coding region of PAX8 in individuals with congenital (CH) or post neonatal hypothyroidism due to dysgenetic (TD) or eutopic thyroid glands... - Cytotoxic effects of carboplatinum and epirubicin in the setting of an elevated serum thyrotropin for advanced poorly differentiated thyroid cancerFerruccio Santini
Department of Endocrinology, University of Pisa, 56124 Pisa, Italy
J Clin Endocrinol Metab 87:4160-5. 2002..In conclusion, the response rate of poorly differentiated thyroid cancer to chemotherapy observed in this study was favorable and promising. TSH stimulation may have contributed to these results... - Thyroid autoimmunity may represent a predisposition for the development of fibromyalgia?L Bazzichi
Division of Rheumatology, Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
Rheumatol Int 32:335-41. 2012.... - Relative potencies and additivity of perchlorate, thiocyanate, nitrate, and iodide on the inhibition of radioactive iodide uptake by the human sodium iodide symporterMassimo Tonacchera
Department of Endocrinology and Metabolism and Research Center of Excellence for the Study of Damages to the Nervous and Endocrine Systems produced by Environmental, Alimentary and Pharmacological Agents, University of Pisa, Italy
Thyroid 14:1012-9. 2004.... - Cathepsin K null mice show reduced adiposity during the rapid accumulation of fat storesMarcella Funicello
Dulbecco Telethon Institute at Department of Endocrinology and Metabolism, University Hospital of Pisa, Pisa, Italy
PLoS ONE 2:e683. 2007..These results also demonstrate that under a HFD, ctsk deficiency confers a partial resistance to the development of dyslipidemia... - The comparative effects of bariatric surgery on weight and type 2 diabetesPierre Levy
LEGOS, University of Paris Dauphine, Paris, France
Obes Surg 17:1248-56. 2007..Weight reduction is beneficial as relative risk is reduced to 0.13 for weight loss >20 kg. This raises the question of effectiveness of bariatric surgery on 1) weight loss and 2) diabetes-related outcomes in morbidly obese patients...