Research Topics
Species | Mariaelvina SalaSummaryAffiliation: University of Milan Country: Italy Publications
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Detail Information
Publications
Learning and memory impairment induced by salvinorin A, the principal ingredient of Salvia divinorum, in wistar ratsDaniela Braida
Department of Pharmacology, Chemotherapy and Medical Toxicology, Universita degli Studi di Milano, Milan, Italy
Int J Toxicol 30:650-61. 2011..These findings demonstrate for the first time that salvinorin A has deleterious effects on learning and memory, through a ?-opioid receptor mechanism...- Endocannabinoids and 3,4-methylenedioxymethamphetamine (MDMA) interactionMariaelvina Sala
Department of Pharmacology, Chemotherapy and Medical Toxicology, Faculty of Sciences, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
Pharmacol Biochem Behav 81:407-16. 2005 - Involvement of kappa-opioid and endocannabinoid system on Salvinorin A-induced rewardDaniela Braida
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Milan, Italy
Biol Psychiatry 63:286-92. 2008..The abuse of selective k-agonists is a novel phenomenon, the mechanism of which is not fully understood... - Potential anxiolytic- and antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodentsDaniela Braida
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Milan, Italy
Br J Pharmacol 157:844-53. 2009..In the present study we investigated the possible anxiolytic- and antidepressant-like effects of the kappa-opioid receptor agonist salvinorin A, the main active ingredient of Salvia divinorum, in rats and mice... - Hallucinatory and rewarding effect of salvinorin A in zebrafish: kappa-opioid and CB1-cannabinoid receptor involvementDaniela Braida
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Via Vanvitelli 32, 20129, Milan, Italy
Psychopharmacology (Berl) 190:441-8. 2007..The hallucinatory effect and potential abuse of salvinorin A, the major ingredient of Salvia divinorum, has not been documented in animals... - Vanilloid VR1 receptor is involved in rimonabant-induced neuroprotectionSimona Pegorini
Department of Pharmacology, Chemotherapy and Medical Toxicology, Faculty of Sciences, University of Milan, Via Vanvitelli 32, Milan 20129, Italy
Br J Pharmacol 147:552-9. 2006..These findings suggest that VR1 vanilloid receptors are involved in rimonabant's neuroprotection even if other mechanisms can contribute to this effect... - Capsaicin exhibits neuroprotective effects in a model of transient global cerebral ischemia in Mongolian gerbilsSimona Pegorini
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
Br J Pharmacol 144:727-35. 2005..8. These results suggest that the neuroprotective effect of capsaicin may be attributable, at least in part, to VR1 desensitization and provide a valuable target for development of interventional pharmacological strategies... - Delta9-tetrahydrocannabinol-induced conditioned place preference and intracerebroventricular self-administration in ratsDaniela Braida
Department of Pharmacology, Chemotherapy and Medical Toxicology, Faculty of Sciences, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
Eur J Pharmacol 506:63-9. 2004..In conclusion, these findings demonstrate, for the first time, that low doses of Delta9-THC can act as an effective reinforcer in Wistar rats providing a reliable animal model of human marijuana abuse... - Diazepam protects against the enhanced toxicity of cocaine adulterated with atropineDaniela Braida
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Milan, Italy
J Pharmacol Sci 107:408-18. 2008..The present findings provide, for the first time, details of a synergistic toxic effect of the cocaine/atropine mixture and of the potential of diazepam for treating cocatropine-related hospital emergencies... - Effects of clioquinol on memory impairment and the neurochemical modifications induced by scrapie infection in golden hamstersSilvio R Bareggi
Department of Pharmacology, Chemotherapy and Medical Toxicology, School of Medicine, Milano, Italy
Brain Res 1280:195-200. 2009.... - Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a neurobehavioral model of autismMariaelvina Sala
Department of Pharmacology, Chemotherapy and Medical Toxicology, Universita degli Studi di Milano, Milan, Italy
Biol Psychiatry 69:875-82. 2011..Accordingly, the OT (Oxt(-/-)) and the OT receptor null mice (Oxtr(-/-)) display autistic-like deficits in social behavior, increased aggression, and reduced ultrasonic vocalization... - 5-HT1A receptors are involved in the anxiolytic effect of Delta9-tetrahydrocannabinol and AM 404, the anandamide transport inhibitor, in Sprague-Dawley ratsDaniela Braida
Department of Pharmacology, Chemotherapy and Medical Toxicology, Faculty of Sciences, University of Milan, Via Vanvitelli 32, 20129, Milan, Italy
Eur J Pharmacol 555:156-63. 2007..These data suggest that the anxiolytic effect produced by endo- and eso-cannabinoids is modulated by 5-HT1A receptors... - Role of the endocannabinoid system in MDMA intracerebral self-administration in ratsDaniela Braida
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Faculty of Mathematical, Physical and Natural Sciences, Via Vanvitelli 32, Italy
Br J Pharmacol 136:1089-92. 2002..5 mg kg(-1) i.p.), 15 min before each daily session, significantly increased MDMA self-administration. These findings suggest that MDMA self-administration is under endogenous tonic control by the endocannabinoid system... - Cognitive function in young and adult IL (interleukin)-6 deficient miceDaniela Braida
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Via Vanvitelli 32 A, 20129 Milan, Italy
Behav Brain Res 153:423-9. 2004..ChAT activity was inversely correlated with memory performance. These findings suggest a possible involvement of IL-6 on memory processes, even if the mechanism remains still unclear... - Neuroprotective effects of genistein in Mongolian gerbils: estrogen receptor-? involvementAndrea Donzelli
Department of Pharmacology, Chemotherapy and Medical Toxicology, Universita degli Studi di Milano, Italy
J Pharmacol Sci 114:158-67. 2010.... - Post-ischemic treatment with cannabidiol prevents electroencephalographic flattening, hyperlocomotion and neuronal injury in gerbilsDaniela Braida
Department of Pharmacology, Faculty of Sciences, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
Neurosci Lett 346:61-4. 2003..These findings suggest a potential therapeutic role of cannabidiol in cerebral ischemia, though the clear mechanism of action remains to be elucidated... - 3,4 methylenedioxymethamphetamine (ecstasy) impairs eight-arm radial maze performance and arm entry pattern in ratsDaniela Braida
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Italy
Behav Neurosci 116:298-304. 2002..These findings suggest that acute ecstasy mainly affects the long-term components of working memory and disrupts the pattern of arm entry in a way similar to serotonergic agents... - Pharmacokinetics and distribution of clioquinol in golden hamstersGianpietro Bondiolotti
Department of Pharmacology, Chemotherapy and Medical Toxicology, School of Medicine, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
J Pharm Pharmacol 59:387-93. 2007.... - Cellular mechanisms underlying the anxiolytic effect of low doses of peripheral Delta9-tetrahydrocannabinol in ratsTiziana Rubino
DBSF, Pharmacology Section and Center of Neuroscience, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio, Varese, Italy
Neuropsychopharmacology 32:2036-45. 2007.... - Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brainAnna L M Ferri
Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
Development 131:3805-19. 2004..These findings highlight a crucial and unexpected role for Sox2 in the maintenance of neurones in selected brain areas, and suggest a contribution of neural cell proliferative defects to the pathological phenotype...