Research Topics
Genomes and Genes | Innocenzo RaineroSummaryAffiliation: University of Turin Country: Italy Publications
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Publications
Association between the tumor necrosis factor-alpha -308 G/A gene polymorphism and migraineI Rainero
Neurology III Headache Center, Department of Neuroscience, University of Torino, Italy
Neurology 62:141-3. 2004..30, p < 0.001) but not in migraine with aura. These data suggest that the TNFalpha gene or a linked locus significantly modulates the risk for migraine...- Association between the G1246A polymorphism of the hypocretin receptor 2 gene and cluster headache: a meta-analysisInnocenzo Rainero
Neurology II Headache Centre, Department of Neuroscience, University of Turin, Via Cherasco 15, I 10126 Turin, Italy
J Headache Pain 8:152-6. 2007..75, CI 95% 1.37-2.25; RE OR 1.69, CI 95% 1.11-2.58). Our data confirm that the G1246A polymorphism of the HCRTR2 gene may modulate the genetic risk for CH... - Absence of linkage between the interleukin-6 gene (-174 G/C) polymorphism and migraineInnocenzo Rainero
Neurology III Headache Center, Department of Neuroscience, University of Torino, Via Cherasco 15 10126, Turin, Italy
Neurosci Lett 343:155-8. 2003..In conclusion, we found no significant association between the -174 G/C IL-6 polymorphism and the occurrence or the clinical features of migraine... - Haemochromatosis gene (HFE) polymorphisms and migraine: an association studyI Rainero
Neurology II, Headache Centre, Department of Neuroscience, University of Torino, Torino, Italy
Cephalalgia 27:9-13. 2007..Our data suggest that the HFE gene is not a major disease gene for migraine. However, the H63D polymorphism of the HFE gene may be considered a modifying genetic factor in migraine... - Association between migraine and HLA-DRB1 gene polymorphismsInnocenzo Rainero
Neurology III Headache Center, Department of Neuroscience, University of Turin, Via Cherasco 15, I 10126, Turin, Italy
J Headache Pain 6:185-7. 2005..We conclude that, in Italian patients, migraine is associated with different alleles of the HLA-DRB1 locus. Our data suggest the presence of a genetic susceptibility factor for migraine within the HLA region... - Association between the interleukin-1alpha gene and Alzheimer's disease: a meta-analysisI Rainero
Neurology III Headache Center, Department of Neuroscience, University of Turin, Via Cherasco, 15 10126 Torino, Italy
Neurobiol Aging 25:1293-8. 2004..Analysis of subgroups showed a significant association in patients with early-onset AD but not in late-onset AD. Our data support a significant but modest association between the T/T genotype of the IL-1alpha gene and AD... - A polymorphism of the hypocretin receptor 2 gene is associated with cluster headacheI Rainero
Neurology III Headache Center, Department of Neuroscience, University of Turin, Via Cherasco 15 10126 Turin, Italy
Neurology 63:1286-8. 2004..Homozygosity for the G allele was associated with an increased disease risk (OR: 6.79, 95% CI, 2.25 to 22.99). The data suggest that the HCRTR2 gene or a linked locus significantly modulates the risk for cluster headache... - HLA-DRB1 genotyping in Italian migraine patientsInnocenzo Rainero
Neurology III Headache Center, Department of Neuroscience, University of Torino, Via Cherasco 15, Torino 10126, Italy
Neurosci Lett 393:90-3. 2006..Our data suggest the presence of a genetic susceptibility factor for migraine without aura within the HLA region... - Insulin sensitivity is impaired in patients with migraineI Rainero
Neurology III Headache Centre, Department of Neuroscience, University of Turin, Italy
Cephalalgia 25:593-7. 2005..Our data show that insulin sensitivity is impaired in migraine and suggest a role for insulin resistance in the comorbidity between migraine and vascular diseases... - A comparison of familial and sporadic migraine in a headache clinic populationInnocenzo Rainero
Neurology III, Headache Center, Department of Neuroscience, University of Turin, Italy
Funct Neurol 17:193-7. 2002..01) earlier age at onset of the disease. No significant difference in all the remaining features examined was found. Our data suggest that famM and spoM represent a single disease entity... - Lack of association between the 3092 T-->C Clock gene polymorphism and cluster headacheI Rainero
Neurology III, Headache Centre, Department of Neuroscience, University of Torino, Torino, Italy
Cephalalgia 25:1078-81. 2005..In conclusion, our study suggests that the 3092 T-->C polymorphism of the Clock gene is unlikely to play an important role in cluster headache... - Evidence for an association between migraine and the hypocretin receptor 1 geneInnocenzo Rainero
Neurology II, Department of Neuroscience, University of Torino, Via Cherasco 15, 10126 Turin, Italy
J Headache Pain 12:193-9. 2011..In conclusion, our data supports the hypothesis that the HCRTR1 gene could represent a genetic susceptibility factor for migraine without aura and suggests that the hypocretin system may have a role in the pathophysiology of migraine... - Association between major mood disorders and the hypocretin receptor 1 geneInnocenzo Rainero
Neurology II, Department of Neuroscience, University of Turin, Italy
J Affect Disord 130:487-91. 2011.... - Neuroendocrine effects of subcutaneous sumatriptan in patients with migraineI Rainero
Neurology III, Headache Center, Department of Neuroscience, University of Turin, Italy
J Endocrinol Invest 24:310-4. 2001..The neuroendocrine response was not significantly different in the two groups. Our results suggest that 5-HT1D receptor sensitivity is not altered in migraine... - Quantitative EEG responses to ischaemic arm stress in migraineI Rainero
Neurology II Headache Center, Department of Neuroscience, University of Turin Medical School, Torino, Italy
Cephalalgia 21:224-9. 2001..The results of our study show that migraine sufferers display a lower threshold to physical stress and confirm previous studies indicating that migraine is a disease characterized by a state of altered neuronal excitability... - Apolipoprotein E gene polymorphisms in patients with migraineInnocenzo Rainero
Neurology III Headache Center, Department of Neuroscience, University of Torino, Via Cherasco 15, 10126 Turin, Italy
Neurosci Lett 317:111-3. 2002..In conclusion, we observed no significant association between APOE polymorphisms and migraine. The association between the APOE varepsilon2-varepsilon4 genotype and the tension-type headache deserves further evaluation... - Pro-inflammatory cytokine genes influence the clinical features of frontotemporal lobar degenerationInnocenzo Rainero
Neurology II, Department of Neuroscience, University of Turin, IT 10126 Turin, Italy
Dement Geriatr Cogn Disord 27:543-7. 2009..The objective of this study was to evaluate the association of functionally active polymorphisms in pro-inflammatory cytokine genes with the occurrence and the clinical features of the disease... - Hypocretins and primary headaches: neurobiology and clinical implicationsInnocenzo Rainero
Neurology II Headache Centre, Department of Neuroscience, University of Turin, Via Cherasco 15 10126, Torino, Italy
Expert Rev Neurother 8:409-16. 2008..The aim of this review is to describe and discuss recent studies in humans suggesting a role for the hypocretin neuronal system in cluster headache and chronic migraine... - Tumor necrosis factor-alpha gene and cerebral aneurysmsMarco Fontanella
Department of Neuroscience, Division of Neurosurgery, University of Turin, Turin, Italy
Neurosurgery 60:668-72; discussion 672-3. 2007..The purpose of this study is to evaluate the association of a functionally active polymorphism (-308 G<A) in the TNF-alpha gene with the risk and the clinical features of aneurysmal subarachnoid hemorrhage... - Interleukin-1 cluster gene polymorphisms and aneurysmal subarachnoid hemorrhageMarco Fontanella
Division of Neurosurgery, Department of Neuroscience, University of Torino, Torino, Italy
Neurosurgery 66:1058-62; discussion 1062-3. 2010..Interleukin (IL)-1 is a proinflammatory cytokine that plays a pivotal role in both acute and chronic central nervous system injuries... - Prevalence of HFE (hemochromatosis) gene mutations in patients with cluster headacheInnocenzo Rainero
Neurology III Headache Center, Department of Neuroscience, University of Turin, Turin, Italy
Headache 45:1219-23. 2005..To evaluate whether polymorphisms of the HFE gene would modify the occurrence and the clinical features of cluster headache (CH)... - Cluster headache is associated with the alcohol dehydrogenase 4 (ADH4) geneInnocenzo Rainero
Neurology II Headache Center, Department of Neuroscience, University of Torino, Torino, Italy
Headache 50:92-8. 2010..The purpose of this study was to investigate the association of genetic variants within the ADH4 gene with cluster headache susceptibility and phenotype... - Lack of association between the apolipoprotein E gene and aneurysmal subarachnoid hemorrhage in an Italian populationMarco Fontanella
Division of Neurosurgery, Department of Neuroscience, University of Turin, Italy
J Neurosurg 106:245-9. 2007..The purpose of this study was to evaluate whether a particular allele or genotype of the APOE gene would modify the occurrence or the clinical features of SAH... - Loss of expectation-related mechanisms in Alzheimer's disease makes analgesic therapies less effectiveFabrizio Benedetti
Department of Neuroscience, University of Turin Medical School, Turin, Italy
Pain 121:133-44. 2006.... - A polymorphism in the interleukin-1alpha gene influences the clinical features of migraineInnocenzo Rainero
Neurology III, Headache Center, Department of Neuroscience, University of Torino, Italy
Headache 42:337-40. 2002..To evaluate whether a particular genotype of the interleukin-1alpha (IL1A) gene affects the clinical features of migraine... - Pain perception and tolerance in patients with frontotemporal dementiaElisa Carlino
Department of Neuroscience, University of Turin, Turin, Italy
Pain 151:783-9. 2010..Our results suggest differences in pain processing changes in distinct types of dementia, while at the same time caution that pain perception assessment may depend on the criteria adopted for diagnosis... - Haplotype analysis confirms the association between the HCRTR2 gene and cluster headacheInnocenzo Rainero
Neurology II Headache Center, Department of Neuroscience, Turin, Italy
Headache 48:1108-14. 2008..This association was confirmed in a large study from Germany but was not replicated in a dataset of CH patients from Northern Europe... - Proinflammatory cytokine gene polymorphisms and susceptibility to Paget's disease of bone: an association studySalvatore Gallone
Neurology II, Department of Neuroscience, University of Torino, Italy
Cytokine 56:560-3. 2011.... - Brain arteriovenous malformations are associated with interleukin-1 cluster gene polymorphismsMarco Fontanella
Division of Neurosurgery, Department of Neuroscience, University of Torino, Torino, Italy
Neurosurgery 70:12-7. 2012..Functional polymorphisms in proinflammatory cytokines have been associated with various cerebrovascular phenotypes, including ischemic stroke, aneurysmal subarachnoid hemorrhage, and BAVM... - Anger and emotional distress in patients with migraine and tension-type headachePaolo Perozzo
Fondazione Carlo Molo, CE.R.NE, Turin, Italy
J Headache Pain 6:392-9. 2005.... - Absence of TARDBP gene mutations in an italian series of patients with frontotemporal lobar degenerationSalvatore Gallone
Neurology II, Department of Neuroscience, University of Turin, Turin, Italy
Dement Geriatr Cogn Disord 28:239-43. 2009..The aim of this study was to search for mutations of the TARDBP gene in the disease... - Conscious expectation and unconscious conditioning in analgesic, motor, and hormonal placebo/nocebo responsesFabrizio Benedetti
Department of Neuroscience, University of Turin Medical School, Turin, Italy 10125
J Neurosci 23:4315-23. 2003.... - Subarachnoid hemorrhage and negative angiography: clinical course and long-term follow-upMarco Fontanella
Division of Neurosurgery, Department of Neuroscience, University of Torino, Via Cherasco 15, 10126, Torino, Italy
Neurosurg Rev 34:477-84. 2011..D-SAH is probably due to an aneurysm that thrombose early after the bleeding. At short-term follow-up, the sack could frequently recanalize and rebleed, whereas a late follow-up shows that rebleeding is very rare... - Voxel-based morphometry reveals gray matter abnormalities in migraineWalter Valfrè
Neurology II, Headache Center, The Department of Neuroscience, University of Torino, Italy
Headache 48:109-17. 2008..Migraine is generally considered a functional brain disorder lacking structural abnormalities. Recent magnetic resonance imaging (MRI) studies, however, suggested that migraine may be associated with subtle brain lesions... - Anger, depression and personality dimensions in patients with migraine without auraGiovanni Abbate Daga
Psychiatry Section, Department of Neuroscience, Ospedale San Giovanni Battista, Psichiatria Universitaria CPR DCA, Turin, Italy
Psychother Psychosom 76:122-8. 2007..The aim of this study was to identify whether migraine patients and controls share distinctive personality traits... - Genetics of cluster headache: an updateLorenzo Pinessi
Neurology III, Headache Center, Department of Neuroscience, University of Turin, Via Cherasco 15, I 10126, Turin, Italy
J Headache Pain 6:234-6. 2005..Recently, we have reported a significant association between the HCRTR2 gene and the disease. The purpose of this review is to describe recent advances in the genetics of CH... - Endocrine function is altered in chronic migraine patients with medication-overuseInnocenzo Rainero
Department of Neuroscience, Neurology III--Headache Center, University of Turin, Via Cherasco 15, 10126 Torino, Italy
Headache 46:597-603. 2006..CONCLUSIONS: Our study shows that both corticotropic and somatotropic functions are significantly impaired in CM-MOH patients and suggests a role for hormones in the development of chronic migraine... - The 1246G-->A polymorphism of the HCRTR2 gene is not associated with migraineL Pinessi
Neurology II, Headache Centre, Department of Neuroscience, University of Torino, Torino, Italy
Cephalalgia 27:945-9. 2007..Comparison of the clinical features of the disease with the 1246G-->A genotypes showed no significant difference. Our data suggest that the HCRTR2 gene is not a genetic risk factor in migraine... - Pain reactivity in Alzheimer patients with different degrees of cognitive impairment and brain electrical activity deteriorationFabrizio Benedetti
Department of Neuroscience, University of Turin Medical School, Corso Raffaello 30, 10125 Turin, Italy
Pain 111:22-9. 2004..This sensory-affective dissociation is well correlated with the neuropathological findings in AD... - Resolution of cluster headache after closure of an anterior communicating artery aneurysm: the role of pericarotid sympathetic fibresSalvatore Gentile
Neurology III Headache Centre, Department of Neuroscience, University of Torino, Via Cherasco 15, 10126 Torino, Italy
Clin Neurol Neurosurg 108:195-8. 2006..We suggest that the surgical dissection of the pericarotid sympathetic fibres could prevent the onset of the cluster headache attacks by cutting part of the circuit underlying it... - Dehydroepiandrosterone sulfate (DHEA-S) and Alzheimer's dementia in older subjectsMario Bo
Section of Geriatrics, Department of Medical and Surgical Disciplines, University of Turin, Torino, Italy
Int J Geriatr Psychiatry 21:1065-70. 2006.... - Cluster headache attacks and multiple sclerosisSalvatore Gentile
Neurology II Headache Centre, Department of Neuroscience, University of Turin, Via Cherasco 15, I 10126, Torino, Italy
J Headache Pain 8:245-7. 2007..The association between cluster headache and MS has been rarely described before. This case suggests that in patients with cluster headache neuroimaging is often useful in order to exclude structural lesions... - Investigating the genetic role of aquaporin4 gene in migraineElisa Rubino
Neurology II, Department of Neuroscience, University of Turin, Via Cherasco 15, 10126 Turin, Italy
J Headache Pain 10:111-4. 2009..Our data do not support the hypothesis that the AQP4 gene could represent a genetic susceptibility factor for migraine... - Food and headache attacks. A comparison of patients with migraine and tension-type headacheL Savi
Neurology III, Headache Center, Department of Neuroscience, University of Turin, Turin, Italy
Panminerva Med 44:27-31. 2002..Some authors reported that also tension type headache attacks may be provoked by foods. The purpose of this study was to evaluate the role of foods as headache triggers in both groups of patients... - Reversible MRI abnormalities in a patient with recurrent status migrainosusS Gentile
Neurology II Headache Centre, Department of Neuroscience, University of Turin, Via Cherasco 15 10126 Torino, Italy
Cephalalgia 29:687-90. 2009..These abnormalities, confirmed also by positron emission tomography, suggest that status migrainosus can be associated with a condition of vasogenic cerebral oedema... - Interleukin 6 gene polymorphisms are not associated with aneurysmal subarachnoid haemorrhage in an Italian populationM Fontanella
Division of Neurosurgery, Department of Neuroscience, University of Turin, Via Cherasco 15 10126 Torino, Italy
J Neurol Neurosurg Psychiatry 79:471-3. 2008.... - Headache attributed to spontaneous low CSF pressure: report of three cases responsive to corticosteroidsS Gentile
Neurology III Headache Center, Department of Neuroscience, University of Torino, Torino, Italy
Eur J Neurol 11:849-51. 2004..We report three patients with headache attributed to spontaneous low CSF pressure that were successfully treated with oral prednisone. Additional studies may be useful to prove the effectiveness of corticosteroids in this syndrome... - Decreased sensitivity of 5-HT1D receptors in chronic tension-type headacheI Rainero
Neurology III-Headache Center, Department of Neuroscience, University of Turin, Italy
Headache 42:709-14. 2002..01 and <0.05) altered in CTTH patients in comparison with controls. CONCLUSION: Our results suggest that cerebral serotonergic functions mediated by 5-HT1D receptors are altered in CTTH... - Association of the C677T polymorphism in the MTHFR gene with migraine: a meta-analysisE Rubino
Neurology II, Headache Centre, Department of Neuroscience, University of Torino, Torino, Italy
Cephalalgia 29:818-25. 2009..32, 95% CI 1.10, 1.59; RE OR 1.63, 95% CI 1.10, 2.43). This study provides evidence for an association of the MTHFR gene only in migraine with aura... - Placebo analgesia and the heartAntonella Pollo
Department of Neuroscience, University of Turin Medical School, Corso Raffaello 30, 10125 Turin, Italy
Pain 102:125-33. 2003..15 Hz) spectral component was reduced during placebo analgesia, an effect that was reversed by naloxone. These findings indicate that placebo analgesia is accompanied by a complex cascade of events which affect the cardiovascular system... - Effects of subcutaneous sumatriptan on plasma growth hormone concentrations in migraine patientsL Pinessi
Neurology III Headache Centre, Department of Neuroscience, University of Turin, Italy
Cephalalgia 20:223-7. 2000..Our results suggest that cerebral serotonergic functions mediated by 5-HT1D receptors are not altered in migraine. Sumatriptan overuse could lead to adverse effects mediated by its neuroendocrine activity... - Pain threshold and tolerance in Alzheimer's diseaseF Benedetti
Department of Neuroscience, CIND Center for the Neurophysiology of Pain, University of Torino Medical School, Italy
Pain 80:377-82. 1999..Thus, pain tolerance is tightly related to the severity of the disease according to the rule, 'the more severe the MMSE and EEG changes, the higher the tolerance to pain'... - Abnormal 5-HT1D receptor function in cluster headache: a neuroendocrine study with sumatriptanL Pinessi
Neurology III, Headache Centre, Department of Neuroscience, Division of Endocrinology, Department of Internal Medicine and Division of Medicine, Department of Internal Medicine, University of Turin, Turin, Italy
Cephalalgia 23:354-60. 2003..05) reduced in patients with cluster headache, both in the active and in the remission period. Our results suggest that cerebral serotonergic functions mediated by 5-HT(1D) receptors are altered in patients with episodic cluster headache... - Chronic Helicobacter pylori infection and migraine: a case-control studyL Pinessi
Neurology III-Headache Center, Department of Neuroscience, University of Turin, Italy
Headache 40:836-9. 2000..CONCLUSIONS: Our study suggests that chronic Helicobacter pylori infection is not more frequent in patients with migraine than in controls and that infection does not modify clinical features of the disease... - Lack of interaction between a polymorphism in the dopamine D2 receptor gene and the clinical features of migraineN Rebaudengo
Neurology Service, Gradenigo Hospital, Turin, Italy
Cephalalgia 24:503-7. 2004..The results of our study do not support a role for the DRD2 gene in modifying the clinical features of migraine... - The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer diseaseEkaterina Rogaeva
Centre for Research in Neurodegenerative Diseases, Department of Medicine, Department, University of Toronto, Toronto, Ontario, Canada
Nat Genet 39:168-77. 2007..These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease... - Migraine headache and mood disorders: a descriptive study in an outpatient psychiatric populationLinda Franchini
Istituto Scientifico H San Raffaele, Department of Neuropsychiatric Sciences, School of Medicine, Universita Vita e Salute, Via Stamira d Ancona 20, 20127 Milan, Italy
J Affect Disord 81:157-60. 2004..Information is sparse concerning migraine distribution in mood disorder subjects based mainly on psychiatric disorder...