Research Topics
| Maria Beatrice PassaniSummaryAffiliation: University of Florence Country: Italy Publications
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Detail Information
Publications
Histamine receptors in the CNS as targets for therapeutic interventionMaria Beatrice Passani
Dipartimento di Farmacologia Preclinica e Clinica, Viale Pieraccini 6, 50139 Firenze I, Italy
Trends Pharmacol Sci 32:242-9. 2011..In this review, we discuss recent developments in the pharmacological manipulation of H3Rs and the implications for H3R-related therapies for neurological and psychiatric disorders. The legacy of Sir James Black...- The histamine H3 receptor and eating behaviorMaria Beatrice Passani
Dip Farmacologia preclinica e clinica, V le G Pieraccini 6, 50139 Firenze, Italy
J Pharmacol Exp Ther 336:24-9. 2011..The aim of this review is to outline the relevance of the histaminergic system in controlling feeding behavior and evaluate the potential therapeutic use of histaminergic ligands for the treatment of eating disorders... - Histamine in the brain: beyond sleep and memoryMaria Beatrice Passani
Dipartimento di Farmacologia Preclinica e Clinica Viale Pieraccini 6, 50139 Firenze, Italy
Biochem Pharmacol 73:1113-22. 2007.... - Regional differential effects of the novel histamine H3 receptor antagonist 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride (GSK189254) on histamine release in the central nervous system of freelyPatrizia Giannoni
Dipartimento di Farmacologia Preclinica e Clinica, Universita di Firenze, Firenze, Italy
J Pharmacol Exp Ther 332:164-72. 2010..Consistent with its effects on cortical ACh release, systemic administration of GSK189254 antagonized the amnesic effects of scopolamine in the rat object recognition test, a cognition paradigm with important cortical components... - Improvement in fear memory by histamine-elicited ERK2 activation in hippocampal CA3 cellsMaria Grazia Giovannini
Dipartimento di Farmacologia Preclinica e Clinica, Universita di Firenze, 50139 Firenze, Italy
J Neurosci 23:9016-23. 2003..Moreover, we demonstrate that the brain histaminergic system regulates hippocampal ERK cascade. Finally, our data indicate that early ERK2 hippocampal activation is not required for the expression of long-term fear memories... - Acetylcholine, histamine, and cognition: two sides of the same coinPatrizio Blandina
Dipartimento di Farmacologia Preclinica e Clinica, V.le G. Pieraccini 6, , 50139 Firenze, Italy
Learn Mem 11:1-8. 2004 - Heterogeneity of histaminergic neurons in the tuberomammillary nucleus of the ratPatrizia Giannoni
Dipartimento di Farmacologia Preclinica e Clinica, V le G Pieraccini 6, Universita di Firenze, 50139 Firenze, Italy
Eur J Neurosci 29:2363-74. 2009..This is the first evidence that histaminergic neurons are organized into functionally distinct circuits that influence different brain regions, and display selective control mechanisms... - The histamine H3 receptor as a novel therapeutic target for cognitive and sleep disordersMaria Beatrice Passani
Dipartimento di Farmacologia Preclinica e Clinica, , Viale Pieraccini 6, 50139 Firenze, Italy
Trends Pharmacol Sci 25:618-25. 2004..In light of the genetic, pharmacological and functional complexity of the H3 receptor, the importance of the histamine system as a therapeutic target to control the sleep-wake cycle and cognitive disorders will be discussed... - Central histaminergic system interactions and cognitionPatrizio Blandina
Dipartimento di Farmacologia Preclinica e Clinica, , Italy
EXS 98:149-63. 2006 - Endogenous histamine in the medial septum-diagonal band complex increases the release of acetylcholine from the hippocampus: a dual-probe microdialysis study in the freely moving ratLucia Bacciottini
Dipartimento di Farmacologia Preclinica e Clinica, Universita di Firenze, V le G Pieraccini 6, Italy
Eur J Neurosci 15:1669-80. 2002..These results indicate a role for endogenous histamine in modulating the cholinergic tone in the hippocampus... - Carbon monoxide modulates the response of human basophils to FcepsilonRI stimulation through the heme oxygenase pathwayAlfredo Vannacci
Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy
Eur J Pharmacol 465:289-97. 2003..This study suggests that CO increases cGMP formation, which in turn induces a fall in intracellular Ca(2+) concentration, thereby resulting in the inhibition of human basophil activation... - Aversive memory reactivation engages in the amygdala only some neurotransmitters involved in consolidationCorrado Bucherelli
Dipartimento di Scienze Fisiologiche, , 50134 Firenze, Italy
Learn Mem 13:426-30. 2006..The lability of retrieved memory affords opportunities to treat disorders such as phobias, post-traumatic stress, or chronic pain, and these results help searching for appropriate therapeutic targets...