M Papotti

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. ncbi Bone sialoprotein is predictive of bone metastases in resectable non-small-cell lung cancer: a retrospective case-control study
    Mauro Papotti
    Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Turin, Italy
    J Clin Oncol 24:4818-24. 2006
  2. ncbi Emerging drugs for adrenocortical carcinoma
    Alfredo Berruti
    Department of Clinical and Biological Science, Oncologia Medica, University of Turin, Azienda Ospedaliera San Luigi, Regione Gonzole 10, 10043 Orbassano, Italy
    Expert Opin Emerg Drugs 13:497-509. 2008
  3. ncbi Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation
    Marco Lo Iacono
    Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
    J Transl Med 9:100. 2011
  4. ncbi Continuous 5-fluorouracil infusion plus long acting octreotide in advanced well-differentiated neuroendocrine carcinomas. A phase II trial of the Piemonte oncology network
    Maria P Brizzi
    Oncologia Medica, Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Azienda Ospedaliera San Luigi, Regione Gonzole, 10, 10043 Orbassano TO, Italy
    BMC Cancer 9:388. 2009
  5. ncbi Role of galectin-3 immunodetection in the cytological diagnosis of thyroid cystic papillary carcinoma
    Mauro Papotti
    Department of Pathology, University of Turin, Italy
    Eur J Endocrinol 147:515-21. 2002
  6. ncbi Adrenocortical tumors with myxoid features: a distinct morphologic and phenotypical variant exhibiting malignant behavior
    Mauro Papotti
    Department of Clinical and Biological Sciences, University of Turin at St Luigi Hospital, Orbassano, Torino, Italy
    Am J Surg Pathol 34:973-83. 2010
  7. ncbi Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis
    M Papotti
    Department of Biomedical Sciences and Oncology, University of Turin, Via Santena 7, 10126 Turin, Italy
    Virchows Arch 440:461-75. 2002
  8. ncbi Pathological and molecular features of adrenocortical carcinoma: an update
    M Volante
    Department of Clinical and Biological Sciences, Division of Pathology, University of Turin at San Luigi Hospital, Orbassano, Torino, Italy
    J Clin Pathol 61:787-93. 2008
  9. ncbi Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors
    Marco Volante
    Department of Biomedical Sciences and Oncology, University of Turin, I 10126 Torino, Italy
    J Clin Endocrinol Metab 87:1300-8. 2002
  10. ncbi Galectin-3 and HBME-1 expression in well-differentiated thyroid tumors with follicular architecture of uncertain malignant potential
    Mauro Papotti
    Department of Clinical and Biological Sciences, University of Turin and St Luigi Hospital, Orbassano, Turin, Italy
    Mod Pathol 18:541-6. 2005

Detail Information

Publications124 found, 100 shown here

  1. ncbi Bone sialoprotein is predictive of bone metastases in resectable non-small-cell lung cancer: a retrospective case-control study
    Mauro Papotti
    Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Turin, Italy
    J Clin Oncol 24:4818-24. 2006
    ..Currently, there are no predictive or diagnostic markers to identify high-risk patients for metastatic bone dissemination...
  2. ncbi Emerging drugs for adrenocortical carcinoma
    Alfredo Berruti
    Department of Clinical and Biological Science, Oncologia Medica, University of Turin, Azienda Ospedaliera San Luigi, Regione Gonzole 10, 10043 Orbassano, Italy
    Expert Opin Emerg Drugs 13:497-509. 2008
    ..Adrenocortical carcinoma (ACC) is an extremely rare aggressive disease. Few data are available on the efficacy of systemic antineoplastic treatments (mitotane and cytotoxic therapy) in the treatment of advanced disease...
  3. ncbi Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation
    Marco Lo Iacono
    Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
    J Transl Med 9:100. 2011
    ..The purpose of the present study was to investigate the expression of AURKA in non small cell lung cancer (NSCLC) specimens and to correlate its mRNA or protein expression with patients' clinico-pathological features...
  4. ncbi Continuous 5-fluorouracil infusion plus long acting octreotide in advanced well-differentiated neuroendocrine carcinomas. A phase II trial of the Piemonte oncology network
    Maria P Brizzi
    Oncologia Medica, Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Azienda Ospedaliera San Luigi, Regione Gonzole, 10, 10043 Orbassano TO, Italy
    BMC Cancer 9:388. 2009
    ..A phase II study was designed to test the activity of protracted 5-fluorouracil (5FU) infusion plus long-acting release (LAR) octreotide in patients with neuroendocrine carcinoma...
  5. ncbi Role of galectin-3 immunodetection in the cytological diagnosis of thyroid cystic papillary carcinoma
    Mauro Papotti
    Department of Pathology, University of Turin, Italy
    Eur J Endocrinol 147:515-21. 2002
    ..The aim of this study was to assess the role of galectin-3 immunodetection in a series of FNA cytological samples of benign and malignant thyroid cystic nodules...
  6. ncbi Adrenocortical tumors with myxoid features: a distinct morphologic and phenotypical variant exhibiting malignant behavior
    Mauro Papotti
    Department of Clinical and Biological Sciences, University of Turin at St Luigi Hospital, Orbassano, Torino, Italy
    Am J Surg Pathol 34:973-83. 2010
    ....
  7. ncbi Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis
    M Papotti
    Department of Biomedical Sciences and Oncology, University of Turin, Via Santena 7, 10126 Turin, Italy
    Virchows Arch 440:461-75. 2002
    ..It is concluded that SSTRs 1-5 are heterogeneously expressed in GEP endocrine tumors and that IHC is a reliable tool to detect SSTR types 2, 3 and 5 in surgical and biopsy specimens...
  8. ncbi Pathological and molecular features of adrenocortical carcinoma: an update
    M Volante
    Department of Clinical and Biological Sciences, Division of Pathology, University of Turin at San Luigi Hospital, Orbassano, Torino, Italy
    J Clin Pathol 61:787-93. 2008
    ..However, these markers are not sufficiently sensitive and specific to replace conventional morphological criteria...
  9. ncbi Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors
    Marco Volante
    Department of Biomedical Sciences and Oncology, University of Turin, I 10126 Torino, Italy
    J Clin Endocrinol Metab 87:1300-8. 2002
    ..Expression of GHS-R in some of the endocrine tumors studied indicates that autocrine/paracrine circuits may be active in neoplastic conditions...
  10. ncbi Galectin-3 and HBME-1 expression in well-differentiated thyroid tumors with follicular architecture of uncertain malignant potential
    Mauro Papotti
    Department of Clinical and Biological Sciences, University of Turin and St Luigi Hospital, Orbassano, Turin, Italy
    Mod Pathol 18:541-6. 2005
    ..The relationship found between the markers investigated and these nuclear changes suggests that the tumors containing them are pathogenetically linked to papillary carcinomas...
  11. ncbi Ghrelin-producing endocrine tumors of the stomach and intestine
    M Papotti
    Department of Biomedical Sciences, University of Turin, Via Santena 7, I 10126 Turin, Italy
    J Clin Endocrinol Metab 86:5052-9. 2001
    ..These hyperplastic/neoplastic conditions could represent the clinical model to clarify the existence and impact of ghrelin hypersecretion on endocrine and nonendocrine functions...
  12. ncbi Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines
    P Cassoni
    Department of Biomedical Sciences and Oncology, University of Turin, 10126 Turin, Italy
    J Clin Endocrinol Metab 86:1738-45. 2001
    ..In conclusion, this study provides the first demonstration of specific GHS binding sites, other than GHS-R1, in breast cancer. These receptors probably mediate growth inhibitory effects on breast carcinoma cells in vitro...
  13. ncbi Biologic activities of growth hormone secretagogues in humans
    E Ghigo
    Department of Internal Medicine, University of Turin, Italy
    Endocrine 14:87-93. 2001
    ..The discovery of ghrelin, a 28 amino acid peptide synthesized in the stomach but also in other tissues, has opened new fascinating perspectives of research in this field...
  14. ncbi Expression of apocrine differentiation markers in neuroendocrine breast carcinomas of aged women
    A Sapino
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126 Turin, Italy
    Mod Pathol 14:768-76. 2001
    ..In addition, the possibility for using Chs or GCDFP-15 serum values in the follow-up of these patients, as demonstrated in two cases of the present series, can justify the immunophenotyping of the tumors...
  15. ncbi Ghrelin and cortistatin in lung cancer: expression of peptides and related receptors in human primary tumors and in vitro effect on the H345 small cell carcinoma cell line
    P Cassoni
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    J Endocrinol Invest 29:781-90. 2006
    ....
  16. ncbi Growth hormone-releasing hormone and growth hormone secretagogue-receptor ligands: focus on reproductive system
    E Arvat
    Department of Internal Medicine, University of Turin, Italy
    Endocrine 14:35-43. 2001
    ..Because GHRH and GHS receptors share the same localization in some peripheral tissues, they may have some interactions even at this level...
  17. ncbi Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone
    E Arvat
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, 10126 Turin, Italy
    J Clin Endocrinol Metab 86:1169-74. 2001
    ..Thus, ghrelin is a new hormone playing a major role in the control of somatotroph secretion in humans, and its effects are imitated by nonnatural GHS...
  18. ncbi Cortistatin-14 inhibits cell proliferation of human thyroid carcinoma cell lines of both follicular and parafollicular origin
    P Cassoni
    Department of Biomedical Sciences and Oncology, University of Turin, Italy
    J Endocrinol Invest 25:362-8. 2002
    ..Taken together, these data firstly demonstrate that EP-80874 has a mixed SRIH/CST antagonist activity and suggest that the oncostatic effect of CST-14 on thyroid cancer cells could be mediated by both sst and/or GHS-R...
  19. ncbi Binding of 125I-labeled ghrelin to membranes from human hypothalamus and pituitary gland
    G Muccioli
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Italy
    J Endocrinol Invest 24:RC7-9. 2001
    ..These receptors are the specific binding sites for GHS and their antagonists, as well as for SRIH analogs (vapreotide and cortistatin- 14), but not for native SRIH...
  20. ncbi Clinical significance of neuroendocrine carcinoma of the breast
    A Sapino
    Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
    Ann Oncol 12:S115-7. 2001
    ..In the present work, the clinical significance of pure' NE differentiation in breast carcinoma and of its 'variants' will be analyzed...
  21. ncbi Somatostatin receptor tissue distribution in lung neuroendocrine tumours: a clinicopathologic and immunohistochemical study of 218 'clinically aggressive' cases
    L Righi
    Division of Pathology, Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Orbassano, Torino
    Ann Oncol 21:548-55. 2010
    ....
  22. ncbi Characterization of thyroid 'follicular neoplasms' in fine-needle aspiration cytological specimens using a panel of immunohistochemical markers: a proposal for clinical application
    E Saggiorato
    Section of Endocrinology, Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Orbassano TO, Italy
    Endocr Relat Cancer 12:305-17. 2005
    ..The combination of three or more markers did not substantially improve the diagnostic accuracy of the test...
  23. ncbi Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans
    F Broglio
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, 10126 Turin, Italy
    J Clin Endocrinol Metab 86:5083-6. 2001
    ....
  24. ncbi Somatostatin, cortistatin and their receptors in tumours
    M Volante
    Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Orbassano, University of Turin, Torino, Italy
    Mol Cell Endocrinol 286:219-29. 2008
    ..Thus, in comparison to SS analogs, CST synthetic analogs may represent additional diagnostic/therapeutic tools in those tumours expressing the receptors for SS, for ghrelin or for both peptides...
  25. ncbi Expression of somatostatin receptor types 2, 3 and 5 in biopsies and surgical specimens of human lung tumours. Correlation with preoperative octreotide scintigraphy
    M Papotti
    Department of Biomedical Sciences and Oncology, University of Turin, Torino, Italy
    Virchows Arch 439:787-97. 2001
    ..IHC can therefore be usefully coupled to radionuclear investigations to better characterize the sst cellular location and subtype in lung tumors...
  26. ncbi Galectin-3: presurgical marker of thyroid follicular epithelial cell-derived carcinomas
    E Saggiorato
    Section of Endocrinology, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
    J Endocrinol Invest 27:311-7. 2004
    ..The routine correct use of galectin-3, by increasing the diagnostic accuracy of conventional cytology, improves the management of thyroid nodules and can lead to a sensitive reduction of useless thyroid surgeries...
  27. ncbi Presence of cortistatin in the human pancreas
    M Papotti
    Department of Biomedical Sciences, Pharmacology and Forensic Medicine, University of Turin, Torino, Italy
    J Endocrinol Invest 26:RC15-8. 2003
    ..Thus, our findings show the presence of CST in the human endocrine pancreas. Local autocrine or paracrine circuits, only in part overlapped with those of SRIF, may be active to modulate insulin and/or glucagon levels...
  28. ncbi Natural and synthetic growth hormone secretagogues: do they have therapeutic potential?
    F Broglio
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy
    Treat Endocrinol 2:153-63. 2003
    ....
  29. ncbi Growth hormone secretagogue binding sites in peripheral human tissues
    M Papotti
    Department of Biomedical Sciences, University of Turin, Italy
    J Clin Endocrinol Metab 85:3803-7. 2000
    ..This study provides the first detailed analysis of the tissue localization of GHS receptors and suggests that a still unknown receptor subtype, specific for peptidyl GHS, may exist in the heart and in other tissues...
  30. ncbi Large cell neuroendocrine carcinoma of the gallbladder: report of two cases
    M Papotti
    Department of Pathology, University of Turin, Italy
    Am J Surg Pathol 24:1424-8. 2000
    ..More importantly, however, the recognition of this rare tumor type carries important clinical implications in regard to the use of chemotherapeutic agents and supplemental treatments (for example, somatostatin analogs)...
  31. ncbi Extensive DNA fragmentation in oxyphilic cell lesions of the thyroid
    M Volante
    Departments of Biomedical Sciences and Oncology, University of Turin, Torino, Italy
    J Histochem Cytochem 49:1003-11. 2001
    ..These findings are consistent with an extensive DNA fragmentation peculiar to oxyphilic cells, which is not directly related to apoptosis and whose origin and biological significance are presently unknown...
  32. ncbi Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans
    Fabio Broglio
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, 10126 Turin, Italy
    J Clin Endocrinol Metab 87:3783-90. 2002
    ....
  33. ncbi Ghrelin expression in fetal, infant, and adult human lung
    Marco Volante
    Department of Pathology, University of Turin, Turin, Italy
    J Histochem Cytochem 50:1013-21. 2002
    ..We conclude that the fetal lung is an additional source of circulating ghrelin, whose functions at the respiratory tract level remain to be clarified...
  34. ncbi Immunohistochemical detection of somatostatin receptor types 1-5 in medullary carcinoma of the thyroid
    M Papotti
    Department of Biomedical Sciences and Oncology, University of Turin, Italy
    Clin Endocrinol (Oxf) 54:641-9. 2001
    ....
  35. ncbi Ghrelin in fetal thyroid and follicular tumors and cell lines: expression and effects on tumor growth
    Marco Volante
    Departments of Pathology, Endocrinology, and Pharmacology, University of Turin, Turin
    Am J Pathol 162:645-54. 2003
    ....
  36. ncbi Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines
    Paola Cassoni
    Department of Biomedical Sciences and Oncology, Division of Pathology, University of Turin, Turin, Italy
    Eur J Endocrinol 150:173-84. 2004
    ..Ghrelin, a natural growth hormone secretagogue (GHS), has been identified in prostate carcinoma cell lines...
  37. ncbi Epidermal growth factor ligand/receptor loop and downstream signaling activation pattern in completely resected nonsmall cell lung cancer
    Marco Volante
    Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
    Cancer 110:1321-8. 2007
    ....
  38. ncbi Ghrelin: more than a natural GH secretagogue and/or an orexigenic factor
    E Ghigo
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Italy
    Clin Endocrinol (Oxf) 62:1-17. 2005
    ....
  39. ncbi Classic and recent special stains used in differential diagnosis of endocrine tumors
    G Bussolati
    Department of Biomedical Sciences and Oncology, University of Turin, Via Santena 7, I 10126 Turin, Italy
    Endocr Pathol 12:379-87. 2001
    ....
  40. ncbi Ectopic secretion of LH by an endocrine pancreatic tumor
    E Brignardello
    Division of Endocrine Oncology, COES, University of Turin, Turin, Italy
    J Endocrinol Invest 27:361-5. 2004
    ..Testosterone was slightly below normal, but the patient reported an increase of libido. This is an unusual case of ectopic secretion of LH from an endocrine tumor of the pancreas...
  41. ncbi Galectin-3 and Ki-67 expression in multiglandular parathyroid lesions
    Enrico Saggiorato
    Section of Endocrinology, University of Turin, Italy
    Am J Clin Pathol 126:59-66. 2006
    ....
  42. ncbi Ghrelin secretion is inhibited by either somatostatin or cortistatin in humans
    Fabio Broglio
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy
    J Clin Endocrinol Metab 87:4829-32. 2002
    ..05) than those at baseline. In conclusion, this study first shows that SRIF and CST strongly inhibits ghrelin secretion that, differently from GH and insulin secretion, persists inhibited even after stopping the infusion of SRIF or CST...
  43. ncbi Obestatin in human neuroendocrine tissues and tumours: expression and effect on tumour growth
    Marco Volante
    Department of Clinical and Biological Sciences at San Luigi Hospital, University of Turin, Orbassano, Turin, Italy
    J Pathol 218:458-66. 2009
    ....
  44. ncbi Galectin-3 and HBME-1 expression in oncocytic cell tumors of the thyroid
    Marco Volante
    Department of Biomedical Sciences and Oncology, University of Turin, Turin, Italy
    Virchows Arch 445:183-8. 2004
    ....
  45. ncbi Expression of cortistatin and MrgX2, a specific cortistatin receptor, in human neuroendocrine tissues and related tumours
    Elena Allia
    Department of Biomedical Sciences and Oncology, University of Turin, Turin, Italy
    J Pathol 207:336-45. 2005
    ....
  46. ncbi Argyrophilic neuroendocrine carcinoma of the male breast
    M Papotti
    Department of Human Oncology, University of Turin, Torino, Italy
    Ultrastruct Pathol 17:115-21. 1993
    ..Argyrophilia, expression of chromogranins at both protein and gene level, and the presence of dense granules of the neurosecretory type by electron microscopy were demonstrated...
  47. ncbi Adrenal pseudocyst mimicking cancer: a case report
    S Bovio
    Division of Internal Medicine I, Department of Biological and Clinical Science, A S O San Luigi, Orbassano, Italy
    J Endocrinol Invest 30:256-8. 2007
    ..We report herein the case of an adrenal hemorrhagic pseudocyst that simulated adrenocortical cancer and argue on the clinical clues for a differential diagnosis with other adrenal tumors...
  48. ncbi New strategies for targeting the therapy of NSCLC: the role of ERCC1 and TS
    P Ceppi
    Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
    Adv Med Sci 55:22-5. 2010
    ..Here is presented a brief overview of the literature regarding these two genes that are currently under prospective investigation as predictive markers of treatment efficacy in NSCLC...
  49. ncbi RET/PTC activation in hyalinizing trabecular tumors of the thyroid
    M Papotti
    Dipartimenti di Anatomia Patologica, Universita di Torino, Italy
    Am J Surg Pathol 24:1615-21. 2000
    ..6%) of HTTs and papillary carcinomas exhibit the same RET proto-oncogene alterations. Thus, HTT may represent the "hyalinizing trabecular" variant of papillary carcinoma rather than a separate entity...
  50. ncbi Secondary and tertiary hyperparathyroidism: causes of recurrent disease after 446 parathyroidectomies
    G Gasparri
    Department of Fisiopatologia Clinica, Universita di Torino, Via Genova, Torino, Italy
    Ann Surg 233:65-9. 2001
    ....
  51. ncbi Polymerase eta mRNA expression predicts survival of non-small cell lung cancer patients treated with platinum-based chemotherapy
    Paolo Ceppi
    Thoracic Oncology Unit, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano Torino, Italy
    Clin Cancer Res 15:1039-45. 2009
    ..The aim of the present study was to investigate the role of Pol eta mRNA expression levels in non-small cell lung cancer (NSCLC)...
  52. ncbi Growth hormone-releasing hormone promotes survival of cardiac myocytes in vitro and protects against ischaemia-reperfusion injury in rat heart
    Riccarda Granata
    Laboratory of Molecular and Cellular Endocrinology, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy
    Cardiovasc Res 83:303-12. 2009
    ..We investigated GHRH effects on cardiac myocyte cell survival and the underlying signalling mechanisms...
  53. ncbi Poorly differentiated thyroid carcinoma: diagnostic features and controversial issues
    Marco Volante
    Department of Clinical and Biological Sciences, San Luigi Hospital, University of Turin, Regione Gonzole 10, 10043, Orbassano, Turin, Italy
    Endocr Pathol 19:150-5. 2008
    ..The present paper aims to review the various aspects of this tumor type, from morphology to immunohistochemistry and molecular abnormalities from a practical and daily practice-oriented point of view...
  54. ncbi Epidermal growth factor receptor gene in primary tumor and metastatic sites from non-small cell lung cancer
    Lorenzo Daniele
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    J Thorac Oncol 4:684-8. 2009
    ..Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors are capable of reducing brain and adrenal metastases. However, the EGFR status may be discordant between primary NSCLC and the corresponding metastases...
  55. ncbi Non-small cell lung cancer exhibits transcript overexpression of genes associated with homologous recombination and DNA replication pathways
    Silvia Saviozzi
    Genomics and Informatics Unit, University of Torino, Turin, Italy
    Cancer Res 69:3390-6. 2009
    ..In conclusion, genes belonging to DNA repair/replication pathways are overexpressed in NSCLC and are associated with a more aggressive phenotype...
  56. ncbi Caveolin-1 expression in lung carcinoma varies according to tumour histotype and is acquired de novo in brain metastases
    Paola Cassoni
    Department of Biomedical Sciences and Oncology, University of Turin, Turin, Italy
    Histopathology 55:20-7. 2009
    ..To study caveolin-1 (Cav-1) expression in metastatic lung carcinomas...
  57. ncbi 99mTc-MIBI Imaging in the presurgical characterization of thyroid follicular neoplasms: relationship to multidrug resistance protein expression
    Enrico Saggiorato
    Section of Endocrinology, Division of Internal Medicine, Department of Clinical and Biological Sciences, Gradenigo Hospital, University of Turin, Turin, Italy
    J Nucl Med 50:1785-93. 2009
    ..This study also aimed to analyze the relationship between (99m)Tc-MIBI images and P-glycoprotein (P-gp)/multidrug resistance-associated protein-1 (MRP1) immunohistochemical expression...
  58. ncbi Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats
    Riccarda Granata
    Division of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy
    J Mol Endocrinol 45:9-17. 2010
    ..Taken together, our results suggest that in STZ-treated newborn rats, UAG and Ob improve glucose metabolism and preserve islet cell mass, granting a therapeutic potential in medical conditions associated with impaired beta-cell function...
  59. ncbi Increased neuroendocrine cells in resected metastases compared to primary colorectal adenocarcinomas
    Marco Volante
    University of Turin at San Luigi Hospital, Orbassano, Torino, Italy
    Virchows Arch 457:521-7. 2010
    ....
  60. ncbi Somatostatin receptor type 2A immunohistochemistry in neuroendocrine tumors: a proposal of scoring system correlated with somatostatin receptor scintigraphy
    Marco Volante
    Department of Clinical and Biological Sciences, San Luigi Hospital, University of Turin, Orbassano, Turin, Italy
    Mod Pathol 20:1172-82. 2007
    ....
  61. ncbi Goblet cell carcinoids and other mixed neuroendocrine/nonneuroendocrine neoplasms
    Marco Volante
    Department of Clinical and Biological Sciences, University of Turin and San Luigi Hospital, Regione Gonzole10, 10043, Orbassano, Torino, Italy
    Virchows Arch 451:S61-9. 2007
    ..Moreover, molecular and clinical aspects, which might help to understand their possible histogenesis and biological behavior, will be reviewed...
  62. ncbi Poorly differentiated thyroid carcinoma: 5 years after the 2004 WHO classification of endocrine tumours
    Marco Volante
    Department of Clinical and Biological Sciences at San Luigi Hospital, University of Turin, Regione Gonzole 10, 10043, Orbassano, Turin, Italy
    Endocr Pathol 21:1-6. 2010
    ....
  63. ncbi Brain-gut communication: cortistatin, somatostatin and ghrelin
    Fabio Broglio
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy
    Trends Endocrinol Metab 18:246-51. 2007
    ..Here, we review the data leading to this working hypothesis and discuss the in vitro, in vivo and clinical implications of potential SST-receptor-independent, GHSR-1a-mediated neuroendocrine and metabolic effects of CST...
  64. ncbi Gemcitabine plus metronomic 5-fluorouracil or capecitabine as a second-/third-line chemotherapy in advanced adrenocortical carcinoma: a multicenter phase II study
    Paola Sperone
    Dipartimento di Scienze Cliniche e Biologiche Università di Torino, Orbassano, Italy
    Endocr Relat Cancer 17:445-53. 2010
    ..3 (range: 1-43) and 9.8 months (range: 3-73) respectively. Gemcitabine plus metronomic fluoropyrimidines is a well-tolerated and moderately active regimen in heavily pretreated ACC patients...
  65. ncbi Six-year stabilisation of a relapsed pelvic mass from rectal cancer after oxaliplatin-containing chemotherapy
    Marco Tampellini
    Department of Medical Oncology, University of Torino at San Luigi Hospital, Regione Gonzole 10, 10043, Orbassano, Torino, Italy
    J Cancer Res Clin Oncol 133:783-5. 2007
    ..Death of all the cancer cells, neuroendocrine cells selection, or cell dormancy are some of the discussed explanations to this unique observation. An intriguing question remains open: Should this patient be considered cured?..
  66. ncbi Obestatin promotes survival of pancreatic beta-cells and human islets and induces expression of genes involved in the regulation of beta-cell mass and function
    Riccarda Granata
    Laboratory of Molecular and Cellular Endocrinology, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti, 14 10126 Turin, Italy
    Diabetes 57:967-79. 2008
    ..We investigated obestatin effect on survival of beta-cells and human pancreatic islets and the underlying signaling pathways...
  67. ncbi Clinicopathological study of a series of 92 adrenocortical carcinomas: from a proposal of simplified diagnostic algorithm to prognostic stratification
    Marco Volante
    Division of Pathology, Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Turin, Italy
    Histopathology 55:535-43. 2009
    ..The aim was to investigate the impact of individual pathological parameters in the diagnosis and prognosis of adrenocortical carcinoma...
  68. ncbi Poorly differentiated carcinoma of the thyroid: validation of the Turin proposal and analysis of IMP3 expression
    Sofia Asioli
    Division of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Mod Pathol 23:1269-78. 2010
    ..Expression of IMP3 appears to be an adverse prognostic factor for poorly differentiated thyroid carcinoma...
  69. ncbi Thymidylate synthase expression in gastroenteropancreatic and pulmonary neuroendocrine tumors
    Paolo Ceppi
    Thoracic Oncology Unit, Pathology Division, Department of Clinical and Biological Sciences, University of Torino, San Luigi Hospital, Torino, Italy
    Clin Cancer Res 14:1059-64. 2008
    ..Neuroendocrine tumors (NET) represent potential targets of antifolate agents, but no data on TS expression level in these tumors are currently available...
  70. ncbi A practical diagnostic approach to solid/trabecular nodules in the thyroid
    Marco Volante
    Department of Clinical and Biological Sciences at San Luigi Hospital, University of Turin, Regione Gonzole 10, Turin, Orbassano, Italy
    Endocr Pathol 19:75-81. 2008
    ..A schematic algorithm is presented, which takes into consideration the diagnostic hallmarks of the most relevant entities that enter in the differential diagnosis in solid/trabecular nodules within the thyroid...
  71. ncbi The usefulness of preoperative dual-phase 99mTc MIBI-scintigraphy and IO-PTH assay in the treatment of secondary and tertiary hyperparathyroidism
    Guido Gasparri
    III degrees General and Esophageal Surgical Unit, Saint John Baptist Hospital, University of Turin, Turin, Italy
    Ann Surg 250:868-71. 2009
    ..Recurrent HPT after total Ptx with autotransplantation is usually due to overgrowth of the autograft or for the previously mentioned reasons...
  72. ncbi RAS mutations are the predominant molecular alteration in poorly differentiated thyroid carcinomas and bear prognostic impact
    Marco Volante
    Department of Clinical and Biological Sciences, San Luigi Hospital, 10043 Orbassano, Italy
    J Clin Endocrinol Metab 94:4735-41. 2009
    ..Recently homogeneous diagnostic criteria have been proposed by our group (Turin proposal) that need to be complemented by detailed molecular characterization...
  73. ncbi p63 and p73 isoform expression in non-small cell lung cancer and corresponding morphological normal lung tissue
    Marco Lo Iacono
    Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
    J Thorac Oncol 6:473-81. 2011
    ..It has been recently hypothesized that altered ?N:TA expression ratio, rather than single isoform overexpression, plays a role in the pathogenesis of many diseases, including lung cancer...
  74. ncbi Diagnostic accuracy and clinical impact of imaging-guided needle biopsy of renal masses. Retrospective analysis on 150 cases
    Andrea Veltri
    Institute of Radiology, University of Torino, Facoltà San Luigi Gonzaga, Orbassano TO, Italy
    Eur Radiol 21:393-401. 2011
    ..To review our method of perform needle biopsies of renal masses...
  75. ncbi Mammalian target of rapamycin signaling activation patterns in neuroendocrine tumors of the lung
    Luisella Righi
    Division of Pathology, Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Regione Gonzole 10, Orbassano, Turin, Italy
    Endocr Relat Cancer 17:977-87. 2010
    ....
  76. ncbi Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach
    Marco Volante
    Department of Clinical and Biological Sciences at San Luigi Hospital, University of Turin, Turin, Italy
    Am J Surg Pathol 31:1256-64. 2007
    ..An algorithmic approach was devised for practical use in the diagnosis of this tumor...
  77. ncbi Absence of RET gene point mutations in sporadic thyroid C-cell hyperplasia
    Enrico Saggiorato
    Section of Endocrinology, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Italy
    J Mol Diagn 9:214-9. 2007
    ....
  78. ncbi Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase
    Paolo Ceppi
    Thoracic Oncology Unit, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Torino, Italy
    Cancer 107:1589-96. 2006
    ..This information may be useful in selecting which patients with NSCLC should receive treatment with TS-inhibiting agents...
  79. ncbi Galectin-3 expression in parathyroid carcinoma: immunohistochemical study of 26 cases
    Nicoletta Bergero
    Division of Pathology, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, 10043 Prbassano, Italy
    Hum Pathol 36:908-14. 2005
    ..We conclude that Gal-3 immunostaining is a valuable tool to support a diagnosis of PC in highly proliferating (Ki67 >6%) tumors affecting a single parathyroid gland...
  80. ncbi Matrix metalloproteinase type 2 expression in malignant adrenocortical tumors: Diagnostic and prognostic significance in a series of 50 adrenocortical carcinomas
    Marco Volante
    Division of Pathology, Department of Clinical and Biological Sciences, University of Turin and San Luigi Hospital, Orbassano, Torino, Italy
    Mod Pathol 19:1563-9. 2006
    ..In addition, a strong metalloproteinase type 2 expression in adrenocortical carcinoma was for the first time recognized as an unfavorable prognostic factor...
  81. ncbi Effects of Src kinase inhibition induced by dasatinib in non-small cell lung cancer cell lines treated with cisplatin
    Paolo Ceppi
    University of Turin, Department of Clinical and Biological Sciences, San Luigi Hospital, Regione Gonzole 10, Orbassano, Italy
    Mol Cancer Ther 8:3066-74. 2009
    ..The data of this study support further clinical studies aimed to evaluate the efficacy of Src-inhibiting agents in combination with cisplatin in the treatment of NSCLC...
  82. ncbi Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inosit
    Riccarda Granata
    Laboratory of Molecular and Cellular Endocrinology, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy
    Endocrinology 148:512-29. 2007
    ..Our data demonstrate that AG and UAG promote survival of both beta-cells and human islets. These effects are independent of GRLN-R, are likely mediated by AG/UAG binding sites, and involve cAMP/PKA, ERK1/2, and PI3K/Akt...
  83. ncbi Co-expression of EGF receptor, TGFalpha and S6 kinase is significantly associated with colorectal carcinomas with distant metastases at diagnosis
    Marco Tampellini
    Division of Medical Oncology, Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Regione Gonzole 10, 10043, Orbassano, Turin, Italy
    Virchows Arch 450:321-8. 2007
    ..4% vs 38.7%; p = 0.02). In agreement with in vitro data, EGFR, TGFalpha and S6K co-expression in human CRC was significantly higher in patients with advanced stage at diagnosis...
  84. ncbi Acromegaly due to ectopic secretion of GHRH by bronchial carcinoid in a patient with empty sella
    G Osella
    Department of Biological and Clinical Sciences, University of Turin, Turin, Italy
    J Endocrinol Invest 26:163-9. 2003
    ..Pituitary radiology showed an empty sella demonstrating for the first time its association with ectopic GHRH syndrome...
  85. ncbi 34betaE12 cytokeratin immunodetection in the differential diagnosis of neuroendocrine carcinomas of the breast
    M Papotti
    Department of Biomedical Sciences and Oncology, University of Turin, Torino, Italy
    Appl Immunohistochem Mol Morphol 9:229-33. 2001
    ..HMW CK can be added to the list of markers useful in the differential diagnosis of NE from non-NE tumors...
  86. ncbi Desmocollin-3: a new marker of squamous differentiation in undifferentiated large-cell carcinoma of the lung
    Valentina Monica
    Department of Clinical and Biological Sciences, San Luigi Hospital, University of Turin, Torino, Italy
    Mod Pathol 22:709-17. 2009
    ....
  87. ncbi Neuroendocrine differentiation in breast cancer: established facts and unresolved problems
    Luisella Righi
    Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Orbassano, Torino, Italy
    Semin Diagn Pathol 27:69-76. 2010
    ..The clinical effect of neuroendocrine breast cancer is still a matter of debate; however, when compared with unselected breast cancers, NEBCs show a less aggressive clinical behavior...
  88. ncbi Galectin-3-expression analysis in the surgical selection of follicular thyroid nodules with indeterminate fine-needle aspiration cytology: a prospective multicentre study
    Armando Bartolazzi
    Department of Pathology, St Andrea University Hospital, Rome, Italy
    Lancet Oncol 9:543-9. 2008
    ..We aimed to assess the diagnostic effect of galectin-3 expression analysis in distinguishing preoperatively benign from malignant follicular thyroid nodules when FNA findings were indeterminate...
  89. ncbi Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity
    Giampiero Muccioli
    Department of Anatomy, University of Turin, Italy
    Eur J Pharmacol 440:235-54. 2002
    ..Particularly, GHS receptor agonists or antagonists acting on appetite could represent new drug intervention in eating disorders...
  90. ncbi Papillary thyroid carcinoma presenting as a solitary soft tissue arm metastasis in an elderly hyperthyroid patient. Case report and review of the literature
    Angela Pucci
    Division of Pathology of Regina Margherita Hospital, Torino, Italy
    Virchows Arch 448:857-61. 2006
    ..Literature data indicate that PTC in elderly patients is increasing and is often clinically aggressive. Radical surgical and radiometabolic treatments are required also in this age group to improve clinical outcome...
  91. ncbi Basaloid adenocarcinoma. A new variant of pulmonary adenocarcinoma
    Valerio Marci
    Department of Pathology, University of Turin at San Luigi Hospital, Orbassano, Turin, Italy
    Virchows Arch 451:729-36. 2007
    ..These findings indicate that a basaloid variant of adenocarcinoma is also existing in the spectrum of basaloid carcinomas of the lung...
  92. ncbi Adjuvant mitotane treatment for adrenocortical carcinoma
    Massimo Terzolo
    Universita di Torino, Turin, Italy
    N Engl J Med 356:2372-80. 2007
    ..Whether the use of mitotane is beneficial as an adjuvant treatment has been controversial. Our aim was to evaluate the efficacy of adjuvant mitotane in prolonging recurrence-free survival...
  93. ncbi The grey zone between pure (neuro)endocrine and non-(neuro)endocrine tumours: a comment on concepts and classification of mixed exocrine-endocrine neoplasms
    Marco Volante
    Department of Clinical and Biological Sciences, University of Turin and San Luigi Hospital, Regione Gonzole10, 10043 Orbassano-Torino, Italy
    Virchows Arch 449:499-506. 2006
    ..The recognition of MEECs may be of relevance for a targeted therapeutic strategy, foreseeing the use of biotherapies similar to those proposed for pure NE tumours...
  94. ncbi ERCC1 and RRM1 gene expressions but not EGFR are predictive of shorter survival in advanced non-small-cell lung cancer treated with cisplatin and gemcitabine
    P Ceppi
    Thoracic Oncology Unit, Orbassano, Torino, Italy
    Ann Oncol 17:1818-25. 2006
    ..Prospective pharmacogenomic studies represent a research priority in early and advanced NSCLC...
  95. ncbi Confocal microscope analysis and tridimensional reconstruction of papillary thyroid carcinoma nuclei
    Mauro Papotti
    Department of Biomedical Sciences and Oncology, University of Turin, Via Santena 7, 10126 Turin, Italy
    Virchows Arch 444:350-5. 2004
    ....
  96. ncbi The prognostic role of immunohistochemical chromogranin a expression in prostate cancer patients is significantly modified by androgen-deprivation therapy
    Alfredo Berruti
    Oncologia Medica, Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Torino, Italy
    Prostate 70:718-26. 2010
    ..This study was undertaken to assess the prognostic role of tissue chromogranin A (CgA) expression in patients addressed to ADT as opposed to those who did not...
  97. ncbi E2F-1 transcription factor is overexpressed in oxyphilic thyroid tumors
    Marco Volante
    Department of Biomedical Sciences and Oncology, University of Turin, Torino, Italy
    Mod Pathol 15:1038-43. 2002
    ..In addition, in oxyphilic tumors, more than two thirds of tumor cells express E2F-1, an event possibly linked to proapoptotic rather than proliferative signals in such neoplasms...
  98. ncbi Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: fact or artifact?
    Eugenio Leonardo
    Division of Pathology, San Luigi Hospital, Orbassano, Torino, Italy
    Appl Immunohistochem Mol Morphol 15:220-3. 2007
    ..We conclude that when Ki67 immunohistochemistry is used for diagnostic purposes in a suspected HTT, only MIB-1 clone at room temperature should be employed...
  99. ncbi Prognostic factors of clinical interest in poorly differentiated carcinomas of the thyroid
    Marco Volante
    Department of Biomedical Sciences, San Luigi Hospital, Orbassano, University of Turin, Italy
    Endocr Pathol 15:313-7. 2004
    ..Therefore, as also proposed for other thyroid carcinomas (e.g., papillary carcinoma) grading of PD carcinomas on the basis of these latter parameters is encouraged to select those cases with a high risk of poor outcome...