Research Topics
| Antonio MuscariSummaryAffiliation: University of Bologna Country: Italy Publications
| Collaborators
|
Detail Information
Publications
The atorvastatin during ischemic stroke study: a pilot randomized controlled trialAntonio Muscari
Department of Internal Medicine, Aging and Nephrological Diseases Stroke Unit, University of Bologna and S Orsola Malpighi Hospital, Bologna, Italy
Clin Neuropharmacol 34:141-7. 2011..This pilot study assessed the possible neuroprotective action of high-dose atorvastatin administration during the first week after an ischemic stroke, to obtain data for planning a wider multicenter study...- Chronic endurance exercise training prevents aging-related cognitive decline in healthy older adults: a randomized controlled trialAntonio Muscari
Department of Internal Medicine, Aging and Nephrological Diseases, University of Bologna, Bologna, Italy
Int J Geriatr Psychiatry 25:1055-64. 2010..To evaluate the effects of endurance exercise training (EET) on the cognitive status of healthy community-dwelling older adults... - A simple scoring system for outcome prediction of ischemic strokeA Muscari
Department of Internal Medicine, Aging and Nephrological Diseases, Stroke Unit, University of Bologna, Italy
Acta Neurol Scand 124:334-42. 2011..According to most existing models, a computer is usually needed for predicting stroke outcome. Our purpose was to construct a simple and reliable prognostic scale not requiring the use of a calculating machine... - Determinants of mean platelet volume (MPV) in an elderly population: relevance of body fat, blood glucose and ischaemic electrocardiographic changesAntonio Muscari
Department of Internal Medicine, Aging and Nephrological Diseases, University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
Thromb Haemost 99:1079-84. 2008..4 fl was 4.2 (95% confidence interval: 2.5-7.1; p = 0.006) with respect to the subjects with lower MPV values. Blood glucose, percent body fat and ischaemic ECG changes were the main MPV determinants in our elderly population... - Mean platelet volume (MPV) increase during acute non-lacunar ischemic strokesAntonio Muscari
University of Bologna and S Orsola Malpighi Hospital, Bologna, Italy
Thromb Res 123:587-91. 2009..Platelet parameters were determined 1.2 days after the onset of symptoms, and after 3.0 further days... - Physical activity is negatively associated with the metabolic syndrome in the elderlyG Bianchi
Department of Internal Medicine, Aging and Nephrological Diseases, University of Bologna, S Orsola Malpighi Hospital, Via Albertoni 15, I 40138 Bologna, Italy
QJM 101:713-21. 2008..Routine clinical and biochemical data (including fasting insulin) were used to assess insulin resistance [Homeostasis Model Assessment (HOMA) method] and the prevalence of metabolic syndrome... - The emerging role of cardiovascular risk factor-induced mitochondrial dysfunction in atherogenesisPaolo Puddu
Department of Internal Medicine, Aging and Nephrological Diseases, University of Bologna and S, Orsola Malpighi Hospital, Bologna, Italy
J Biomed Sci 16:112. 2009..So far clinical studies have been unable to demonstrate that antioxidants have any effect on human atherogenesis. Mitochondrial targeted antioxidants might provide more significant results... - Non-cardiac determinants of NT-proBNP levels in the elderly: relevance of haematocrit and hepatic steatosisAntonio Muscari
Department of Internal Medicine, Cardioangiology, Hepatology, University of Bologna, S Orsola Malpighi Hospital, Via Albertoni, 15, 40138 Bologna, Italy
Eur J Heart Fail 8:468-76. 2006..These relationships are still largely unexplained and it is unclear whether they also apply to the N-terminal portion of BNP precursor (NT-proBNP)... - The putative role of mitochondrial dysfunction in hypertensionPaolo Puddu
Department of Internal Medicine, Cardioangiology, Hepatology, University of Bologna, Bologna, Italy
Clin Exp Hypertens 29:427-34. 2007.... - Serum C3 is a stronger inflammatory marker of insulin resistance than C-reactive protein, leukocyte count, and erythrocyte sedimentation rate: comparison study in an elderly populationAntonio Muscari
Department of Internal Medicine, Cardioangiology, and Hepatology, University of Bologna, Bologna, Italy
Diabetes Care 30:2362-8. 2007..This study was performed to ascertain the relative relevance of some inflammatory markers in insulin resistance... - Molecular aspects of atherogenesis: new insights and unsolved questionsGiovanni Maria Puddu
Department of Internal Medicine and Aging, S. Orsola-Malpighi Hospital, Bologna, Italy
J Biomed Sci 12:839-53. 2005..Despite the relevance of oxidative processes in atherogenesis, anti-oxidants have failed to significantly improve atherosclerosis (ATS) prevention, while statins have proved to be the most successful drugs... - Effects of weight loss and risk factor treatment in subjects with elevated serum C3, an inflammatory predictor of myocardial infarctionAntonio Muscari
Department of Internal Medicine, Cardioangiology, Hepatology, University of Bologna, M Malpighi Hospital Via Albertoni, Italy
Int J Cardiol 100:217-23. 2005..Serum C3 is an inflammatory predictor of myocardial infarction and a covariate of fasting insulin and several endogenous risk factors. This study was performed to ascertain whether risk factor control may reduce elevated C3 concentrations... - The genetic basis of essential hypertensionPaolo Puddu
Department of Internal Medicine, Cardioangiology, Hepatology, University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
Acta Cardiol 62:281-93. 2007..EH is a highly polygenic condition, caused by the combination of small changes in the expression of many genes, in conjunction with a variable collection of environmental factors... - The involvement of circulating microparticles in inflammation, coagulation and cardiovascular diseasesPaolo Puddu
Department of Internal Medicine, University of Bologna and S Orsola Malpighi Hospital, Italy
Can J Cardiol 26:140-5. 2010..From a practical point of view, MPs could be considered to be important markers of cardiovascular risk, as well as surrogate end points for assessing the efficacy of new drugs and therapies... - The molecular sources of reactive oxygen species in hypertensionPaolo Puddu
Department of Internal Medicine, Aging and Nephrological Diseases, University of Bologna and S Orsola Malpighi Hospital, Bologna, Italy
Blood Press 17:70-7. 2008..More clinical studies are needed to fully elucidate this so called "oxidative paradox" of hypertension... - Reduced prevalence of ischemic events and abnormal supraortic flow patterns in patients with liver cirrhosisAnnalisa Berzigotti
Department of Internal Medicine, Cardioangiology, Hepatology, University of Bologna, Bologna 40138, Italy
Liver Int 25:331-6. 2005..CONCLUSIONS: Advanced liver disease is associated with a reduced prevalence of ischemic stroke, which seems to be related to a decreased prevalence of abnormal flow patterns in the supraortic vessels, especially among non-smokers... - Increased prevalence of coeliac disease in autoimmune thyroiditis is restricted to aged patientsGiovanni Ravaglia
Department of Internal Medicine, Cardioangiology and Hepatology, University Hospital S Orsola Malpighi, Via Massarenti, 9, Bologna 40138, Italy
Exp Gerontol 38:589-95. 2003..In conclusion, prevalence of CD is increased in AT but the association is limited to patients aged 65 years or older. Serological screening including anti-tTG-IgA is recommended in these patients... - The complexity of platelet metabolism and its contribution to atherothrombosisPaolo Puddu
Department of Internal Medicine, Ageing and Nephrological Diseases, University of Bologna and S Orsola Malpighi Hospital, Bologna, Italy
Acta Cardiol 64:157-65. 2009..An improved comprehension of the complex platelet pathophysiology could suggest new therapeutic strategies to reduce the impact of atherosclerotic disease... - Mitochondrial dysfunction as an initiating event in atherogenesis: a plausible hypothesisPaolo Puddu
Department of Internal Medicine, Cardioangiology, Hepatology, University of Bologna, Bologna, Italy
Cardiology 103:137-41. 2005..We propose that mitochondrial dysfunction, besides endothelial dysfunction, represents an important early step in the chain of events leading to atherosclerotic disease... - The functional role of dendritic cells in atherogenesis (Review)Paolo Puddu
Department of Internal Medicine, Aging and Nephrological Diseases, University of Bologna and S Orsola Malpighi Hospital, 40138 Bologna, Italy
Mol Med Report 3:551-4. 2010..In particular, diltiazem, peroxisome proliferator activated receptor agonists and statins have been shown to protect endothelial cell function by inhibiting DCs, a mechanism that may play a significant role in the prevention of ATS... - Gene-based therapy for hypertension--do preclinical data suggest a promising future?Giovanni Maria Puddu
Department of Internal Medicine and Aging, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
Cardiology 108:40-7. 2007.... - Lipid-lowering drugs: are adverse effects predictable and reversible?Antonio Muscari
Department of Internal Medicine, Cardioangiology and Hepatology, University of Bologna, Italy
Cardiology 97:115-21. 2002..In order to prevent or minimize adverse clinical outcomes, patients should be closely monitored and informed of the most common symptoms... - The relationships among hyperuricemia, endothelial dysfunction, and cardiovascular diseases: Molecular mechanisms and clinical implicationsPaolo Puddu
Department of Internal Medicine, Aging and Nephrological Diseases, University of Bologna and S Orsola Malpighi Hospital, Bologna, Italy
J Cardiol 59:235-42. 2012..The simultaneous reduction in uric acid levels might contribute to these effects, or be a mere epiphenomenon of the drug action. The molecular mechanisms involved are discussed... - Homocysteine and cognitive function in healthy elderly community dwellers in ItalyGiovanni Ravaglia
Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Bologna, Italy
Am J Clin Nutr 77:668-73. 2003..Elevated plasma total homocysteine (tHcy) concentrations are common in the elderly and have been suggested to be a risk factor for dementia... - Different effects of antihypertensive drugs on endothelial dysfunctionPaolo Puddu
Department of Internal Medicine, Cardioangiology, Hepatology, University of Bologna, Italy
Acta Cardiol 59:555-64. 2004.... - Carotid lesions in outpatients with nonalcoholic fatty liver diseaseStefano Ramilli
Department of Internal Medicine, Maggiore Hospital, Bologna, Italy
World J Gastroenterol 15:4770-4. 2009..To ascertain whether carotid lesions are more prevalent in outpatients with incidental findings of nonalcoholic fatty liver disease (NAFLD) at abdominal ultrasound (US)... - Peroxisome proliferator-activated receptors: are they involved in atherosclerosis progression?Paolo Puddu
Department of Internal Medicine, University of Bologna, S Orsola Hospital, Via Massarenti 9, 40138, Bologna, Italy
Int J Cardiol 90:133-40. 2003..New controlled clinical studies will provide the information necessary to understand the true significance and usefulness of PPAR alpha, gamma and delta activators in the control of atherosclerotic disease...