Research Topics
| Andrea MorelliSummaryAffiliation: University of Rome La Sapienza Country: Italy Publications
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Publications
Effects of levosimendan on right ventricular afterload in patients with acute respiratory distress syndrome: a pilot studyAndrea Morelli
Department of Anesthesiology and Intensive Care, University of Rome La Sapienza, Italy
Crit Care Med 34:2287-93. 2006..A large multiple-center trial is needed to investigate whether levosimendan is able to improve the overall prognosis of patients with sepsis and ARDS...- Effects of vasopressinergic receptor agonists on sublingual microcirculation in norepinephrine-dependent septic shockAndrea Morelli
Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Viale del Policlinico 155, Rome I 00161, Italy
Crit Care 15:R217. 2011..The primary study end point was a difference of ? 20% in the microvascular flow index of small vessels among groups... - Role of selective V2-receptor-antagonism in septic shock: a randomized, controlled, experimental studySebastian Rehberg
Department of Anesthesiology and Intensive Care, University of Muenster, Albert Schweitzer Str, 33, Muenster 48149, Germany
Crit Care 14:R200. 2010..the mixed V(1a)R/V(2)R-agonist arginine vasopressin (AVP) or placebo in an established ovine model of septic shock... - Dobutamine reverses the vasopressin-associated impairment in cardiac index and systemic oxygen supply in ovine endotoxemiaChristian Ertmer
Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Albert Schweitzer Strasse 33, 48149 Muenster, Germany
Crit Care 10:R144. 2006..The purpose of the present study was to evaluate whether dobutamine may be titrated to reverse the AVP-related decrease in cardiac index (CI) and systemic oxygen delivery index (DO2I) in an established model of ovine endotoxemia... - Levosimendan for resuscitating the microcirculation in patients with septic shock: a randomized controlled studyAndrea Morelli
Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Viale del Policlinico 155, Rome 00161, Italy
Crit Care 14:R232. 2010..e. dobutamine). The primary end point was a difference of ? 20% in the microvascular flow index of small vessels (MFIs) among groups... - Glibenclamide dose response in patients with septic shock: effects on norepinephrine requirements, cardiopulmonary performance, and global oxygen transportAndrea Morelli
Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Rome, Italy
Shock 28:530-5. 2007..These data suggest that oral glibenclamide in doses from 10 to 30 mg fails to counteract arterial hypotension and thus to reduce norepinephrine requirements in catecholamine-dependent human septic shock... - Reducing the risk of major elective non-cardiac surgery: is there a role for levosimendan in the preoperative optimization of cardiac function?A Morelli
Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Rome, Italy
Curr Drug Targets 10:863-71. 2009..Nevertheless, large-scale trials are needed before final conclusions can be drawn on the use of levosimendan in this indication... - Terlipressin: a promising vasoactive agent in hemodynamic support of septic shockAndrea Morelli
Department of Anesthesiology and Intensive Care, University of Rome La Sapienza, Rome 00161, Italy
Expert Opin Pharmacother 10:2569-75. 2009..Owing to its high and relatively selective affinity to vascular V1 receptors, terlipressin is also increasingly used as an adjunct vasopressor agent in the management of vasodilatory hyperdynamic septic shock... - Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): a randomized, controlled pilot studyAndrea Morelli
Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Viale del Policlinico 155, Rome 00161, Italy
Crit Care 13:R130. 2009.... - Phenylephrine versus norepinephrine for initial hemodynamic support of patients with septic shock: a randomized, controlled trialAndrea Morelli
Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Viale del Policlinico 155, Rome 00161, Italy
Crit Care 12:R143. 2008..The aim of the present study was, therefore, to investigate the effects of a first-line therapy with either phenylephrine or norepinephrine on systemic and regional hemodynamics in patients with septic shock... - Short-term effects of phenylephrine on systemic and regional hemodynamics in patients with septic shock: a crossover pilot studyAndrea Morelli
Department of Anesthesiology and Intensive Care, University of Rome, La Sapienza, Rome, Italy
Shock 29:446-51. 2008..Our results suggest that for the same MAP, phenylephrine causes a more pronounced hepatosplanchnic vasoconstriction as compared with NE... - "Terlipressin in the treatment of septic shock: the earlier the better"?Andrea Morelli
Department of Anaesthesiology and Intensive Care, University of Rome, La Sapienza, Rome, Italy
Best Pract Res Clin Anaesthesiol 22:317-21. 2008..Randomised, clinical multicenter trials are now needed to investigate whether or not early institution of low-dose continuous terlipressin infusion improves overall outcome of patients suffering from vasodilatory shock states... - Short-term effects of terlipressin bolus infusion on sublingual microcirculatory blood flow during septic shockAndrea Morelli
Department of Anesthesiology and Intensive Care, University of Rome, Sapienza, Viale del Policlinico 155, 00161 Rome, Italy
Intensive Care Med 37:963-9. 2011..The objective of the present study was, therefore, to elucidate the effects of a single terlipressin bolus dose of 0.5 mg on microcirculatory perfusion in patients with catecholamine-dependent septic shock... - Effects of terlipressin on systemic and regional haemodynamics in catecholamine-treated hyperkinetic septic shockAndrea Morelli
Department of Anaesthesiology and Intensive Care, University of Rome La Sapienza, Viale del Policlinico 155, 00161 Rome, Italy
Intensive Care Med 30:597-604. 2004.... - Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depressionAndrea Morelli
Department of Anesthesiology and Intensive Care, University of Rome La Sapienza, Rome, Italy
Intensive Care Med 31:638-44. 2005..Calcium desensitization plays an important part in the pathophysiology of septic myocardial depression. We postulated that levosimendan, a new calcium sensitizer, would be beneficial in sepsis-induced cardiac dysfunction... - Terlipressin versus norepinephrine to counteract anesthesia-induced hypotension in patients treated with renin-angiotensin system inhibitors: effects on systemic and regional hemodynamicsAndrea Morelli
Department of Anesthesiology and Intensive Care, University of Rome La Sapienza, Rome, Italy
Anesthesiology 102:12-9. 2005.... - Effects of short-term fenoldopam infusion on gastric mucosal blood flow in septic shockAndrea Morelli
Department of Anesthesiology and Intensive Care, University of Rome La Sapienza, Rome, Italy
Anesthesiology 101:576-82. 2004..1 microg x kg(-1) x min(-1)) to a combination of norepinephrine and dobutamine (5 microg x kg(-1) x min(-1)) may improve gastric mucosal perfusion in septic shock... - Prophylactic fenoldopam for renal protection in sepsis: a randomized, double-blind, placebo-controlled pilot trialAndrea Morelli
Department of Anesthesiology and Intensive Care, University of Rome La Sapienza, Rome, Italy
Crit Care Med 33:2451-6. 2005..The clinical significance of this finding is uncertain. A large multiple-center trial is now needed to confirm these findings... - Monitoring renal oxygen supply in critically-ill patients using urinary oxygen tensionAndrea Morelli
Department of Anesthesiology and Intensive Care, University of Rome La Sapienza Rome, Italy
Anesth Analg 97:1764-8. 2003..Using continuous measurement of urinary oxygen tension, which could indirectly provide real-time data regarding renal oxygenation, our study showed that fenoldopam increases the ratio between oxygen supply and demand... - Rescue treatment for noninvasive ventilation failure due to interface intolerance with remifentanil analgosedation: a pilot studyMonica Rocco
Department of Anesthesiology and Intensive Care, University of Rome La Sapienza, Rome, Italy
Intensive Care Med 36:2060-5. 2010..To assess the feasibility of remifentanil-based sedation in hypoxemic acute respiratory failure (HARF) patients refusing to continue noninvasive ventilation (NPPV) for intolerance to two different interfaces-helmet and total face mask... - A comparative evaluation of thermodilution and partial CO2 rebreathing techniques for cardiac output assessment in critically ill patients during assisted ventilationMonica Rocco
Department of Anesthesiology and Intensive Care, University of Rome La Sapienza, Viale del Policlinico 155, 00161 Rome, Italy
Intensive Care Med 30:82-7. 2004..To evaluate the reliability and clinical value of partial noninvasive CO2 (NICO2) rebreathing technique for measuring cardiac output compared with standard thermodilution in a group of intensive care nonpostoperative patients... - Noninvasive ventilation by helmet or face mask in immunocompromised patients: a case-control studyMonica Rocco
Dipartimento di Anestesia e Rianimazione, Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy
Chest 126:1508-15. 2004..To compare the efficacy of noninvasive positive pressure ventilation (NPPV) by helmet and face mask in immunocompromised patients with hypoxemic acute respiratory failure (ARF)... - Effects of levosimendan on mortality and hospitalization. A meta-analysis of randomized controlled studiesGiovanni Landoni
Department of Anesthesia and Intensive Care, Universita Vita Salute San Raffaele, Milano, Italy
Crit Care Med 40:634-46. 2012..Levosimendan is a calcium sensitizer that enhances myocardial contractility without increasing myocardial oxygen use. A meta-analysis was conducted to determine the impact of levosimendan on mortality and hospital stay... - Clinical effects of laparotomy with perioperative continuous peritoneal lavage and postoperative hemofiltration in patients with severe acute pancreatitisRoberto Caronna
University of Rome La Sapienza, Department of Surgery Francesco Durante, General Surgery N, Viale del Policlinico 155, Rome, 00161, Italy
World J Emerg Surg 4:45. 2009..As the major clinical outcome variables we measured morbidity, mortality and changes in the Acute Physiology and Chronic Health Evaluation (APACHE II) score and cytokine concentrations in serum and peritoneal lavage fluid over time... - Levo is in the air: take a deep breath!Christian Ertmer
Crit Care Med 36:1979-81. 2008 - Methylprednisolone reverses vasopressin hyporesponsiveness in ovine endotoxemiaChristian Ertmer
Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
Shock 27:281-8. 2007.... - Dear levosimendan, the right ventricle will thank you!Martin Westphal
Crit Care Med 35:952-3. 2007 - Continuously infused glipizide reverses the hyperdynamic circulation in ovine endotoxemiaMatthias Lange
Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
Shock 27:701-6. 2007..From these results, we conclude that continuous glipizide infusion may represent a useful therapeutic option in the treatment of arterial hypotension related to sepsis and systemic inflammatory response syndrome... - Continuous terlipressin infusion in patients with septic shock: less may be best, and the earlier the better?Andrea Morelli
Intensive Care Med 33:1669-70. 2007 - Role of adenosine triphosphate-sensitive potassium channel inhibition in shock states: physiology and clinical implicationsMatthias Lange
Department of Anesthesiology and Intensive Care, University of Muenster, Germany
Shock 28:394-400. 2007.... - Continuous versus bolus infusion of terlipressin in ovine endotoxemiaMatthias Lange
Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Muenster, Germany
Shock 28:623-9. 2007..Continuous low-dose terlipressin infusion may represent a useful alternative treatment of arterial hypotension related to sepsis and systemic inflammatory response syndrome... - Employing dobutamine as a useful agent to reverse the terlipressin-linked impairments in cardiopulmonary hemodynamics and global oxygen transport in healthy and endotoxemic sheepKatrin Bröking
Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
Shock 29:71-7. 2008..This study provides evidence that dobutamine in a dosage of 2 microg x kg(1) x min(1) is useful to reverse the terlipressin-linked depressions in CI, DO(2)I and SvO(2) in ovine endotoxemia without obvious side effects... - Role of vasopressinergic V1 receptor agonists in the treatment of perioperative catecholamine-refractory arterial hypotensionMatthias Lange
Department of Anaesthesiology and Intensive Core, University Hospital of Muenster, Albert Schweitzes Strasse 33, D 48149 Muenster, Germany
Best Pract Res Clin Anaesthesiol 22:369-81. 2008..Future large-scale randomized, controlled clinical trials are warranted to evaluate the role of V1 agonists in the treatment of perioperative hypotension in more detail... - Calcium sensitizing in sepsis: is levosimendan on the right path?Andrea Morelli
Crit Care Med 36:1981-2. 2008 - Letter by Guarracino et al regarding article, "Direct myocardial effects of levosimendan in humans with left ventricular dysfunction: alteration of force-frequency and relaxation-frequency relationships"Fabio Guarracino
Circulation 116:e346; author reply e347. 2007 - Ten years of vasopressin research in septic shock: constant dripping wears the stoneAndrea Morelli
Crit Care Med 35:2447-8. 2007 - Inhibition of potassium channels in critical illnessMatthias Lange
Department of Anesthesiology and Intensive Care, University of Muenster, Muenster, Germany
Curr Opin Anaesthesiol 21:105-10. 2008..Pharmacological blockade of ATP-sensitive potassium channels has been proposed as a goal-directed therapeutic approach to stabilize hemodynamics in septic patients...