Research Topics
| A MigliettaSummaryAffiliation: University of Turin Country: Italy Publications
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Detail Information
Publications
Antimicrotubular and cytotoxic activity of geiparvarin analogues, alone and in combination with paclitaxelA Miglietta
Department of Experimental Medicine and Oncology, University of Torino, Corso Raffaello 30, 10125 Torino, Italy
Cell Biochem Funct 19:181-9. 2001..Cytotoxicity studies showed a dose-dependent effect, whereas combined administration of drugs and paclitaxel increased cytotoxicity, more effectively in paclitaxel versus derivatives administration alone...- Extracellular signal-regulated kinase 1/2 and protein phosphatase 2A are involved in the antiproliferative activity of conjugated linoleic acid in MCF-7 cellsAntonella Miglietta
Department of Experimental Medicine and Oncology, University of Turin, C Raffaello 30, 10125, Turin, Italy
Br J Nutr 96:22-7. 2006..Thus, PP2A likely participates in deactivation of ERK1/2, and its up-regulation may represent a novel mechanism for CLA-induced inhibition of cell proliferation... - Microtubule-interfering activity of parthenolideAntonella Miglietta
Department of Experimental Medicine and Oncology, University of Torino, Corso Raffaello 30, 10125 Torino, Italy
Chem Biol Interact 149:165-73. 2004..The tubulin/microtubule system may represent a novel molecular target for parthenolide, to be utilized in developing new combinational anticancer strategies... - Insulin can modulate MCF-7 cell response to paclitaxelAntonella Miglietta
Department of Experimental Medicine and Oncology, University of Torino, Corso Raffaello 30, Torino 10125, Italy
Cancer Lett 209:139-45. 2004..Our findings indicate that insulin seems to modulate MCF-7 cell response to paclitaxel; consequently, elevated levels of insulin could influence tumor cell resistance... - Biological properties of jatrophane polyesters, new microtubule-interacting agentsAntonella Miglietta
Department of Experimental Medicine and Oncology, Universita di Torino, Corso Raffaello 30, 10125 Torino, Italy
Cancer Chemother Pharmacol 51:67-74. 2003..have not been evaluated in depth. We investigated the microtubule-interacting and antiproliferative activities of these drugs and the molecular mechanisms underlying their effects... - Comparative studies on biological activity of certain microtubule-interacting taxanesAntonella Miglietta
Department of Experimental Medicine and Oncology, University of Torino, Corso Raffaello 30, 10125 Torino, Italy
Chem Biol Interact 139:283-99. 2002..By virtue of this mechanism, some of these taxanes may provide usefulness for therapeutic improvements... - Cytoskeleton-interacting activity of geiparvarin, diethylstilbestrol and conjugatesC Bocca
Department of Experimental Medicine and Oncology, University of Torino, Corso Raffaello 30, 10125, Torino, Italy
Chem Biol Interact 137:285-305. 2001..Unlike other anti-microtubule agents, they do not exhibit cell-cycle compartment specificity and do not influence thymidine uptake in the cell... - CLA reduces breast cancer cell growth and invasion through ERalpha and PI3K/Akt pathwaysC Bocca
Department of Experimental Medicine and Oncology, University of Torino, C so Raffaello 30, 10125 Torino, Italy
Chem Biol Interact 183:187-93. 2010..These findings suggest that CLA may induce the down-regulation of ERalpha signalling and the reduction of cell invasion through the modulation of balancing between phosphatases and kinases... - Antiproliferative effect of conjugated linoleic acid in caco-2 cells: involvement of PPARgamma and APC/beta-catenin pathwaysFrancesca Bozzo
Department of Experimental Medicine and Oncology, University of Torino, C Raffaello 30, 10125 Torino, Italy
Chem Biol Interact 169:110-21. 2007.... - Involvement of PPAR gamma and E-cadherin/beta-catenin pathway in the antiproliferative effect of conjugated linoleic acid in MCF-7 cellsClaudia Bocca
Department of Experimental Medicine and Oncology, University of Torino, Torino, Italy
Int J Cancer 121:248-56. 2007..These studies indicate that CLA regulates PPAR gamma expression by selectively acting as an agonist and may influence cell-cell adhesion and invasiveness of MCF-7 cells... - Conjugated linoleic acid inhibits Caco-2 cell growth via ERK-MAPK signaling pathwayClaudia Bocca
Department of Experimental Medicine and Oncology, University of Torino, 10125, Torino, Italy
J Nutr Biochem 18:332-40. 2007..Our data suggest that CLA is dependent, at least in part, on the ERK kinase pathway for its ability to inhibit the growth of Caco-2 cancer cells... - Evidence that low doses of Taxol enhance the functional transactivatory properties of p53 on p21 waf promoter in MCF-7 breast cancer cellsM Luisa Panno
Department of Cellular Biology, University of Calabria, Ponte Pietro Bucci, Cubo 4C, 87030, Arcavacata di Rende, Cosenza, Italy
FEBS Lett 580:2371-80. 2006..Prolonged exposure of MCF-7 cells to Taxol (48 h) resulted in an increased co-association between p21 and PCNA compared to control and this well fits with the simultaneous block of cell cycle into the G2/M phase... - Conjugated linoleic acid induces apoptosis in MDA-MB-231 breast cancer cells through ERK/MAPK signalling and mitochondrial pathwayAntonella Miglietta
Department of Experimental Medicine and Oncology, University of Torino, Corso Raffaello 30, 10125 Turin, Italy
Cancer Lett 234:149-57. 2006..From the above data, we are induced to think that CLA may trigger apoptosis in the estrogen unresponsive MDA-MB-231 cell line via mechanisms involving above all the mitochondrial pathway... - An overview of the effect of linoleic and conjugated-linoleic acids on the growth of several human tumor cell linesMarina Maggiora
Dipartimento di Medicina e Oncologia Sperimentale, , Torino, Italy
Int J Cancer 112:909-19. 2004..In conclusion, CLA may be regarded as a component of the diet that exerts antineoplastic activity and its effect may be antiproliferative or pro-apoptotic... - Microtubule-interacting activity and cytotoxicity of the prenylated coumarin ferulenolClaudia Bocca
Department of Experimental Medicine and Oncology, University of Torino, Torino, Italy
Planta Med 68:1135-7. 2002..medium EGTA:ethylenebis(oxyethylenenitrilo)tetraacetic acid FBS:fetal bovine serum FITC:fluoresceine isothiocyanate GTP:guanosine 5'-triphosphate MES:2-[N-morpholino]ethane-sulfonic acid MTP:microtubule protein SDS:sodium dodecyl sulfate.. - A sesquiterpene lactone, costunolide, interacts with microtubule protein and inhibits the growth of MCF-7 cellsClaudia Bocca
Department of Experimental Medicine and Oncology, University of Torino, Corso Raffaello 30, 10125 Torino, Italy
Chem Biol Interact 147:79-86. 2004..Our data suggest an interaction of costunolide with microtubules, which may represent a new intracellular target for this drug...