Research Topics
Genomes and Genes | Alessandra MiceraSummaryAffiliation: University Campus Bio-Medico Country: Italy Publications
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Publications
The role of neuromediators in ocular allergyAlessandra Micera
CIR Laboratory of Ophthalmology, Bietti Eye Foundation, University Campus Bio Medico, Italy
Curr Opin Allergy Clin Immunol 8:466-71. 2008....- Conjunctival expression of thymosin-beta4 in vernal keratoconjunctivitisAlessandra Micera
Istituto di Ricovero e Cura a Carattere Scientifico Gian Battista Bietti Eye Foundation and CIR, Laboratory of Ophthalmology, University Campus Bio Medico, Rome, Italy
Mol Vis 12:1594-600. 2006.... - In vitro evidence of nerve growth factor effects on human conjunctival epithelial cell differentiation and mucin gene expressionAlessandro Lambiase
CIR Laboratory of Ophthalmology, University Campus Bio Medico, Rome, Italy
Invest Ophthalmol Vis Sci 50:4622-30. 2009..The aim of this study was to evaluate in vitro the effect of NGF on conjunctival goblet cell differentiation and mucin production and secretion... - Nerve growth factor modulates toll-like receptor (TLR) 4 and 9 expression in cultured primary VKC conjunctival epithelial cellsAlessandra Micera
CIR, Laboratory of Ophthalmology, University Campus Bio Medico, Rome, Italy
Mol Vis 15:2037-44. 2009..To investigate if nerve growth factor (NGF) might modulate toll-like receptor (TLR) 4 and 9 expression in primary cultures of vernal keratoconjunctivitis (VKC)-derived conjunctival epithelial cells (VKC-ECs)... - Nerve growth factor has a modulatory role on human primary fibroblast cultures derived from vernal keratoconjunctivitis-affected conjunctivaAlessandra Micera
CIR Laboratory of Ophthalmology, University Campus Bio Medico, Rome, Italy
Mol Vis 13:981-7. 2007..NGF, a pleiotrophic factor with documented profibrogenic activities, is produced by inflammatory and structural cells populating the VKC conjunctiva and is increased in the serum and tears of VKC patients... - Nerve growth factor effect on human primary fibroblastic-keratocytes: possible mechanism during corneal healingAlessandra Micera
CIR Laboratory of Ophthalmology, University Campus Bio-Medico and G.B.Bietti, Foundation, Via Emilio Longoni 83, 00155 Rome, Italy
Exp Eye Res 83:747-57. 2006..To sum up, the findings of this study indicate that NGF can modulate some functional activities of fibroblastic-keratocytes, thus substantiating the healing effects of NGF on corneal wound-healing... - Retinal p75 and bax overexpression is associated with retinal ganglion cells apoptosis in a rat model of glaucomaMarco Coassin
CIR, Laboratory of Ophthalmology, University Campus Bio Medico, Via Alvaro del Portillo, 21, 00128, Rome, Italy
Graefes Arch Clin Exp Ophthalmol 246:1743-9. 2008..Therefore, this study sought to address whether timely changes in NGF and its receptors, trkA(NGFR) and p75(NTR), might explain the progression of retinal damage during experimental glaucoma... - Itchy-dry eye associated with polycystic ovary syndromeStefano Bonini
Interdisciplinary Center for Biomedical Research CIR, Laboratory of Ophthalmology, University Campus Bio Medico of Rome, Rome, Italy
Am J Ophthalmol 143:763-771. 2007..The authors aimed to define the ocular symptomatology of women with polycystic ovaries and hyperandrogenism... - Human idiopathic epiretinal membranes express NGF and NGF receptorsSimona Minchiotti
IRCCS G B Bietti Eye Foundation, Rome, Italy
Retina 28:628-37. 2008..Therefore, the authors evaluated myoFBs in ERMs and NGF, trkA(NGFR and p75(NTR) expression, as well as TGF-beta1/TGF-betaRII levels in both ERMs and vitreous... - Topical treatment with nerve growth factor in an animal model of herpetic keratitisAlessandro Lambiase
Interdisciplinary Center for Biomedical Research CIR, Laboratory of Ophthalmology, University Campus Bio Medico of Rome, Via E Longoni, 83 00155, Rome, Italy
Graefes Arch Clin Exp Ophthalmol 246:121-7. 2008..The aims of this study were to evaluate the role of endogenous NGF in HSV corneal infection, and the effects of topical NGF treatment on herpetic keratitis... - Tear levels of neuropeptides increase after specific allergen challenge in allergic conjunctivitisMarta Sacchetti
Department of Ophthalmology, University of Rome Campus Bio Medico, Rome, Italy
Mol Vis 17:47-52. 2011..In this study, we aimed at evaluating the role of substance P (SP), calcitonine gene related peptide (CGRP), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) in allergic reactions of the ocular surface... - Nerve growth factor modulates in vitro the expression and release of TGF-beta1 by amniotic membraneMarco Coassin
Interdisciplinary Center for Biomedical Research (CIR, Laboratory of Ophthalmology, University of Rome Campus Bio-Medico, Via E Longoni, 83, 00155, Rome, Italy
Graefes Arch Clin Exp Ophthalmol 244:485-91. 2006..Moreover, the addition of NGF to the culture medium stimulates the amniotic membrane to significantly increase the production and release of TGF-beta1... - Expression of Toll-like receptors in healthy and allergic conjunctivaStefano Bonini
CIR Laboratory of Ophthalmology, Campus Bio Medico and G B Bietti Eye Foundation, Rome, Italy
Ophthalmology 112:1528; discussion 1548-9. 2005..To investigate the expression of toll-like receptors (TLRs) in healthy and active vernal keratoconjunctivitis (VKC) conjunctiva... - Preliminary evidence of the efficacy of probiotic eye-drop treatment in patients with vernal keratoconjunctivitisAlfonso Iovieno
Interdisciplinary Center for Biomedical Research CIR, Laboratory of Ophthalmology, University of Rome Campus Bio Medico, Via E Longoni, 83, 00155, Rome, Italy
Graefes Arch Clin Exp Ophthalmol 246:435-41. 2008..Probiotics have been shown to improve allergic inflammation. The aim of this study was to evaluate the efficacy of Lactobacillus Acidophilus eye-drops in controlling signs and symptoms of vernal keratoconjunctivitis (VKC)... - Neurogenic inflammation of the ocular surfaceFlavio Mantelli
Department of Ophthalmology, Campus Bio Medico University of Rome, Rome, Italy
Curr Opin Allergy Clin Immunol 10:498-504. 2010.... - Nerve growth factor involvement in the visual system: implications in allergic and neurodegenerative diseasesAlessandra Micera
CIR Laboratorio di Oftalmologia, Campus Bio-Medico and Fondazione GB Bietti, Rome, Italy
Cytokine Growth Factor Rev 15:411-7. 2004..The present review of experimental and clinical studies will highlight old and recent strategies for treating ocular surface and tear disorders with NGF... - Pharmacokinetics of conjunctivally applied nerve growth factor in the retina and optic nerve of adult ratsAlessandro Lambiase
Interdisciplinary Research Center, Laboratory of Ophthalmology, University of Rome Campus Bio Medico, Italy
Invest Ophthalmol Vis Sci 46:3800-6. 2005..The present study sought to establish the bioavailability of topical NGF to the retina and optic nerve in rats... - Allergic bronchial airway inflammation in nerve growth factor (NGF)-deprived rats: evidence suggesting a neuroimmunomodulatory role of NGFBarbara Stampachiacchiere
Institute of Neurobiology and Molecular Medicine, Section of Neurobiology, National Research Council CNR, Rome, Italy
Exp Lung Res 32:305-20. 2006..The present findings suggest that at least NGF does not act as a proper proinflammatory factor but most probably as a neuroimmune modulator molecule of the allergic state... - Natural killer cells in vernal keratoconjunctivitisAlessandro Lambiase
Interdisciplinary Center for Biomedical Research CIR, Laboratory of Ophthalmology, University Campus Bio Medico of Rome, Italy
Mol Vis 13:1562-7. 2007..The aim of this study was to evaluate NK in the blood and the conjunctiva of patients with vernal keratoconjunctivitis (VKC)... - NGF topical application in patients with corneal ulcer does not generate circulating NGF antibodiesAlessandro Lambiase
Laboratory of Ophthalmology, CIR, University Campus Bio Medico, Rome, Italy
Pharmacol Res 56:65-9. 2007..None of the patients suffered any adverse reaction, except for mild and transient conjunctival hyperaemia and photophobia. Moreover, none of the treated patients developed circulating antibodies to NGF... - MUC5AC overexpression in tear film of neonatesFlavio Mantelli
Interdisciplinary Center for Biomedical Research Laboratory of Ophthalmology, Campus Bio Medico University of Rome, Rome, Italy
Graefes Arch Clin Exp Ophthalmol 245:1377-81. 2007..However, tear-film stability is not only based on the integrity of the lipid layer, but also reflects properties of the underlying mucus layer. Characteristics of the neonatal mucus tear-film layer have not yet been described... - T-helper 17 lymphocytes in ocular cicatricial pemphigoidAlessandro Lambiase
Interdisciplinary Center for Biomedical Research CIR, Laboratory of Ophthalmology, University of Rome, Rome, Italy
Mol Vis 15:1449-55. 2009..T-helper 17 lymphocytes (Th17) were identified in the healthy conjunctiva and in patients with ocular cicatricial pemphigoid (OCP), a disease characterized by chronic ocular surface inflammation... - Molecular basis for keratoconus: lack of TrkA expression and its transcriptional repression by Sp3Alessandro Lambiase
Department of Ophthalmology, University Campus Bio Medico, G B Bietti Eye Foundation, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
Proc Natl Acad Sci U S A 102:16795-800. 2005..This mechanism for the transcriptional repression of the TrkA(NGFR) gene can provide the platform for the development of a therapeutic strategy... - Nerve growth factor and the immune system: old and new concepts in the cross-talk between immune and resident cells during pathophysiological conditionsAlessandro Lambiase
CIR Ophthalmology Laboratory, Campus Bio-Medico' and G.B. Bietti Eye Foundation, and San Raffaele H Research, Rome, Italy
Curr Opin Allergy Clin Immunol 4:425-30. 2004..Understanding these complex mechanisms will introduce new therapeutic approaches for nerve growth factor in the immune system, in addition to those already established in the nervous system... - Conjunctival mucin deficiency in complete androgen insensitivity syndrome (CAIS)Flavio Mantelli
Interdisciplinary Center for Biomedical Research CIR Laboratory of Ophthalmology, Campus Bio Medico University of Rome, Rome, Italy
Graefes Arch Clin Exp Ophthalmol 245:899-902. 2007..Decreased mucin levels contribute in explaining the tear film instability in CAIS and should be considered an additional cause of dry eye in sex steroid hormone pathology... - Multiple action agents and the eye: do they really stabilize mast cells?Alessandro Lambiase
CIR Laboratory of Ophthalmology, University Campus Bio Medico, Italy
Curr Opin Allergy Clin Immunol 9:454-65. 2009..This pharmaceutical class is, therefore, rapidly becoming the first choice for prevention and treatment for allergic conjunctivitis... - Toll-like receptors and the eyeAlessandra Micera
CIR Laboratory of Ophthalmology, University of Rome Campus Bio-Medico, Rome, Italy
Curr Opin Allergy Clin Immunol 5:451-8. 2005.... - Nerve growth factor (NGF) and lenses: effects of NGF in an in vitro rat model of cataractEmiliano Ghinelli
Department of Ophthalmology, University of Rome, Rome, Italy
Graefes Arch Clin Exp Ophthalmol 241:845-51. 2003.... - Nerve growth factor and tissue repair remodeling: trkA(NGFR) and p75(NTR), two receptors one fateAlessandra Micera
Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel
Cytokine Growth Factor Rev 18:245-56. 2007..In summary, these novel findings on the potential pro-healing capacity of NGF might open new possibilities for this growth factor in modulating the healing processes in several pathological conditions... - Nerve growth factor and eosinophils in inflamed juvenile conjunctival nevusFrancesca Levi-Schaffer
Department of Pharmacology and the David R Bloom Center for Pharmacy School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
Invest Ophthalmol Vis Sci 43:1850-6. 2002.... - New insights on the involvement of Nerve Growth Factor in allergic inflammation and fibrosisAlessandra Micera
Department of Pharmacology, Faculty of Medicine, School of Pharmacy, The Hebrew University of Jerusalem, PO Box 12065, Jerusalem 91120, Israel
Cytokine Growth Factor Rev 14:369-74. 2003..Recent evidences link NGF and these two processes. While NGF is clearly a new tool in the management of untreatable ulcers, its role in allergic inflammation, although appearing to be pro-inflammatory, is still not clearly defined...