Research Topics
Genomes and GenesSpecies | Paolo MartellettiSummaryAffiliation: University of Rome La Sapienza Country: Italy Publications
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Publications
CGRP receptor antagonists: an expanding drug class for acute migraine?Andrea Negro
Sapienza University of Rome and Regional Referral Headache Centre, Sant Andrea Hospital, Department of Clinical and Molecular Medicine, Via di Grottarossa 1035 1039, 00189, Rome, 39 06 33 77 67 78 39 06 33 77 53 23
Expert Opin Investig Drugs 21:807-18. 2012..New CGRP-R antagonists, such as BMS-927711 and BI 44370 TA, are in the pipeline and their developments will outline the future of this drug class...- The definitive position of headache among the major public health challenges. An end to the slippery slope of disregardPaolo Martelletti
J Headache Pain 8:149-51. 2007 - Cervicogenic headache: practical approaches to therapyPaolo Martelletti
Department of Internal Medicine, 2nd School of Medicine, Headache Centre, University La Sapienza, 00189 Rome, Italy
CNS Drugs 18:793-805. 2004.... - The Global Campaign (GC) to Reduce the Burden of Headache Worldwide. The International Team for Specialist Education (ITSE)Paolo Martelletti
ITSE 2nd School of Medicine, Rome University La Sapienza, Via Vitorchiano 81, I 00189, Rome, Italy
J Headache Pain 6:261-3. 2005..In this way they will give life to a cultural chain raising awareness locally of headache, its burden and its medical control... - Inflammatory mechanisms in cervicogenic headache: an integrative viewPaolo Martelletti
Department of Internal Medicine, Headache Center, 2nd School of Medicine, University La Sapienza, Policlinico Sant Andrea, Via di Grottarossa 1035 1039, 00189 Rome, Italy
Curr Pain Headache Rep 6:315-9. 2002..This report represents a series of pathophysiologic studies performed for patients with cervicogenic headache and the results achieved by a new pharmacologic treatment for the disease... - Acute migraine in the Emergency Department: extending European principles of managementPaolo Martelletti
Department of Medical Sciences, Internal Medicine, Regional Referral Headache Centre, 2nd School of Medicine, Sapienza University of Rome, Sant Andrea Hospital, Via di Grottarossa 1035, 00189 Rome, Italy
Intern Emerg Med 3:S17-24. 2008.... - Genetic polymorphisms related to efficacy and overuse of triptans in chronic migraineGiovanna Gentile
Department of Biochemical Sciences, Advanced Molecular Diagnostic Unit, 2nd School of Medicine, Sant Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1035, Rome, Italy
J Headache Pain 11:431-5. 2010..Further stratification of patients in abuser and non-abuser groups revealed a significant association with triptan overuse and, within the abusers, with drug response to the CYP1A2*1F variant... - Mental turmoil, suicide risk, illness perception, and temperament, and their impact on quality of life in chronic daily headacheSergio de Filippis
Department of Medical Sciences, 2nd School of Medicine, Sant Andrea Hospital, Sapienza University of Rome, Rome, Italy
J Headache Pain 9:349-57. 2008..The investigation of the interplay of factors that precipitate suicide risk should include assessment of chronic headache and its effects on wellbeing... - Chronic migraine: comorbidities, risk factors, and rehabilitationAndrea Negro
Regional Referral Headache Centre and Internal Medicine, Department of Clinical and Molecular Sciences, II School of Medicine, Sant Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189, Rome, Italy
Intern Emerg Med 5:S13-9. 2010..The feasible diagnostic setting for a CM tailored treatment based on the application of pharmacogenomics will allow us to predetermine the efficacy of single old and new drugs by avoiding abuse due to non-responsivity of the acute drug... - Gene polymorphisms involved in triptans pharmacokinetics and pharmacodynamics in migraine therapyGiovanna Gentile
Sapienza University, 2nd School of Medicine, Advanced Molecular Diagnostic Unit, Department of Biochemical Sciences, Rome, Italy
Expert Opin Drug Metab Toxicol 7:39-47. 2011..Pharmacogenomics may offer a new way to rationalise triptans administration, based on characterisation of the individual genomic profile... - Psychiatric comorbidity and suicide risk in patients with chronic migraineMaurizio Pompili
Department of Neurosciences, Mental Health and Sensory Functions, Suicide Prevention Center, Sant Andrea Hospital, Sapienza University of Rome, Rome, Italy
Neuropsychiatr Dis Treat 6:81-91. 2010..Future research should include sound methodologically-based studies focusing on the interplay of factors behind the relationship between migraine, suicide risk, and mental illness... - Future drugs for migraineIvano Farinelli
Department of Medical and Molecular Sciences, Regional Referral Headache Centre, II School of Medicine, Sapienza University of Rome, Sant Andrea Hospital, Via di Grottarossa 1039, 00189 Rome, Italy
Intern Emerg Med 4:367-73. 2009..The immediate future of a preventative treatment for migraine headaches is well represented by botulinum toxin type-A, glutamate NMDA receptor antagonists, gap-junction blocker tonabersat and an angiotensin type 1 blocker candesartan... - Frequencies of genetic polymorphisms related to triptans metabolism in chronic migraineGiovanna Gentile
Department of Biochemical Sciences, Advanced Molecular Diagnostic Unit, 2nd School of Medicine, Sapienza University, Sant Andrea Hospital, Via di Grottarossa 1035, Rome, Italy
J Headache Pain 11:151-6. 2010..Such genomic analysis is part of an integrated platform able to evaluate different levels of metabolic pathways of drugs in CM and their influence in the chronicization process... - Pharmacokinetic evaluation of frovatriptanAndrea Negro
Sapienza University, Regional Referral Headache Center, School of Health Sciences, Department of Medical and Molecular Sciences, Rome, Italy
Expert Opin Drug Metab Toxicol 7:1449-58. 2011..2) and the longer half-life (26 h). These parameters determine the clinical properties of frovatriptan; in particular the lowest rate of headache recurrence in comparison with other triptans... - The validation of the Italian Perceived Disability Scale (IPDS) in chronic daily headache sufferersMarco Innamorati
Università Europea di Roma, Rome, Italy
J Headache Pain 10:21-6. 2009..The IPDS is a brief instrument that is useful for comparisons with other chronic illnesses, and it may be used both for basic research and clinical applications when screening for comorbidity with emotional distress and disorders... - Salivary cortisol, dehydroepiandrosterone-sulphate (DHEA-S) and testosterone in women with chronic migraineFrancesca Romana Patacchioli
Department of Human Physiology and Pharmacology V Erspamer, 2nd School of Medicine, S Andrea Hospital, Piazza Aldo Moro 5, I 00185, Rome, Italy
J Headache Pain 7:90-4. 2006.... - Migraine with aura, bipolar depression, ACM aneurysm. A case reportSergio de Filippis
Regional Referral Headache Centre, Department of Medicine, Sant Andrea Hospital, II School of Medical Sciences, University La Sapienza, Via di Grottarossa 1035, I 00189 Rome, Italy
J Headache Pain 6:93-6. 2005..One year after the operation, the patient reports a decrease of headache events with a frequency of 2 per month, lasting only a few hours, which she can now solve with COXIB... - Headache and mood disordersSergio de Filippis
Regional Referral Headache Centre, II School of Medicine, University La Sapienza, Sant Andrea Hospital, Via di Grottarossa 1035, I 00189, Rome
J Headache Pain 6:250-3. 2005..In consideration of these results, more exhaustive evaluations relating to the psychopathological aspects in patients affected by headache are necessary... - Cytotoxic T lymphocyte antigen 4 polymorphism 49 (A>G) and migrainePatrizia Lulli
Clinical Genetics, 2nd School of Medicine, Rome University La Sapienza, Sant Andrea Hospital, Via di Grottarossa 1035, I 00189 Rome, Italy
J Headache Pain 6:188-90. 2005..These results would indicate no association between MA and MO migraine and CTLA-4 polymorphism, excluding any possible role of the CTLA-4 gene as a genetic factor determining susceptibility to migraine... - Proinflammatory mediators and migraine pathogenesis: moving towards CGRP as a target for a novel therapeutic classIvano Farinelli
Department of Medical Sciences, 2nd School of Medicine, Sapienza University, Sant Andrea Hospital, Via di Grottarossa 1035, I 00189 Rome, Italy
Expert Rev Neurother 8:1347-54. 2008..These results are important since they confirm the current pathophysiological concept of migraine. The future introduction of CGRP antagonists in clinical practice could represent a progress for migraine therapy... - Genetics of migraine and pharmacogenomics: some considerationsMaria Piane
Department of Diagnostic Sciences, Medical Genetics Section, 2nd School of Medicine, University of Rome La Sapienza, I 00185, Rome, Italy
J Headache Pain 8:334-9. 2007.... - Rehabilitating chronic migraine complicated by medication overuse headaches: how can we prevent migraine relapse?Ivano Farinelli
Department of Medical and Molecular Sciences, II School of Medicine, Sant Andrea Hospital, Sapienza University of Roma, Rome, Italy
Intern Emerg Med 6:23-8. 2011.... - Aspirin and tension-type headacheIvano Farinelli
Department of Clinical Sciences, Sapienza University of Rome, 2nd School of Medicine, Sant Andrea Hospital, Via di Grottarossa 1035, I 00189, Rome, Italy
J Headache Pain 8:49-55. 2007..Furthermore, a new Aspirin formulation with a greater rapidity of action has been introduced. In conclusion, little information exists on the subject and more studies are required... - Tumor necrosis factor gene polymorphism in migraineSimonetta Trabace
Section of Medical Genetics, Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy
Headache 42:341-5. 2002..To better define the involvement of human leukocyte antigen region (HLA) genes in migraine via an association study of the tumor necrosis factor (TNF) genes, located in the HLA class III region, with migraine with and without aura... - Psychiatric comorbidity in patients with chronic daily headache and migraine: a selective overview including personality traits and suicide riskMaurizio Pompili
Department of Psychiatry, Sant Andrea Hospital, Sapienza University of Rome, 1035 Via di Grottarossa, Rome 00189, Italy
J Headache Pain 10:283-90. 2009..The increase in self-efficacy and mental health associated with pharmaceutical care may be instrumental in improving the long-term pharmacotherapy of patients with migraine and headache... - Long-term benefits of botulinum toxin type A (BOTOX) in chronic daily headache: a five-year long experienceIvano Farinelli
Department of Clinical Sciences, Sapienza University of Rome, 2nd School of Medicine, Sant'Andrea Hospital, Via di Grottarossa 1035, I-00189, Rome, Italy
J Headache Pain 7:407-12. 2006..In conclusion, BoNT-A therapy appears to be an efficacious new therapeutic choice in the prophylaxis of CDH, especially for patients not responding to previous prophylactic treatments... - Chronic migraine plus medication overuse headache: two entities or not?Andrea Negro
Department of Medical and Molecular Sciences, Sapienza University, Rome, Italy
J Headache Pain 12:593-601. 2011..Furthermore, it provided an injection paradigm that can be used as a guide for a correct administration of onabotulinumtoxinA... - Improving care through health economics analyses: cost of illness and headacheFrancesco Saverio Mennini
CEIS Sanità Centre for Health Economics and Management CHEM, Faculty of Economics, University of Rome Tor Vergata, Rome, Italy
J Headache Pain 9:199-206. 2008..Finally, a brief review on advantages of new pharmaceuticals and preventive treatments for migraine for patients and society will outline improvements in the context of cost-effectiveness and cost-utility analysis... - Prevalence and burden of primary headache in Akaki textile mill workers, EthiopiaGetahun Mengistu Takele
School of Medicine, Department of Neurology, Addis Ababa University, Addis Ababa, Ethiopia
J Headache Pain 9:119-28. 2008..We recommend the availability and administration of specific therapy to the factory workers with primary headaches, and community based well-designed study for the whole nation's rural and urban population... - Headache medicine: academic teaching in Europe. The Sapienza University Master's DegreePaolo Martelletti
Headache 47:1224-5; author reply 1225-7. 2007 - Neuroendocrine derangement in chronic migraineFrancesca Romana Patacchioli
Headache 46:1309-10. 2006 - Academic specialist education in headache medicine. Next move for the headache communityPaolo Martelletti
J Headache Pain 6:103-4. 2005