Research Topics
Species | Giulia MarchettiSummaryAffiliation: University of Milan Country: Italy Publications
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Detail Information
Publications
Interleukin-2 immunotherapy exerts a differential effect on CD4 and CD8 T cell dynamicsGiulia Marchetti
Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Italy
AIDS 18:211-6. 2004....- Partial immune reconstitution following highly active antiretroviral therapy: can adjuvant interleukin-2 fill the gap?Giulia Marchetti
Institute of Infectious Disease and Tropical Medicine, University of Milan, Luigi Sacco Hospital, Milan, Italy
J Antimicrob Chemother 55:401-9. 2005..However, whether or not these immunological effects translate into an actual immunological competency and therefore clinical benefit, still awaits demonstration from ongoing large, controlled clinical studies... - Serum alpha-fetoprotein levels predict early virologic response in HIV-positive subjects treated for chronic hepatitis CMarco Bongiovanni
J Acquir Immune Defic Syndr 48:361-3. 2008 - Circulating sCD14 is associated with virological response to pegylated-interferon-alpha/ribavirin treatment in HIV/HCV co-infected patientsGiulia Marchetti
Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases and Tropical Medicine, University of Milan, San Paolo Hospital, Milan, Italy
PLoS ONE 7:e32028. 2012..We asked whether increased MT and immune activation may hamper anti-HCV response in HIV/HCV patients... - Low-dose prolonged intermittent interleukin-2 adjuvant therapy: results of a randomized trial among human immunodeficiency virus-positive patients with advanced immune impairmentGiulia Marchetti
Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Milan, Italy
J Infect Dis 186:606-16. 2002..Thus, adjuvant IL-2 therapy in immunologic nonresponders resulted in a clinical benefit, suggesting that the quantitative cell recovery involves functionally competent immune cells... - Microbial translocation predicts disease progression of HIV-infected antiretroviral-naive patients with high CD4+ cell countGiulia Marchetti
Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Italy
AIDS 25:1385-94. 2011..We investigated the significance of microbial translocation measured on average 3 years after HIV seroconversion in driving disease progression in HIV untreated patients with high CD4(+) cell count... - Skewed T-cell maturation and function in HIV-infected patients failing CD4+ recovery upon long-term virologically suppressive HAARTGiulia Marchetti
Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy
AIDS 24:1455-60. 2010..Analysis of functionally defined T-cell differentiation in HIV-infected patients with low CD4(+) on virologically suppressive HAART is crucial to design clinically efficacious treatments... - HIV-infected long-term nonprogressors display a unique correlative pattern between the interleukin-7/interleukin-7 receptor circuit and T-cell homeostasisG Marchetti
Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Via A Di Rudini, Milan 8 20142, Italy
HIV Med 10:422-31. 2009.... - Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapyGiulia Marchetti
Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy
AIDS 22:2035-8. 2008..These data provide novel insight into INRs pathogenesis, since they correlate augmented systemic translocation of microbial bioproducts with T-cell hyperactivation... - The challenge of IL-2 immunotherapy in HIV disease: "no through road" or turning point?Giulia Marchetti
Clinic of Infectious Diseases and Tropical Medicine, Department of Medicine, Surgery and Dentistry, San Paolo Hospital, University of Milan, Milan, Italy
Curr HIV Res 6:189-99. 2008..This review is meant to thoroughly explore the possibility that the immunological advantages described during IL-2 immunotherapy might translate into actual clinical benefits in the treatment of HIV/AIDS disease... - Comparative analysis of T-cell turnover and homeostatic parameters in HIV-infected patients with discordant immune-virological responses to HAARTGiulia Marchetti
Department of Clinical Sciences, Chair of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Via G B Grassi 74, 20157 Milan, Italy
AIDS 20:1727-36. 2006..A better understanding of the relationship between T-cell dynamics and the HIV intracellular reservoir in HIV-infected patients failing to recover CD4 cell count following long-term HAART, is required... - IL-7/IL-7 receptor system regulation following IL-2 immunotherapy in HIV-infected patientsGiulia Marchetti
Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Milan, Italy
Antivir Ther 9:447-52. 2004..Our data confirm the pivotal role of IL-2 and IL-7 in the regulation of T-lymphocyte homeostasis in HIV infection... - Early initiation of highly active antiretroviral therapy fails to reverse immunovirological abnormalities in gut-associated lymphoid tissue induced by acute HIV infectionCamilla Tincati
Department of Internal Medicine, Clinic of Infectious Diseases and Tropical Medicine, San Paolo Hospital, University of Milan, Milan, Italy
Antivir Ther 14:321-30. 2009..During the acute phase of HIV infection, large CD4+ T-cell depletion occurs in the gastrointestinal tract. The kinetics of CD4+ T-cell decrease and highly active antiretroviral therapy (HAART)-mediated immune reconstitution were evaluated... - Increased bone marrow interleukin-7 (IL-7)/IL-7R levels but reduced IL-7 responsiveness in HIV-positive patients lacking CD4+ gain on antiviral therapyGiusi Maria Bellistri
Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy
PLoS ONE 5:e15663. 2010.... - The absence of CD4+ T cell count recovery despite receipt of virologically suppressive highly active antiretroviral therapy: clinical risk, immunological gaps, and therapeutic optionsLidia Gazzola
Department of Medicine, Surgery, and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy
Clin Infect Dis 48:328-37. 2009.... - Reduced CD127 expression on peripheral CD4+ T cells impairs immunological recovery in course of suppressive highly active antiretroviral therapyFrancesca Bai
Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases and Tropical Medicine, University of Milan, San Paolo Hospital, Milan, Italy
AIDS 24:2590-3. 2010..These results suggest a possible role for the IL-7/IL-7R system in the pathogenesis of poor immunological recovery during HAART... - Immunomodulation induced by tucaresol in HIV infection: results of a 16 week pilot Phase I/II trialAndrea Gori
Institute of Infectious Diseases and Tropical Medicine, L Sacco Hospital, University of Milan, Milan, Italy
Antivir Ther 9:603-14. 2004..In a Phase I/II clinical trial performed on HIV-positive patients we analysed the safety and immunomodulating effects of tucaresol, a novel compound that has previously been described tn enhance cell-mediated immune responses... - Spoligotyping and Mycobacterium tuberculosisAndrea Gori
Institute of Infectious Diseases, L Sacco Hospital, University of Milan, Milan, Italy
Emerg Infect Dis 11:1242-8. 2005..The rapidity of this method in detection and typing could make it useful in the management of tuberculosis in a clinical setting... - Successful rescue therapy with a darunavir/ritonavir and etravirine antiretroviral regimen in a child with vertically acquired multidrug-resistant HIV-1Alessandra Vigano
Luigi Sacco Hospital, University of Milan, Milan, Italy
Antivir Ther 13:839-43. 2008..The use of experimental agents might become a compelling issue in vertically HIV-infected children born in the era of highly active ART... - Evidence for polymicrobic flora translocating in peripheral blood of HIV-infected patients with poor immune response to antiretroviral therapyEsther Merlini
Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy
PLoS ONE 6:e18580. 2011..Failure to control microbial translocation on HAART is associated with a polymicrobic flora circulating in peripheral blood that is not substantially modified by therapy... - Sudden cardiac death in a young HIV-positive man on effective antiretroviral therapyCamilla Tincati
Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases and Tropical Medicine, San Paolo Hospital, University of Milan, Italy
Curr HIV Res 6:560-2. 2008..As T-cell activation is known to mediate atherosclerosis, the authors suggest that surrogate immunologic markers should be identified to better assess cardiovascular risk in the setting of HIV infection... - Role of in vitro stimulation with lipopolysaccharide on T-Cell activation in HIV-infected antiretroviral-treated patientsCamilla Tincati
Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases and Tropical Medicine, San Paolo Hospital, University of Milan, Via A Di Rudini 8, 20142 Milan, Italy
Clin Dev Immunol 2012:935425. 2012.... - Rhodococcus equi infection in a patient with spinocellular carcinoma of unknown originElisa Borghi
Department of Public Health Microbiology Virology, University of Milan, Milan, Italy
J Med Microbiol 57:1431-3. 2008..The patient, a knife-grinder, was promptly treated with levofloxacin plus amikacin followed by rifampicin for 2 months, and he is still in good clinical condition after an 8-month follow-up... - Effective nocturnal oxygen therapy increases circulating level of tumor necrosis factor-alpha in heart failureStefano Guzzetti
Medicina I, Ospedale Luigi Sacco, Milano, Italy
J Cardiovasc Med (Hagerstown) 9:64-7. 2008..The aim of the present study was to evaluate whether standard O2 hospital therapy affects plasma concentration of TNF-alpha in stable CHF patients... - Comparison between spoligotyping and IS6110 restriction fragment length polymorphisms in molecular genotyping analysis of Mycobacterium tuberculosis strainsAndrea Gori
Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Via G B Grassi 74, Milan 20157, Italy
Mol Cell Probes 19:236-44. 2005.... - Early impairment of gut function and gut flora supporting a role for alteration of gastrointestinal mucosa in human immunodeficiency virus pathogenesisAndrea Gori
Division of Infectious Diseases, Department of Internal Medicine, San Gerardo Hospital, University of Milano Bicocca, Via Solferino 16 20052, Milan, Italy
J Clin Microbiol 46:757-8. 2008..This impairment is associated with alterations in gut microbiota and intestinal inflammatory parameters. These findings support the hypothesis that alterations at the gastrointestinal-tract level are a key factor in HIV pathogenesis... - Noncirrhotic portal hypertension in HIV-infected patients: a case control evaluation and review of the literatureMiriam Cesari
Section of Infectious Diseases and Immunopathology, Department of Clinical Sciences, Universita di Milano, L Sacco Hospital, Milan, Italy
AIDS Patient Care STDS 24:697-703. 2010.... - Untangling the immunological implications of nadir on CD4+ cell recovery during suppressive highly active antiretroviral therapyLaurenzia Ferraris
Clin Infect Dis 46:149-50. 2008 - Delayed-type hypersensitivity skin testing can predict CD4 count increase in HIV patients with poor immunologic response to HAARTLuca Meroni
J Acquir Immune Defic Syndr 33:277-8. 2003