Research Topics
Genomes and Genes | Lorenzo LeonciniSummaryAffiliation: University of Siena Country: Italy Publications
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Publications
HIV-1 Tat mimetic of VEGF correlates with increased microvessels density in AIDS-related diffuse large B-cell and Burkitt lymphomasJ Nyagol
Department of Human Pathology and Oncology, University of Siena, Via delle Scotte 6, 53100, Siena, Italy
J Hematop 1:3-10. 2008....- Expression of p34(cdc2) and cyclins A and B compared to other proliferative features of non-Hodgkin's lymphomas: a multivariate cluster analysisL Leoncini
Institute of Pathology, University of Sassari, Sassari, Italy
Int J Cancer 83:203-9. 1999..Anaplastic large-cell lymphomas predominated in cluster 3 and responded best to therapy... - Aggressive B-cell lymphomas: a review based on the workshop of the XI Meeting of the European Association for HaematopathologyL Leoncini
Dipartimento di Patologia Umana ed Oncologia, University of Siena, Nuovo Policlinico Le Scotte, Italy
Histopathology 46:241-55. 2005.... - Burkitt's lymphoma: new insights into molecular pathogenesisC Bellan
Institute of Pathological Anatomy and Histology, University of Siena, Nuovo Policlinico Le Scotte, Via delle Scotte, 6, 53100 Siena, Italy
J Clin Pathol 56:188-92. 2003..The results point out the heterogeneity of BL and suggest that AIDS related BL may have a different pathogenesis from that of classic BL... - Retinoblastoma gene family expression in lymphoid tissuesL Leoncini
Department of Human Pathology and Oncology, University of Siena, Siena, Italy
Oncogene 25:5309-14. 2006..In this review, we will summarize the current knowledge about the role of the RB proteins in reactive and neoplastic lymphoid tissue... - Cell kinetics and cell cycle regulation in lymphomasL Leoncini
Institute of Pathological Anatomy and Histology, University of Siena, Italy
J Clin Pathol 55:648-55. 2002..A re-evaluation of parameters of cell kinetics in view of our increasing knowledge of the molecular pathways of cell cycle control may provide more prognostic information for the management of patients with malignant lymphomas... - B-cell differentiation in EBV-positive Burkitt lymphoma is impaired at posttranscriptional level by miRNA-altered expressionEleonora Leucci
Department of Human Pathology and Oncology, University of Siena, 53100 Siena, Italy
Int J Cancer 126:1316-26. 2010..The overexpression of this miRNA may thus represent a key event in the lymphomagenesis of EBV positive BL, by blocking the B-cell differentiation process... - Cdk9/Cyclin T1 complex: a key player during the activation/differentiation process of normal lymphoid B cellsGiulia De Falco
Department of Human Pathology and Oncology, University of Siena, Siena, Italy
J Cell Physiol 215:276-82. 2008..Taken together this data suggests an active role for the Cdk9/Cyclin T1 complex during lymphoid differentiation through germinal center reaction... - Interaction between HIV-1 Tat and pRb2/p130: a possible mechanism in the pathogenesis of AIDS-related neoplasmsGiulia De Falco
Department of Human Pathology and Oncology, University of Siena, Siena, Italy
Oncogene 22:6214-9. 2003..The interaction between Tat and pRb2/p130 seems to result in the deregulation of the control exerted by pRb2/p130 on the cell cycle. Taken together, these results open a window on the role of pRb2/p130 in AIDS-related oncogenesis... - Immunoglobulin gene analysis reveals 2 distinct cells of origin for EBV-positive and EBV-negative Burkitt lymphomasCristiana Bellan
Department of Human Pathology and Oncology, University of Siena, Italy
Blood 106:1031-6. 2005..The different types of C-MYC translocation reported in BL may also be related to the different stages of B-cell maturation... - Gene-expression analysis identifies novel RBL2/p130 target genes in endemic Burkitt lymphoma cell lines and primary tumorsGiulia De Falco
Department of Human Pathology and Oncology, University of Siena, Italy
Blood 110:1301-7. 2007..In conclusion, these data suggest that, as RBL2/p130 modulates the expression of target genes, which are important for cell growth and viability, its inactivation may be relevant for the occurrence of BL... - The role of the Cdk9/Cyclin T1 complex in T cell differentiationEleonora Leucci
Department of Human Pathology and Oncology, University of Siena, Siena, Italy
J Cell Physiol 212:411-5. 2007.... - Missing expression of pRb2/p130 in human retinoblastomas is associated with reduced apoptosis and lesser differentiationCristiana Bellan
Institute of Pathologic Anatomy and Histology, University of Siena, Italy
Invest Ophthalmol Vis Sci 43:3602-8. 2002..CONCLUSIONS: These observations give evidence that expression of p130 is inversely correlated with higher rates of apoptosis in human retinoblastomas and give an additional example of this regulator's role in cellular differentiation... - Geographic variation and environmental conditions as cofactors in Chlamydia psittaci association with ocular adnexal lymphomas: a comparison between Italian and African samplesAlessandro Carugi
Department Human Pathology and Oncology, University of Siena, 53100 Siena, Italy
Hematol Oncol 28:20-6. 2010..psittaci-positive cases. We may conclude that the role of epidemiologic, environmental and genetic factors, must be considered in the aetiology of this disease... - Rare lymphoid neoplasms coexpressing B- and T-cell antigens. The role of PAX-5 gene methylation in their pathogenesisStefano Lazzi
Department of Human Pathology and Oncology, University of Siena, 53100 Siena, Italy
Hum Pathol 40:1252-61. 2009..Interestingly, these cases were all characterized by poor clinical outcome... - Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 infection in reactive lymphoid tissues: a model for KSHV/HHV-8-related lymphomas?Stefano Lazzi
Department of Human Pathology and Oncology, University of Siena, 53100, Italy
Hum Pathol 37:23-31. 2006..In conclusion, the maturation stage of KSHV/HHV-8-positive B cells as well as the type of viral infection may well determine the morphological, phenotypic, and clinical characteristics of KSHV/HHV-8-associated lymphomas... - CDK9/CYCLIN T1 expression during normal lymphoid differentiation and malignant transformationCristiana Bellan
Department of Human Pathology and Oncology, University of Siena, Italy
J Pathol 203:946-52. 2004..The molecular mechanism through which the CDK9/CYCLIN T1 complex is altered in malignant transformation needs to be elucidated... - Role of EBV in microRNA dysregulation in Burkitt lymphomaGiulia De Falco
Department of Human Pathology and Oncology, University of Siena, Via delle Scotte, 6, 53100 Siena, Italy
Semin Cancer Biol 19:401-6. 2009..In this review, we will focus on the role of EBV in malignant transformation of Burkitt lymphoma, with a particular insight in the interplay between the virus and cellular miRNAs... - CD34+ cord blood cell-transplanted Rag2-/- gamma(c)-/- mice as a model for Epstein-Barr virus infectionMario Cocco
Department of Human Pathology and Oncology, Division of Pathological Anatomy, University of Siena, Siena, Italy
Am J Pathol 173:1369-78. 2008..Future experiments might allow understanding of the mechanisms responsible for persistent EBV infection and provide targets for more highly tailored therapeutic interventions... - Urocortin expression is downregulated in human endometrial carcinomaPasquale Florio
Department of Paediatrics, Obstetrics and Reproductive Medicine, University of Siena, Italy
J Endocrinol 190:99-105. 2006..These data and the evidence that endometrial cancer expresses UCN receptors and UCN is involved in tumorigenesis of several tissues together suggest a role for UCN in endometrial tumoral cell growth and proliferation... - Cdk9 regulates neural differentiation and its expression correlates with the differentiation grade of neuroblastoma and PNET tumorsGiulia De Falco
Department of Human Pathology and Oncology, University of Siena, Siena, Italy
Cancer Biol Ther 4:277-81. 2005..Conversely, no significant alteration of Cdk9 expression was observed in astrocytoma tumor samples of different grades, thus confirming the results obtained for the cell lines... - VEGF-D is expressed in activated lymphoid cells and in tumors of hematopoietic and lymphoid tissuesMonia Bardelli
Department of Molecular Biology, University of Siena, Siena, Italy
Leuk Lymphoma 48:2014-21. 2007..These data suggest that VEGF-D could contribute to leukemia and lymphoma growth via the induction of angiogenesis in bone marrow and lymphoid tissues... - High maternal and fetal plasma urocortin levels in pregnancies complicated by hypertensionPasquale Florio
Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy
J Hypertens 24:1831-40. 2006.... - Selective influences in the expressed immunoglobulin heavy and light chain gene repertoire in hairy cell leukemiaFrancesco Forconi
DM, Sezione di Ematologia e Trapianti, Dipartimento di Medicina Clinica e Scienze Immunologiche, Universita di Siena, AOUS, Viale Bracci, 53100 Siena, Italy
Haematologica 93:697-705. 2008..Those analyses raised questions on the incidence and type of selective influences occurring on the tumor B-cell receptor of hairy cell leukemia... - Expression of RB2/p130 tumor-suppressor gene in AIDS-related non-Hodgkin's lymphomas: implications for disease pathogenesisStefano Lazzi
Institute of Pathological Anatomy and Histology, University of Siena, Siena, Italy
Hum Pathol 33:723-31. 2002..In conclusion, our results seem to suggest that pRb2/p130 oncosuppressor protein may be a target in the interaction between the HIV-1 gene products and host proteins... - Human peripheral blood lymphocytes and fibroblasts as Notch3 expression modelsGiuseppe Di Maio
Department of Neurological, Neurosurgical and Behavioural Sciences, University of Siena, Policlinico Le Scotte, Siena, Italy
J Cell Physiol 227:1771-5. 2012.... - Analysis of the IgVH genes in T cell-mediated and antibody-mediated rejection of the kidney graftCristiana Bellan
Section of Pathological Anatomy, Department of Human Pathology and Oncology, University of Siena, Siena, Italy
J Clin Pathol 64:47-53. 2011..Analysis of gene-expression patterns also provides a window on the biology and pathogenesis of renal allograft rejection... - pRb2/p130 and VEGF expression in endometrial carcinoma in relation to angiogenesis and histopathologic tumor gradeFrancesca Sanseverino
Department of Gynecology, University of Siena, Nuovo Policlinico Le Scotte, Siena, Italy
Cancer Biol Ther 5:84-8. 2006..005). CONCLUSIONS: These results open up a new perspective including novel markers that, combined together, may be useful in patient screening for endometrial cancer aggressiveness... - A review of the trends of lymphomas in the equatorial belt of AfricaEmily A Rogena
Department of Human Pathology and Oncology, University of Siena, Siena, Italy
Hematol Oncol 29:111-5. 2011..In this review, we will summarize the state-of-the-art of lymphoma epidemiology, pathobiology and therapy, and will highlight the still existing gaps between developed and African countries... - Hairy cell leukemias with unmutated IGHV genes define the minor subset refractory to single-agent cladribine and with more aggressive behaviorFrancesco Forconi
Ematologia e Trapianti, Universita di Siena, Azienda Ospedaliera Universitaria Senese, Siena, Italy
Blood 114:4696-702. 2009..High incidence of TP53 dysfunction indicates a potential mechanism of resistance to cladribine in the UM-HCL group. Overall, our data provide new molecular elements relevant for treatment concerns in HCL... - Routine assessment of hormonal receptor and her-2/neu status underscores the need for more therapeutic targets in Kenyan women with breast cancerJoshua Nyagol
Department of Human Pathology and Oncology, University of Siena, Italy
Anal Quant Cytol Histol 28:97-103. 2006.... - Activity of rituximab monotherapy in refractory splenic marginal zone lymphoma complicated with autoimmune hemolytic anemiaAlberto Fabbri
Division of Hematology and Transplants, Policlinico S Maria alle Scotte, and University of Siena, Italy
Clin Lymphoma Myeloma 6:496-9. 2006..Maintenance therapy, although expensive, could be useful to improve event-free survival in patients with unfavorable clinical behavior... - High incidence of familial gastric cancer in Tuscany, a region in ItalyFranco Roviello
Department of Human Pathology and Oncology, University of Siena, Siena, Italy
Oncology 72:243-7. 2007..We studied a large cohort of gastric cancer patients from Tuscany, a region in Italy, to evaluate the presence of familial clustering of gastric cancer... - Patients with thymomas have an increased risk of developing additional malignancies: lack of immunological surveillance?Felice Granato
Thoracic Surgery Unit, Department of Cardiothoracic and Vascular Surgery, Siena University Hospital, Siena, Italy
Histopathology 60:437-42. 2012..To assess the risk, for patients with thymoma, of developing an additional malignancy (AM)... - Infectious agents and lymphomaGiulia De Falco
Department of Human Pathology and Oncology, University of Siena, Siena, Italy
Semin Diagn Pathol 28:178-87. 2011..In this review, we will focus on the association between infectious agents and lymphomas, with a look at the molecular mechanisms they use to disturb cell regulation and eventually result in cancer... - Subcutaneous panniculitis lymphoma: erythema nodosum-likeMassimiliano Risulo
Department of Clinical Medicine and Immunological Sciences, Section of Dermatology, University of Siena, Italy
Clin Lymphoma Myeloma 7:239-41. 2006.... - Immunoglobulin gene rearrangement analysis in composite hodgkin disease and large B-cell lymphoma: evidence for receptor revision of immunoglobulin heavy chain variable region genes in Hodgkin-Reed-Sternberg cells?Cristiana Bellan
Institute of Pathologic Anatomy and Histopathology, University of Siena, Italy
Diagn Mol Pathol 11:2-8. 2002.... - The effects of HIV-1 Tat protein on cell cycle during cervical carcinogenesisJ Nyagol
Department of Human Pathology and Oncology, University of Siena, Italy
Cancer Biol Ther 5:684-90. 2006..We also found that this HIV-1 Tat-induced cell proliferation was not dependent on the E2F family of transcription factors, and therefore postulate that Sp factors may be involved... - Expression of the ALK protein by anaplastic large-cell lymphomas correlates with high proliferative activityL Leoncini
Institute of Pathology, University of Sassari, Sassari, Italy
Int J Cancer 86:777-81. 2000..Our findings support the notion that ALK(+) and ALK(-) ALCLs are 2 distinct disease entities... - p53 mutation in breast cancer. Correlation with cell kinetics and cell of originT Megha
Institute of Pathologic Anatomy and Histology, University of Siena, 53100, Italy
J Clin Pathol 55:461-6. 2002.... - MYC translocation-negative classical Burkitt lymphoma cases: an alternative pathogenetic mechanism involving miRNA deregulationE Leucci
Department of Human Pathology and Oncology, University of Siena, Italy
J Pathol 216:440-50. 2008..These results indicate for the first time that hsa-mir-34b may influence c-Myc expression in Burkitt lymphoma as the more common aberrant control exercised by the immunoglobulin enhancer locus... - Pathologic aspects of AIDS malignanciesC Bellan
Department of Human Pathology and Oncology, University of Siena, Siena, Italy
Oncogene 22:6639-45. 2003..The aim of this paper is to review the pathology of AIDS-related malignancies, taking into account the pathogenetic mechanisms and their potential for improving the treatment of these tumors... - Cytokeratin-positive interstitial cell neoplasm: a case report and classification issuesK Schuerfeld
Department of Human Pathology and Oncology, Siena University, Siena, Italy
Histopathology 43:491-4. 2003..Careful clinical and pathological evaluation is necessary to exclude this possibility... - Hodgkin's lymphoma: the pathologist's viewpointS A Pileri
Pathologic Anatomy and Haematopathology, Bologna University, Policlinico S Orsola, Via Massarenti 9, 40138 Bologna, Italy
J Clin Pathol 55:162-76. 2002..Treatments adjusted to the pathobiological characteristics of the tumour in at risk patients have been proposed and are on the way to being applied... - Predicting high-risk human papillomavirus infection, progression of cervical intraepithelial neoplasia, and prognosis of cervical cancer with a panel of 13 biomarkers tested in multivariate modelingMargherita Branca
Unità Citoistopatologia, Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute, Istituto Superiore di Sanita, Rome, Italy
Int J Gynecol Pathol 27:265-73. 2008..However, testing the performance of this marker combination in a screening setting necessitates their analysis in cytological samples... - Update on extranodal lymphomas. Conclusions of the Workshop held by the EAHP and the SH in Thessaloniki, GreeceE Campo
Department of Pathology, Vienna General Hospital, Medical University of Vienna, Vienna, Austria
Histopathology 48:481-504. 2006.... - [The Haemolymphopathology Italian Group (H.I.G.): an essential resource for the new technical and organization problems troubling modern haemolymphopathology diagnostics]M Paulli
Sezione di Anatomia Patologica, Dipartimento di Patologia Umana ed Ereditaria, I.R.C.C.S. Policlinico S. Matteo, Universita di Pavia
Pathologica 98:37-40. 2006.... - Diffuse large B-cell lymphoma: one or more entities? Present controversies and possible tools for its subclassificationS A Pileri
Chair of Pathologic Anatomy and Lymphoma Unit, L and A Serà gnoli Institute of Haematology and Clinical Oncology, Bologna University, Via Massarenti 9, 40138 Bologna, Italy
Histopathology 41:482-509. 2002..The more recent acquisitions on the pathobiology of DLBCLs are reviewed in the light of the authors' experience, aiming to contribute to the existing debate on the topic...