Research Topics
Genomes and Genes | Silvia GiordanoSummaryAffiliation: University of Turin Country: Italy Publications
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Detail Information
Publications
Semaphorin pathways orchestrate osteogenesisLuca Tamagnone
Nat Cell Biol 8:545-7. 2006- The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-MetAnnalisa Petrelli
CNR CIOS and Department of Genetics, Biology and Biochemistry, University of Torino, 10126 Torino, Italy
Nature 416:187-90. 2002..These data provide further evidence of a relationship between receptor-mediated signalling and endocytosis, and disclose a novel functional role for Cbl in HGF receptor signalling... - Sema4D induces angiogenesis through Met recruitment by Plexin B1Paolo Conrotto
Division of Molecular Oncology, Department of Oncological Sciences, IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Strada Provinciale 142 10060, Candiolo, Torino, Italy
Blood 105:4321-9. 2005..In sum, we identify a proangiogenic semaphorin and provide insight about the signaling machinery exploited by Plexin B1 to control angiogenesis... - The semaphorin 4D receptor controls invasive growth by coupling with MetSilvia Giordano
Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy
Nat Cell Biol 4:720-4. 2002..This work identifies a novel biological function of semaphorins and suggests the involvement of an unexpected signalling mechanism, namely, the coupling of a plexin to a tyrosine kinase receptor... - Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibitionSimona Corso
Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo Torino, Italy
Mol Cancer 9:121. 2010..Perspective studies are thus mandatory to identify the molecular mechanisms that could cause resistance to these therapies... - Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activityAnnalisa Petrelli
Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, 10060 Candiolo, Italy
Proc Natl Acad Sci U S A 103:5090-5. 2006..Interestingly, the "decoy effect" generated by the shed ectodomain, acting as a dominant negative molecule, enhanced the inhibitory effect of the Ab... - MicroRNAs impair MET-mediated invasive growthCristina Migliore
Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Torino, Italy
Cancer Res 68:10128-36. 2008..In conclusion, we have identified miRNAs that behave as oncosuppressors by negatively targeting MET and might thus provide an additional option to inhibit this oncogene in tumors displaying its deregulation... - Interplay between scatter factor receptors and B plexins controls invasive growthPaolo Conrotto
Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Torino Medical School, I 10060 Candiolo, Torino, Italy
Oncogene 23:5131-7. 2004.... - MET and KRAS gene amplification mediates acquired resistance to MET tyrosine kinase inhibitorsVirna Cepero
Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Turin, Italy
Cancer Res 70:7580-90. 2010.... - Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophagesJose Rafael Sierra
Institute for Cancer Research and Treatment, University of Torino Medical School, 10060 Candiolo, Torino, Italy
J Exp Med 205:1673-85. 2008..This study helps to explain the protumoral role of inflammatory cells of the tumor stroma and leads to the identification of an angiogenic molecule that might be a novel therapeutic target... - CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytesLuisa Granziero
Department of Oncological Sciences, University of Torino, Institute for Cancer Research and Treatment IRCC, Candiolo TO and Division of Clinical Immunology and Hematology, Ospedale Mauriziano Umberto I, Torino, Italy
Blood 101:1962-9. 2003..The crosstalk operated by the CD100/Plexin-B1 interaction is not malignancy related but reproduces a mechanism used by normal CD5+ B cells... - Cancer therapy: can the challenge be MET?Simona Corso
IRCC, Institute for Cancer Research and Treatment, University of Turin School of Medicine, Division of Molecular Oncology, 10060 Candiolo, Turin, Italy
Trends Mol Med 11:284-92. 2005..Interfering with Met activation is thus a new and challenging approach to hamper tumorigenic and metastatic processes... - Semaphorin 4D regulates gonadotropin hormone-releasing hormone-1 neuronal migration through PlexinB1-Met complexPaolo Giacobini
Department of Human and Animal Biology, University of Turin, Turin 10123, Italy
J Cell Biol 183:555-66. 2008..This work identifies a function for PlexinB1 during brain development and provides evidence that Sema4D controls migration of GnRH-1 neurons... - Molecular cancer therapy: can our expectation be MET?Cristina Migliore
IRCC, Institute for Cancer Research and Treatment, University of Turin School of Medicine, Division of Molecular Oncology, Strada Provinciale 142, 10060 Candiolo, Turin, Italy
Eur J Cancer 44:641-51. 2008..In this review, we will discuss the molecular mechanisms underlying MET involvement in tumourigenesis and present pre-clinical and clinical data obtained with compounds aimed at targeting MET in the frame of cancer therapy... - Hypoxia promotes invasive growth by transcriptional activation of the met protooncogeneSelma Pennacchietti
Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Italy
Cancer Cell 3:347-61. 2003..These data show that hypoxia promotes tumor invasion by sensitizing cells to HGF stimulation, providing a molecular basis to explain Met overexpression in cancer... - Rilotumumab, a mAb against human hepatocyte growth factor for the treatment of cancerSilvia Giordano
University of Torino Medical School, Institute for Cancer Research and Treatment IRCC, Torino, Italy
Curr Opin Mol Ther 11:448-55. 2009..Which tumor types might benefit most from treatment with rilotumumab remains to be determined, and the identification of candidate patients will be a critical issue for the further development of this drug... - Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapyJ Rafael Sierra
Institute for Cancer Research and Treatment, University of Torino Medical School, 10060 Candiolo Torino, Italy
Mol Cancer 9:75. 2010..The knowledge obtained from these studies will help to design better therapies that prevent and overcome resistance to treatment in cancer patients... - MiR-1 Downregulation Cooperates with MACC1 in Promoting MET Overexpression in Human Colon CancerCristina Migliore
Authors Affiliations IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Turin, Italy Department of Toxicology, Unit of Oncology and Molecular Pathology and Department of Surgery Colorectal Unit AOU, University of Cagliari, Cagliari, Italy
Clin Cancer Res 18:737-47. 2012..We aimed to evaluate the role of its negative regulators, miR-1 and miR-199a*, and its transcriptional activator, the metastasis-associated in colon cancer 1 (MACC1), in controlling MET expression in human colon cancer samples... - TGFalpha expression impairs Trastuzumab-induced HER2 downregulationGiorgio Valabrega
Division of Medical Oncology, Institute for Cancer Research and Treatment, University of Turin Medical School, Str. Prov. 142, Km 3.95, 10060 Candiolo, Italy
Oncogene 24:3002-10. 2005..Our results suggest that unresponsiveness to Trastuzumab may not be due to intrinsic defects in the machinery responsible for HER2 downregulation, but can be associated with a TGFalpha-related mechanism of escape to HER2 downregulation... - Invasive growth: a two-way street for semaphorin signallingPaolo M Comoglio
Nat Cell Biol 6:1155-7. 2004 - Plexin-B3 is a functional receptor for semaphorin 5AStefania Artigiani
Institute for Cancer Research and Treatment IRCC, University of Torino Medical School, 10060 Candiolo To, Italy
EMBO Rep 5:710-4. 2004..We thus conclude that Sema5A is able to elicit multiple functional responses through its receptor plexin-B3... - Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogeneClaudia Ghigna
Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Pavia, Italy
Mol Cell 20:881-90. 2005..This demonstrates a direct link between SF2/ASF-regulated splicing and cell motility, an activity important for embryogenesis, tissue formation, and tumor metastasis... - Negative receptor signallingIvan Dikic
Ludwig Institute for Cancer Research, Husargatan 3, SE 75 124 Uppsala, Sweden
Curr Opin Cell Biol 15:128-35. 2003..e. Sprouty), cytoplasmic kinases (i.e. activated Cdc42-associated kinase) and phosphoinositol metabolites. These inhibitory signals are essential for normal cell functioning, and their deregulation often results in human diseases... - Hepatocyte growth factor and its receptor are required for malaria infectionMargarida Carrolo
, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal
Nat Med 9:1363-9. 2003..Our findings identify HGF and MET as potential targets for new approaches to malaria prevention... - Reactive oxygen species mediate Met receptor transactivation by G protein-coupled receptors and the epidermal growth factor receptor in human carcinoma cellsOliver M Fischer
Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
J Biol Chem 279:28970-8. 2004.... - Methylation analysis of the promoter F of estrogen receptor alpha gene: effects on the level of transcription on human osteoblastic cellsLetizia Penolazzi
Dipartimento di Biochimica e Biologia Molecolare, Universita degli Studi di Ferrara, Via L Borsari, 46 44100, Italy
J Steroid Biochem Mol Biol 91:1-9. 2004..The overall results suggest that methylation of the CpG sites inside ERalpha gene promoter F here analyzed may contribute to ERalpha transcriptional control, directly or indirectly, influencing the tissue specific expression of the gene... - Targeting Plasmodium host cells: survival within hepatocytesMaria M Mota
Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
Trends Mol Med 10:487-92. 2004..Hepatocyte growth factor and its receptor on hepatocytes might enhance early Plasmodium development within these cells. We anticipate that this might be the basis for further studies on host-cell requirements for Plasmodium development... - Drug development of MET inhibitors: targeting oncogene addiction and expediencePaolo M Comoglio
Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin School of Medicine, Candiolo, Turin 10060, Italy
Nat Rev Drug Discov 7:504-16. 2008..Here we discuss recent progress in the development of molecules that inhibit MET function and consider their application in a subset of human tumours that are potentially responsive to MET-targeted therapies... - HGF/MET signalling protects Plasmodium-infected host cells from apoptosisPatricia Leiriao
Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
Cell Microbiol 7:603-9. 2005..These results demonstrate for the first time that active inhibition of apoptosis in host cell during infection by Plasmodium is required for a successful infection...