C Ghelardini

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. ncbi DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer
    C Ghelardini
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy
    Naunyn Schmiedebergs Arch Pharmacol 365:419-26. 2002
  2. ncbi Investigation into atropine-induced antinociception
    C Ghelardini
    Department of Preclinical and Clinical Pharmacology, University of Florence, Firenze, Italy
    Br J Pharmacol 101:49-54. 1990
  3. ncbi Antisense 'knockdowns' of M1 receptors induces transient anterograde amnesia in mice
    C Ghelardini
    Department of Pharmacology, University of Florence, Italy
    Neuropharmacology 38:339-48. 1999
  4. ncbi Effect of K+ channel modulation on mouse feeding behaviour
    C Ghelardini
    Department of Pharmacology, University of Florence, Italy
    Eur J Pharmacol 329:1-8. 1997
  5. ncbi Role of potassium channels in the antinociception induced by agonists of alpha2-adrenoceptors
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, Florence, Italy
    Br J Pharmacol 126:1214-20. 1999
  6. ncbi Supraspinal role of protein kinase C in oxaliplatin-induced neuropathy in rat
    M Norcini
    Department of Clinical and Preclinical Pharmacology, University of Florence, Italy
    Pain 146:141-7. 2009
  7. ncbi An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuropharmacology 55:1156-64. 2008
  8. ncbi Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuroscience 153:814-22. 2008
  9. ncbi Acetyl-L-carnitine increases artemin level and prevents neurotrophic factor alterations during neuropathy
    E Vivoli
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy
    Neuroscience 167:1168-74. 2010
  10. ncbi Antiamnesic activity of metoclopramide, cisapride and SR-17 in the mouse passive avoidance test
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
    Pharmacol Res 36:59-67. 1997

Collaborators

Detail Information

Publications40

  1. ncbi DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer
    C Ghelardini
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy
    Naunyn Schmiedebergs Arch Pharmacol 365:419-26. 2002
    ..Indeed, its potency is about 1,000 times higher than that of the most active piracetam-like compounds...
  2. ncbi Investigation into atropine-induced antinociception
    C Ghelardini
    Department of Preclinical and Clinical Pharmacology, University of Florence, Firenze, Italy
    Br J Pharmacol 101:49-54. 1990
    ..8. The antagonism by pirenzepine and dicyclomine of oxotremorine and atropine antinociception suggests that M1 muscarinic receptor subtypes are responsible for cholinergic analgesia...
  3. ncbi Antisense 'knockdowns' of M1 receptors induces transient anterograde amnesia in mice
    C Ghelardini
    Department of Pharmacology, University of Florence, Italy
    Neuropharmacology 38:339-48. 1999
    ..Neither aODN, dODN nor vehicle produced any behavioral impairment of mice. These results indicate that the integrity and functionality of M1 receptors are fundamental in the modulation of memory processes...
  4. ncbi Effect of K+ channel modulation on mouse feeding behaviour
    C Ghelardini
    Department of Pharmacology, University of Florence, Italy
    Eur J Pharmacol 329:1-8. 1997
    ..The integrity and functionality of central K+ channels appears, therefore, to be fundamental in the regulation of food intake by mice...
  5. ncbi Role of potassium channels in the antinociception induced by agonists of alpha2-adrenoceptors
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, Florence, Italy
    Br J Pharmacol 126:1214-20. 1999
    ..7. The present data demonstrate that both K(ATP) and mKv1.1 K+ channels represent an important step in the transduction mechanism underlying central antinociception induced by activation of alpha2 adrenoceptors...
  6. ncbi Supraspinal role of protein kinase C in oxaliplatin-induced neuropathy in rat
    M Norcini
    Department of Clinical and Preclinical Pharmacology, University of Florence, Italy
    Pain 146:141-7. 2009
    ....
  7. ncbi An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuropharmacology 55:1156-64. 2008
    ..These results indicate the involvement of the InsP3R-mediated pathway in the modulation of depressive conditions and may be useful for the development of new therapeutical strategies for the treatment of mood disorders...
  8. ncbi Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuroscience 153:814-22. 2008
    ..A selective involvement of RyR1 and RyR3 in supraspinal muscarinic analgesia was demonstrated whereas RyR2 appears not to play an essential role in acute thermal and inflammatory pain...
  9. ncbi Acetyl-L-carnitine increases artemin level and prevents neurotrophic factor alterations during neuropathy
    E Vivoli
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy
    Neuroscience 167:1168-74. 2010
    ..These data offer a new point of view on the mechanism of the antihyperalgesic as well as the neuroprotective effect of ALCAR...
  10. ncbi Antiamnesic activity of metoclopramide, cisapride and SR-17 in the mouse passive avoidance test
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
    Pharmacol Res 36:59-67. 1997
    ..These results suggest that metoclopramide, cisapride and SR-17 play an important role in the modulation of memory processes. On these bases, these compounds could be useful in the treatment of cognitive deficits...
  11. ncbi Antinociception induced by SM 32 depends on a central cholinergic mechanism
    C Ghelardini
    Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
    Pharmacol Res 35:141-7. 1997
    ..On the basis of the above data, it can be postulated that SM 32 exerts its antinociceptive effect through a potentiation of central cholinergic transmission...
  12. ncbi Binding profiles of a series of 2-arylpropionic acid esters on cloned human muscarinic receptor subtypes (m1-m5) and their relationship to nootropic activity
    C Ghelardini
    Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
    Arzneimittelforschung 49:483-8. 1999
    ..p.) in the mouse passive-avoidance test. Compounds 1 and 7, at the highest antiamnesic doses, do not modify motor coordination and spontaneous motility as evaluated by the rota-rod test and Animex apparatus experiments...
  13. ncbi Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition enhancers
    M N Romanelli
    Dipartimento di Scienze Farmaceutiche, University of Florence, Sesto Fiorentino, Italy
    CNS Drug Rev 12:39-52. 2006
    ..In vitro experiments, performed on hippocampal slices, also supported the hypothesis of a role of the AMPA receptors for the cognition-enhancing properties of unifiram and sunifiram...
  14. ncbi M1 receptor activation is a requirement for arecoline analgesia
    C Ghelardini
    Department of Pharmacology, University of Florence, Italy
    Farmaco 56:383-5. 2001
    ..This effect was detected 24 h after the last i.c.v. injection of aODN. These results indicate that arecoline antinociception is mediated by the activation of central M1 muscarinic receptors...
  15. ncbi Differential prevention of morphine amnesia by antisense oligodeoxynucleotides directed against various Gi-protein alpha subunits
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G. Pieraccini 6, I-50139 Florence, Italy
    Br J Pharmacol 133:267-74. 2001
    ..These results suggest the important role played by Gi1 and Gi3 protein subtypes in the transduction mechanism involved in the impairment of memory processes produced by morphine...
  16. ncbi The neuropathy-protective agent acetyl-L-carnitine activates protein kinase C-gamma and MAPKs in a rat model of neuropathic pain
    L Di Cesare Mannelli
    University of Florence, Department of Preclinical and Clinical Pharmacology, Florence, Italy
    Neuroscience 165:1345-52. 2010
    ..These findings may represent a different approach in the study of the complex balance between pain and neuroregeneration and could constitute the basis for developing new disease modifying agents in the treatment of neuropathic pain...
  17. ncbi AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram)
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G. Pieraccini 6, 50139 Florence, Italy
    Naunyn Schmiedebergs Arch Pharmacol 368:538-45. 2003
    ..These results suggest that DM 232 and DM 235 act as cognition enhancers through the activation of the AMPA-mediated neurotransmission system...
  18. ncbi Methylamine and benzylamine induced hypophagia in mice: modulation by semicarbazide-sensitive benzylamine oxidase inhibitors and aODN towards Kv1.1 channels
    R Pirisino
    Department of Preclinical and Clinical Pharmacology, Viale Pieraccini, 6, 50134 Florence, Italy
    Br J Pharmacol 134:880-6. 2001
    ..1 blocking activity. Through a reduction of the endogenous breakdown of MET, Bz-SSAO inhibitors enhance the central pharmacological activity of this amine...
  19. ncbi Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuroscience 149:409-20. 2007
    ..These results indicate a selective involvement of type 2 and 3 IP3R in central muscarinic antinociception in mice...
  20. ncbi Hypofunctionality of Gi proteins as aetiopathogenic mechanism for migraine and cluster headache
    N Galeotti
    Department of Pharmacology, University of Florence, Italy
    Cephalalgia 21:38-45. 2001
    ..These results indicate Gi protein hypofunctionality as an aetiopathogenic mechanism in migraine and cluster headache...
  21. ncbi Investigation into the role of histamine receptors in rodent antinociception
    C Lamberti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Firenze, Italy
    Pharmacol Biochem Behav 53:567-74. 1996
    ..It is suggested that the histaminergic system modulates nociception via activation of the H2-receptor...
  22. ncbi New "drug-in cyclodextrin-in deformable liposomes" formulations to improve the therapeutic efficacy of local anaesthetics
    F Maestrelli
    Department of Pharmaceutical Sciences, University of Florence, via Schiff 6, Sesto Fiorentino, 50019 Florence, Italy
    Int J Pharm 395:222-31. 2010
    ..For both drugs, double-loaded liposomes, exploiting the favourable effects of drug-CD complexation, allowed a significant (P<0.05) enhancement of intensity and duration of anaesthetic effect with respect to those single-loaded...
  23. ncbi Loss of muscarinic antinociception by antisense inhibition of M(1) receptors
    C Ghelardini
    Department of Pharmacology, Viale G Pieraccini 6, University of Florence, I 50139 Florence, Italy
    Br J Pharmacol 129:1633-40. 2000
    ..These results indicate that activation of M(1) muscarinic receptor subtype is fundamental to induce central cholinergic analgesia in mice...
  24. ncbi Neuropathy-induced apoptosis: protective effect of physostigmine
    L Di Cesare Mannelli
    Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
    J Neurosci Res 87:1871-6. 2009
    ..This protection correlates with the induction of XIAP. Therefore, apoptosis, central to tissue degeneration, is prevented by repeated physostigmine treatment of CCI animals...
  25. ncbi Diphenhydramine-induced amnesia is mediated by Gi-protein activation
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G. Pieraccini 6, I-50139 Florence, Italy
    Neuroscience 122:471-8. 2003
    ..These results suggest the important role played by the Gi(1)- and Gi(2)-protein pathway in the transduction mechanism involved in the impairment of memory processes produced by the H(1)-antihistamine diphenhydramine...
  26. ncbi Alpha-2 agonists induce amnesia through activation of the Gi-protein signalling pathway
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G. Pieraccini 6, I-50139 Florence, Italy
    Neuroscience 126:451-60. 2004
    ..These results indicate the involvement of Gi1, Gi3, and Go1, but not Gi2 and Go2, protein subtypes in the transduction mechanism responsible for the induction of amnesia by clonidine and guanabenz...
  27. ncbi Effects of a new potent analog of tocainide on hNav1.7 sodium channels and in vivo neuropathic pain models
    C Ghelardini
    Department of Preclinical and Clinical Pharmacology, Faculty of Pharmacy, University of Florence, Florence, Italy
    Neuroscience 169:863-73. 2010
    ..Overall, these results indicate NeP1 as a new promising lead compound for further development in the treatment of chronic pain of neuropathic origin...
  28. ncbi Pharmacological identification of SM-21, the novel sigma(2) antagonist
    C Ghelardini
    Department of Preclinical and Clinical Pharmacology, Viale G Pieraccini 6, University of Florence, I 50139, Florence, Italy
    Pharmacol Biochem Behav 67:659-62. 2000
    ..5 microl) in the red nucleus. These data indicate that SM-21 is a potent and selective sigma(2) antagonist...
  29. ncbi Local anaesthetic activity of the essential oil of Lavandula angustifolia
    C Ghelardini
    Department of Pharmacology, University of Florence, Italy
    Planta Med 65:700-3. 1999
    ....
  30. ncbi Role of muscarinic receptor subtypes in central antinociception
    A Bartolini
    Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
    Br J Pharmacol 105:77-82. 1992
    ..Nevertheless, presynaptic autoreceptors (M2 subtype) may play a role in pain regulation since they are involved in modulation of endogenous ACh release...
  31. ncbi Role of histamine in rodent antinociception
    P Malmberg Aiello
    Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
    Br J Pharmacol 111:1269-79. 1994
    ..Involvement of the histaminergic system in the modulation of nociceptive stimuli is thus proposed...
  32. ncbi A reduced functionality of Gi proteins as a possible cause of fibromyalgia
    N Galeotti
    Department of Pharmacology, Headache Center, University of Florence, Italy
    J Rheumatol 28:2298-304. 2001
    ....
  33. ncbi Local anaesthetic activity of beta-caryophyllene
    C Ghelardini
    Department of Pharmacology, University of Florence, Italy
    Farmaco 56:387-9. 2001
    ..In conclusion, these data evidence the local anaesthetic activity of beta-caryophyllene, which appears to be strictly dependent on its chemical structure...
  34. ncbi Protective effect of acetyl-L-carnitine on the apoptotic pathway of peripheral neuropathy
    Lorenzo Di Cesare Mannelli
    Department of Preclinical and Clinical Pharmacology, University of Florence, 50139, Florence, Italy
    Eur J Neurosci 26:820-7. 2007
    ..Taken together these results show that CCI is a valuable model to investigate neuropathies-related apoptosis phenomena and that ALCAR is able to prevent regulated cell death in the damaged sciatic nerve...
  35. ncbi Antihistamine antinociception is mediated by Gi-protein activation
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G. Pieraccini 6, I-50139 Florence, Italy
    Neuroscience 109:811-8. 2002
    ..These results suggest an important role played by the Gi-protein pathway in the transduction mechanism involved in the enhancement of the pain threshold produced by H(1)-antihistamines...
  36. ncbi Pharmacological in vivo test to evaluate the bioavailability of some St John's Wort innovative oral preparations
    B Isacchi
    Department of Pharmaceutical Sciences, University of Florence, Italy
    Phytother Res 23:197-205. 2009
    ....
  37. ncbi Methylamine-dependent release of nitric oxide and dopamine in the CNS modulates food intake in fasting rats
    L Raimondi
    Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
    Br J Pharmacol 150:1003-10. 2007
    ..The aim of this work was to show whether methylamine also modifies feeding behaviour in rats and, if so, to identify the mediator(s) responsible for such effects...
  38. ncbi Endogenous morphine modulates acute thermonociception in mice
    M Guarna
    Neuroscience Research Institute, State University of New York, USA
    J Neurochem 80:271-7. 2002
    ....
  39. ncbi Structure-affinity relationships of a unique nicotinic ligand: N(1)-dimethyl-N(4)-phenylpiperazinium iodide (DMPP)
    M N Romanelli
    Dipartimento di Scienze Farmaceutiche, , Via Gino Capponi 9, 50121 Firenze, Italy
    J Med Chem 44:3946-55. 2001
    ....
  40. ncbi Central cholinergic challenging of migraine by testing second-generation anticholinesterase drugs
    M Nicolodi
    Interuniversity Center, Neurochemistry and Clinical Pharmacology of Idiopathic Headache, Viale G. Pieraccini 18, 1-50139, Florence, Italy
    Headache 42:596-602. 2002
    ..Clinical results also indicate that the activation of the cholinergic system can represent a novel prophylactic approach to migraine...