G L Gessa

Summary

Affiliation: University of Cagliari
Country: Italy

Publications

  1. ncbi Co-release of noradrenaline and dopamine in the cerebral cortex elicited by single train and repeated train stimulation of the locus coeruleus
    Paola Devoto
    Department of Neuroscience B B Brodie University of Cagliari, Italy
    BMC Neurosci 6:31. 2005
  2. ncbi Suppressing effect of the cannabinoid CB1 receptor antagonist, SR147778, on alcohol intake and motivational properties of alcohol in alcohol-preferring sP rats
    Gian Luigi Gessa
    C N R Institute of Neuroscience, Section of Cagliari, Viale Diaz 182, I 09126 Cagliari CA, Italy
    Alcohol Alcohol 40:46-53. 2005
  3. ncbi Inhibition of hippocampal acetylcholine release by cannabinoids: reversal by SR 141716A
    G L Gessa
    Bernard B Brodie Department of Neuroscience, University of Cagliari, Italy
    Eur J Pharmacol 327:R1-2. 1997
  4. ncbi Foreword. The clinical aspects of deficit in dopaminergic ways
    Gian Luigi Gessa
    B.B. Brodie Department of Neuroscience, University of Cagliari, Cagliari, Italy
    Int Clin Psychopharmacol 17:2 p following table of contents. 2002
  5. ncbi Cannabinoids decrease acetylcholine release in the medial-prefrontal cortex and hippocampus, reversal by SR 141716A
    G L Gessa
    B B Brodie Department of Neuroscience, University of Cagliari, Italy
    Eur J Pharmacol 355:119-24. 1998
  6. ncbi Selective breeding of two rat lines differing in sensitivity to GHB and baclofen
    G Colombo
    C N R Center for Neuropharmacology, c o Bernard B Brodie Department of Neuroscience, University of Cagliari, SS 554, Km 4 5, I 09042, Monserrato CA, Italy
    Brain Res 902:127-30. 2001
  7. ncbi Role of GABA(B) receptors in the sedative/hypnotic effect of gamma-hydroxybutyric acid
    M A Carai
    Bernard B Brodie Department of Neuroscience, University of Cagliari, S S 554 Km 4 5, I 09042 Monserrato, CA, Italy
    Eur J Pharmacol 428:315-21. 2001
  8. ncbi Medial forebrain bundle stimulation evokes endocannabinoid-mediated modulation of ventral tegmental area dopamine neuron firing in vivo
    Giuliano Pillolla
    B B Brodie Department of Neuroscience, University of Cagliari, Cittadella Universitaria di Monserrato, 09042, Monserrato, Cagliari, Italy
    Psychopharmacology (Berl) 191:843-53. 2007
  9. ncbi Adolescent exposure to cannabinoids induces long-lasting changes in the response to drugs of abuse of rat midbrain dopamine neurons
    Marco Pistis
    Bernard Beryl Brodie Department of Neuroscience, University of Cagliari, Monserrato, Italy
    Biol Psychiatry 56:86-94. 2004
  10. ncbi Involvement of GABA(A) and GABA(B) receptors in the mediation of discriminative stimulus effects of gamma-hydroxybutyric acid
    G Colombo
    C N R Center for Neuropharmacology, Cagliari, Italy
    Physiol Behav 64:293-302. 1998

Detail Information

Publications105 found, 100 shown here

  1. ncbi Co-release of noradrenaline and dopamine in the cerebral cortex elicited by single train and repeated train stimulation of the locus coeruleus
    Paola Devoto
    Department of Neuroscience B B Brodie University of Cagliari, Italy
    BMC Neurosci 6:31. 2005
    ..To rule out possible stressful effects of electrical stimulation, experiments were performed on chloral hydrate anaesthetised rats...
  2. ncbi Suppressing effect of the cannabinoid CB1 receptor antagonist, SR147778, on alcohol intake and motivational properties of alcohol in alcohol-preferring sP rats
    Gian Luigi Gessa
    C N R Institute of Neuroscience, Section of Cagliari, Viale Diaz 182, I 09126 Cagliari CA, Italy
    Alcohol Alcohol 40:46-53. 2005
    ..The present study investigated the effect of the newly synthesized cannabinoid CB(1) receptor antagonist, SR147778, on alcohol intake and the motivational properties of alcohol in selectively bred Sardinian alcohol-preferring (sP) rats...
  3. ncbi Inhibition of hippocampal acetylcholine release by cannabinoids: reversal by SR 141716A
    G L Gessa
    Bernard B Brodie Department of Neuroscience, University of Cagliari, Italy
    Eur J Pharmacol 327:R1-2. 1997
    ..The results also suggest that the negative effects of marijuana on learning and memory may depend on cannabinoid receptor-mediated inhibition of acetylcholine release...
  4. ncbi Foreword. The clinical aspects of deficit in dopaminergic ways
    Gian Luigi Gessa
    B.B. Brodie Department of Neuroscience, University of Cagliari, Cagliari, Italy
    Int Clin Psychopharmacol 17:2 p following table of contents. 2002
  5. ncbi Cannabinoids decrease acetylcholine release in the medial-prefrontal cortex and hippocampus, reversal by SR 141716A
    G L Gessa
    B B Brodie Department of Neuroscience, University of Cagliari, Italy
    Eur J Pharmacol 355:119-24. 1998
    ..Conversely, cannabinoid receptor antagonists may offer potential treatments for cognitive deficits...
  6. ncbi Selective breeding of two rat lines differing in sensitivity to GHB and baclofen
    G Colombo
    C N R Center for Neuropharmacology, c o Bernard B Brodie Department of Neuroscience, University of Cagliari, SS 554, Km 4 5, I 09042, Monserrato CA, Italy
    Brain Res 902:127-30. 2001
    ....
  7. ncbi Role of GABA(B) receptors in the sedative/hypnotic effect of gamma-hydroxybutyric acid
    M A Carai
    Bernard B Brodie Department of Neuroscience, University of Cagliari, S S 554 Km 4 5, I 09042 Monserrato, CA, Italy
    Eur J Pharmacol 428:315-21. 2001
    ..These results indicate that the sedative/hypnotic effect of GHB is mediated by the stimulation of GABA(B) receptors and add further support to the hypothesis that the GABA(B) receptor constitutes a central site of action of GHB...
  8. ncbi Medial forebrain bundle stimulation evokes endocannabinoid-mediated modulation of ventral tegmental area dopamine neuron firing in vivo
    Giuliano Pillolla
    B B Brodie Department of Neuroscience, University of Cagliari, Cittadella Universitaria di Monserrato, 09042, Monserrato, Cagliari, Italy
    Psychopharmacology (Berl) 191:843-53. 2007
    ..However, their functional and/or behavioural correlates are yet to be determined...
  9. ncbi Adolescent exposure to cannabinoids induces long-lasting changes in the response to drugs of abuse of rat midbrain dopamine neurons
    Marco Pistis
    Bernard Beryl Brodie Department of Neuroscience, University of Cagliari, Monserrato, Italy
    Biol Psychiatry 56:86-94. 2004
    ..CONCLUSIONS: Our study suggests that an enduring form of neuronal adaptation occurs in DA neurons after subchronic cannabinoid intake at a young age, affecting subsequent responses to drugs of abuse...
  10. ncbi Involvement of GABA(A) and GABA(B) receptors in the mediation of discriminative stimulus effects of gamma-hydroxybutyric acid
    G Colombo
    C N R Center for Neuropharmacology, Cagliari, Italy
    Physiol Behav 64:293-302. 1998
    ....
  11. ncbi Ability of baclofen in reducing alcohol intake and withdrawal severity: I--Preclinical evidence
    G Colombo
    CNR Center for Neuropharmacology, Bernard B Brodie Department of Neuroscience, University of Cagliari, Italy
    Alcohol Clin Exp Res 24:58-66. 2000
    ....
  12. ncbi Cannabinoid modulation of intestinal propulsion in mice
    G Colombo
    C N R Center for Neuropharmacology, Cagliari, Italy
    Eur J Pharmacol 344:67-9. 1998
    ..The results of the present study suggest a role for cannabinoid CB1 receptors in the control of propulsive activity in the mouse small intestine...
  13. ncbi Selective gamma-hydroxybutyric acid receptor ligands increase extracellular glutamate in the hippocampus, but fail to activate G protein and to produce the sedative/hypnotic effect of gamma-hydroxybutyric acid
    M Paola Castelli
    Neuroscienze S.c.a r.l, Cagliari, Italy
    J Neurochem 87:722-32. 2003
    ..The GHB analogues constitute important tools for understanding the physiological role of endogenous GHB and its receptor...
  14. ncbi Evidence for co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex
    P Devoto
    Department of Neuroscience BB Brodie, University of Cagliari, Via Porcell 4, I 09124 Cagliari, Italy
    Mol Psychiatry 6:657-64. 2001
    ..The co-release of NA and DA seems to be controlled by alpha(2)-receptors located on NA nerve terminals...
  15. ncbi Effects of cannabinoids on prefrontal neuronal responses to ventral tegmental area stimulation
    M Pistis
    B B Brodie Department of Neuroscience, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy
    Eur J Neurosci 14:96-102. 2001
    ..This study may be relevant in helping to understand the influence of cannabinoids on cognitive processes mediated by the prefrontal cortex...
  16. ncbi Different sensitivity to ethanol in alcohol-preferring sP and -nonpreferring sNP rats
    G Colombo
    CNR Center for Neuropharmacology, Cagliari, Italy
    Alcohol Clin Exp Res 24:1603-8. 2000
    ....
  17. ncbi Specific reduction of alcohol's motivational properties by the positive allosteric modulator of the GABAB receptor, GS39783--comparison with the effect of the GABAB receptor direct agonist, baclofen
    Paola Maccioni
    C N R Institute of Neuroscience, Cagliari, Italy
    Alcohol Clin Exp Res 32:1558-64. 2008
    ..The present study was conducted to assess and compare the effect of baclofen and GS39783 on the motivational properties of alcohol...
  18. ncbi Prenatal exposure to a cannabinoid agonist produces memory deficits linked to dysfunction in hippocampal long-term potentiation and glutamate release
    Giampaolo Mereu
    Department of Experimental Biology, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato, Italy
    Proc Natl Acad Sci U S A 100:4915-20. 2003
    ..These findings could provide an explanation of cognitive alterations observed in children born from women who use marijuana during pregnancy...
  19. ncbi Effects of chronic Delta(9)-tetrahydrocannabinol treatment on hippocampal extracellular acetylcholine concentration and alternation performance in the T-maze
    F Nava
    Department of Neuroscience, Bernard B Brodie, University of Cagliari, Cittadella Universitaria Monserrato, S S 554 km 4 500, 09042, Cagliari, Italy
    Neuropharmacology 41:392-9. 2001
    ..However, the major outcome of this work is the demonstration that no tolerance to the two inhibitory effects develops after a chronic Delta(9)-THC treatment...
  20. ncbi Quantitative autoradiographic distribution of gamma-hydroxybutyric acid binding sites in human and monkey brain
    M P Castelli
    Neuroscience S c a r l, Via Palabanda 9, I 09123, Cagliari, Italy
    Brain Res Mol Brain Res 78:91-9. 2000
    ..The present study is the first report on the autoradiographic distribution of specific GHB binding sites in the primate and human brain: such distribution is in both species in good agreement with the distribution found in the rat brain...
  21. ncbi Activation of GABA(B) receptors reverses spontaneous gating deficits in juvenile DBA/2J mice
    Marco Bortolato
    Department of Neuroscience Bernard B Brodie, University of Cagliari, Cittadella Universitaria, S S 554 Km 4, 500, 09042, Monserrato CA, Italy
    Psychopharmacology (Berl) 194:361-9. 2007
    ..We previously reported that baclofen, the prototypical GABA(B) agonist, elicits antipsychotic-like effects in the rat paradigm of prepulse inhibition (PPI) of the startle, a highly validated animal model of schizophrenia...
  22. ncbi Baclofen-induced reduction of alcohol reinforcement in alcohol-preferring rats
    Paola Maccioni
    Bernard B. Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I-09126 Cagliari, Italy
    Alcohol 36:161-8. 2005
    ..These data are also in agreement with the results of recent preliminary clinical studies suggesting that baclofen may have therapeutic efficacy in the treatment of alcohol dependence...
  23. ncbi Co-dergocrine (Hydergine) regulates striatal and hippocampal acetylcholine release through D2 receptors
    A Imperato
    Bernard B Brodie Department of Neuroscience, University of Cagliari, Italy
    Neuroreport 5:674-6. 1994
    ....
  24. ncbi GABA(B) receptor inhibition causes locomotor stimulation in mice
    G Colombo
    C N R Institute of Neurogenetics and Neuropharmacology, c o Bernard B Brodie Department of Neuroscience, University of Cagliari, S S 554, Km 4 5, I 09042 Monserrato Ca, Italy
    Eur J Pharmacol 433:101-4. 2001
    ..1 mg/kg, i.p.), suggesting that hyperactivity induced by blockade of the GABA(B) receptor is mediated by enhanced dopamine release. These results suggest the existence of a GABA(B) receptor-mediated tonic inhibition of dopamine neurons...
  25. ncbi Sardinian alcohol-preferring rats prefer chocolate and sucrose over ethanol
    G Colombo
    C N R Center for Neuropharmacology, Cagliari, Italy
    Alcohol 14:611-5. 1997
    ..g., response to the presentation of palatable fluids), which might parallel the different types of alcoholism observed in humans...
  26. ncbi Characterization of the discriminative stimulus effects of gamma-hydroxybutyric acid as a means for unraveling the neurochemical basis of gamma-hydroxybutyric acid actions and its similarities to those of ethanol
    G Colombo
    C N R Center for Neuropharmacology, University of Cagliari, Via Porcell 4, I 09124, Cagliari, Italy
    Alcohol 20:237-45. 2000
    ....
  27. ncbi Inhibition of peristaltic activity by cannabinoids in the isolated distal colon of mouse
    R Mancinelli
    Department of Applied Sciences to Biosystems, University of Cagliari, Italy
    Life Sci 69:101-11. 2001
    ..The present results further support the hypothesis that cannabinoids perform a neuromodulatory role in various tracts of gastrointestinal system and first demonstrate their action also in the distal colon of rodents...
  28. ncbi Gamma-hydroxybutyric acid intake in ethanol-preferring sP and -nonpreferring sNP rats
    G Colombo
    CNR Center for Neuropharmacology, Cagliari, Italy
    Physiol Behav 64:197-202. 1998
    ..The results are also discussed in terms of differences in GHB receptors contributing to the predisposition to ethanol preference and avoidance, respectively...
  29. ncbi Suppression of GABA(B) receptor function in vivo by disulfide reducing agent, DL-dithiothreitol (DTT)
    Mauro A M Carai
    Bernard B Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, 09126 Cagliari, Italy
    Psychopharmacology (Berl) 174:283-90. 2004
    ....
  30. ncbi Cue-induced reinstatement of ethanol seeking in Sardinian alcohol-preferring rats
    Paola Maccioni
    C N R Institute of Neuroscience, Viale Diaz 182, I 09126, Cagliari, Italy
    Alcohol 41:31-9. 2007
    ..The latter finding concurs with clinical observations that odor and taste of alcoholic beverages elicit immediate craving responses in abstinent alcoholics...
  31. ncbi Alcohol stimulates motor activity in selectively bred Sardinian alcohol-preferring (sP), but not in Sardinian alcohol-nonpreferring (sNP), rats
    R Agabio
    Bernard B. Brodie Department of Neuroscience, University of Cagliari, I-09124, Cagliari, Italy
    Alcohol 23:123-6. 2001
    ..These results suggest to us that a positive relationship exists between ethanol preference and ethanol-induced motor stimulation in sP/sNP rat lines...
  32. ncbi Stimulation of locomotor activity by voluntarily consumed ethanol in Sardinian alcohol-preferring rats
    G Colombo
    C N R Center for Neuropharmacology, Bernard B Brodie Department of Neuroscience, University of Cagliari, Italy
    Eur J Pharmacol 357:109-13. 1998
    ..These results suggest that the euphorigenic effects of ethanol, supposedly represented by the stimulation of locomotor activity, are part of the reinforcing properties of ethanol in sP rats...
  33. ncbi Up-regulation of GABA(B) receptors by chronic administration of the GABA(B) receptor antagonist SCH 50,911
    Fabio Pibiri
    B.B. Brodie Department of Neuroscience, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato (CA, Italy
    Eur J Pharmacol 515:94-8. 2005
    ..The results indicate that persistent blockade of GABA(B) receptors leads to their compensatory up-regulation and suggest that GABA(B) receptors are tonically activated by endogenous GABA...
  34. ncbi Differential distribution of functional cannabinoid CB1 receptors in the mouse gastroenteric tract
    Maria Antonietta Casu
    Neuroscienze Scarl, Via Palabanda, 9 09124-I, Cagliari, Italy
    Eur J Pharmacol 459:97-105. 2003
    ..Moreover, the dose of 0.3 microg/kg of HU 210, devoid per se of any activity on mouse intestinal propulsion, blocked the increased gastroenteric transit induced by the cannabinoid CB(1) antagonist SR 141716A...
  35. ncbi Sub-chronic treatment with classical but not atypical antipsychotics produces morphological changes in rat nigro-striatal dopaminergic neurons directly related to "early onset" vacuous chewing
    Giorgio Marchese
    Neuroscienze S.c.a.r.l, and B.B. Brodie Department of Neuroscience, University of Cagliari, Italy
    Eur J Neurosci 15:1187-96. 2002
    ..These results suggest that haloperidol induces a morphological impairment of the dopaminergic nigro-striatal neurons which is directly associated with the arising, permanency and disappearance of VCMs in rats...
  36. ncbi The positive allosteric modulator of the GABA(B) receptor, rac-BHFF, suppresses alcohol self-administration
    Paola Maccioni
    CNR Neuroscience Institute, Viale Diaz 182, I 09126 Cagliari, Italy
    Drug Alcohol Depend 109:96-103. 2010
    ..The present data constitute a further piece of evidence on the capacity of positive allosteric modulators of the GABA(B) receptor to reduce alcohol's reinforcing properties in rats...
  37. ncbi Suppression by the cannabinoid CB1 receptor antagonist, rimonabant, of the reinforcing and motivational properties of a chocolate-flavoured beverage in rats
    Paola Maccioni
    CNR Institute of Neuroscience, Cagliari, Italy
    Behav Pharmacol 19:197-209. 2008
    ..These results also suggest that the cannabinoid CB1 receptor is a crucial component of the neural substrate mediating the reinforcing and motivational properties of a highly palatable food such as a chocolate-flavoured beverage...
  38. ncbi Blockade by the cannabinoid CB(1) receptor antagonist, SR 141716, of alcohol deprivation effect in alcohol-preferring rats
    Salvatore Serra
    Neuroscienze S.c.a r.l, Via Palabanda 9, I-09123, Cagliari, Italy
    Eur J Pharmacol 443:95-7. 2002
    ..These results suggest that the cannabinoid CB(1) receptor is part of the neural substrate mediating the alcohol deprivation effect and that SR 141716 may possess anti-relapse properties...
  39. ncbi Reduction of alcohol's reinforcing and motivational properties by the positive allosteric modulator of the GABA(B) receptor, BHF177, in alcohol-preferring rats
    Paola Maccioni
    CNR Institute of Neuroscience, Cagliari, Italy
    Alcohol Clin Exp Res 33:1749-56. 2009
    ....
  40. ncbi Salvia miltiorrhiza extract inhibits alcohol absorption, preference, and discrimination in sP rats
    G Colombo
    CNR Center for Neuropharmacology, Cagliari, Italy
    Alcohol 18:65-70. 1999
    ..Collectively, the results are discussed as being suggestive that drugs curbing ethanol absorption from the gastrointestinal tract may constitute a novel strategy for controlling excessive alcohol consumption in human alcoholics...
  41. ncbi Procedure of bidirectional selective outbreeding for production of two rat lines differing in sensitivity to the sedative/hypnotic effect of gamma-hydroxybutyric acid
    C Lobina
    Bernard B. Brodie' Department of Neuroscience, University of Cagliari, S.S. 554, Km. 4.5, I-09042 (CA, Monserrato, Italy
    Brain Res Brain Res Protoc 8:74-81. 2001
    ..The selective breeding of GHB-S and GHB-R rats: (a) suggests that sensitivity to GHB is under genetic control, and (b) may constitute a unique model for investigation of the physiological function of GHB...
  42. ncbi Cannabinoid receptor CB1 mRNA is highly expressed in the rat ciliary body: implications for the antiglaucoma properties of marihuana
    A Porcella
    Center for Neuropharmacology, C N R and B B Brodie Department of Neuroscience, University of Cagliari, via Porcell, 09124 I Cagliari, Italy
    Brain Res Mol Brain Res 58:240-5. 1998
    ..06+/-0.005% of beta2m). CB2 mRNA was undetectable. This expression pattern supports a specific role for the CB1 receptor in controlling intraocular pressure, helping to explain the antiglaucoma property of cannabinoids...
  43. ncbi gamma-Hydroxybutyric acid and baclofen decrease extracellular acetylcholine levels in the hippocampus via GABA(B) receptors
    F Nava
    Department of Neuroscience Bernard B Brodie, University of Cagliari, Cagliari, Italy
    Eur J Pharmacol 430:261-3. 2001
    ....
  44. ncbi Reduction of blood ethanol levels by the gamma-hydroxybutyric acid receptor antagonist, NCS-382
    G Colombo
    Centro C N R per la Neurofarmacologia, Cagliari, Italy
    Alcohol 17:93-5. 1999
    ..The reducing effect of NCS-382 on BELs is likely due to a lessened absorption of ethanol from the gastrointestinal tract...
  45. ncbi Different sensitivity to the motor incoordinating effects of gamma-hydroxybutyric acid (GHB) and baclofen in GHB-sensitive and GHB-resistant rats
    Carla Lobina
    Bernard B. Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I-09126 Cagliari, Italy
    Brain Res 1033:109-12. 2005
    ..These results are discussed in terms of the GABA(B) receptor being the likely neural substrate on which the differential sensitivity of GHB-S and GHB-R rats resides...
  46. ncbi Boosting effect of morphine on alcohol drinking is suppressed not only by naloxone but also by the cannabinoid CB1 receptor antagonist, SR 141716
    Giovanni Vacca
    Neuroscienze S.c.a r.l, Via Palabanda 9, I-09123, Cagliari, Italy
    Eur J Pharmacol 445:55-9. 2002
    ....
  47. ncbi Withdrawal syndrome from gamma-hydroxybutyric acid (GHB) and 1,4-butanediol (1,4-BD) in Sardinian alcohol-preferring rats
    Mauro A M Carai
    Department of Neuroscience, University of Cagliari, Viale Diaz 182, I-09126 Cagliari, Italy
    Brain Res Brain Res Protoc 15:75-8. 2005
    ..We propose that the inherent sensitivity of sP rats to different GHB-associated responses may have contributed to the unraveling of a phenomenon which was otherwise not recognizable in other rat strains...
  48. ncbi The R100Q mutation of the GABA(A) alpha(6) receptor subunit may contribute to voluntary aversion to ethanol in the sNP rat line
    L Saba
    Neuroscienze S.c.a.r.l, Cagliari, Italy
    Brain Res Mol Brain Res 87:263-70. 2001
    ....
  49. ncbi Reducing effect of the positive allosteric modulator of the GABA(B) receptor, GS39,783, on alcohol self-administration in alcohol-preferring rats
    Paola Maccioni
    Bernard B Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, 09126, Cagliari, Italy
    Psychopharmacology (Berl) 193:171-8. 2007
    ..The present study was designed to extend the characterization of the "anti-alcohol" effects of GS39,783 to oral self-administration of alcohol under an operant procedure...
  50. ncbi gamma-Hydroxybutyric acid (GHB) suppresses alcohol's motivational properties in alcohol-preferring rats
    Paola Maccioni
    Bernard B Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I 09126 Cagliari, Italy
    Alcohol 42:107-13. 2008
    ..These results are consistent with the anticraving properties of GHB observed in clinical studies...
  51. ncbi Reducing effect of a Phaseolus vulgaris dry extract on food intake, body weight, and glycemia in rats
    Noemi Fantini
    CNR Institute of Neuroscience, Cagliari, Italy
    J Agric Food Chem 57:9316-23. 2009
    ....
  52. ncbi Involvement of the endogenous cannabinoid system in the effects of alcohol in the mesolimbic reward circuit: electrophysiological evidence in vivo
    Simona Perra
    B.B. Brodie Department of Neuroscience, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato, CA, Italy
    Psychopharmacology (Berl) 183:368-77. 2005
    ..CONCLUSIONS: These results corroborate the notion of the involvement of endocannabinoids and their receptors in the actions of alcohol and highlight the endocannabinoid system as a valuable target in the therapy for alcoholism...
  53. ncbi Anti-relapse properties of IDN 5082, a standardized extract of Salvia miltiorrhiza, in alcohol-preferring rats
    Salvatore Serra
    Bernard B. Brodie Department of Neuroscience, University of Cagliari, Cagliari, Italy
    J Ethnopharmacol 88:249-52. 2003
    ..These results suggest that IDN 5082 may possess anti-relapse properties...
  54. ncbi The role of stress in the pathophysiology of the dopaminergic system
    L Pani
    CNR Center for Neuropharmacology and BB Brodie Department of Neuroscience, University of Cagliari, Cagliari, Italy
    Mol Psychiatry 5:14-21. 2000
    ..Thus it appears that a critical range of DA turnover is necessary for optimal cognitive functioning after stress, in the response of the CNS to ever-changing environmental demands. Molecular Psychiatry (2000) 5, 14-21...
  55. ncbi Distribution of GABA(B) receptor mRNAs in the rat brain and peripheral organs
    M P Castelli
    Department of Neuroscience, University of Cagliari, Italy
    Life Sci 64:1321-8. 1999
    ..The peripheral distribution of GABA(B)R1 mRNAs supports the notion of a physiological role for GABA in the control of a wide range of peripheral organs...
  56. ncbi Gamma-hydroxybutyric acid (GHB) and the mesoaccumbens reward circuit: evidence for GABA(B) receptor-mediated effects
    M Pistis
    B B Brodie Department of Neuroscience, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato CA, Italy
    Neuroscience 131:465-74. 2005
    ..Moreover, it is concluded that addictive and rewarding properties of GHB do not necessarily involve a putative high affinity GHB receptor...
  57. ncbi The substituted benzamides and their clinical potential on dysthymia and on the negative symptoms of schizophrenia
    L Pani
    Center for Neuropharmacology, National Research Council, Neuroscienze Scarl, Via Porcell 4, 09124 I Cagliari, Italy
    Mol Psychiatry 7:247-53. 2002
    ..Interestingly, recent evidence in the literature suggests that depressive episodes belonging to the bipolar spectrum are among "alternative indications" of other atypical antipsychotics such as olanzapine and risperidone...
  58. ncbi Suppression of acquisition of alcohol-drinking behavior by the concurrent availability of saccharin in Sardinian alcohol-preferring (sP) rats
    Giancarlo Colombo
    C N R Institute of Neuroscience, Section of Cagliari, Italy
    Alcohol 35:27-33. 2005
    ....
  59. ncbi Rimonabant: the first therapeutically relevant cannabinoid antagonist
    Mauro A M Carai
    Bernard B Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I 09126 Cagliari CA, Italy
    Life Sci 77:2339-50. 2005
    ..Taken together, the data reviewed here suggest that rimonabant may constitute a new and potentially effective medication for the treatment of drug addiction and obesity-related disorders...
  60. ncbi Endocannabinoid system and alcohol addiction: pharmacological studies
    Giancarlo Colombo
    C N R Institute of Neuroscience, Viale Diaz, 182 I 09126 Cagliari CA, Italy
    Pharmacol Biochem Behav 81:369-80. 2005
    ....
  61. ncbi Resuscitative treatments on 1,4-butanediol mortality in mice
    Mauro A M Carai
    Department of Neuroscience, School of Medicine, University of Cagliari, National Research Council, Institute of Neuroscience, Cagliari, Italy
    Ann Emerg Med 47:184-9. 2006
    ....
  62. ncbi Identification of miltirone as active ingredient of Salvia miltiorrhiza responsible for the reducing effect of root extracts on alcohol intake in rats
    Giancarlo Colombo
    C N R Institute of Neuroscience, Cagliari, Italy
    Alcohol Clin Exp Res 30:754-62. 2006
    ..The present study was designed to evaluate whether miltirone, one of the possible active constituents of S. miltiorrhiza, might be responsible for the reducing effect of the extracts on alcohol intake...
  63. ncbi The cannabinoid CB1 receptor antagonist, rimonabant, as a promising pharmacotherapy for alcohol dependence: preclinical evidence
    Giancarlo Colombo
    C N R Institute of Neuroscience, Viale Diaz 182, Cagliari CA, 182 I 09126, Italy
    Mol Neurobiol 36:102-12. 2007
    ....
  64. ncbi Alcohol use disorders, and at-risk drinking in patients affected by a mood disorder, in Cagliari, Italy: sensitivity and specificity of different questionnaires
    Roberta Agabio
    Bernard B Brodie Department of Neuroscience, University of Cagliari, Viale Diaz, 182 I 09126 Cagliari, Italy
    Alcohol Alcohol 42:575-81. 2007
    ....
  65. ncbi Baclofen-induced suppression of alcohol deprivation effect in Sardinian alcohol-preferring (sP) rats exposed to different alcohol concentrations
    Giancarlo Colombo
    C N R Institute of Neuroscience, Cagliari, Italy
    Eur J Pharmacol 550:123-6. 2006
    ..These results suggest that the GABA(B) receptor is part of the neural substrate mediating alcohol deprivation in sP rats...
  66. ncbi Phenotypic characterization of genetically selected Sardinian alcohol-preferring (sP) and -non-preferring (sNP) rats
    Giancarlo Colombo
    C N R Institute of Neuroscience, Cagliari, CA, Italy
    Addict Biol 11:324-38. 2006
    ....
  67. ncbi Reducing effect of a Phaseolus vulgaris dry extract on operant self-administration of a chocolate-flavoured beverage in rats
    Paola Maccioni
    CNR Neuroscience Institute, Viale Diaz 182, I 09126 Cagliari, Italy
    Br J Nutr 104:624-8. 2010
    ..These results indicate the capacity of a P. vulgaris preparation to reduce the reinforcing properties of a highly palatable fluid in rats...
  68. ncbi Gamma-aminobutyric acidB (GABAB)-receptor mediation of different in vivo effects of gamma-butyrolactone
    Mauro A M Carai
    CNR Institute of Neuroscience, Cagliari, Italy
    J Pharmacol Sci 106:199-207. 2008
    ..Vice versa, NCS-382 failed to exert any antagonistic or protective effect. These results suggest that the in vivo GBL effects tested in the present study are mediated by activation of the GABA(B) receptor...
  69. ncbi Investigation on the relationship between cannabinoid CB1 and opioid receptors in gastrointestinal motility in mice
    Mauro A M Carai
    C N R Institute of Neuroscience, Cagliari, Viale Armando Diaz 182, I 09126 Cagliari, Italy
    Br J Pharmacol 148:1043-50. 2006
    ....
  70. ncbi Protective activation of the endocannabinoid system during ischemia in dopamine neurons
    Miriam Melis
    Centre of Excellence Neurobiology of Addiction, University of Cagliari, Italy
    Neurobiol Dis 24:15-27. 2006
    ..Lastly, they point to CB1 receptors as valuable targets in protection of DA neurons against ischemic injury and emphasize the need for a better understanding of endocannabinoid actions in the fine control of DA transmission...
  71. ncbi Efficacy of rimonabant and other cannabinoid CB1 receptor antagonists in reducing food intake and body weight: preclinical and clinical data
    Mauro A M Carai
    C N R Institute of Neuroscience, University of Cagliari, Cagliari CA, Italy
    CNS Drug Rev 12:91-9. 2006
    ..The data reviewed in this paper suggest that cannabinoid CB(1) receptor antagonists may constitute a novel class of drugs potentially effective in the treatment of obesity-related disorders...
  72. ncbi Stimulation of the locus coeruleus elicits noradrenaline and dopamine release in the medial prefrontal and parietal cortex
    Paola Devoto
    B B Brodie Department of Neuroscience, University of Cagliari, Cagliari, Italy
    J Neurochem 92:368-74. 2005
    ..These results indicate that electrical stimulation-induced increase of dopamine is a nerve impulse exocytotic process and suggest that cortical dopamine and noradrenaline may be coreleased from noradrenergic terminals...
  73. ncbi Rapid tolerance to the intestinal prokinetic effect of cannabinoid CB1 receptor antagonist, SR 141716 (Rimonabant)
    Mauro A M Carai
    Bernard B Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I 09126 Cagliari, Italy
    Eur J Pharmacol 494:221-4. 2004
    ..On day 1, SR 141716 markedly activated intestinal peristalsis, but complete tolerance to this effect developed within the third day of treatment. The results may have some relevance to the proposed future clinical use of SR 141716...
  74. ncbi Origin of extracellular dopamine from dopamine and noradrenaline neurons in the medial prefrontal and occipital cortex
    Paola Devoto
    B B Brodie Department of Neuroscience, University of Cagliari, Monserrato, Italy
    Synapse 50:200-5. 2003
    ....
  75. ncbi Stable preference for high ethanol concentrations after ethanol deprivation in Sardinian alcohol-preferring (sP) rats
    Salvatore Serra
    Neuroscienze S.c.a r.l, I-09123, Cagliari, Italy
    Alcohol 29:101-8. 2003
    ..These results provide further evidence on the heterogeneity of ethanol-drinking behavior among rat lines selectively bred for high ethanol preference and consumption...
  76. ncbi Suppression by baclofen of alcohol deprivation effect in Sardinian alcohol-preferring (sP) rats
    Giancarlo Colombo
    C N R Institute for Neurogenetics and Neuropharmacology, c o Bernard B Brodie Department of Neuroscience, University of Cagliari, S S 554, Km 4 5, I 09042, Monserrato, CA, Italy
    Drug Alcohol Depend 70:105-8. 2003
    ..These results implicate the GABA(B) receptor in the neural substrate mediating ADE and suggest that baclofen may possess anti-relapse properties...
  77. ncbi Baclofen suppresses motivation to consume alcohol in rats
    Giancarlo Colombo
    C N R Institute of Neurogenetics and Neuropharmacology, c o Bernard B Brodie Department of Neuroscience, University of Cagliari, Km 4 5, S S 554, 09042 Monserrato, Italy
    Psychopharmacology (Berl) 167:221-4. 2003
    ....
  78. ncbi Co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex induced by clozapine, the prototype atypical antipsychotic
    Paola Devoto
    B B Brodie Department of Neuroscience, University of Cagliari, Cittadella Universitaria, SS 554 Km 4 500, 09042, Monserrato, Italy
    Psychopharmacology (Berl) 167:79-84. 2003
    ..A recent study of ours suggested that extracellular DA in the PFC originates not only from dopaminergic but also from noradrenergic terminals, its release being controlled by alpha(2)-adrenoceptors...
  79. ncbi IDN 5082, a standardized extract of Salvia miltiorrhiza, delays acquisition of alcohol drinking behavior in rats
    Giuliana Brunetti
    Neuroscienze S.c.a r.l, Cagliari, Italy
    J Ethnopharmacol 85:93-7. 2003
    ..These results add further support to the preclinical anti-alcohol profile of S. miltiorrhiza extracts...
  80. ncbi Co-release of noradrenaline and dopamine in the prefrontal cortex after acute morphine and during morphine withdrawal
    Paola Devoto
    Dipartimento di Neuroscienze, Cittadella Universitaria, SS 554, Km 4, 5, 09042 Monserrato CA, Italy
    Psychopharmacology (Berl) 160:220-4. 2002
    ..In contrast, extracellular DA in the prefrontal cortex (PFC) is not modified by acute morphine and is markedly increased during abstinence syndrome...
  81. ncbi The GABA(B) receptor agonists baclofen and CGP 44532 prevent acquisition of alcohol drinking behaviour in alcohol-preferring rats
    Giancarlo Colombo
    C.N.R. Institute of Neurogenetics and Neuropharmacology, Cagliari, Italy
    Alcohol Alcohol 37:499-503. 2002
    ....
  82. ncbi The CB receptor agonist WIN 55,212-2 fails to elicit disruption of prepulse inhibition of the startle in Sprague-Dawley rats
    Marco Bortolato
    Department of Neuroscience B B Brodie, Center of Excellence Neurobiology of Dependence, University of Cagliari, Cittadella Universitaria, S S 554 Km 4, 500, 09042, Monserrato, CA, Italy
    Psychopharmacology (Berl) 177:264-71. 2005
    ..In this respect, recent studies have displayed controversial results on the ability of cannabinoids to elicit sensorimotor gating alterations and attentional filtering, whose disruption is a distinctive feature of psychosis...
  83. ncbi Delta(9)-tetrahydrocannabinol decreases extracellular GABA and increases extracellular glutamate and dopamine levels in the rat prefrontal cortex: an in vivo microdialysis study
    Marco Pistis
    BB Brodie Department of Neuroscience, University of Cagliari, Cittadella Universitaria SS 554, 09042 Monserrato CA, Italy
    Brain Res 948:155-8. 2002
    ..These results suggest that delta(9)-THC disrupt the normal interplay between neurotransmitters in this area and may bear relevance in understanding neuronal mechanisms underlying cannabinoid-induced cognitive deficits...
  84. ncbi Effect of the combination of naltrexone and baclofen, on acquisition of alcohol drinking behavior in alcohol-preferring rats
    Giancarlo Colombo
    C N R Institute of Neuroscience, Section of Cagliari, Viale Diaz 182, 1 09126 Cagliari, Italy
    Drug Alcohol Depend 77:87-91. 2005
    ..These results are discussed in terms of naltrexone and baclofen exerting a concomitant and reciprocally potentiating inhibitory action on alcohol-induced activation of mesolimbic dopamine transmission...
  85. ncbi Stereoselectivity of NCS-382 binding to gamma-hydroxybutyrate receptor in the rat brain
    M Paola Castelli
    Neuroscienze S c a r l, Via Palabanda 9, I 09123, Cagliari, Italy
    Eur J Pharmacol 446:1-5. 2002
    ..Neither RS-NCS-382 nor its enantiomers inhibited [(3)H]baclofen binding up to a concentration of 1 mM. Our results demonstrate that R-NCS-382 is the enantiomer of RS-NCS-382 with higher affinity for GHB receptors...
  86. ncbi Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons
    Miriam Melis
    Center of Excellence Neurobiology of Addiction, Institute of Neuroscience, University of Cagliari, 09042 Monserrato, CA, Italy
    J Neurosci 24:10707-15. 2004
    ..This novel endocannabinoid-mediated self-regulatory role of dopamine neurons may bear relevance in the pathogenesis of neuropsychiatric disorders such as schizophrenia and addiction...
  87. ncbi Role of GABA(B) receptor in alcohol dependence: reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics
    Giancarlo Colombo
    C N R Institute of Neuroscience, University of Cagliari, Viale Diaz, 182, I 09126 Cagliari, Italy
    Neurotox Res 6:403-14. 2004
    ..In both clinical studies, baclofen was well tolerated with minimal side effects. These results suggest that baclofen may represent a potentially effective medication in the treatment of alcohol-dependent patients...
  88. ncbi In vivo effectiveness of CGP7930, a positive allosteric modulator of the GABAB receptor
    Mauro A M Carai
    Bernard B Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I 09126 Cagliari CA, Italy
    Eur J Pharmacol 504:213-6. 2004
    ..These results confirm that CGP7930 may constitute an interesting tool for pharmacological studies in the GABAB receptor field...
  89. ncbi Protection by the GABAB receptor antagonist, SCH 50911, of gamma-hydroxybutyric acid-induced mortality in mice
    Mauro A M Carai
    Bernard B Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I 09126 Cagliari CA, Italy
    Eur J Pharmacol 503:77-80. 2004
    ....
  90. ncbi Suppressing effect of the cannabinoid CB1 receptor antagonist, SR 141716, on alcohol's motivational properties in alcohol-preferring rats
    Giancarlo Colombo
    C N R Institute of Neuroscience, Section of Cagliari, c o Bernard B Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I 09126 Cagliari, Italy
    Eur J Pharmacol 498:119-23. 2004
    ..The results also implicate the cannabinoid CB1 receptor in the neural substrate mediating alcohol's motivational properties in this rat line...
  91. ncbi (-)S amisulpride binds with high affinity to cloned dopamine D(3) and D(2) receptors
    M P Castelli
    Neuroscienze S c a r l, Via Palabanda 9, 09124 I, Cagliari, Italy
    Eur J Pharmacol 432:143-7. 2001
    ..Our results show that (-)S amisulpride is the active enantiomer of amisulpride, showing high affinity for dopamine D(3) and dopamine D(2) receptors...
  92. ncbi The cannabinoid receptor antagonist SR 141716 prevents acquisition of drinking behavior in alcohol-preferring rats
    S Serra
    Neuroscienze S.c.a r.l, Via Palabanda 9, I-09123, Cagliari, Italy
    Eur J Pharmacol 430:369-71. 2001
    ..The results suggest that activation of cannabinoid CB(1) receptors is essential for the acquisition of alcohol drinking behavior in animals with a genetically determined alcohol preference...
  93. ncbi The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein
    A Porcella
    Center for Neuropharmacology, C N R and B B Brodie Department of Neuroscience, University of Cagliari, and Neuroscienze Scarl, Cagliari, Italy
    Eur J Neurosci 12:1123-7. 2000
    ..These results further support the proposed role of the CB1 receptor in controlling intraocular pressure, helping to explain the antiglaucoma properties of marijuana...
  94. ncbi Clonidine fails to modify dopaminergic neuronal activity during morphine withdrawal
    G Gobbi
    B.B. Brodie Department of Neuroscience, University of Cagliari, Cagliari, Italy
    Psychopharmacology (Berl) 158:1-6. 2001
    ....
  95. ncbi Gamma-hydroxybutyric acid in alcohol preference, dependence and withdrawal
    G Colombo
    CNR Center for Neuropharmacology, University of Cagliari, Cagliari, Italy
    Addict Biol 5:389-403. 2000
    ....
  96. ncbi Reduced DAT- and DBH-immunostaining in the limbic system of Sardinian alcohol-preferring rats
    Maria Antonietta Casu
    Neuroscienze Scarl, Via Palabanda 9, 09125 Cagliari, Italy
    Brain Res 948:192-202. 2002
    ..This genetically-determined difference may be involved in the opposite alcohol preference and consumption of sP and sNP rats...
  97. ncbi Central effects of 1,4-butanediol are mediated by GABA(B) receptors via its conversion into gamma-hydroxybutyric acid
    Mauro A M Carai
    Neuroscienze S c a r l, Via Palabanda 9, I 09123 Cagliari, Italy
    Eur J Pharmacol 441:157-63. 2002
    ..Accordingly 1,4-butanediol, unlike GHB, failed to displace [(3)H]GHB and [(3)H]baclofen in brain membranes...
  98. ncbi Gamma-hydroxybutyrate reduces GABA(A)-mediated inhibitory postsynaptic potentials in the CA1 region of hippocampus
    Maurizio Cammalleri
    Department of Physiology and Biochemistry G. Moruzzi, University of, Pisa, Italy
    Neuropsychopharmacology 27:960-9. 2002
    ..Finally, GHB failed to reduce the amplitude of GABA(A)-IPSPs in the presence of BaCl(2), suggesting that the effect of GHB is due to GHB receptor-mediated presynaptic inhibition of Ca(2)+ influx...
  99. ncbi Reduced TH-immunoreactive fibers in the limbic system of Sardinian alcohol-preferring rats
    Maria Antonietta Casu
    Neuroscienze S c a r l, Via Palabanda 9, 09125 Cagliari, Italy
    Brain Res 924:242-51. 2002
    ....