Research Topics
Genomes and GenesSpecies | N GaglianoSummaryAffiliation: University of Milan Country: Italy Publications
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Publications
Sperm protein 17 is expressed in the sperm fibrous sheathMaurizio Chiriva-Internati
Division of Hematology and Oncology, Texas Tech University Health Sciences Center Lubbock, TX, USA
J Transl Med 7:61. 2009..These data all indicate that Sp17 is widely distributed in humans, expressed not only in germinal cells and in a variety of somatic tissues, but also in neoplastic cells of unrelated origin...- Protective CD8+ T-cell responses to cytomegalovirus driven by rAAV/GFP/IE1 loading of dendritic cellsYuefei Yu
Division of Hematology and Oncology, Texas Tech University Health Sciences Center and Southwest Cancer Treatment and Research Center, Lubbock, TX, USA
J Transl Med 6:56. 2008..Recent studies demonstrate that recombinant adeno-associated virus (rAAV)-based antigen loading of dendritic cells (DCs) generates in vitro, significant and rapid cytotoxic T-lymphocyte (CTL) responses against viral antigens... - The pituitary tumor transforming gene 1 (PTTG-1): an immunological target for multiple myelomaMaurizio Chiriva-Internati
Department of Microbiology and Immunology, Texas Tech University Health Sciences Center and Southwest Cancer Treatment and Research Center, Lubbock, TX, USA
J Transl Med 6:15. 2008..The purpose was to investigate the presence/rate of expression of PTTG-1 in multiple myeloma patients... - Ochratoxin A-induced renal cortex fibrosis and epithelial-to-mesenchymal transition: molecular mechanisms of ochratoxin A-injury and potential effects of red wineNicoletta Gagliano
Department of Human Morphology, University of Milan, Italy
Mol Med 11:30-8. 2005.... - Effect of resveratrol on matrix metalloproteinase-2 (MMP-2) and Secreted Protein Acidic and Rich in Cysteine (SPARC) on human cultured glioblastoma cellsNicoletta Gagliano
Department of Human Morphology, University of Milan, Via Fratelli Cervi 93, 20090 LITA Segrate, Milan, Italy
Biomed Pharmacother 59:359-64. 2005..Resveratrol has been reported to be one of the most potent chemopreventive agents inhibiting the cellular processes associated with tumor development, including initiation, promotion, and progression... - Effect of Ukrain on matrix metalloproteinase-2 and Secreted Protein Acidic and Rich in Cysteine (SPARC) expression in human glioblastoma cellsNicoletta Gagliano
Departments of Human Morphology LITA Segrate, University of Milan, Milan, Italy
Anticancer Drugs 17:189-94. 2006.... - Effect of cyclosporin A on human gingival fibroblast collagen turnover in relation to the development of gingival overgrowth: an in vitro studyNicoletta Gagliano
Department of Human Morphology LITA, University of Milan, Via Fratelli Cervi 93, 20090 Segrate, Milan, Italy
Biomed Pharmacother 58:231-8. 2004..However, interindividual differences of collagenase levels after CsA treatment suggest that a genetic predisposition to develop gingival overgrowth may be relevant... - Immunosuppression and gingival overgrowth: gene and protein expression profiles of collagen turnover in FK506-treated human gingival fibroblastsNicoletta Gagliano
Department of Human Morphology LITA, Via Fratelli Cervi 93, 20090 Segrate, Milan, Italy
J Clin Periodontol 32:167-73. 2005.... - Early cytotoxic effects of ochratoxin A in rat liver: a morphological, biochemical and molecular studyNicoletta Gagliano
Department of Human Morphology LITA Segrate, Via Fratelli Cervi 93, 20090 Segrate, Milan, Italy
Toxicology 225:214-24. 2006..This suggests that mild oxidative damage might be a key factor, in combination with other cytotoxic effects, in triggering the promotion of liver tumors after exposure to OTA... - Differential effect of Cyclosporin A and FK506 on SPARC mRNA expression by human gingival fibroblastsNicoletta Gagliano
Department of Human Morphology LITA, University of Milan, Via Fratelli Cervi 93, 20090 Segrate, Milan, Italy
Biomed Pharmacother 59:249-52. 2005..By contrast, clinical trials showed that FK506 is not related to GO. SPARC expression and its involvement in GO is unknown. Our aim was, therefore, to analyze the effect of CsA and FK506 on SPARC gene expression... - Morphological and molecular analysis of idiopathic gingival fibromatosis: a case reportNicoletta Gagliano
Department of Human Morphology LITA Segrate, University of Milan, Milan, Italy
J Clin Periodontol 32:1116-21. 2005..As this overgrowth involves collagen accumulation in the gingival connective tissue, we measured the collagen turnover to clarify the pathogenic mechanisms potentially involved... - Effect of a topical treatment in organotypic culture of human breast skin after exposure to gamma-raysNicoletta Gagliano
Department of Human Morphology, Extracellular Matrix Laboratory, University of Milan, Via Fratelli Cervi, 93 20090 Segrate, Milan, Italy
Eur J Histochem 51:283-90. 2007..TGF-beta1 seems not affected in cream treated samples. HWE may stimulate skin to mount an early defensive response against damage induced by gamma rays... - A therapeutic dose of FK506 does not affect collagen turnover pathways in healthy human gingival fibroblastsN Gagliano
Department of Human Morphology, Extracellular Matrix Laboratory EML, University of Milan, Milan, Italy
Transplant Proc 40:1419-24. 2008..This effect did not seem to be dose-dependent... - Expression profiling of genes involved in collagen turnover in tendons from cerebral palsy patientsNicoletta Gagliano
Department of Human Morphology, Extracellular Matrix Laboratory, University of Milan School of Medicine, Milan, Italy
Connect Tissue Res 50:203-8. 2009..Interestingly, hypertonic quadriplegic subjects displayed the highest mRNA levels of COL1A2, LH2b, TGF-beta1, and SPARC, suggesting that their tendons undergo higher mechanical loading stimulation... - Glioma-astrocyte interaction modifies the astrocyte phenotype in a co-culture experimental modelNicoletta Gagliano
Department of Human Morphology and Biomedical Sciences Citta Studi, Extracellular Matrix Laboratory EML, School of Medicine, University of Milan, Milano, Italy
Oncol Rep 22:1349-56. 2009..Glioma/astrocyte interaction could possibly trigger an astrocyte phenotype modification consistent with a malignant transformation, and favouring a more permissive environment for glioma cells invasion... - The potential of resveratrol against human gliomasNicoletta Gagliano
Department of Human Morphology and Biomedical Sciences Citta Studi, Universita di Milano, School of Medicine, Extracellular Matrix Laboratory, Via Fratelli Cervi 93, 20090 Segrate, Milan, Italy
Anticancer Drugs 21:140-50. 2010..This study discusses current knowledge with regard to the effects of resveratrol in relation to its potential as a chemopreventive and/or chemotherapeutic molecule against human gliomas... - Extracellular glycosaminoglycan changes in healthy and overgrown gingiva fibroblasts after cyclosporin A and cytokine treatmentsG Stabellini
Department of Human Morphology LITA Segrate, State University of Milan, Milan, Italy
J Oral Pathol Med 33:346-53. 2004..This cytokine, such as transforming growth factor-alpha (TGF-alpha), induces deposition of glycosaminoglycans (GAG), proteoglycans and collagen fibres in the ECM... - Left ventricular response to beta-adrenergic stimulation in aging ratsS Masson
Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
J Gerontol A Biol Sci Med Sci 55:B35-41; discussion B42-3. 2000.... - Early epidermal response after a single dose of gamma-rays in organotypic culture of human breast skinE Donetti
Department of Human Morphology, University of Milan, Via Mangiagalli 31, 20133 Milan, Italy
Br J Dermatol 153:881-6. 2005..Skin reaction is the most common side-effect of radiation therapy. Radiation-induced dermal fibrosis has been characterized histologically, but little is known about the epidermis overlying fibronecrotic lesions... - Ukrain modulates glial fibrillary acidic protein, but not connexin 43 expression, and induces apoptosis in human cultured glioblastoma cellsNicoletta Gagliano
Department of Human Morphology, San Paolo School of Medicine, University of Milan, Italy
Anticancer Drugs 18:669-76. 2007..Considered as a whole, these findings provide new information to complete the understanding of the mechanisms of Ukrain antitumor and chemopreventive effect, and support the possible potential of Ukrain for the therapy of brain tumors... - Effects of aging and cyclosporin a on collagen turnover in human gingivaN Gagliano
Department of Human Morphology and Biomedical Sciences Citta Studi, EML Extracellular Matrix Laboratory, Universita degli Studi di Milano, School of Medicine, Milan, Italy
Open Dent J 3:219-26. 2009..ii) the effect of cyclosporin A administration in human cultured gingival fibroblasts obtained from aging compared to young subjects... - Gene expression profile of extracellular matrix of tendons in cerebral palsyN Gagliano
Department of Human Morphology, University of Milan, Milan, Italy
Dev Med Child Neurol 49:557-8. 2007 - Effect of ethanol and red wine on ochratoxin a-induced experimental acute nephrotoxicityAlberto A E Bertelli
University of Milan, Milan, Italy
J Agric Food Chem 53:6924-9. 2005..Red wine may exert a protective effect against OTA nephrotoxicity by limiting oxidative damage. The ostensible protection afforded by ethanol deserves further investigation... - Reduced collagenolytic activity of matrix metalloproteinases and development of liver fibrosis in the aging ratNicoletta Gagliano
Department of Internal Medicine and Geriatrics, Milan University and Ospedale Maggiore IRCCS, Via Pace 9, 20122, Milan, Italy
Mech Ageing Dev 123:413-25. 2002.... - Extracellular signal-regulated kinases 1 and 2 phosphorylated neurons in the tele- and diencephalon of rat after visceral pain stimulation: an immunocytochemical studyM Gioia
Department of Human Anatomy, University of Milan, Milan, Italy
Neurosci Lett 308:177-80. 2001..Our data suggest an association of erks activation with the emotional component of nociception; moreover, they show that erks activation is not suppressed by anaesthesia... - Mast cell density, hepatic stellate cell activation and TGF-beta1 transcripts in the aging Sprague-Dawley rat during early acute liver injuryF Grizzi
Istituto Clinico Humanitas, Rozzano, Milan, Italy
Toxicol Pathol 31:173-8. 2003..In conclusion. MC density may be an index of acute liver inflammation after CCl4 intoxication... - Methionine oxidation as a major cause of the functional impairment of oxidized actinI Dalle-Donne
Department of Biology, University of Milan, Italy
Free Radic Biol Med 32:927-37. 2002..Therefore, methionine oxidation could be a damaging event preceding the appearance of carbonyl groups on actin and a major cause for the functional impairment of the carbonylated protein recently observed both in vivo and in vitro... - Actin carbonylation: from a simple marker of protein oxidation to relevant signs of severe functional impairmentI Dalle-Donne
Department of Biology, Laboratory of Biochemistry and Biophysics of the Cytoskeleton, University of Milan, Milan, Italy
Free Radic Biol Med 31:1075-83. 2001..Therefore, the increase in actin content of carbonyl groups found in vivo would indicate drastic oxidative modification leading to drastic functional impairments... - Age-dependent expression of fibrosis-related genes and collagen deposition in the rat myocardiumG Annoni
Department of Geriatrics, University of Milan and Ospedale Maggiore IRCCS, Italy
Mech Ageing Dev 101:57-72. 1998.... - Acute liver CCl(4) intoxication causes low HSP70 gene expression and a delayed transition through the cell cycle in aged ratsNicoletta Gagliano
Cattedra di Geron. e Geriatria Dept. of Geriatrics, Ospedale Maggiore IRCCS, Via Pace 9, Milan, Italy
Exp Gerontol 37:791-801. 2002..GSH content was reduced with aging. In conclusion, during aging the liver regenerative machinery is preserved but its activation is reduced and delayed... - Molecular mechanisms and potential clinical significance of S-glutathionylationIsabella Dalle-Donne
Department of Biology, University of Milan, Milan, Italy
Antioxid Redox Signal 10:445-73. 2008..Recently, specific PSSG have been identified in the inferior parietal lobule in Alzheimer's disease. However, much investigation is needed to clarify the actual involvement of protein S-glutathionylation in many human diseases... - Downregulated gene expression in human palate fibroblasts after cyclosporin A treatmentGiordano Stabellini
Department of Human Morphology, State University of Milan, Milan, Italy
Arch Med Res 38:717-22. 2007.... - Immunocytochemical localization of extracellular signal-regulated kinases 1 and 2 phosphorylated neurons in the brainstem of rat following visceral noxious stimulationMagda Gioia
Department of Human Anatomy, LITA Segrate, University of Milan, Via Mangiagalli 31, 20133 Milan, Italy
Neurosci Lett 349:167-70. 2003..The comparison between ENS and UNS rats shows that the long acting anaesthetic urethane attenuates the number of the ERKs activated neurons compared to the short acting ether... - Effects of interleukin-1beta on chondroblast viability and extracellular matrix changes in bovine articular cartilage explantsGiordano Stabellini
Department of Human Anatomy, L I T A Segrate, University of Milan, Via Mangiagalli 31, 20133 Milan, Italy
Biomed Pharmacother 57:314-9. 2003..Moreover, the ultrastructure and viability of cells did not change in treated cartilage. Our data show that interleukin-1 beta modifies the ECM turnover without toxic effect on chondrocytes... - GM3 synthase overexpression results in reduced cell motility and in caveolin-1 upregulation in human ovarian carcinoma cellsAlessandro Prinetti
Department of Medical Chemistry, Biochemistry and Biotechnology, Center of Excellence on Neurodegenerative Diseases, Biochemistry and Biotechnology, University of Milan, Italy
Glycobiology 20:62-77. 2010.... - Distribution of extracellular signal-regulated kinase 1- and 2-activated neurons in the rat periaqueductal gray matter after noxious stimulationMagda Gioia
Department of Human Morphology, Laboratori Interdisciplinari Tecnologie Avanzante L I T A Segrate, University of Milan, Milan, Italy
Anat Rec A Discov Mol Cell Evol Biol 284:460-5. 2005..These findings suggest that noxious stimulation activates ERKs in neurons involved in the different functional activities related to nociception, overlapping in the PAG columns, and strengthens the role of PAG in integration... - Depletion of polyamines and increase of transforming growth factor-beta1, c-myc, collagen-type I, matrix metalloproteinase-1, and metalloproteinase-2 mRNA in primary human gingival fibroblastsGiordano Stabellini
Department of Human Morphology Interdisciplinary Laboratories of Advanced Technologies, Segrate, University of Milan, Milan, Italy
J Periodontol 76:443-9. 2005..The aim of this study was to investigate whether DFMO treatment could modify the genes involved in cell proliferation and extracellular matrix turnover... - Desmocollin 1 and desmoglein 1 expression in human epidermis and keratinizing oral mucosa: a comparative immunohistochemical and molecular studyElena Donetti
Department of Human Morphology, Universita degli Studi di Milano, Via Mangiagalli 31, 20133 Milan, Italy
Arch Dermatol Res 297:31-8. 2005..The intrinsic and specific regulation of the molecular composition of desmosomes can contribute in defining a specific keratinocyte phenotype in KOM and in epidermis... - D.D.S.H.: developmental dysplasia of the spastic hip: strategies of management in cerebral palsy. A new suggestive algorithmN Portinaro
Department of Paediatric Orthpaedic Surgery, Clinical Institute Humanitas, University of Milan, 20090 Rozzano, Italy
Hip Int 19:S69-74. 2009..This approach has been adopted in the last 4 years to prevent bone deformities and give early mobilisation and early control of the pain. EMMA is simple to apply even in infants, both for hip containment and to decrease spasticity... - Megaesophagus in an asthmatic patient and beta2 stimulant treatment by inhalationG Stabellini
Department of Human Morphology, L I T A Segrate, State University of Milan, Via Mangiagalli 31, Milan 20133, Italy
Biomed Pharmacother 58:194-5. 2004..Our case could be due to chronic beta2 receptor stimulation with imbalance of alpha and beta receptor, without any implication of favism... - Polyamine levels and ornithine decarboxylase activity in blood and erythrocytes in human diseasesG Stabellini
Department of Human Anatomy Lita di Segrate, University of Milan, Italy
Int J Clin Pharmacol Res 23:17-22. 2003..Since polyamines stimulate protooncogene expression, their high levels could be considered an important cofactor in malignant cell transformation... - Cellular redox potential and hemoglobin S-glutathionylation in human and rat erythrocytes: A comparative studyGraziano Colombo
Department of Biology, Universita degli Studi di Milano, Milan, Italy
Blood Cells Mol Dis 44:133-9. 2010.... - CHF-1024, a DA2/alpha2 agonist, blunts norepinephrine excretion and cardiac fibrosis in pressure overloadS Masson
Department of Cardiovascular Research, Istituto di Ricerche Farmcologiche-Mario Negri, Milan, Italy
Cardiovasc Drugs Ther 15:131-8. 2001..The DA2/alpha2 agonist CHF-1024 effectively blunts adrenergic drive and cardiac fibrosis in a rat model of pressure overload... - Mechanisms of aging and liver functionsNicoletta Gagliano
Department of Human Morphology, University of Milan, Milan, Italy
Dig Dis 25:118-23. 2007..The aim of this study was to analyze some aspects of the early phases of liver regeneration, its capacity to mount a stress response, and the inflammatory response in the early stage of an acute injury... - Changes in polyamines, c-myc and c-fos gene expression in osteoblast-like cells exposed to pulsed electromagnetic fieldsMonica De Mattei
Department of Morphology and Embryology, Section of Histology and Embryology, University of Ferrara, Italy
Bioelectromagnetics 26:207-14. 2005..These observations provide evidence that in vitro PEMF affects the mechanisms involved in cell proliferation and differentiation... - Mast cell density: a quantitative index of acute liver inflammationFabio Grizzi
Scientific Direction, Istituto Clinico Humanitas, Rozzano MI, Italy
Anal Quant Cytol Histol 24:63-9. 2002....