Carlo Foresta

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. ncbi Testis transcriptome analysis in male infertility: new insight on the pathogenesis of oligo-azoospermia in cases with and without AZFc microdeletion
    Valentina Gatta
    Department of Biomedical Sciences, G D Annunzio University, Chieti Pescara, Italy
    BMC Genomics 11:401. 2010
  2. ncbi A novel circulating hormone of testis origin in humans
    Carlo Foresta
    Department of Histology, Microbiology, and Medical Biotechnologies, Center for Male Gamete Cryopreservation, University of Padova, 35121 Padova, Italy
    J Clin Endocrinol Metab 89:5952-8. 2004
  3. ncbi Follicle-stimulating hormone treatment of male infertility
    Carlo Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy
    Curr Opin Urol 18:602-7. 2008
  4. ncbi Genetic abnormalities among severely oligospermic men who are candidates for intracytoplasmic sperm injection
    Carlo Foresta
    Department of Histology, Microbiology, and Medical Biotechnologies, Center for Male Gamete Cryopreservation, University of Padova, Via Gabelli 63, 35121 Padova, Italy
    J Clin Endocrinol Metab 90:152-6. 2005
  5. ncbi Role of INSL3 and LGR8 in cryptorchidism and testicular functions
    Carlo Foresta
    University of Padova, Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, Via Gabelli 63, 35121 Padova, Italy
    Reprod Biomed Online 9:294-8. 2004
  6. ncbi Suppression of the high endogenous levels of plasma FSH in infertile men are associated with improved Sertoli cell function as reflected by elevated levels of plasma inhibin B
    C Foresta
    Centre for Male Gamete Cryopreservation, Department of Medical and Surgical Sciences, Via Ospedale 105, 35128 Padova, Italy
    Hum Reprod 19:1431-7. 2004
  7. ncbi Erectile dysfunction: symptom or disease?
    C Foresta
    Center for Male Gamete Cryopreservation, Department of Medical and Surgical Sciences, University of Padua, Italy
    J Endocrinol Invest 27:80-95. 2004
  8. ncbi Clinical and metabolic evaluation of subjects with erectile dysfunction: a review with a proposal flowchart
    C Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy
    Int J Androl 32:198-211. 2009
  9. ncbi Effect of vardenafil on endothelial progenitor cells in hypogonadotrophic hypogonadal patients: role of testosterone treatment
    Carlo Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    Clin Endocrinol (Oxf) 71:412-6. 2009
  10. ncbi Human papillomavirus found in sperm head of young adult males affects the progressive motility
    Carlo Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, University of Padova, Italy
    Fertil Steril 93:802-6. 2010

Collaborators

Detail Information

Publications129 found, 100 shown here

  1. ncbi Testis transcriptome analysis in male infertility: new insight on the pathogenesis of oligo-azoospermia in cases with and without AZFc microdeletion
    Valentina Gatta
    Department of Biomedical Sciences, G D Annunzio University, Chieti Pescara, Italy
    BMC Genomics 11:401. 2010
    ..Hierarchical clustering was performed pooling the data set from 26 experiments (16 patients, 10 replicates)...
  2. ncbi A novel circulating hormone of testis origin in humans
    Carlo Foresta
    Department of Histology, Microbiology, and Medical Biotechnologies, Center for Male Gamete Cryopreservation, University of Padova, 35121 Padova, Italy
    J Clin Endocrinol Metab 89:5952-8. 2004
    ..Analysis of men treated with different combinations of hormones of the hypothalamus-pituitary-testis axis suggests that the production of INSL3 is related to LH in a manner similar to that of the LH-testosterone axis...
  3. ncbi Follicle-stimulating hormone treatment of male infertility
    Carlo Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy
    Curr Opin Urol 18:602-7. 2008
    ..The success of follicle-stimulating hormone (FSH) treatment in these men has brought the utilization of the same therapy in infertile oligozoospermic patients, aimed at obtaining a quantitative increase in sperm count...
  4. ncbi Genetic abnormalities among severely oligospermic men who are candidates for intracytoplasmic sperm injection
    Carlo Foresta
    Department of Histology, Microbiology, and Medical Biotechnologies, Center for Male Gamete Cryopreservation, University of Padova, Via Gabelli 63, 35121 Padova, Italy
    J Clin Endocrinol Metab 90:152-6. 2005
    ..Genetic tests and genetic counseling should therefore be considered in oligozoospermic men who are candidates for intracytoplasmic sperm injection...
  5. ncbi Role of INSL3 and LGR8 in cryptorchidism and testicular functions
    Carlo Foresta
    University of Padova, Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, Via Gabelli 63, 35121 Padova, Italy
    Reprod Biomed Online 9:294-8. 2004
    ..The results show that INSL3 circulates in adult men, it is a male-specific hormone, and it is of almost exclusively testicular origin. The role of this hormonal system in adulthood is, however, to date unknown...
  6. ncbi Suppression of the high endogenous levels of plasma FSH in infertile men are associated with improved Sertoli cell function as reflected by elevated levels of plasma inhibin B
    C Foresta
    Centre for Male Gamete Cryopreservation, Department of Medical and Surgical Sciences, Via Ospedale 105, 35128 Padova, Italy
    Hum Reprod 19:1431-7. 2004
    ..To evaluate the presence of a desensitization of FSH receptor on Sertoli cells in vivo, we performed a controlled clinical study in 97 men affected by severe oligozoospermia...
  7. ncbi Erectile dysfunction: symptom or disease?
    C Foresta
    Center for Male Gamete Cryopreservation, Department of Medical and Surgical Sciences, University of Padua, Italy
    J Endocrinol Invest 27:80-95. 2004
    ....
  8. ncbi Clinical and metabolic evaluation of subjects with erectile dysfunction: a review with a proposal flowchart
    C Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy
    Int J Androl 32:198-211. 2009
    ..This approach may constitute an improvement in disease prognosis and either induce a spontaneous reduction of ED or facilitate its specific therapy...
  9. ncbi Effect of vardenafil on endothelial progenitor cells in hypogonadotrophic hypogonadal patients: role of testosterone treatment
    Carlo Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    Clin Endocrinol (Oxf) 71:412-6. 2009
    ..EPCs are also reduced in hypogonadal men and testosterone (T) treatment restores their concentration...
  10. ncbi Human papillomavirus found in sperm head of young adult males affects the progressive motility
    Carlo Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, University of Padova, Italy
    Fertil Steril 93:802-6. 2010
    ..To evaluate the prevalence of human papillomavirus (HPV) sperm infection and its correlation with sperm parameters in a cohort of young adult males...
  11. ncbi Insulin-like factor 3 as a marker of testicular function in obese men
    Carlo Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, University of Padova, Via Gabelli 63, Padova, Italy
    Clin Endocrinol (Oxf) 71:722-6. 2009
    ..To better evaluate the hormonal function of the testis in obese men, we analysed their INSL3 plasma levels and compared them with the obesity status and the other reproductive hormones...
  12. ncbi Recombinant FSH in the treatment of oligozoospermia
    Carlo Foresta
    Department of Histology, Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    Expert Opin Biol Ther 9:659-66. 2009
    ..This physiological role in spermatogenesis has induced various attempts to treat idiopathic oligozoospermic men with FSH, often inducing the restoration of normal spermatogenesis and spontaneous pregnancy...
  13. ncbi Circulating endothelial progenitor cells in subjects with erectile dysfunction
    C Foresta
    Department of Histology, Microbiology, and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    Int J Impot Res 17:288-90. 2005
    ..These subjects have lower number of circulating progenitor cells, confirming the existence of an endothelial dysfunction and supplying the evidence that ED may be the first symptom of an endothelial damage...
  14. ncbi PDE-5 inhibitor, Vardenafil, increases circulating progenitor cells in humans
    C Foresta
    Department of Histology, Microbiology, and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    Int J Impot Res 17:377-80. 2005
    ..In our study, we found a significant increase in the number of these cells after the drug administration...
  15. ncbi The PDE5 inhibitor sildenafil increases circulating endothelial progenitor cells and CXCR4 expression
    Carlo Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padova, Italy
    J Sex Med 6:369-72. 2009
    ..CXC-motif chemochine receptor 4 (CXCR4) receptor seems to play a critical role in this process...
  16. ncbi Oestrogen stimulates endothelial progenitor cells via oestrogen receptor-alpha
    Carlo Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padua, Padova, Italy
    Clin Endocrinol (Oxf) 67:520-5. 2007
    ..A subset of these stem cells, endothelial progenitor cells (EPCs), have recently been described as a population of pluripotent cells within the peripheral blood capable of differentiating into endothelial cells...
  17. ncbi Relationship between vascular damage degrees and endothelial progenitor cells in patients with erectile dysfunction: effect of vardenafil administration and PDE5 expression in the bone marrow
    Carlo Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padova, Via Giustiniani 2 c o Palafellin, 35121 Padua, Italy
    Eur Urol 51:1411-7; discussion 1417-9. 2007
    ....
  18. ncbi Expression of the PDE5 enzyme on human retinal tissue: new aspects of PDE5 inhibitors ocular side effects
    C Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy
    Eye (Lond) 22:144-9. 2008
    ....
  19. ncbi Androgens stimulate endothelial progenitor cells through an androgen receptor-mediated pathway
    Carlo Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    Clin Endocrinol (Oxf) 68:284-9. 2008
    ..Design and patients EPCs obtained from healthy male anonymous blood donors were analysed after androgen stimulation with and without AR antagonist administration (flutamide)...
  20. ncbi Reduced number of circulating endothelial progenitor cells in hypogonadal men
    C Foresta
    Department of Histology, Microbiology, and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    J Clin Endocrinol Metab 91:4599-602. 2006
    ..Even though there is increasing evidence that estrogens play a beneficial role on EPCs and, even if debated, on the cardiovascular system, less is known about androgens...
  21. ncbi Hormonal treatment of male infertility: FSH
    C Foresta
    University of Padova, Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, Via Gabelli 63, 35121 Padova, Italy
    Reprod Biomed Online 15:666-72. 2007
    ..In this paper, the literature is reviewed and the authors' experience on using FSH in male infertility is discussed...
  22. ncbi Circulating endothelial progenitor cells and endothelial function after chronic Tadalafil treatment in subjects with erectile dysfunction
    C Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy
    Int J Impot Res 18:484-8. 2006
    ..05) and between basal FMD and PCs increase after Tadalafil treatment (P < 0.05). Tadalafil promotes a mobilization of PCs and improves endothelial function in ED patients...
  23. ncbi Diagnosing erectile dysfunction: flow-chart
    C Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    Int J Androl 28:64-8. 2005
    ..The andrologist's cultural baggage must include the ability to identify the pathology that can determine ED and the capacity to programme a specific diagnostic workup...
  24. ncbi Treatment of male idiopathic infertility with recombinant human follicle-stimulating hormone: a prospective, controlled, randomized clinical study
    Carlo Foresta
    Centre for Male Gamete Cryopreservation, Department of Histology, Microbiology, and Medical Biotechnologies, University of Padova, Padova, Italy
    Fertil Steril 84:654-61. 2005
    ..To evaluate the effects of treatment with FSH on seminal parameters and spontaneous pregnancy in male infertility...
  25. ncbi Role of hormones, genes, and environment in human cryptorchidism
    Carlo Foresta
    University of Padova, Department of Histology, Microbiology and Medical Biotechnologies, Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, Via Gabelli 63, 35121 Padova, Italy
    Endocr Rev 29:560-80. 2008
    ..Obviously, the interaction of environmental and genetic factors is fundamental, and many aspects have been clarified only recently...
  26. ncbi Male hypogonadism in cirrhosis and after liver transplantation
    C Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padua, 35128 Padua, Italy
    J Endocrinol Invest 31:470-8. 2008
    ..Further studies will explain the relationship between hypogonadism and OLT outcome, and the role of androgen therapy in hypogonadism after OLT, in the early months and in the long term...
  27. ncbi Gonadotropin administration after gonadotropin-releasing-hormone agonist: a therapeutic option in severe testiculopathies
    Carlo Foresta
    Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, Department of Histology, Microbiology, and Medical Biotechnologies, University of Padova, Padova, Italy
    Fertil Steril 92:1326-32. 2009
    ....
  28. ncbi Human papilloma virus in the sperm cryobank: an emerging problem?
    C Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, Section of Clinical Pathology, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    Int J Androl 34:242-6. 2011
    ..Further studies are needed to understand whether screening for HPV should be performed in all semen samples before sperm banking or before intra-cytoplasmic sperm injection procedures...
  29. ncbi Bone mass in subjects with Klinefelter syndrome: role of testosterone levels and androgen receptor gene CAG polymorphism
    Alberto Ferlin
    Department of Histology, Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, University of Padova, 35121 Padova, Italy
    J Clin Endocrinol Metab 96:E739-45. 2011
    ....
  30. ncbi Increased levels of osteocalcin-positive endothelial progenitor cells in patients affected by erectile dysfunction and cavernous atherosclerosis
    Carlo Foresta
    University of Padova, Department of Histology, Microbiology, and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, Padova, Italy
    J Sex Med 7:751-7. 2010
    ..Recently, increased levels of osteocalcin (OCN)-positive EPC have been reported in coronary patients...
  31. ncbi Bone mineral density and testicular failure: evidence for a role of vitamin D 25-hydroxylase in human testis
    Carlo Foresta
    Department of Histology, Microbiology, and Medical Biotechnologies, Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, University of Padova, Via Gabelli 63, 35121 Padova, Italy
    J Clin Endocrinol Metab 96:E646-52. 2011
    ..Mutations in the CYP2R1 gene, highly expressed in the testis and encoding vitamin D 25-hydroxylase, result in a vitamin D deficiency and a defective calcium homeostasis leading to rickets...
  32. ncbi Blood levels, apoptosis, and homing of the endothelial progenitor cells after skin burns and escharectomy
    Carlo Foresta
    Department of Histology, Microbiology, and Medical Biotechnologies, Center for Male Gamete Cryopreservation, Section of Clinical Pathology, Clinic of Plastic and Reconstructive Surgery, University of Padova, Padova, Italy
    J Trauma 70:459-65. 2011
    ..Recent data showed an increase in EPC number in burned patients and a positive correlation between EPC number and total body surface area (TBSA) burnt, but data were limited to the first 5 days after thermal injury...
  33. ncbi Semen washing procedures do not eliminate human papilloma virus sperm infection in infertile patients
    Carlo Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, Clinical Pathology Section and Centre for Male Gamete Cryopreservation, University of Padova, Italy
    Fertil Steril 96:1077-82. 2011
    ..To determine the effectiveness of three sperm washing protocols for removing human papillomavirus (HPV)-infected cells from semen samples of infertile patients...
  34. ncbi Phosphodiesterase-5 inhibitor tadalafil acts on endothelial progenitor cells by CXCR4 signalling
    Carlo Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padova, Italy
    Curr Drug Deliv 7:274-82. 2010
    ..We thus demonstrated that PDE5 inhibition acts on CXCR4 signalling in EPC and we can suppose an involvement of cGMP second messenger system in both EPC release from the bone marrow and EPC-mediated peripheral re-endothelization...
  35. ncbi Clinical and prognostic significance of human papillomavirus DNA in the sperm or exfoliated cells of infertile patients and subjects with risk factors
    Carlo Foresta
    Department of Histology, Microbiology, and Medical Biotechnologies, Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, University of Padova, Italy
    Fertil Steril 94:1723-7. 2010
    ..To evaluate human papillomavirus (HPV) sperm infection and its correlation with sperm parameters in infertile patients and subjects with risk factors...
  36. ncbi Increased osteocalcin-positive endothelial progenitor cells in hypogonadal male patients
    C Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, University of Padua, Via Gabelli 63, 35121 Padua, Italy
    J Endocrinol Invest 33:439-42. 2010
    ..The molecular phenotype of EPC is not univocally defined and recent studies identified an osteocalcin (OCN)-positive (EPC-OCN+) subpopulation of EPC highly correlated with atherosclerosis progression...
  37. ncbi Asymmetric development of peripheral atherosclerosis in patients with erectile dysfunction: an ultrasonographic study
    Carlo Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padova, Via Modena 9, 35128 Padova, Italy
    Atherosclerosis 197:889-95. 2008
    ..0 cm/s). These data confirm the strong relation between atherosclerosis and ED, an asymmetric development of atherosclerotic lesions in ED patients and suggest to perform an US study of both femoral and carotid district in these subjects...
  38. ncbi Evidence for osteocalcin production by adipose tissue and its role in human metabolism
    Carlo Foresta
    Department of Histology, Internal Medicine 3, University of Padova, Italy
    J Clin Endocrinol Metab 95:3502-6. 2010
    ..The adipose tissue (AT), which is an endocrine organ, is linked to several metabolic abnormalities. Undercarboxylated osteocalcin (ucOCN) regulates insulin and adiponectin secretion...
  39. ncbi Clinical implication of endothelial progenitor cells
    Carlo Foresta
    University of Padova, Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, Padova, Italy
    Expert Rev Mol Diagn 10:89-105. 2010
    ....
  40. ncbi Male infertility and androgen receptor gene mutations: clinical features and identification of seven novel mutations
    Alberto Ferlin
    University of Padova, Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, Padova, Italy
    Clin Endocrinol (Oxf) 65:606-10. 2006
    ..The aim of his study was to analyse the prevalence of AR gene mutations in male infertility and to clarify the genotype-phenotype relation...
  41. ncbi New roles for INSL3 in adults
    Alberto Ferlin
    Department of Histology, Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    Ann N Y Acad Sci 1160:215-8. 2009
    ..This study identified for the first time a role for INSL3 in adults, demonstrating a modulating effect on bone metabolism and linking RXFP2 gene mutations with human osteoporosis...
  42. ncbi Relaxin stimulates osteoclast differentiation and activation
    Alberto Ferlin
    Section of Clinical Pathology and Center for Male Gamete Cryopreservation, Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Via Gabelli 63, 35121 Padova, Italy
    Bone 46:504-13. 2010
    ....
  43. ncbi Androgen receptor is expressed in both X- and Y-carrier human spermatozoa
    Daniela Zuccarello
    Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    Fertil Steril 91:193-200. 2009
    ..To quantify the amount of AR messenger RNA (mRNA) and to analyze the presence and functionality of the AR protein in X- and Y-carrier human spermatozoa...
  44. ncbi Reduced endothelial progenitor cell number and function in inflammatory bowel disease: a possible link to the pathogenesis
    Andrea Garolla
    Department of Histology, Microbiology, and Medical Biotechnologies, Center for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    Am J Gastroenterol 104:2500-7. 2009
    ..The aim of our study was to investigate the number and function of EPCs in patients with IBD and to assess their endothelial function...
  45. ncbi Association of testicular germ cell tumor with polymorphisms in estrogen receptor and steroid metabolism genes
    Alberto Ferlin
    Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Via Gabelli 63, 35121 Padova, Italy
    Endocr Relat Cancer 17:17-25. 2010
    ....
  46. ncbi Role of estrogen receptors in menstrual cycle-related neoangiogenesis and their influence on endothelial progenitor cell physiology
    Carlo Foresta
    Department of Histology, Microbiology and Medical Biotechnologies, Center for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    Fertil Steril 93:220-8. 2010
    ..To study whether estrogen receptors (ERs) are expressed in vitro and in vivo by female circulating endothelial progenitor cells (EPCs); and the role of ERs in the periodic vascular damage and repair that occurs during the menstrual cycle...
  47. ncbi Genetic alterations associated with cryptorchidism
    Alberto Ferlin
    Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Via Gabelli 63, 35121 Padova, Italy
    JAMA 300:2271-6. 2008
    ..Major regulators of testicular descent are the hormones insulin-like factor 3 (INSL3) and testosterone, and disruption of these pathways might cause cryptorchidism...
  48. ncbi FSH receptor gene polymorphisms in fertile and infertile Italian men
    Manuel Pengo
    University of Padova, Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, Via Gabelli 63, 35121 Padova, Italy
    Reprod Biomed Online 13:795-800. 2006
    ..The data showed that in the Italian population, FSHR genotypes have no influence on FSH concentrations both in normal and infertile males and do not associate with spermatogenetic impairment...
  49. ncbi The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism
    Alberto Ferlin
    University of Padova, Department of Medical and Surgical Sciences, Clinica Medica 3, Center for Male Gamete Cryopreservation, 35128 Padova, Italy
    J Clin Endocrinol Metab 88:4273-9. 2003
    ....
  50. ncbi Androgen receptor gene CAG and GGC repeat lengths in cryptorchidism
    Alberto Ferlin
    University of Padova, Department of Histology, Microbiology, and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, 35121 Padova, Italy
    Eur J Endocrinol 152:419-25. 2005
    ..In this study we analysed CAG and GGC repeat lengths in men with a history of cryptorchidism, associated or not with impairment of sperm production, in comparison with normal fertile subjects...
  51. ncbi Male infertility: role of genetic background
    Alberto Ferlin
    University of Padova, Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, Via Gabelli 63, 35121 Padova, Italy
    Reprod Biomed Online 14:734-45. 2007
    ....
  52. ncbi Molecular and clinical characterization of Y chromosome microdeletions in infertile men: a 10-year experience in Italy
    Alberto Ferlin
    University of Padova, Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, Via Gabelli 63, 35121 Padova, Italy
    J Clin Endocrinol Metab 92:762-70. 2007
    ..However, despite the progresses in the biology of this chromosome, a number of molecular and clinical concerns are not supported by definitive data...
  53. ncbi Mutations in INSL3 and RXFP2 genes in cryptorchid boys
    Alberto Ferlin
    Department of Histology, Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    Ann N Y Acad Sci 1160:213-4. 2009
    ..3%) in persistent cryptorchid boys, with a higher prevalence of bilateral forms (5/120, 4.2%). No mutations were found in controls. This study confirmed the association between INSL3 and RXFP2 gene mutations and human cryptorchidism...
  54. ncbi High-power microscopy for selecting spermatozoa for ICSI by physiological status
    Andrea Garolla
    Centre for Male Gamete Cryopreservation, Department of Histology, Microbiology, and Medical Biotechnologies, University of Padova, Via Gabelli 63 35100, Padova, Italy
    Reprod Biomed Online 17:610-6. 2008
    ..These results suggest a strong relationship between high-magnification morphology and the status of spermatozoa, and they may explain the better results of ICSI obtained using spermatozoa selected by high-magnification microscopy...
  55. ncbi Changes in serum insulin-like factor 3 during normal male puberty
    Alberto Ferlin
    University of Padova, Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, Via Gabelli 63, 35121 Padova, Italy
    J Clin Endocrinol Metab 91:3426-31. 2006
    ..However, a prolonged exposure to LH seems to be necessary to reach INSL3 concentrations of adults. A possible use of INSL3 in puberty disorders is promising...
  56. ncbi Use of recombinant human follicle-stimulating hormone in the treatment of male factor infertility
    Carlo Foresta
    Department of Medical and Surgical Sciences, Clinica Medica 3, University of Padova, Via Ospedale 105, 35128 Padua, Italy
    Fertil Steril 77:238-44. 2002
    ..To evaluate the effects of treatment with recombinant human FSH (r-hFSH) on seminal parameters and seminiferous epithelium in idiopathic patients with oligozoospermia with normal FSH plasma levels...
  57. ncbi Improvements in human sperm quality by long-term in vitro co-culture with isolated porcine Sertoli cells
    Massimo Menegazzo
    Department of Histology, Microbiology and Medical Biotechnologies, Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, University of Padova, 35128 Padova, Italy
    Hum Reprod 26:2598-605. 2011
    ..However, sperm culture is only possible for short periods of time, since long-term culture would invariably and irreversibly damage the cells with negative impact on their fertilization potential...
  58. ncbi Analysis of single nucleotide polymorphisms of FSH receptor gene suggests association with testicular cancer susceptibility
    Alberto Ferlin
    Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padova, Via Gabelli 63, 35121 Padova, Italy
    Endocr Relat Cancer 15:429-37. 2008
    ..The variants with higher activity of the FSHR are associated with higher risk, suggesting a role for FSH in the carcinogenesis of this tumour...
  59. ncbi Inhibin B plasma concentrations in infertile patients with DAZ gene deletions treated with FSH
    Carlo Foresta
    University of Padua, Department of Medical and Surgical Sciences, Clinica Medica 3, Centre for Male Gamete Cryopreservation, Via Ospedale 105, 35128 Padua, Italy
    Eur J Endocrinol 146:801-6. 2002
    ..The aim of the study was to assess Sertoli cell function in subjects with AZFc deletions...
  60. ncbi RXFP1 is expressed on the sperm acrosome, and relaxin stimulates the acrosomal reaction of human spermatozoa
    Lisa Gianesello
    Department of Histology, Section of Clinical Pathology, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    Ann N Y Acad Sci 1160:192-3. 2009
    ..These data suggest a physiological role on sperm for relaxin produced by the prostate and/or the female genital tract...
  61. ncbi Analysis of the DAZ gene family in cryptorchidism and idiopathic male infertility
    Alberto Ferlin
    University of Padova, Padova, Italy
    Fertil Steril 81:1013-8. 2004
    ..To investigate whether partial deletions of the DAZ gene family on the Y chromosome are associated with cryptorchidism, similar to that found for complete AZF deletions...
  62. ncbi INSL3 plays a role in the balance between bone formation and resorption
    Anastasia Pepe
    Department of Histology, Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    Ann N Y Acad Sci 1160:219-20. 2009
    ..Stimulation of human primary osteoblasts with INSL3 at serial concentrations (1 pM, 1 nM, and 1 microM) induced a dose-dependent increase in osteoblast proliferation and expression of specific osteoblast genes...
  63. ncbi Role of relaxin in human osteoclastogenesis
    Arianna Facciolli
    Department of Histology, Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    Ann N Y Acad Sci 1160:221-5. 2009
    ..This study shows, for the first time, that relaxin has an effect on bone metabolism, facilitating the differentiation of osteoclasts. A possible role for relaxin in osteolytic bone metastasis is also proposed...
  64. ncbi Association of age-related macular degeneration with polymorphisms in vascular endothelial growth factor and its receptor
    Alessandro Galan
    S Antonio Hospital, Department of Ophthalmology, Padova, Italy
    Ophthalmology 117:1769-74. 2010
    ..Previous studies investigated the possible association between VEGF-A gene polymorphisms and AMD, with contrasting data. No study examined the possible role of VEGF receptor KDR gene polymorphisms...
  65. ncbi Cavernous artery intima-media thickness: a new parameter in the diagnosis of vascular erectile dysfunction
    Nicola Caretta
    Department of Histology, Microbiology and Medical Biotechnologies, Section of Clinical Pathology, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    J Sex Med 6:1117-26. 2009
    ....
  66. ncbi High incidence of sperm sex chromosomes aneuploidies in two patients with Klinefelter's syndrome
    C Foresta
    Third Chair of Medical Pathology, University of Padova, Italy
    J Clin Endocrinol Metab 83:203-5. 1998
    ....
  67. ncbi Metabolic syndrome and erectile dysfunction: the ultrasound evaluation of cavernosal atherosclerosis
    Mirko Schipilliti
    Department of Histology, University of Padova, Padova, Italy
    Diabetes Care 34:1875-7. 2011
    ..To study the relation between metabolic syndrome (MS), cavernosal morphological vasculopathy, and peripheral vascular alterations (carotid and femoral wall) in patients with erectile dysfunction...
  68. ncbi Genetic variations of gpx-4 and male infertility in humans
    Matilde Maiorino
    Department of Biological Chemistry, University of Padova, I 35121 Padova, Italy
    Biol Reprod 68:1134-41. 2003
    ....
  69. ncbi Estradiol inhibits the effects of extracellular ATP in human sperm by a non genomic mechanism of action
    Marco Rossato
    Department of Medical and Surgical Sciences, Clinica Medica 3, University of Padova, Italy
    Purinergic Signal 1:369-75. 2005
    ..The effects of 17betaE(2) were specific since its inactive steroisomer 17alphaE(2) was inactive. Furthermore the effects of 17betaE(2) were not inhibited by tamoxifen, an antagonist of the classic 17betaE(2) intracellular receptor...
  70. ncbi Insulin-like factor 3: a novel circulating hormone of testicular origin in humans
    Alberto Ferlin
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padua, Centre for Male Gamete Cryopreservation, Via Gabelli 63, 35127 Padua, Italy
    Ann N Y Acad Sci 1041:497-505. 2005
    ..Analysis of men treated with different combinations of hormones of the hypothalamus-pituitary-testis axis suggests that the production of INSL3 is related to the luteinizing hormone...
  71. ncbi Male fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione peroxidase
    Carlo Foresta
    Department of Medical and Surgical Sciences, Clinica Medica 3, University of Padova, I 35128 Padova, Italy
    Biol Reprod 67:967-71. 2002
    ..Because the content of PHGPx, irrespective of the cause of alteration, is correlated with fertility-related parameters, PHGPx can be considered a predictive measure for fertilization capacity...
  72. ncbi Progress in the development of childhood cancer therapy
    Andrea Garolla
    Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padova, Italy
    Reprod Toxicol 22:126-32. 2006
    ..In conclusion, our results confirm data of literature reporting the high gonadal toxicity of cyclophosphamide and suggest that ifosfamide treatment seems to be safer for testicular function and fertility...
  73. ncbi Hormonal and genetic control of testicular descent
    Alberto Ferlin
    University of Padova, Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, Via Gabelli 63, 35121 Padova, Italy
    Reprod Biomed Online 15:659-65. 2007
    ....
  74. ncbi Clinical use of testicular fine needle aspiration cytology in oligozoospermic and azoospermic dogs
    S Romagnoli
    Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, University of Padova, Padova, Italy
    Reprod Domest Anim 44:329-33. 2009
    ..Two dogs with an obstructive lesion were treated with corticosteroids; one of them recovered and sired two litters of puppies...
  75. ncbi Role of seminal osmolarity in the reduction of human sperm motility
    M Rossato
    Department of Medical and Surgical Sciences, Clinica Medica 3, University of Padova, Italy
    Int J Androl 25:230-5. 2002
    ....
  76. ncbi Human sperm express cannabinoid receptor Cb1, the activation of which inhibits motility, acrosome reaction, and mitochondrial function
    M Rossato
    Department of Medical and Surgical Sciences, Clinica Medica 3, University of Padova, Via Ospedale 105, 35128 Padova, Italy
    J Clin Endocrinol Metab 90:984-91. 2005
    ....
  77. ncbi Testicular fine needle aspiration as a diagnostic tool in non-obstructive azoospermia
    A Bettella
    Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padova, Via Gabelli 63, 35121 Padova, Italy
    Asian J Androl 7:289-94. 2005
    ..CONCLUSION: These findings suggest that FNAC may be a simple and valid diagnostic parameter in non-obstructive azoospermic men and it may represent a valid positive prognostic parameter for sperm recovery at TESE...
  78. ncbi Y-chromosome deletions in idiopathic severe testiculopathies
    C Foresta
    University of Padova, Italy
    J Clin Endocrinol Metab 82:1075-80. 1997
    ..Screening for deletion within AZF or at least an informed consent should, therefore, be obtained in all idiopathic infertile male undergoing a program of intracytoplasmic sperm injection of a spermatozoon into the oocyte...
  79. ncbi A novel gene (PD1) with a potential role on rat spermatogenesis
    M Onisto
    Institute of Histology and Embryology, University of Padova, Italy
    J Endocrinol Invest 23:605-8. 2000
    ..These findings suggest that PD1 may play a role in the regulation of spermatogenesis and may be a potential candidate gene for defects of male fertility...
  80. ncbi Antisperm antibodies modify plasma membrane functional integrity and inhibit osmosensitive calcium influx in human sperm
    M Rossato
    University of Padova, Department of Medical and Surgical Sciences, Center for Male Gamete Cryopreservation, Clinica Medica 3, Via Ospedale 105, 35128 Padova, Italy
    Hum Reprod 19:1816-20. 2004
    ....
  81. ncbi Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility
    C Foresta
    University of Padova, Department of Medical and Surgical Sciences, Clinica Medica 3, 35128 Padova, Italy
    Hum Mol Genet 9:1161-9. 2000
    ..This hypothesis is further supported by the high similarity of DBY to other DEAD box proteins belonging to the PL10 subclass...
  82. ncbi FSH in the treatment of oligozoospermia
    C Foresta
    Department of Medical and Surgical Sciences, University of Padova, Clinica Medica 3, Via Ospedale 105, 35128, Padova, Italy
    Mol Cell Endocrinol 161:89-97. 2000
    ..These data suggest that FSH treatment may have a role in oligozoospermic subjects only when the spermatogenetic alterations consist in germ cell depopulation without maturative disturbances and with normal FSH concentrations...
  83. ncbi Sertoli cell function in infertile patients with and without microdeletions of the azoospermia factors on the Y chromosome long arm
    C Foresta
    Department of Medical and Surgical Sciences, University of Padova, 35128 Padova, Italy
    J Clin Endocrinol Metab 86:2414-9. 2001
    ..This study elucidated the multifactorial mechanisms underlying spermatogenic defects, where Sertoli cells may be normally functioning or damaged depending on the primary cause that has determined the testicular damage...
  84. ncbi Evidence for FSH-dependent upregulation of SPATA2 (spermatogenesis-associated protein 2)
    M Onisto
    Department of Experimental Biomedical Sciences, University of Padova, Padua, 35121, Italy
    Biochem Biophys Res Commun 283:86-92. 2001
    ....
  85. ncbi Y chromosome microdeletions in cryptorchidism and idiopathic infertility
    C Foresta
    Department of Medical and Surgical Sciences, Clinica Medica 3, Padova, Italy
    J Clin Endocrinol Metab 84:3660-5. 1999
    ..Microdeletions in Yq may be responsible for severe bilateral testicular damage that could be phenotypically expressed by unilateral cryptorchidism, as well as by idiopathic infertility...
  86. ncbi cDNA cloning and characterization of PD1: a novel human testicular protein with different expressions in various testiculopathies
    R Graziotto
    Institute of Histology and Embryology, Department of Biology, Department of Biochemistry, University of Padova, Viale G Colombo 3, Padua, 35121, Italy
    Exp Cell Res 248:620-6. 1999
    ....
  87. ncbi Oral carnitine supplementation increases sperm motility in asthenozoospermic men with normal sperm phospholipid hydroperoxide glutathione peroxidase levels
    Andrea Garolla
    Histology, Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy
    Fertil Steril 83:355-61. 2005
    ..CONCLUSION(S): Phospholipid hydroperoxide glutathione peroxidase has an important role in male infertility, and carnitine treatment might improve sperm motility in the presence of normal mitochondrial function...
  88. ncbi Y chromosome microdeletions and alterations of spermatogenesis
    C Foresta
    University of Padova, Department of Medical and Surgical Sciences, Clinica Medica 3, 35128 Padua, Italy
    Endocr Rev 22:226-39. 2001
    ..This possibility raises a number of medical and ethical concerns, since the use of spermatozoa carrying Y chromosome deletions may produce pregnancies, but in such cases the genetic anomaly will invariably be passed on to male offspring...
  89. ncbi Endothelial progenitor cells as a new cardiovascular risk factor in Klinefelter's syndrome
    A Di Mambro
    Department of Histology, Microbiology and Medical Biotechnologies, Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, University of Padova, Via Gabelli 63, Padova 35121, Italy
    Mol Hum Reprod 16:411-7. 2010
    ....
  90. ncbi Store-operated calcium influx and stimulation of steroidogenesis in rat Leydig cells: role of Ca(2+)-activated K(+) channels
    M Rossato
    University of Padova, Clinica Medica 3, 35128 Padova, Italy
    Endocrinology 142:3865-72. 2001
    ..These results suggest that internal Ca(2+) stores depletion in rat Leydig cells induces a rise in intracellular Ca(2+), determining important plasma membrane potential variations that influence testosterone secretion...
  91. ncbi Intracellular calcium store depletion and acrosome reaction in human spermatozoa: role of calcium and plasma membrane potential
    M Rossato
    University of Padova, Department of Medical and Surgical Sciences, Clinica Medica 3, Via Ospedale 105, 35128 Padova, Italy
    Mol Hum Reprod 7:119-28. 2001
    ....
  92. ncbi Male infertility caused by a de novo partial deletion of the DAZ cluster on the Y chromosome
    E Moro
    Department of Medical and Surgical Sciences, Clinica Medica 3, University of Padova, Italy
    J Clin Endocrinol Metab 85:4069-73. 2000
    ..The absence of this deletion in the fertile brother of the patient suggests that this de novo mutation indeed caused the spermatogenic failure...
  93. ncbi Evidence for a stimulatory role of follicle-stimulating hormone on the spermatogonial population in adult males
    C Foresta
    Clinica Medica 3, University of Padova, Italy
    Fertil Steril 69:636-42. 1998
    ..To evaluate the effects of treatment with FSH on seminal indices and on the seminiferous epithelium of oligozoospermic subjects with normal FSH plasma levels...
  94. ncbi Insulin-like factor 3 gene mutations in testicular dysgenesis syndrome: clinical and functional characterization
    A Ferlin
    Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    Mol Hum Reprod 12:401-6. 2006
    ..Although a role for mutations of INSL3 and LGR8 genes in cryptorchidism is reasonable, additional studies are needed to establish an association between the disruption of INSL3 pathway and higher risk of infertility or testicular cancer...
  95. ncbi Erectile dysfunction in aging men: testosterone role in therapeutic protocols
    N Caretta
    Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padua, 35128 Padua, Italy
    J Endocrinol Invest 28:108-11. 2005
    ..Testosterone plus PDE5 inhibitors may be beneficial in improving erectile function in hypogonadal men with erectile dysfunction who were unresponsive to PDE5 inhibitors alone...
  96. ncbi Mutations in the insulin-like factor 3 receptor are associated with osteoporosis
    Alberto Ferlin
    Department of Histology, Microbiology and Medical Biotechnologies, Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    J Bone Miner Res 23:683-93. 2008
    ..The aim of this study was to verify whether reduced INSL3 activity could cause or contribute to some signs of hypogonadism, such as reduced BMD, currently attributed to testosterone deficiency...
  97. ncbi Testicular contrast harmonic imaging to evaluate intratesticular perfusion alterations in patients with varicocele
    Nicola Caretta
    Section of Clinical Pathology, Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Centre for Male Gamete Cryopreservation, Padova, Italy
    J Urol 183:263-9. 2010
    ..To determine whether changes in intratesticular microcirculation perfusion affect spermatogenesis in patients with left varicocele we performed testicular contrast harmonic imaging...
  98. ncbi Genetic causes of male infertility
    Alberto Ferlin
    University of Padova, Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, Via Gabelli 63, 35121 Padova, Italy
    Reprod Toxicol 22:133-41. 2006
    ..In this review we will report and discuss the genetic causes of male infertility known up to date and we will analyse genetic polymorphisms possibly associated with male infertility...
  99. ncbi Immunostaining for placental alkaline phosphatase on fine-needle aspiration specimens to detect noninvasive testicular cancer: a prospective evaluation in cryptorchid men
    Ivan M Tavolini
    Department of Urology, Padova Medical School, University of Padova, Italy
    BJU Int 97:950-4. 2006
    ....
  100. ncbi Analysis of meiosis in intratesticular germ cells from subjects affected by classic Klinefelter's syndrome
    C Foresta
    University of Padua, Department of Medical and Surgical Sciences, Clinica Medica 3, Italy
    J Clin Endocrinol Metab 84:3807-10. 1999
    ..These data further suggest the need to evaluate the sex chromosome status of sperm from patients affected by Klinefelter's syndrome undergoing assisted reproductive techniques...
  101. ncbi Extracellular ATP stimulates estradiol secretion in rat Sertoli cells in vitro: modulation by external sodium
    M Rossato
    Department of Medical and Surgical Sciences, Clinica Medica 3, University of Padova, Via Ospedale 105, 35128, Padova, Italy
    Mol Cell Endocrinol 178:181-7. 2001
    ....