Research Topics
| Giorgio CruccuSummaryAffiliation: University of Rome La Sapienza Country: Italy Publications
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Detail Information
Publications
Treating pain in multiple sclerosisAndrea Truini
University of Rome La Sapienza, Department of Neurology and Psychiatry, Viale Università 30, 00185 Rome, Italy
Expert Opin Pharmacother 12:2355-68. 2011..Hence, current treatment should be based on the general principles for treating peripheral neuropathic pain, taking into account drug-induced adverse effects...
EFNS guidelines on neurostimulation therapy for neuropathic painG Cruccu
EFNS Panel on Neuropathic Pain, Vienna, Austria
Eur J Neurol 14:952-70. 2007..These chronically implanted techniques provide satisfactory pain relief in many patients, including those resistant to medication or other means...
Diagram of reliability and net gain: a new method for summarizing and displaying the results of controlled trialsGiorgio Cruccu
Department of Neurological Science, La Sapienza University, Roma, Italy
Pain Pract 7:230-3. 2007....
Inhibition of cortical responses to Adelta inputs by a preceding C-related response: testing the "first come, first served" hypothesis of cortical laser evoked potentialsA Truini
Department of Neurological Sciences, University La Sapienza, Rome, Italy
Pain 131:341-7. 2007..Such dedicated networks aimed at detecting energy changes may be related to orienting reactions, and can be dissociated from subjective perception...
Sumatriptan fast-disintegrating/rapid-release tablets in the acute treatment of migrainePiero Barbanti
Headache and Pain Unit, Department of Neurological, Motor and Sensorial Sciences, IRCCS San Raffaele, Rome, Italy
Expert Rev Neurother 7:927-34. 2007..The drug is well tolerated. In an oral formulation, which is the patients' preferred dosing route, sumatriptan FDT/RRT may therefore constitute an advance in the management of acute migraine attacks...
Palmitoylethanolamide restores myelinated-fibre function in patients with chemotherapy-induced painful neuropathyA Truini
Dip Neurologia e Psichiatria, Sapienza Universita di Roma, Roma, Italy
CNS Neurol Disord Drug Targets 10:916-20. 2011..In a severe condition such as painful neuropathy associated with multiple myeloma and chemotherapy, a safe substance such as PEA provides significant restoration of nerve function...
Iatrogenic damage to the mandibular nerves as assessed by the masseter inhibitory reflexA Biasiotta
Department of Neurology and Psychiatry, Sapienza University, Viale Università 30, 00185 Rome, Italy
J Headache Pain 12:485-8. 2011..We propose that MIR testing, when used for legal purposes, be considered reliable in one direction only, i.e. abnormality does prove nerve damage, normality does not disprove it...
Unmyelinated trigeminal pathways as assessed by laser stimuli in humansG Cruccu
Department of Neurological Sciences, Università La Sapeinza, Roma, Italy
Brain 126:2246-56. 2003..The opercular-insular region and the cingulate gyrus are involved in the processing of C-fibre trigeminal inputs. The method we describe may prove useful in patients with lesions affecting the trigeminal thermal pain pathways...
Trigeminal neuralgia and pain related to multiple sclerosisG Cruccu
Centro Dolore Neuropatico, Dipartimento Scienze Neurologiche, Universita La Sapienza, Roma, Italy
Pain 143:186-91. 2009..The other sensory disturbances, including ongoing pain and dysaesthesia, may arise from damage to the second-order neurons in the spinal trigeminal complex...
Treatment of painful neuropathyGiorgio Cruccu
EFNS Panel Neuropathic Pain, Department of Neurological Sciences, La Sapienza University, Rome, Italy
Curr Opin Neurol 20:531-5. 2007..With the aging of the population, treatment of painful neuropathies is becoming more and more important for neurological practice. This short review highlights recent findings and current problems...
Clinical utility of pain--laser evoked potentialsG Cruccu
Department of Neurological Sciences, La Sapienza University, , 00185 Rome, Italy
Suppl Clin Neurophysiol 57:101-10. 2004
EFNS guidelines on neuropathic pain assessmentG Cruccu
EFNS Panel on Neuropathic Pain Department of Neurological Sciences, La Sapienza University, Rome, Italy
Eur J Neurol 11:153-62. 2004..A laboratory measure of pain that by-passes the subjective report, and thus cognitive influences, is a hopeful aim for the future...
Diagnostic accuracy of trigeminal reflex testing in trigeminal neuralgiaG Cruccu
Department of Neurological Sciences, La Sapienza University, Rome, Italy
Neurology 66:139-41. 2006..In contrast, electrophysiologic testing of trigeminal reflexes accurately distinguished symptomatic from classic TN (sensitivity 96%, specificity 93%)...
AAN-EFNS guidelines on trigeminal neuralgia managementG Cruccu
Department of Neurological Sciences, La Sapienza University, Rome, Italy
Eur J Neurol 15:1013-28. 2008..The role of surgery versus pharmacotherapy in the management of TN in patients with multiple sclerosis remains uncertain...
Recommendations for the clinical use of somatosensory-evoked potentialsG Cruccu
Department of Neurological Sciences, La Sapienza University, Viale Università 30, 00185 Rome, Italy
Clin Neurophysiol 119:1705-19. 2008..However, to prove clinically useful each of them requires a dedicated knowledge, both technical and pathophysiological. In this article we give technical advice, report normative values, and discuss clinical applications...
EFNS guidelines on neuropathic pain assessment: revised 2009G Cruccu
Department of Neurological Sciences, La Sapienza University, Rome, Italy
Eur J Neurol 17:1010-8. 2010....
The clinical use of brainstem reflexes and hand-muscle reflexesG Cruccu
Dipartimento Scienze Neurologiche, Universita di Roma La Sapienza, Viale Università 30, 00185, Rome, Italy
Clin Neurophysiol 111:371-87. 2000....
Diagnosis of trigeminal neuralgia: a new appraisal based on clinical and neurophysiological findingsG Cruccu
Department of Neurological Sciences, La Sapienza University, 00185 Rome, Italy
Suppl Clin Neurophysiol 58:171-86. 2006
Small-fiber dysfunction in trigeminal neuralgia: carbamazepine effect on laser-evoked potentialsG Cruccu
Department of Neurological Sciences, University La Sapienza, Roma, Italy
Neurology 56:1722-6. 2001..Reflex and evoked potential studies have already provided information on large-afferent (non-nociceptive) function. Using laser-evoked potentials (LEP), the authors sought information on small-afferent (nociceptive) function...
Brainstem reflex circuits revisitedG Cruccu
Department of Neurological Sciences, La Sapienza University, Rome, Italy
Brain 128:386-94. 2005..The jaw jerk, perhaps the brainstem reflex most widely used in clinical neurophysiology, had no apparent topodiagnostic value, probably because it depends strongly on peripheral variables, including dental occlusion...
Neuropathic pain and its assessmentGiorgio Cruccu
Department of Neurological Sciences, University La Sapienza, Rome, Italy
Surg Oncol 19:149-54. 2010....
Evidence of a specific spinal pathway for the sense of warmth in humansG D Iannetti
Dipartimento Scienze Neurologiche, , 00185 Rome, Italy
J Neurophysiol 89:562-70. 2003..Our results support the existence of slow-conducting second-order neurons specific for the sense of warmth...
Excitability of the Adelta nociceptive pathways as assessed by the recovery cycle of laser evoked potentials in humansA Truini
Department of Neurological Sciences, University La Sapienza, , 00185, Rome, Italy
Exp Brain Res 155:120-3. 2004....
Excitability of the human trigeminal motoneuronal pool and interactions with other brainstem reflex pathwaysG Cruccu
Department of Neurological Sciences, University of Rome 'La Sapienza, Italy
J Physiol 531:559-71. 2001....
Is the cutaneous silent period an opiate-sensitive nociceptive reflex?Maurizio Inghilleri
Department of Neurological Sciences, University of Rome La Sapienza, Viale dell Universita 30, 00185 Rome, Italy
Muscle Nerve 25:695-9. 2002....
Laser-evoked potentials as a tool for assessing the efficacy of antinociceptive drugsA Truini
Department of Neurological Sciences, La Sapienza University and IRCCS San Raffaele, Rome, Italy
Eur J Pain 14:222-5. 2010..The opioid antagonist naloxone partially reversed the tramadol-induced LEP amplitude decrease. We conclude that LEPs may be reliably used in clinical practice and research for assessing the efficacy of antinociceptive drugs...
Cutaneous silent period in hand muscle is evoked by laser stimulation of the palm, but not the hand dorsumA Romaniello
Department of Neurological Sciences, University La Sapienza, , 00185 Rome, Italy
Muscle Nerve 29:870-2. 2004....
Laser-evoked potentials in post-herpetic neuralgiaA Truini
Department of Neurological Sciences, University La Sapienza, , 00185, Rome, Italy
Clin Neurophysiol 114:702-9. 2003..Although PHN severely impairs small myelinated fibres, the lack of a significant correlation between LEP abnormalities and pain suggests that pain in PHN does not chiefly arise from a dysfunction of small-myelinated afferents...
Neurophysiological assessment of craniofacial painFrancesca Galeotti
Department of Neurological Sciences, University of Rome La Sapienza, , I-00185, Rome, Italy
J Headache Pain 7:61-9. 2006..This review briefly describes the physiology of trigeminal reflexes and LEPs, reports normal values and highlights the neurophysiological abnormalities in the main clinical conditions...
Sympathetic skin response evoked by laser skin stimulationPaolo Rossi
Department of Clinical Neurology and Otorhinolaryngology, University La Sapienza, Rome, Italy
Funct Neurol 17:129-32. 2002..Our findings show that SSRs can easily be induced by laser stimuli and that this method shares the technical limitations of conventional eSSRs...
Is Ross syndrome a dysautonomic disorder only? An electrophysiologic and histologic studyA Perretti
Department of Neurological Sciences, University of Naples 'Federico II, Via Sergio Pansini 5, Naples, Italy
Clin Neurophysiol 114:7-16. 2003..CONCLUSIONS: Our data suggest that Ross syndrome is a degenerative disorder involving progressive sudomotor fibers, and then epidermal sensory unmyelinated and myelinated fibers...
Trigeminal responses to laser stimuliA Romaniello
Department of Neurological Sciences, University La Sapienza, , 00185 Rome, Italy
Neurophysiol Clin 33:315-24. 2003....
Laser evoked potentials for assessing sensory neuropathy in human patientsA Truini
Department of Neurological Sciences, University 'La Sapienza, , 00185 Rome, Italy
Neurosci Lett 361:25-8. 2004..LEPs often disclosed subclinical dysfunction of Adelta fibres and proved a sensitive and reliable diagnostic tool for assessing small-fibre function in sensory neuropathy...
Laser evoked potentials and carbamazepine in epileptic patientsF Galeotti
Department of Neurological Sciences, University La Sapienza, Rome, Italy
Neurophysiol Clin 35:93-6. 2005..The CBZ-induced effect in patients with trigeminal neuralgia is possibly related to pathophysiological changes specific to this disease...
Shortened cortical silent period in facial muscles of patients with migraineAntonio Curra
Department of Neurological Sciences, La Sapienza University, Rome, Italy
Pain 132:124-31. 2007....
New insight into trigeminal neuralgiaAndrea Truini
Department of Neurological Sciences, University La Sapienza, Viale dell Universita 30, I 00185, Rome, Italy
J Headache Pain 6:237-9. 2005..We propose a short review on trigeminal neuralgia reporting its main clinical aspects, unsolved problems and highlighting differential diagnosis between classical and symptomatic trigeminal neuralgia...
Differential involvement of A-delta and A-beta fibres in neuropathic pain related to carpal tunnel syndromeA Truini
Department of Neurological Sciences, University La Sapienza, Rome, Italy
Pain 145:105-9. 2009..Our findings suggest that whereas paroxysmal pain and abnormal sensations reflect demyelination of non-nociceptive Abeta-fibres, spontaneous constant pain arises from damage to nociceptive Adelta-fibres...
Mechanisms of pain in distal symmetric polyneuropathy: a combined clinical and neurophysiological studyA Truini
Department of Neurological Sciences, University La Sapienza, Rome, Italy
Pain 150:516-21. 2010..Because clinical and neurophysiological abnormalities followed similar patterns regardless of aetiology, pain should be classified and treated on mechanism-based grounds...
Laser evoked potentials in patients with trigeminal disease: the absence of Adelta potentials does not unmask C-fibre potentialsA Truini
Department of Neurological Sciences, La Sapienza University, Viale Universita, 30, 00185 Rome, Italy
Clin Neurophysiol 119:1905-8. 2008..In this study, we aimed at verifying whether in the trigeminal territory the impairment of Adelta-fibres unmasks the C-LEP...
Dissociation between cutaneous silent period and laser evoked potentials in assessing neuropathic painA Truini
Department of Neurological Sciences, La Sapienza University, Viale Università 30, Rome, Italy
Muscle Nerve 39:369-73. 2009..005) but not with CSP duration (P > 0.5). Our findings indicate that the CSP is not useful for assessing nociceptive pathway function in patients with neuropathic pain...
Pathophysiology of pain in postherpetic neuralgia: a clinical and neurophysiological studyA Truini
Department of Neurological Sciences, La Sapienza University, Viale Università 30, 00185 Rome, Italy
Pain 140:405-10. 2008..These findings might be useful for a better understanding of pain mechanisms in postherpetic neuralgia...
Trigeminal small-fibre function assessed with contact heat evoked potentials in humansA Truini
Department of Neurological Sciences, La Sapienza University, Viale Università 30, 00185 Rome, Italy
Pain 132:102-7. 2007..Contact heat stimulation, as well as laser stimulation, easily yields large-amplitude brain potentials and nociceptive reflexes, both related to the Adelta input. However CHEPs are not suitable for C-fibres potentials recording...
Trigeminal sensory pathway function in patients with SUNCTA Truini
Department of Neurological Sciences, University La Sapienza, Rome, Italy
Clin Neurophysiol 117:1821-5. 2006..To seek information on its pathophysiology, we studied the trigeminal Abeta and Adelta pathways by recording trigeminal reflexes and laser evoked potentials (LEPs) in patients with SUNCT...
Experimental skin pain and muscle pain induce distinct changes in human trigeminal motoneuronal excitabilityA Truini
Department of Neurological Sciences, University La Sapienza, Rome, Italy
Exp Brain Res 174:622-9. 2006..Due to the differences between the two experimental models, we cannot conclude that such inhibitory reflex pathway does not exist from muscle nociceptors to trigeminal motoneurones...
Reduced habituation to experimental pain in migraine patients: a CO(2) laser evoked potential studyM Valeriani
Department of Neurology, Universita Cattolica del Sacro Cuore, L go A Gemelli 8, 00168, Rome, Italy
Pain 105:57-64. 2003..But patients with migraine had a reduced habituation, which probably reflects an abnormal excitability of the cortical areas involved in pain processing...
Laser-evoked potentials: normative valuesA Truini
Department of Neurological Sciences, La Sapienza University, , 00185 Rome, Italy
Clin Neurophysiol 116:821-6. 2005..SIGNIFICANCE: Our data may help to improve the clinical reliability of LEPs as a diagnostic tool...
Headache in cranial and cervical dystoniaP Barbanti
Department of Neurosciences, University La Sapienza, Rome, Italy
Neurology 64:1308-9. 2005
Diazepam effects on the cerebral responses to tonic pain: a SPET studyV Di Piero
Department of Neurological Sciences, University of Rome La Sapienza, Viale dell Universita 30, 00185 Rome, Italy
Psychopharmacology (Berl) 158:252-8. 2001..Pain is a complex phenomenon with a strong affective-emotional component in addition to a sensory-discriminative one. This causes the activation of multiple brain areas, which process different aspects of pain simultaneously...
Jaw-opening reflex after CO2 laser stimulation of the perioral region in manG Cruccu
Dipartimento Scienze Neurologiche, Viale Università 30, Rome, Italy
Exp Brain Res 118:564-8. 1998..We also propose that a common centre processes the various inputs for jaw opening...
Nociceptive quality of the laser-evoked blink reflex in humansA Romaniello
Department of Neurological Sciences, University of Rome La Sapienza, , I-00185 Rome, Italy
J Neurophysiol 87:1386-94. 2002..The LBR may prove useful for studying the pathophysiology of orofacial pain syndromes...
Bladder filling inhibits somatic spinal motoneuronesM Inghilleri
Dipartimento di Scienze Neurologiche, , 00185, Rome, Italy
Clin Neurophysiol 112:2255-60. 2001..This vesical-induced inhibition is probably mediated by the propriospinal system rather than by the diffuse noxious inhibitory control circuit...
Excitability of the central masticatory pathways in patients with painful temporomandibular disordersG Cruccu
Dipartimento Scienze Neurologiche, Universita La Sapienza, Roma, Italy
Pain 73:447-54. 1997....
Validation of the Italian version of the Neuropathic Pain Symptom Inventory in peripheral nervous system diseasesLuca Padua
Department of Neurosciences, Institute of Neurology, UCSC University, Largo F Vito 1, 00168, Rome, Italy
Neurol Sci 30:99-106. 2009..The I-NPSI scores represent reliable measurements to assess neuropathic symptoms and effectiveness of treatment on them...
Representation of different trigeminal divisions within the primary and secondary human somatosensory cortexG D Iannetti
Dipartimento Scienze Neurologiche, , Roma, Italy
Neuroimage 19:906-12. 2003..These results to some extent contrast with electrophysiological data in monkeys and disclose distinct cortical representations within facial territories in humans...
Tools for assessing neuropathic painGiorgio Cruccu
Department of Neurological Sciences, La Sapienza University, Rome, Italy
PLoS Med 6:e1000045. 2009b>Giorgio Cruccu and Andrea Truini discuss a new pain assessment tool published in PLoS Medicine called Standardized Evaluation of Pain and they review other tools to assess neuropathic pain.
Pathophysiological mechanisms of neuropathic painA Truini
EFNS Panel on Neuropathic Pain and Department of Neurological Sciences, La Sapienza University, , I-00185, Rome, Italy
Neurol Sci 27:S179-82. 2006..This short review summarises the current understanding of pathophysiology of neuropathic pain and focuses on how symptoms translate in mechanisms...
Usefulness of dorsal laser evoked potentials in patients with spinal cord damage: report of two casesG D Iannetti
Department of Neurological Sciences, University of Rome La Sapienza, , 00185 Roma, Italy
J Neurol Neurosurg Psychiatry 71:792-4. 2001..Dorsal LEP recordings may prove a useful tool in localising lesions and in the neurophysiological assessment of focal spinal cord lesions involving the anterolateral quadrants of the spinal cord...
Medullary infarcts may cause ipsilateral masseter reflex abnormalitiesFrank Thömke
Department of Neurology, University of Mainz, Langenbeckstr 1, D 55101, Mainz, Germany
Muscle Nerve 36:477-81. 2007..MassR abnormalities with medullary lesions restrict the topodiagnostic value of the MassR...
Painful sensory neuropathyAndrea Truini
N Engl J Med 349:306-7; author reply 306-7. 2003
Modulation of trigeminal laser evoked potentials and laser silent periods by homotopical experimental painAntonietta Romaniello
Orofacial Pain Laboratory, Center for Sensory-Motor Interaction, Aalborg University, Fredrik Bajers Vej 7, D-3, DK-9220 Aalborg, Denmark
Pain 98:217-28. 2002..These effects could be mediated through the activation of segmental and suprasegmental inhibitory systems that may function interdependently...
The lower limb flexion reflex in humansGiorgio Sandrini
University Center for Adaptive Disorders and Headache, IRCCS C Mondino Institute of Neurology Foundation, University of Pavia, Via Mondino 2, 27100 Pavia, Italy
Prog Neurobiol 77:353-95. 2005....
Laser talks in florenceGiorgio Cruccu
Neurophysiol Clin 33:255-8. 2003
Somatotopic organization of the corticospinal tract in the human brainstem: a MRI-based mapping analysisJuergen J Marx
Department of Neurology, Johannes Gutenberg University Mainz, Mainz, Germany
Ann Neurol 57:824-31. 2005....
Trends in European CNGiorgio Cruccu
Clin Neurophysiol 116:2507-9. 2005
3D brainstem topodiagnosis--a voxel-based model analyzing MR imaging dataJuergen J Marx
Department of Neurology, University of Mainz, D-55101 Mainz, Germany
Suppl Clin Neurophysiol 58:26-37. 2006
Topodiagnostic implications of hemiataxia: an MRI-based brainstem mapping analysisJuergen J Marx
Department of Neurology, Johannes Gutenberg University Mainz, Langenbeckstr 1, Mainz, Germany
Neuroimage 39:1625-32. 2008..3) Finally, bilateral ataxia probably reflects a lesion of cerebellar outflow on a central, rostral pontomesencephalic level...
