Research Topics
Genomes and Genes | Sabrina CorbettaSummaryAffiliation: University of Milan Country: Italy Publications
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Publications
Modulation of cyclin D1 expression in human tumoral parathyroid cells: effects of growth factors and calcium sensing receptor activationS Corbetta
Endocrinology and Diabetology Unit, Department of Medical Surgical Sciences, University of Milan, Policlinico SDonato IRCCS, Via Morandi 30, 20097, SDonato Mse MI, Italy
Cancer Lett 255:34-41. 2007..These data further support the oncogenic role of cyclin D1, which resulted to be target for stimulation by bFGF and EGF and inhibition by CaSR and TGFbeta signalling in the parathyroid...- Adiponectin expression in human fetal tissues during mid- and late gestationS Corbetta
Institute of Endocrine Sciences, Ospedale Maggiore IRCCS, Via F Sforza, 35, 20122 Milan, Italy
J Clin Endocrinol Metab 90:2397-402. 2005..The unexpected pattern of ApN expression in the human fetus may account for the high ApN levels in cord blood and predicts novel roles for ApN during fetal development... - High prevalence of simple kidney cysts in patients with primary hyperparathyroidismS Corbetta
Endocrinology and Diabetology Unit, Department of Medical Surgical Sciences, University of Milan, IRCCS Policlinico S Donato, 20097 S Donato M se MI, Italy
J Endocrinol Invest 32:690-4. 2009..In conclusion, simple renal cysts might be considered as a benign kidney complication of PHPT and might be related to the action of the chronic elevated PTH levels on tubular epithelial cells... - Expression of parathyroid-specific genes in vascular endothelial progenitors of normal and tumoral parathyroid glandsSabrina Corbetta
Endocrinology and Diabetology Unit, Department of Medical Surgical Sciences, University of Milan, IRCCS Policlinico S Donato, Via Morandi 30, S Donato M se MI, Milan, Italy
Am J Pathol 175:1200-7. 2009.... - Differential expression of microRNAs in human parathyroid carcinomas compared with normal parathyroid tissueS Corbetta
Endocrinology and Diabetology Unit, Department of Medical Surgical Sciences, Universita di Milano, IRCCS Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Milan, Italy
Endocr Relat Cancer 17:135-46. 2010..These results suggest the existence of an altered microRNA expression pattern in PaCs together with a potential role of miR-296 as novel oncosuppressor gene in these neoplasia... - Effects of retinoid therapy on insulin sensitivity, lipid profile and circulating adipocytokinesS Corbetta
Institute of Endocrine Sciences, University of Milan, Ospedale Maggiore IRCCS, Via F Sforza, 35 20122, Milan, Italy
Eur J Endocrinol 154:83-6. 2006..We aimed to evaluate the effects of chronic treatment with acitretin, an all-trans retinoic acid, on glucose metabolism, lipid profile and adiponectin and resistin levels... - Gonadal structures in a fetus with complete androgen insensitivity syndrome and persistent Müllerian derivatives: comparison with normal fetal developmentSabrina Corbetta
Endocrinology Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy
Fertil Steril 95:1119.e9-14. 2011..To report a case of complete androgen insensitivity syndrome (CAIS) with Müllerian duct persistence... - Risk factors associated to kidney stones in primary hyperparathyroidismS Corbetta
Institute of Endocrine Sciences, Fondazione Ospedale Maggiore IRCCS, University of Milan, Milan, Italy
J Endocrinol Invest 28:122-8. 2005..In conclusion, hypercalciuria, higher oxalate excretion and severe PHPT are associated with kidney stones in PHPT... - Fibrosis is associated with adiponectin resistance in chronic hepatitis C virus infectionSabrina Corbetta
Endocrinology and Diabetology Unit, Department of Medical Surgical Sciences, University of Milan, Milan, Italy
Eur J Clin Invest 41:898-905. 2011..Adiponectin, an adipocyte-derived insulin-sensitizing hormone, might play a protective role against hepatic fibrosis... - Analysis of the 206M polymorphic variant of the SLC26A6 gene encoding a Cl- oxalate transporter in patients with primary hyperparathyroidismS Corbetta
Endocrinology and Diabetology Unit, Department of Medical Surgical Sciences, University of Milan, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Milan, Italy
Eur J Endocrinol 160:283-8. 2009..Hypercalciuria and urine oxalate excretion are considered risk factors for urolithiasis in PHPT as well as in idiopathic stone-formers. Recently, the anion-exchanger SLC26A6 has been involved in the oxalate metabolism... - Genetic analysis and evaluation of resistance to thyrotropin and growth hormone-releasing hormone in pseudohypoparathyroidism type IbGiovanna Mantovani
Department of Medical Sciences, Endocrine Unit, Fondazione Policlinico Instituto di Ricovero e Cura a Carattere Scientifico, University of Milan, 20122 Milan, Italy
J Clin Endocrinol Metab 92:3738-42. 2007..No study addressed the question of GH deficiency in PHP-Ib patients... - Effect of 9-cis retinoic acid on dopamine D2 receptor expression in pituitary adenoma cellsSara Bondioni
Endocrine Unit, Department of Medical Sciences, University of Milan, Fondazione Ospedale Maggiore IRCCS, 20122 Milan, Italy
Exp Biol Med (Maywood) 233:439-46. 2008..05). In conclusion, this study provides novel evidence for a permissive role of retinoids on the expression of D2R in a good proportion of pituitary tumors and on the generation of pro-apoptotic signals in GH3 cell line... - Calcium-sensing receptor expression and signalling in human parathyroid adenomas and primary hyperplasiaS Corbetta
Institute of Endocrine Sciences, University of Milan, Milan, Italy
Clin Endocrinol (Oxf) 52:339-48. 2000.... - Influence of the d3GH receptor polymorphism on the metabolic and biochemical phenotype of GH-deficient adults at baseline and during short- and long-term recombinant human GH replacement therapyClaudia Giavoli
Department of Medical Sciences, University of Milan, Milan, Italy
Eur J Endocrinol 163:361-8. 2010..The aim of the study was to investigate the impact of the GHR genotype on the phenotype of GHD adults and on the metabolic effect of rhGH therapy... - Gonadotropin-releasing hormone initiates multiple signaling pathways in human GH-secreting adenomasA Lania
Institute of Endocrine Sciences, Milan, Italy
J Endocrinol Invest 27:328-33. 2004..The ability of GnRH to signal through Gsalpha protein may account for the lack of GH responses to GnRH observed in acromegalic patients with tumors carrying gsp mutation... - Protein kinase A regulatory subunits in human adipose tissue: decreased R2B expression and activity in adipocytes from obese subjectsGiovanna Mantovani
Endocrine Unit, Department of Medical Sciences, University of Milan, Fondazione Ospedale Maggiore Policlinico IRCCS, Milan, Italy
Diabetes 58:620-6. 2009..The aim of the study was to investigate possible differences in R2B expression, PKA activity, and lipolysis in adipose tissues from obese and nonobese subjects... - Effect of recombinant human growth hormone (GH) replacement on the hypothalamic-pituitary-adrenal axis in adult GH-deficient patientsClaudia Giavoli
Institute of Endocrine Sciences, University of Milan, Ospedale Maggiore IRCCS, Pad. Granelli, Via F. Sforza, 35, 20122 Milan, Italy
J Clin Endocrinol Metab 89:5397-401. 2004..Therefore, the reassessment of HPA function in GHD patients during rhGH therapy is mandatory... - Effect of cyclic adenosine 3',5'-monophosphate/protein kinase a pathway on markers of cell proliferation in nonfunctioning pituitary adenomasG Mantovani
Institute of Endocrine Sciences, Ospedale Maggiore, IRCCS, University of Milan, Italy
J Clin Endocrinol Metab 90:6721-4. 2005.... - Role of Tc-99m sestamibi scintigraphy in the diagnosis and surgical decision-making process in primary hyperparathyroid diseaseM Castellani
Department of Nuclear Medicine, Ospedale Maggiore, Milan, Italy
Clin Nucl Med 26:139-44. 2001.... - Absence of thyroid transcription factor-1 expression in human parathyroid and pituitary glandsG Mantovani
Institute of Endocrine Sciences, University of Milan-Ospedale Maggiore IRCCS, Pad. Granelli, Via Francesco Sforza 35, 21022 Milan, Italy
Mol Cell Endocrinol 182:13-7. 2001.... - Effects of hypothalamic neuropeptides on extracellular signal-regulated kinase (ERK1 and ERK2) cascade in human tumoral pituitary cellsA Lania
Institute of Endocrine Sciences, University of Milan, Ospedale Maggiore Instituto di Ricovero e Cura a Carattere Scientifico, Italy
J Clin Endocrinol Metab 88:1692-6. 2003..Moreover, a stimulatory effect of the protein kinase A-dependent pathway on ERK1/2 cascade occurred selectively in GH-omas, probably contributing to the mitogenic potential of the cAMP pathway in this cell type... - Evaluation of IGF-I levels during long-term somatostatin analogs treatment in patients with gastroenteropancreatic endocrine tumorsC L Ronchi
Unit of Endocrinology, Department of Medical Sciences, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, University of Milan, 20122 Milan, Italy
J Endocrinol Invest 30:241-6. 2007.... - Prevalence of GH deficiency in cured acromegalic patients: impact of different previous treatmentsC L Ronchi
Department of Medical Sciences, University of Milan, 20122 Milan, Italy
Eur J Endocrinol 161:37-42. 2009..Data on the effects of surgery alone (S) on dynamic GH secretion are limited. The aim of the study was to investigate the occurrence of GHD in acromegalic patients treated with different therapeutic options... - Immunohistochemical study of subepidermal connective of molluscan integumentS Corbetta
Dipartimento di Fisiologia e Biochimica Generali, Sezione di Istologia ed Anatomia Umana, Universita degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy
Eur J Histochem 46:259-72. 2002.... - Somatostatin receptor subtype 2 and 5 in human GH-secreting pituitary adenomas: analysis of gene sequence and mRNA expressionS Corbetta
Ospedale Maggiore IRCCS, University of Milan, San Raffaele IRCCS, Via Francesco Sforza 35, 21022 Milan, Italy
Eur J Clin Invest 31:208-14. 2001..Moreover, both SSTR2 and SSTR5 DNA from tumours resistant to somatostatin analogues were found to possess intact coding sequences... - Analysis of GNAS1 and PRKAR1A gene mutations in human cardiac myxomas not associated with multiple endocrine disordersG Mantovani
Endocrine Unit, Department of Medical Sciences, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena IRCCS, 20122 Milan, Italy
J Endocrinol Invest 32:501-4. 2009..This is the first study including a large series of sporadic, isolated cardiac myxomas and showing that these cardiac neoplasms do not share the same mutations found in familial forms... - Activity and function of the nuclear factor kappaB pathway in human parathyroid tumorsS Corbetta
Institute of Endocrine Sciences, Fondazione Ospedale Maggiore IRCCS, University of Milan, Italy
Endocr Relat Cancer 12:929-37. 2005.... - Immunocytochemical localization of protein p27BBP in human skin and invertebrate (Sepia officinalis) integumentA Bairati
Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita di Milano, Via Celoria 26, 20133, Milan, Italy
Cell Tissue Res 321:115-21. 2005.... - Plasma chromogranin A in patients with sporadic gastro-entero-pancreatic neuroendocrine tumors or multiple endocrine neoplasia type 1M Peracchi
Institute of Endocrine Sciences, University of Milan, Ospedale Maggiore IRCCS, Padiglione Granelli, Via F Sforza 35, 20122, Milan, Italy
Eur J Endocrinol 148:39-43. 2003.... - Mitogen-activated protein kinase cascade in human normal and tumoral parathyroid cellsS Corbetta
Institute of Endocrine Science, Ospedale Maggiore IRCCS, Milan, Italy 20122
J Clin Endocrinol Metab 87:2201-5. 2002..Interestingly, this signaling pathway is disrupted in parathyroid tumors... - Sporadic and MEN1-related primary hyperparathyroidism: differences in clinical expression and severityCristina Eller-Vainicher
Unit of Endocrinology Diabetology, Department of Medical Sciences, University of Milan, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, IRCCS, Milan, Italy
J Bone Miner Res 24:1404-10. 2009..Normal PTH levels and young age are associated with MEN1 presence... - Calcimimetic R-568 effects on activity of R990G polymorphism of calcium-sensing receptorAnnalisa Terranegra
Department of Medicine Surgery and Dentistry, IRCCS Policlinico San Donato, Milan, Italy
J Mol Endocrinol 45:245-56. 2010..Our findings demonstrated that the 990G allele is associated with high sensitivity to R-568, which provided new evidence for differences in CASR signaling... - Different effects of short- and long-term recombinant hGH administration on ghrelin and adiponectin levels in GH-deficient adultsClaudia Giavoli
Institute of Endocrine Sciences, University of Milan, Ospedale Maggiore IRCCS, Milan, Italy
Clin Endocrinol (Oxf) 61:81-7. 2004..Conversely, the decrease in ghrelin levels observed after short-term rhGH administration may be consistent with an inhibitory feedback of GH and/or IGF-I on ghrelin release... - Circulating adiponectin levels and cardiovascular risk factors in acromegalic patientsC L Ronchi
Institute of Endocrine Sciences, University of Milan, Ospedale Maggiore IRCCS, Milan, Italy
Eur J Endocrinol 150:663-9. 2004.... - Circulating ghrelin levels in patients with pancreatic and gastrointestinal neuroendocrine tumors: identification of one pancreatic ghrelinomaS Corbetta
Institute of Endocrine Sciences, Ospedale Maggiore IRCCS, Milan, Italy
J Clin Endocrinol Metab 88:3117-20. 2003..In conclusion, the study showed that carcinoids and pancreatic tumors rarely cause ghrelin hypersecretion. However, in this series, 1 pancreatic ghrelinoma not associated with clinical features of acromegaly was identified... - Mutation of somatostatin receptor type 5 in an acromegalic patient resistant to somatostatin analog treatmentE Ballare
Institute of Endocrine Sciences, University of Milano 20122, Ospedale Maggiore IRCCS, 20122 Milan, Italy
J Clin Endocrinol Metab 86:3809-14. 2001..We suggest that this mutation that abrogates the antiproliferative action of somatostatin and activates mitogenic pathways may be involved in the resistance to somatostatin treatment... - R990G polymorphism of the calcium-sensing receptor and renal calcium excretion in patients with primary hyperparathyroidismS Corbetta
Unità Operativa di Endocrinologia e Diabetologia, Department of Medical Surgical Sciences, University of Milan, Policlinico San Donato IRCCS, San Donato M se, Milan, Italy
Eur J Endocrinol 155:687-92. 2006..Data concerning the association between polymorphic variants of the gene encoding the calcium-sensing receptor (CaSR) and clinical characteristics of PHPT are not conclusive... - SNPs and real-time quantitative PCR method for constitutional allelic copy number determination, the VPREB1 marker caseMarcello Frigerio
Research Laboratories Molecular Biology, IRCCS Policlinico San Donato, San Donato Milanese MI, Italy
BMC Med Genet 12:61. 2011..2 microdeletions detection as a first-level screening approach in a genetically unknown series of patients with congenital heart defects. A technical issue related to the VPREB1 qPCR marker was pointed out... - Parental origin of Gsalpha mutations in the McCune-Albright syndrome and in isolated endocrine tumorsGiovanna Mantovani
Institute of Endocrine Sciences, University of Milan, Ospedale Maggiore IRCCS, 20122 Milan, Italy
J Clin Endocrinol Metab 89:3007-9. 2004..These data confirm the importance of Gsalpha imprinting in the pituitary gland and point out the high degree of tissue specificity of this phenomenon... - Maternal and foetal resistin and adiponectin concentrations in normal and complicated pregnanciesDonatella Cortelazzi
Endocrine Unit, Department of Medical Sciences, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
Clin Endocrinol (Oxf) 66:447-53. 2007..The aim of this study was to evaluate how resistin and adiponectin (ApN) are involved in maternal energy metabolism and foetal growth... - Brown jaw tumors: today's unusual presentation of primary hyperparathyroidismS Corbetta
Institute of Endocrine Sciences, University of Milan, Ospedale Maggiore IRCCS, Milano, Italy
J Endocrinol Invest 26:675-8. 2003..Moreover, such a complication seems to be independent from vitamin D deficiency, suggesting the involvement of other pathogenetic factors... - Increased risk for non-autoimmune hypothyroidism in young patients with congenital heart defectsE Passeri
Endocrinology and Diabetology Unit, Dipartimento di Scienze Medico Chirurgiche, Universita degli Studi di Milano, Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico San Donato, 20097 San Donato Milanese, Italy
J Clin Endocrinol Metab 96:E1115-9. 2011..Newborns with congenital hypothyroidism (CH) have an increased risk for congenital heart defects (CHD) due to a common embryonic developmental program between thyroid gland and heart and great vessels... - Peripheral insulin-like factor 3 concentrations are reduced in men with type 2 diabetes mellitus: effect of glycemic control and visceral adiposity on Leydig cell functionF Ermetici
Endocrinology and Diabetology Unit, Department of Medical Surgical Sciences, Universita degli Studi di Milano, IRCCS Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Milano, Italy
Eur J Endocrinol 161:853-9. 2009..This study aimed to assess the Leydig cell function, including the new sensitive marker insulin-like factor 3 (INSL3), in T2DM patients without overt hypogonadism and the influence of either glycemic control or visceral adiposity... - Soluble adhesion molecules levels in patients with Cushing's syndrome before and after cureF Ermetici
Endocrinology Unit, Department of Medical and Surgical Sciences, IRCCS Policlinico San Donato, University of Milan, Milan, Italy
J Endocrinol Invest 31:389-92. 2008..This study aimed to evaluate sICAM-1 and sVCAM-1 levels in patients with CS before and after successful cure... - In vitro release of activin A from human normal and pathological thyroid tissuesP S Morpurgo
Institute of Endocrine Sciences, University of Milan, Italy
J Endocrinol Invest 24:RC25-7. 2001..We conclude that activin A is secreted by follicle thyroid cells in normal and pathological conditions...