Research Topics
| L CipollaSummaryAffiliation: University of Milano-Bicocca Country: Italy Publications
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Detail Information
Publications
New targets for antibacterial design: Kdo biosynthesis and LPS machinery transport to the cell surfaceL Cipolla
Department of Biotechnology and Biosciences, University of Milano Bicocca, Italy
Curr Med Chem 18:830-52. 2011..In addition, very recent advances in deciphering the molecular mechanisms of LPS transport to the cell surface, as a new target to develop novel antibacterials, will be reported. Future directions and perspectives will also be outlined...- Glycoconjugates in cancer therapyLaura Cipolla
Department of Biotechnology and Biosciences, University of Milano Bicocca, P za della Scienza 2, 20126 Milano, Italy
Anticancer Agents Med Chem 8:92-121. 2008..Different approaches including the use of clustered glycoconjugates such as multiple antigenic glycopeptides (MAG), and glyconanoparticles as potential anti-tumour therapeutics will be considered... - The Kdo biosynthetic pathway toward OM biogenesis as target in antibacterial drug design and developmentLaura Cipolla
Department of Biotechnology and Biosciences, University of Milano Bicocca, P za della Scienza 2, 20126 Milano, Italy
Curr Drug Discov Technol 6:19-33. 2009..Kdo is a monsaccharide essential for OM biogenesis, OM being an essential cellular structure shared by all Gram-negative bacteria. Hence, inhibitors of its biosynthesis can have a broad-spectrum antibacterial activity... - Pyrrolo[2,1-c][1,4]benzodiazepine as a scaffold for the design and synthesis of anti-tumour drugsLaura Cipolla
Dept of Biotechnology and Biosciences, University of Milano Bicocca, P zza della Scienza 2, 20126, Milano, Italy
Anticancer Agents Med Chem 9:1-31. 2009..This review will focus on design, synthesis and structure activity relationship studies of pyrrolobenzodiazepines as anticancer therapeutics reported since 2003... - Synthesis and biological evaluation of a small library of nojirimycin-derived bicyclic iminosugarsLaura Cipolla
Department of Biotechnology and Biosciences, University of Milano Bicocca, P za della Scienza 2, 20126 Milano, Italy
Carbohydr Res 342:1813-30. 2007.... - Straightforward synthesis of novel Akt inhibitors based on a glucose scaffoldLaura Cipolla
Department of Biotechnology and Biosciences, University of Milano Bicocca P za della Scienza 2, 20126 Milano, Italy
Carbohydr Res 345:1291-8. 2010..In addition, RNA interference experiments (siRNA) provide evidence of the ability of the compound to exert biological effects specifically through Akt signalling... - Combinatorial approaches to iminosugars as glycosidase and glycosyltransferase inhibitorsLaura Cipolla
Department of Biotechnology and Biosciences, University of Milano Bicocca, P za della Scienza 2, 20126 Milano, Italy
Comb Chem High Throughput Screen 9:571-82. 2006..This review will focus on synthetic efforts for the preparation of combinatorial libraries of glyco-enzyme inhibitors... - Carbohydrate-based bioactive compounds for medicinal chemistry applicationsL Cipolla
Department of Biotechnology and Biosciences, University of Milano Bicocca, P zza della Scienza 2, 20126 Milano, Italy
Mini Rev Med Chem 11:39-54. 2011..In this context, sugar mimetics and sugar-derived compounds have been employed as tools for exploring biology according to the "chemical genetic" approach... - Combinatorial libraries of biocatalysts: application and screeningLaura Cipolla
Department of Biotechnology and Biosciences, University of Milano Bicocca, P za della Scienza 2, I 20126 Milano, Italy
Comb Chem High Throughput Screen 7:101-14. 2004..Methods of screening and/or selection for the desired properties will also be described. Finally, the efforts in de novo enzyme design are mentioned... - Glycans in magnetic resonance imaging: determinants of relaxivity to smart agents, and potential applications in biomedicineLaura Cipolla
Department of Biotechnology and Biosciences, University of Milano Bicocca, P za della Scienza 2, 20126 Milano, Italy
Curr Med Chem 18:1002-18. 2011.... - Novel Tn antigen-containing neoglycopeptides: synthesis and evaluation as anti tumor vaccinesLaura Cipolla
Department of Biotechnology and Biosciences, Universita degli Studi di Milano Bicocca, P za della Scienza 2, 20126, Milan, Italy
Bioorg Med Chem 10:1639-46. 2002..Neoglycopeptides 1--3 could be presented to and recognized by the T cell receptor; neoglycopeptide 3, bearing two B-epitopes, was presented to the TCR with higher efficiency, compared to neoglycopeptide 2, having only one B-epitope... - Synthesis of a non-natural T-antigen containing glycosphingolipidL Cipolla
Department of Chemistry, Valby, Denmark
Carbohydr Lett 4:29-34. 2000..The product has potential as a cancer vaccine... - Synthesis and biological evaluation of an anticancer vaccine containing the C-glycoside analogue of the Tn epitopeF Peri
Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, I-20126 Milano, Italy
Bioconjug Chem 12:325-8. 2001..These observations constitute an important starting point for the use of this molecule as vaccine against the Tn-expressing TA3-Ha mouse mammary carcinoma... - A membrane-bound trehalase from Chironomus riparius larvae: purification and sensitivity to inhibitionMatilde Forcella
Department of Environmental Sciences, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
Glycobiology 20:1186-95. 2010..Results indicate substantial differences between midge trehalase and mammalian trehalase suggesting that, in principle, inhibitors against insect pests having trehalase as biochemical targets can be developed... - Targeting bacterial membranes: NMR spectroscopy characterization of substrate recognition and binding requirements of D-arabinose-5-phosphate isomeraseCristina Airoldi
Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, 20126, Milan, Italy
Chemistry 16:1897-902. 2010..Due to the essential role of API enzymes in LPS biosynthesis and gram-negative bacteria survival, by exploiting these data, a new generation of potent antibacterial drugs could be developed... - Carbohydrate mimetics and scaffolds: sweet spots in medicinal chemistryLaura Cipolla
Department of Biotechnology and Biosciences, University of Milano Biococca, Piazza della Scienza 2, I 20126 Milano, Italy
Future Med Chem 2:587-99. 2010..This mini-review will present examples of how to exploit carbohydrates mimics and scaffolds in drug research... - Molecular dynamics investigation of cyclic natriuretic peptides: dynamic properties reflect peptide activityElena Papaleo
Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
J Mol Graph Model 28:834-41. 2010.... - Carbohydrate scaffolds in chemical genetic studiesFrancesco Nicotra
Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza, 2, 20126 Milano, Italy
J Biotechnol 144:234-41. 2009..An example of solid phase combinatorial synthesis of a library of 37 compounds is reported... - Synthesis and biological activity of Akt/PI3K inhibitorsC Redaelli
Department of Biotechnology and Biosciences, University of Milano Bicocca, I 20126 Milano, Italy
Mini Rev Med Chem 6:1127-36. 2006..The development of kinase inhibitors, with particular attention to small molecule analogues of natural phosphoinositides for pathway interruption and therapeutic applications will be reviewed... - General methods for iminosugar synthesisLaura Cipolla
Department of Biotechnology and Biosciences, University of Milano-Bicocca, Italy
Curr Top Med Chem 3:485-511. 2003..Finally the synthesis of glycoconjugate-related iminosugars, where the "pseudoanomeric" centre is linked to amino acid or peptide residues, and iminosugar phosphonates and nucleosides have been reviewed... - C-type natriuretic peptide: Structural studies, fragment synthesis, and preliminary biological evaluation in human osteosarcoma cell linesNasrin Shaikh
Department of Biotechnology and Biosciences, University of Milano Bicocca, P za della Scienza 2 20126 Milano, Italy
Biopolymers 94:213-9. 2010.... - Chemoselective neoglycosylationFrancesco Nicotra
Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, Milan, Italy
Adv Carbohydr Chem Biochem 61:353-98. 2007 - Role of the N terminus in enzyme activity, stability and specificity in thermophilic esterases belonging to the HSL familyLuigi Mandrich
Institute of Protein Biochemistry, CNR, Via P. Castellino 111, 80131 Napoli, Italy
J Mol Biol 345:501-12. 2005..This is the first report highlighting the importance of the "cap" domain in the HSL family, since the N terminus partly contributes to the building up of this structure... - Synthesis and conformational analysis of fructose-derived scaffolds: molecular diversity from a single moleculeLaura Cipolla
Dipartmento di Biotecnologie e Bioscienze, , Italy
Chemistry 8:3976-83. 2002..Conformational analysis of compounds 10, 11, 17, and 20 by NMR experiments assisted by molecular mechanics, allowed the determination of the distances between the relevant functional groups, that is the azido and carboxy functionalities...