Research Topics
Species | M ChilosiSummaryAffiliation: University of Verona Country: Italy Publications
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Publications
The pathogenesis of COPD and IPF: distinct horns of the same devil?Marco Chilosi
Department of Pathology, University of Verona, Italy
Respir Res 13:3. 2012....
High resolution CT and histological findings in idiopathic pleuroparenchymal fibroelastosis: features and differential diagnosisSara Piciucchi
Department of Radiology, Scientific Institute for study and treatment of Cancer IRST Via Piero Maroncelli 40 42 47014 Meldola Forlì Italy
Respir Res 12:111. 2011..The aim of this report is to describe two further cases of this rare disease, reviewing CT, clinical and histological features...
Constitutive expression of DeltaN-p63alpha isoform in human thymus and thymic epithelial tumoursMarco Chilosi
Department of Pathology, University of Verona, Policlinico G B Rossi, 37134 Verona, Italy
Virchows Arch 443:175-83. 2003..Among lymphomas, T-cell-precursor lymphomas did not express p63, whereas most PMLBCL expressed TA-p63alpha (7/8)...
Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosisMarco Chilosi
Department of Pathology, University of Verona, Verona, Italy
Am J Pathol 162:1495-502. 2003....
[New diagnostic markers for mesothelioma]M Chilosi
Anatomia Patologica, Dipartimento di Patologia,
Pathologica 99:452. 2007
Mixed adenocarcinomas of the lung: place in new proposals in classification, mandatory for target therapyMarco Chilosi
Department of Pathology, University of Verona, Italy
Arch Pathol Lab Med 134:55-65. 2010..In this evolving scenario, pathologists face new challenging diagnostic roles that include not only the precise morphologic definition of carcinoma subtypes but also their molecular characterization...
Cathepsin-k expression in pulmonary lymphangioleiomyomatosisMarco Chilosi
Department of Pathology, University of Verona, Verona, Italy
Mod Pathol 22:161-6. 2009..It is possible to speculate that mTOR inhibitors may exert part of their action by limiting the destructive remodelling of lung structure...
Migratory marker expression in fibroblast foci of idiopathic pulmonary fibrosisMarco Chilosi
Department of Pathology, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
Respir Res 7:95. 2006..This important morphogenetic pathway is able to trigger epithelial-mesenchymal-transition (EMT), a mechanism involved in developmental and metastatic processes, which is also potentially involved in pulmonary fibrosis...
Epithelial stem cell exhaustion in the pathogenesis of idiopathic pulmonary fibrosisM Chilosi
Department of Pathology, University of Verona, Policlinico G B Rossi, 37134 Verona, Italy
Sarcoidosis Vasc Diffuse Lung Dis 27:7-18. 2010..g. Wnt/ -catenin, TGF-beta, caveolin-1, etc.) potentially involved in epithelial-mesenchymal transition and irreversible lung remodelling...
The pathologist's role in the diagnosis of idiopathic pulmonary fibrosisM Chilosi
Department of Pathology, University of Verona, Italy
Pathologica 102:443-52. 2010..New data regarding the complex pathogenesis of IPF is helping to understand the severe lung remodeling that characterizes this disease, and may also provide new diagnostic criteria...
Lymphoproliferative lung disordersMarco Chilosi
Department of Pathology, University of Verona, Italy
Semin Respir Crit Care Med 26:490-501. 2005..Radiological features include pulmonary consolidation, solid pulmonary opacities, hilar adenopathy, or pleural effusion. Principles of treatment vary with the different histology...
Fluorescent cytogenetics of renal cell neoplasmsM Brunelli
Department of Pathology, University of Verona, Italy
Pathologica 100:454-60. 2008....
Primary mediastinal B-cell lymphoma: hypermutation of the BCL6 gene targets motifs different from those in diffuse large B-cell and follicular lymphomasGiorgio Malpeli
Dipartimento di Patologia, Sezione di Anatomia Patologica Università di Verona, Strada Le Grazie I 37134 Verona, Italy
Haematologica 89:1091-9. 2004..Thus, analysis of BCL6 may aid in clarifying the relationship between primary mediastinal B-cell lymphoma (PMBL) and other non-thymic diffuse large cell lymphomas (DLCL)...
Constitutive p63 expression in airway basal cells. A molecular target in diffuse lung diseasesM Chilosi
Department of Pathology, University of Verona, Italy
Sarcoidosis Vasc Diffuse Lung Dis 18:23-6. 2001..This finding underlines the key role of p63 in epithelial renewal in human lung, with important implications in the understanding of the mechanisms of tissue remodelling occurring in diffuse lung diseases...
CDX-2 homeobox gene expression is a reliable marker of colorectal adenocarcinoma metastases to the lungsM Barbareschi
Department of Pathology, Santa Chiara Hospital, Trento, Italy
Am J Surg Pathol 27:141-9. 2003....
Linker for activation of T cells (LAT), a novel immunohistochemical marker for T cells, NK cells, mast cells, and megakaryocytes: evaluation in normal and pathological conditionsF Facchetti
Department of Pathology, University of Brescia, Brescia, Italy
Am J Pathol 154:1037-46. 1999..These data indicate that the anti-LAT antibody may be of value to diagnostic histopathologists for the identification of T cell neoplasms...
Cathepsin-K immunoreactivity distinguishes MiTF/TFE family renal translocation carcinomas from other renal carcinomasG Martignoni
Anatomia Patologica, Universita di Verona, Verona, Italy
Mod Pathol 22:1016-22. 2009..3) These results further support the concept that the overexpression of TFE3 or TFEB in these neoplasms activates the expression of genes normally regulated by microphthalmia transcription factor in other cell types...
Cathepsin-k as a diagnostic marker in the identification of micro-granulomas in Crohn's diseaseF Pedica
Anatomic Pathology, Department of Pathology, University of Verona, Italy
Pathologica 101:109-11. 2009..Based on these results, Cathepsin-k appears to be a reliable tool for the precise and rapid identification of small epithelioid granulomas in Crohn's disease...
Blastic OKT6-positive proliferation preceding malignant histiocytosisF Bonetti
Istituto di Anatomia Patologica, , Italy
Histol Histopathol 1:391-7. 1986..The relevance of this observation in the debate on the origin of Langerhans cells and the relationships existing between macrophages and dendritic cells is discussed...
Molecular characterization of composite mantle cell and follicular lymphomaAlberto Zamo
Department of Pathology, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy
Virchows Arch 448:639-43. 2006..The light chain approach, and particularly the kappa and kappa/Kde recombination detection, proved very useful for solving the clonality issue...
Establishment of the MAVER-1 cell line, a model for leukemic and aggressive mantle cell lymphomaAlberto Zamo
Department of Pathology, University of Verona, Verona, Italy
Haematologica 91:40-7. 2006..Mantle cell lymphoma (MCL) cell lines are difficult to generate; only nine lines have been described so far and few of them have been thoroughly characterized...
Abnormal re-epithelialization and lung remodeling in idiopathic pulmonary fibrosis: the role of deltaN-p63Marco Chilosi
Department of Pathology, University of Verona, Verona, Italy
Lab Invest 82:1335-45. 2002....
Most cases of primary salivary mucosa-associated lymphoid tissue lymphoma are associated either with Sjoegren syndrome or hepatitis C virus infectionAchille Ambrosetti
Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
Br J Haematol 126:43-9. 2004..The close association of SGML with either autoimmune diseases or HCV infection in our series (73%) confirms their possible role in the pathogenesis of these lymphomas...
CD138/syndecan-1: a useful immunohistochemical marker of normal and neoplastic plasma cells on routine trephine bone marrow biopsiesM Chilosi
Department of Pathology, University of Verona, Italy
Mod Pathol 12:1101-6. 1999..In addition, because of its clear-cut cell membrane localization, CD138 can be used successfully in double-marker immunostaining reactions to evaluate precisely nuclear prognostic markers such as Ki67 and p53 in MMs...
ZAP-70 expression, as detected by immunohistochemistry on bone marrow biopsies from early-phase CLL patients, is a strong adverse prognostic factorR Zanotti
Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
Leukemia 21:102-9. 2007..In conclusion, immunohistological detection of ZAP-70 on formalin-fixed BM biopsies at diagnosis appears a useful methodological approach to identify patients with poor prognosis in CLL...
Role of molecular markers in diagnosis and prognosis of renal cell carcinomaGuido Martignoni
Department of Pathology, University of Verona, Verona, Italy
Anal Quant Cytol Histol 29:41-9. 2007..A wide variety of molecular markers have been examined, but further research is required to prove their value as prognostic tools...
MEN1 in pancreatic endocrine tumors: analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of casesVincenzo Corbo
ARC NET Research Center Department of Pathology, University of Verona, Policlinico G B Rossi c o Piastra Odontoiatrica, Piazzale L A Scuro 10, Verona, Italy
Endocr Relat Cancer 17:771-83. 2010....
Diagnostic utility of S100A1 expression in renal cell neoplasms: an immunohistochemical and quantitative RT-PCR studyPaolo Cossu Rocca
Department of Pathology, University of Sassari, Sassari, Italy
Mod Pathol 20:722-8. 2007..Further, S100A1 protein expression is constantly detected in the normal parenchyma of the adult and fetal kidney...
Signal transduction pathways of mantle cell lymphoma: a phosphoproteome-based studyDaniela Cecconi
Laboratorio di Proteomica, Dipartimento Scientifico e Tecnologico, University of Verona, Verona, Italy
Proteomics 8:4495-506. 2008..A second-level analysis identified MAPK1, CK2, CK1, PKCzeta, and PKCepsilon as candidate upstream molecules. Our study provides new insights in MCL pathogenesis and helps to form the basis for testing new target-specific therapeutics...
Expression pattern of claudins 5 and 7 distinguishes solid-pseudopapillary from pancreatoblastoma, acinar cell and endocrine tumors of the pancreasFabrizio Comper
Dipartimento di Patologia, Universita e Azienda Ospedaliera di Verona, Verona, Italy
Am J Surg Pathol 33:768-74. 2009..SPT shows a peculiar claudin expression profile and the highly specific pattern of claudins 5 and 7 differentiates SPT from PET, ACC, and PB...
Utility of racemase and other immunomarkers in the detection of adenocarcinoma in prostatic tissue damaged by high intensity focused ultrasound therapyDaniela Dalfior
Department of Pathology, Universita di Verona, Italy
Pathology 42:1-5. 2010....
Two-dimensional molecular profiling of mantle cell lymphomaFrancesca Antonucci
Department of Agricultural and Industrial Biotechnologies, University of Verona, Italy
Electrophoresis 24:2376-85. 2003..Western blot and immunohistochemical analyses were applied to obtain further information about stathmin (Op18) and TCL1, respectively...
Induction of apoptosis in Jeko-1 mantle cell lymphoma cell line by resveratrol: a proteomic analysisDaniela Cecconi
Dipartimento Scientifico e Tecnologico, Laboratorio di Proteomica, University of Verona, Verona, Italy
J Proteome Res 7:2670-80. 2008..These findings may improve the understanding of mechanisms mediating the pro-apoptotic effects of resveratrol on MCL cells, and form the basis for its potential use as a therapeutic agent...
HER-2/neu assessment in breast cancer using the original FDA and new ASCO/CAP guideline recommendations: impact on selecting patients for herceptin therapyMatteo Brunelli
Department of Pathology, Universita di Verona, Verona, Italy
Am J Clin Pathol 129:907-11. 2008..The ASCO/CAP scheme has a great concordance coefficient between strong 3+ immunohistochemical cases and cases with high-grade, granular HER-2/neu amplification...
Molecular pathology of lymphangioleiomyomatosis and other perivascular epithelioid cell tumorsGuido Martignoni
Department of Pathology, Universita di Verona, Italy
Arch Pathol Lab Med 134:33-40. 2010..3) genes with the regulation of the Rheb/m-TOR/p70S6K pathway. These data have opened a new era in the comprehension of the pathogenesis of LAM and have also suggested new therapeutic strategies for this potentially lethal disease...
Her-2/neu evaluation in Sister Mary Joseph's nodule from breast carcinoma: a case report and review of the literatureMatteo Brunelli
Department of Pathology, University of Verona, Verona, Italy
J Cutan Pathol 36:702-5. 2009....
Microfluidic deletion/insertion analysis for rapid screening of KIT and PDGFRA mutations in CD117-positive gastrointestinal stromal tumors: diagnostic applications and report of a new KIT mutationAlberto Zamo
Department of Pathology, University of Verona, Verona, Italy
J Mol Diagn 9:151-7. 2007....
Chromosomal gains in the sarcomatoid transformation of chromophobe renal cell carcinomaMatteo Brunelli
Anatomia Patologica, Dipartimento di Patologia, Universita di Verona, Verona, Italy
Mod Pathol 20:303-9. 2007....
CD10 is expressed in a subset of chromophobe renal cell carcinomasGuido Martignoni
Anatomia Patologica, Universita di Sassari, Sassari, Italy
Mod Pathol 17:1455-63. 2004..04). Parvalbumin was strongly expressed in all primary and metastatic chromophobe renal cell carcinomas. Western blot analysis was utilized to confirm the expression of both CD10 and parvalbumin in chromophobe renal cell carcinomas...
ZAP-70 expression is associated with increased risk of autoimmune cytopenias in CLL patientsRoberta Zanotti
Department of Medicine, University of Verona, Italy
Am J Hematol 85:494-8. 2010..75; 95% CI: 1.06-2.86). The high risk of developing AIC in ZAP-70 positive CLL, particularly when IGHV unmutated, should be considered in the clinical management...
Genotypic intratumoral heterogeneity in breast carcinoma with HER2/neu amplification: evaluation according to ASCO/CAP criteriaMatteo Brunelli
Anatomic Pathology, Department of Pathology, University of Verona, Verona, Italy
Am J Clin Pathol 131:678-82. 2009..The clinical relevance and impact on treatment outcome of intratumoral heterogeneity in breast cancer with low-grade HER2/neu amplification or chromosome 17 polysomy need further investigation...
Oncocytic papillary renal cell carcinoma: a clinicopathologic, immunohistochemical, ultrastructural, and interphase cytogenetic study of 12 casesOndrej Hes
Department of Special Diagnostics SPAU, University Hospital Plzen, Czech Republic
Ann Diagn Pathol 10:133-9. 2006..One patient died of metastases. Interphase cytogenetic analysis by fluorescent in situ hybridization can be a diagnostic tool in cases mimicking an oncocytoma...
Bronchoalveolar lavage in malignancyVenerino Poletti
Department of Thoracic Diseases, Ospedale GB Morgagni, Forli, Italy
Semin Respir Crit Care Med 28:534-45. 2007....
Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell deathAlberto Zamo
Department of Pathology and Kaplan Comprehensive Cancer Center, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
Oncogene 21:1038-47. 2002..These studies support a pathogenic mechanism whereby stimulation of anti-apoptotic signals through activation of Stat3 contributes to the successful outgrowth of ALK positive tumor cells...
BAX expression in Hodgkin and Reed-Sternberg cells of Hodgkin's disease: correlation with clinical outcomeGeorge Z Rassidakis
Department of Lymphoma Myeloma, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Clin Cancer Res 8:488-93. 2002..Therefore, we correlated BAX expression with presenting features and clinical outcome in untreated patients with HD...
Transcriptionally targeted retroviral vector for combined suicide and immunomodulating gene therapy of thyroid cancerLuisa Barzon
Department of Histology, Microbiology, and Medical Biotechnologies, University of Padua, Via Gabelli 63, I-35121 Padua, Italy
J Clin Endocrinol Metab 87:5304-11. 2002..Thus, the combined thyroid-specific expression of two therapeutic genes (cytokine and suicide genes), although a safe tumor-targeted treatment, would allow an increased anticancer effect...
BCL-2 expression in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease predicts a poorer prognosis in patients treated with ABVD or equivalent regimensGeorge Z Rassidakis
Department of Lymphoma Myeloma, University of Texas M D Anderson Cancer Center, Houston 77030, USA
Blood 100:3935-41. 2002..We conclude that BCL-2 is frequently expressed by HRS cells in cHD and is associated with inferior FFS in patients treated with ABVD or equivalent regimens...
Chronic B cell malignancies and bone marrow microenvironmentPaolo Ghia
Department of Biomedical Sciences and Human Oncology, University of Torino, Italy
Semin Cancer Biol 12:149-55. 2002..In contrast, MM takes advantage of the actual BM microenvironment by 'instructing' it through an abnormal activation state...
CD20 expression in Hodgkin and Reed-Sternberg cells of classical Hodgkin's disease: associations with presenting features and clinical outcomeGeorge Z Rassidakis
Department of Lymphoma-Myeloma, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
J Clin Oncol 20:1278-87. 2002..CONCLUSION: CD20 is expressed by HRS cells in 22% of patients with classical HD but is not associated with different FFS after treatment with equivalent regimens...
Proteomics and immunomapping of reactive lymph-node and lymphomaFrancesca Antonucci
Department of Agricultural and Industrial Biotechnologies, University of Verona, Italy
Electrophoresis 23:356-62. 2002..Accordingly, we could detect a much increased level of expression of CD5 in mantle cell lymphoma, up to ten times higher than in the control. In addition, CD5 in tumor tissues seems to be microheterogeneous as compared to normal samples...
Idiopathic bronchiolitis mimicking diffuse panbronchiolitisVenerino Poletti
Dipartimento di Malattie dell Apparato Respiratorio e del Torace, Ospedale G B Morgagni, Forli, Italy
Sarcoidosis Vasc Diffuse Lung Dis 20:62-8. 2003..We suggest that diseases classified as IB in this study might be homogeneous entities which are clinically and radiologically similar to DPB...
S-phase kinase-associated protein 2 expression in non-Hodgkin's lymphoma inversely correlates with p27 expression and defines cells in S phaseRoberto Chiarle
Department of Pathology and Kaplan Comprehensive CancerCenter, New York University School of Medicine, New York, New York
Am J Pathol 160:1457-66. 2002..The detection of Skp2 protein either by flow cytometry or by immunohistochemistry represents a simple method to precisely assess the S phase of lymphomas. The potential diagnostic and prognostic value of Skp2 is discussed...
Role of dendritic cell-derived CXCL13 in the pathogenesis of Bartonella henselae B-rich granulomaWilliam Vermi
Department of Pathology and the Section of General Pathology and Immunology, University of Brescia, Italy
Blood 107:454-62. 2006..These findings suggest that the humoral immune response to B henselae initiates in the extrafollicular areas of infected lymph nodes and is regulated by DCs...
The crazy-paving pattern in granulomatous mycosis fungoides: high-resolution computed tomography-pathological correlationNicola Sverzellati
Department of Clinical Sciences, Section of Radiology, University of Parma, Italy
J Comput Assist Tomogr 30:843-5. 2006..It was possible to reconcile the crazy-paving appearance on thin-section computed tomography scan with the histopathologic pattern termed acute fibrinous organizing pneumonia pattern...
CDX-2 homeobox gene product expression in neuroendocrine tumors: its role as a marker of intestinal neuroendocrine tumorsMattia Barbareschi
Department of Histopathology, S. Chiara Hospital, Trento, Italy
Am J Surg Pathol 28:1169-76. 2004..Conversely, a limited diagnostic role is suggested for CDX-2 in NEC because of its frequent expression in nongastrointestinal tumors...
The impact of P53 and P21(waf1) expression on the survival of patients with the germinal center phenotype of diffuse large B-cell lymphomaCarlo Visco
Department of Hematology, Ospedale S Bortolo, Vicenza, Italy
Haematologica 91:687-90. 2006..Our results show that immunohistochemistry can parallel gene expression profiling in addressing clinical variability of DLBCL patients...
Pathological assessment of pericolonic tumor deposits in advanced colonic carcinoma: relevance to prognosis and tumor stagingGiacomo Puppa
Division of Pathology, CRO National Cancer Institute, Aviano, Italy
Mod Pathol 20:843-55. 2007..Our findings suggest that pericolonic tumor deposits are a destructive type of venous invasion different from other types of vessel involvement, and that these lesions may rather be included in the M category for staging purposes...
An international collaborative pathologic study of surgical lung biopsies from mustard gas-exposed patientsMostafa Ghanei
Research Center of Chemical Injuries, Baqiyatallah Medical Science University, Mollasadra Street, PO Box 19945 546, Tehran, Iran
Respir Med 102:825-30. 2008..This study is the first to examine the histopathologic spectrum of changes in a large number of surgical lung biopsies from patients exposed to SM...
[Molecular morphology and histopathological diagnosis: prospects and problems]Marco Chilosi
Pathologica 95:419-21. 2003
Diagnostic invasive procedures in diffuse infiltrative lung diseasesVenerino Poletti
Dipartimento di Malattie dell Apparato Respiratorio e del Torace, Ospedale GB Morgagni, Forli, Italia
Respiration 71:107-19. 2004..In this article invasive diagnostic procedures in patients with diffuse lung infiltrates are discussed from the perspective of their clinical context and their imaging characteristics...
In situ study of chemokine and chemokine-receptor expression in Kaposi sarcomaStefania Uccini
Department of Experimental Medicine and Pathology, University La Sapienza, Roma
Am J Dermatopathol 25:377-83. 2003..The demonstration of chemokine receptors in KS cells raises the possibility that recruitment of KS cells in response to locally produced chemotactic stimuli may be one of the events involved in the pathogenesis of Kaposi sarcoma...
Multivariate statistical tools applied to the characterization of the proteomic profiles of two human lymphoma cell lines by two-dimensional gel electrophoresisEmilio Marengo
Department of Environmental and Life Sciences, University of Eastern Piedmont, Alessandria, Italy
Electrophoresis 27:484-94. 2006..It is thus suggested that, in future work in differential proteomic profiling, both univariate and multivariate statistical tools should be adopted...
