Research Topics
| M CariniSummaryAffiliation: University of Milan Country: Italy Publications
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Publications
In vitro metabolism of a nitroderivative of acetylsalicylic acid (NCX4016) by rat liver: LC and LC-MS studiesMarina Carini
Istituto Chimico Farmaceutico Tossicologico, Viale Abruzzi 42, Milan, Italy
J Pharm Biomed Anal 29:1061-71. 2002..The relevance of this new metabolic pathway in NCX4016 detoxification by rat liver is discussed...- LC-ESI-MS/MS determination of 4-hydroxy-trans-2-nonenal Michael adducts with cysteine and histidine-containing peptides as early markers of oxidative stress in excitable tissuesMarica Orioli
Istituto Chimico Farmaceutico Tossicologico, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
J Chromatogr B Analyt Technol Biomed Life Sci 827:109-18. 2005.... - Mass spectrometric strategies and their applications for molecular mass determination of recombinant therapeutic proteinsMarina Carini
Department of Pharmaceutical Sciences Pietro Pratesi, Universita degli Studi di Milano, Via Mangiagalli 25, 20133, Milan, Italy
Curr Pharm Biotechnol 12:1548-57. 2011..The paper is a review of the most used and advanced MS strategies so far reported as well as of their applications in the biopharmaceutical field... - LC coupled to ion-trap MS for the rapid screening and detection of polyphenol antioxidants from Helichrysum stoechasM Carini
Istituto Chimico Farmaceutico Tossicologico, Milano, Italy
J Pharm Biomed Anal 24:517-26. 2001.... - Mass spectrometry for detection of 4-hydroxy-trans-2-nonenal (HNE) adducts with peptides and proteinsMarina Carini
Istituto Chimico Farmaceutico Tossicologico, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
Mass Spectrom Rev 23:281-305. 2004.... - Nitric oxide release and distribution following oral and intraperitoneal administration of nitroaspirin (NCX 4016) in the ratMarina Carini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
Life Sci 74:3291-305. 2004..This indicates that NCX 4016 does not undergo biotransformation in the upper part of gastrointestinal tract (no direct release of NO in this district) and that the stomach acts as a reservoir for the drug... - Chemiluminescence and LC-MS/MS analyses for the study of nitric oxide release and distribution following oral administration of nitroaspirin (NCX 4016) in healthy volunteersMarina Carini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
J Pharm Biomed Anal 35:277-87. 2004..0 +/- 0.6 h versus 5.4 +/- 1.2 h)... - Acrolein-sequestering ability of endogenous dipeptides: characterization of carnosine and homocarnosine/acrolein adducts by electrospray ionization tandem mass spectrometryMarina Carini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
J Mass Spectrom 38:996-1006. 2003.... - Antioxidant and photoprotective activity of a lipophilic extract containing neolignans from Krameria triandra rootsMarina Carini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Italy
Planta Med 68:193-7. 2002..The results of this study indicate the potential use of Rhatany extracts, standardized in neolignans, as topical antioxidants/radical scavengers against skin photodamage... - Procyanidins from Vitis vinifera seeds inhibit the respiratory burst of activated human neutrophils and lysosomal enzyme releaseM Carini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Italy
Planta Med 67:714-7. 2001..These results evidence that procyanidins efficiently restrain the inflammatory response of activated neutrophils in vitro and whenever absorbed in vivo can prevent their oxidative discharge at the site(s) of their adhesion... - Nitrosylhemoglobin, an unequivocal index of nitric oxide release from nitroaspirin: in vitro and in vivo studies in the rat by ESR spectroscopyM Carini
Istituto Chimico Farmaceutico e Tossicologico, Universita degli Studi di Milano, Viale Abruzzi 42, 20131 Milan, Italy
J Pharm Biomed Anal 26:509-18. 2001..The results of this study emphasize the great potentiality of ESR spectroscopy for the study of the release, the metabolic fate and distribution of NO from nitrovasodilators... - Complexation of Ginkgo biloba extract with phosphatidylcholine improves cardioprotective activity and increases the plasma antioxidant capacity in the ratM Carini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Milan, Italy
Planta Med 67:326-30. 2001.... - Fluorescent probes as markers of oxidative stress in keratinocyte cell lines following UVB exposureM Carini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Italy
Farmaco 55:526-34. 2000..The use of these fluorescent probes provides a reliable tool to detect the early signs of damage in keratinocyte cultures (when the apoptotic phenomenon has not yet been triggered) useful for future screening of protective molecules... - UVB-induced hemolysis of rat erythrocytes: protective effect of procyanidins from grape seedsM Carini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Italy
Life Sci 67:1799-814. 2000.... - Sparing effect of procyanidins from Vitis vinifera on vitamin E: in vitro studiesR Maffei Facino
Istituto Chimico Farmaceutico Tossicologico, Milan, Italy
Planta Med 64:343-7. 1998.... - Diet enriched with procyanidins enhances antioxidant activity and reduces myocardial post-ischaemic damage in ratsR M Facino
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Italy
Life Sci 64:627-42. 1999.... - Hydroxynimesulide, the main metabolite of nimesulide, prevents hydroperoxide/hemoglobin-induced hemolysis of rat erythrocytesR Maffei Facino
Istituto Chimico Farmaceutico Tossicologico, Milan, Italy
Drugs Exp Clin Res 23:157-65. 1997.... - Panax ginseng administration in the rat prevents myocardial ischemia-reperfusion damage induced by hyperbaric oxygen: evidence for an antioxidant interventionR Maffei Facino
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Italy
Planta Med 65:614-9. 1999..05-0.5 mg/ml) to explain by itself the cardiac and extra-cardiac protective effects, and this suggests a role also for an indirect antioxidant action of the drug (endothelial nitric oxide synthase stimulation)... - Intravenous infusion of nitric oxide in experimental pulmonary hypertension: biotransformation and haemodynamicsF Pirrone
Department of Animal Pathology, Hygiene and Public Veterinary Health, University of Milan, Milan, Italy
Vet Res Commun 31:185-7. 2007 - Efficacy of glutathione for treatment of fascioliasis. An investigation in the experimentally infested ratR Maffei Facino
Istituto Chimico Farmaceutico Tossicologico, Universita di Milano, Italy
Arzneimittelforschung 43:455-60. 1993..abstract truncated at 250 words).. - Nitrosylhemoglobin as a potential bioactive storage form of nitric oxide (NO)F Pirrone
Department of Animal Pathology, Hygiene and Public Veterinary Healt, Section of Biochemistry and Physiology, Faculty of Veterinary Medicine, University of Milan, 20133, Milan, Italy
Vet Res Commun 29:199-202. 2005 - The use of a polymeric sealant for prevention of posttransplantation lymphoceleL Berardinelli
General Surgery and Kidney Transplantation Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
Transplant Proc 43:1072-3. 2011..although the preliminary results are interesting, a prospective randomized study is required to assess the cost-effectiveness of PEG sealant to prevent lymphocele formation... - Hepatitis B immune memory in children primed with hexavalent vaccines and given monovalent booster vaccines: an open-label, randomised, controlled, multicentre studyAlessandro Remo Zanetti
Department of Public Health Microbiology Virology, University of Milan, Milan, Italy
Lancet Infect Dis 10:755-61. 2010..In 2005, hexavac was suspended because of concerns about the long-term immunogenicity of its hepatitis B component. We aimed to assess the duration of immunity and need for booster injections in children primed with these vaccines... - Long-term outcome of living donors older than 60 yearsL Berardinelli
General Surgery and Kidney Transplantation Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
Transplant Proc 42:1111-3. 2010..Therefore, significantly better noncensored death-censored graft survivals, were observed among the recipients of older LD compared with recipients of the younger donor group... - A tandem MS precursor-ion scan approach to identify variable covalent modification of albumin Cys34: a new tool for studying vascular carbonylationGiancarlo Aldini
Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Faculty of Pharmacy, University of Milan, Via Mangiagalli 25, I 20133 Milan, Italy
J Mass Spectrom 43:1470-81. 2008.... - Intervention strategies to inhibit protein carbonylation by lipoxidation-derived reactive carbonylsGiancarlo Aldini
Institute of Pharmaceutical and Toxicological Chemistry, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, I 20131, Milan, Italy
Med Res Rev 27:817-68. 2007..Inhibition of ALE formation, based on carbonyl-sequestering agents, seems to be the most promising pharmacological tool and is reviewed in detail... - Alpha,beta-unsaturated aldehydes adducts to actin and albumin as potential biomarkers of carbonylation damageGiancarlo Aldini
Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Faculty of Pharmacy, University of Milan, Milan, Italy
Redox Rep 12:20-5. 2007.... - Actin Cys374 as a nucleophilic target of alpha,beta-unsaturated aldehydesIsabella Dalle-Donne
Department of Biology, University of Milan, Via Celoria 26, I 20133 Milan, Italy
Free Radic Biol Med 42:583-98. 2007.... - Identification of actin as a 15-deoxy-Delta12,14-prostaglandin J2 target in neuroblastoma cells: mass spectrometric, computational, and functional approaches to investigate the effect on cytoskeletal derangementGiancarlo Aldini
Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Faculty of Pharmacy, University of Milan, I 20131 Milan, Italy
Biochemistry 46:2707-18. 2007.... - Effects of UVB radiation on 4-hydroxy-2-trans-nonenal metabolism and toxicity in human keratinocytesGiancarlo Aldini
Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, I 20131 Milan, Italy
Chem Res Toxicol 20:416-23. 2007.... - A sensitive and specific precursor ion scanning approach in liquid chromatography/electrospray ionization tandem mass spectrometry to detect methylprednisolone acetate and its metabolites in rat urineAlessia Panusa
Dipartimento di Scienze Farmaceutiche Pietro Pratesi, Universita degli Studi di Milano, Via L Mangiagalli 25, 20133 Milan, Italy
Rapid Commun Mass Spectrom 24:1583-94. 2010..Six different metabolites were detected in rat urine, and their chemical structures were assigned with a computational study... - Albumin is the main nucleophilic target of human plasma: a protective role against pro-atherogenic electrophilic reactive carbonyl species?Giancarlo Aldini
Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Faculty of Pharmacy, University of Milan, I 20131, Milan, Italy
Chem Res Toxicol 21:824-35. 2008..81 +/- 0.17 M (-1) s (-1)), as explained by molecular modeling studies. In conclusion, we suggest that albumin, through nucleophilic residues, and in particular Cys34, can act as an endogenous detoxifying agent of circulating RCS... - Water-Soluble alpha,beta-unsaturated aldehydes of cigarette smoke induce carbonylation of human serum albuminGraziano Colombo
Dipartimento di Biologia, Universita degli Studi di Milano, Milan, Italy
Antioxid Redox Signal 12:349-64. 2010..Carbonylation of HSA associated with cigarette smoking might result in modifications of its antioxidant properties and transport functions of both endogenous and exogenous compounds... - Protein carbonylation: 2,4-dinitrophenylhydrazine reacts with both aldehydes/ketones and sulfenic acidsIsabella Dalle-Donne
Department of Biology, University of Milan, Italy
Free Radic Biol Med 46:1411-9. 2009..beta-Mercaptoethanol prevents the formation of the DNPH derivative because it reacts with the oxidized Cys residue, forming the corresponding disulfide... - Mass spectrometric characterization of covalent modification of human serum albumin by 4-hydroxy-trans-2-nonenalGiancarlo Aldini
Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, I 20131 Milan, Italy
J Mass Spectrom 41:1149-61. 2006..These albumin modifications are suitable tags of HNE-adducted albumin and could be useful biomarkers of oxidative and carbonylation damage in humans... - Electron spin resonance and chemiluminescence analyses to elucidate the vasodilating mechanism of sodium nitroprussideGiancarlo Aldini
Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
Mol Pharmacol 70:1672-80. 2006..In conclusion, SNP is rapidly metabolized to HbFe(II)NO, but the pharmacological response is mediated by a direct mechanism of NO release of the parent compound at the cellular target... - Detoxification of 4-hydroxynonenal (HNE) in keratinocytes: characterization of conjugated metabolites by liquid chromatography/electrospray ionization tandem mass spectrometryGiancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
J Mass Spectrom 38:1160-8. 2003..This is the first demonstration that skin epidermal cells are able to detoxify the cytotoxic products of lipid peroxidation... - Nitrosylhemoglobin formation after infusion of NO solutions: ESR studies in pigsGiancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, Milan 20131, Italy
Biochem Biophys Res Commun 318:405-14. 2004..Thus, in normoxic/physiological conditions, HbFe(II)NO does not induce significant NO-dependent vasorelaxation... - (-)-Epigallocatechin-3-gallate prevents oxidative damage in both the aqueous and lipid compartments of human plasmaGiancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Milan, Italy
Biochem Biophys Res Commun 302:409-14. 2003..Further, ESR experiments confirmed that EGCG recycled alpha-tocopherol through a H-transfer mechanism at the aqueous/lipid interface affording an additional protective mechanism to the lipid compartment of plasma... - Detoxification of cytotoxic alpha,beta-unsaturated aldehydes by carnosine: characterization of conjugated adducts by electrospray ionization tandem mass spectrometry and detection by liquid chromatography/mass spectrometry in rat skeletal muscleGiancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
J Mass Spectrom 37:1219-28. 2002..The results indicate that beside GSH, histidine-containing dipeptides could be involved in the detoxification pathway of reactive aldehydes from lipid peroxidation generated in skeletal muscle during physical endurance... - Profiling histidine-containing dipeptides in rat tissues by liquid chromatography/electrospray ionization tandem mass spectrometryGiancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
J Mass Spectrom 39:1417-28. 2004..HCAR was found only in the brain and cerebellum. No histidine-containing dipeptides were detectable in plasma, liver, kidney and lung... - Covalent modification of actin by 4-hydroxy-trans-2-nonenal (HNE): LC-ESI-MS/MS evidence for Cys374 Michael adductionGiancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Viale Abruzzi 42, I 20131 Milan, Italy
J Mass Spectrom 40:946-54. 2005..Computational studies showed that the reactivity of Cys374 residue is due to a significant accessible surface and substantial thiol acidity due to the particular microenvironment surrounding Cys374... - Lipoxidation-derived reactive carbonyl species as potential drug targets in preventing protein carbonylation and related cellular dysfunctionGiancarlo Aldini
Institute of Pharmaceutical and Toxicological Chemistry Pietro Pratesi, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, 20131, Milan, Italy
ChemMedChem 1:1045-58. 2006 - Carnosine is a quencher of 4-hydroxy-nonenal: through what mechanism of reaction?Giancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
Biochem Biophys Res Commun 298:699-706. 2002..The biological role of carnosine as a quencher of alpha,beta-unsaturated aldehydes was verified by detecting carnosine-HNE reaction adducts in oxidized rat skeletal muscle homogenate... - Carnosine and related dipeptides as quenchers of reactive carbonyl species: from structural studies to therapeutic perspectivesGiancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
Biofactors 24:77-87. 2005.... - Protein carbonylation, cellular dysfunction, and disease progressionIsabella Dalle-Donne
Department of Biology, University of Milan, Italy
J Cell Mol Med 10:389-406. 2006.... - Metabolic profile of NO-flurbiprofen (HCT1026) in rat brain and plasma: a LC-MS studyGiancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
Life Sci 71:1487-500. 2002..These data indicate that the NO molecule is not released from the parent drug within the brain... - Procyanidins from grape seeds protect endothelial cells from peroxynitrite damage and enhance endothelium-dependent relaxation in human artery: new evidences for cardio-protectionGiancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Viale Abruzzi 42 20131 Milan, Italy
Life Sci 73:2883-98. 2003.... - Preservation of endothelium nitric oxide release during beating heart surgery with respect to continuous flow cardiopulmonary bypassEttore Lanzarone
Laboratory of Biological Structures Mechanics, Department of Structural Engineering, Politecnico di Milano, Milan, Italy
Perfusion 25:57-64. 2010.... - HNE Michael adducts to histidine and histidine-containing peptides as biomarkers of lipid-derived carbonyl stress in urines: LC-MS/MS profiling in Zucker obese ratsMarica Orioli
Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Faculty of Pharmacy, University of Milan, Via Mangiagalli 25, I 20133 Milan, Italy
Anal Chem 79:9174-84. 2007.... - Design, synthesis, and evaluation of carnosine derivatives as selective and efficient sequestering agents of cytotoxic reactive carbonyl speciesGiulio Vistoli
Dipartimento di Scienze Farmaceutiche Pietro Pratesi, Facolta di Farmacia, Universita degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy
ChemMedChem 4:967-75. 2009..This study describes a set of aryl derivatives that are characterized by high stability in human plasma and a quenching activity toward 4-hydroxy-trans-2-nonenal (HNE), chosen as a model of RCS, up to threefold greater than D-carnosine... - Preservation of endothelium nitric oxide release by pulsatile flow cardiopulmonary bypass when compared with continuous flowEttore Lanzarone
Laboratory of Mechanical Biological Structures, Department of Structural Engineering, Politecnico di Milano, Milan, Italy
Artif Organs 33:926-34. 2009..The similar erythrocyte eNOS activity between the groups revealed that the differences in blood NO metabolites are mainly ascribable to the endothelium release... - Hemoglobin glutathionylation can occur through cysteine sulfenic acid intermediate: electrospray ionization LTQ-Orbitrap hybrid mass spectrometry studiesLuca Regazzoni
Dipartimento di Scienze Farmaceutiche Pietro Pratesi, Universita degli Studi di Milano, Milan, Italy
J Chromatogr B Analyt Technol Biomed Life Sci 877:3456-61. 2009..Hb glutathionylation is also mediated by a thiol-disulfide transfer mechanism, but this requires a concentration of GSSG which is far to be achieved in physiopathological conditions... - Edaravone inhibits protein carbonylation by a direct carbonyl-scavenging mechanism: focus on reactivity, selectivity, and reaction mechanismsGiancarlo Aldini
Dipartimento di Scienze Farmaceutiche Pietro Pratesi, Universita degli Studi di Milano, Milan, Italy
Antioxid Redox Signal 12:381-92. 2010..The same combined approach indicated that EDA is not a selective RCS scavenger, being able to react also with nontoxic, physiologically relevant aldehydes, such as pyridoxal... - Value of intraoperative resistive index in kidney transplantM Raiteri
U O Vascular Surgery and Kidney Transplantation, Ospedale Maggiore Policlinico Milan, Milan, Italy
Transplant Proc 37:2472-3. 2005..62 +/- 0.07 vs 0.76 +/- 0.04; P = .0004). We conclude that the value of RI in the early posttransplant phase should be considered an important aid for the early diagnosis of posttransplant complications... - LC-MS/MS and FT-IR analyses of stones from a patient with Crohn's disease: a case reportMarica Orioli
Istituto Chimico Farmaceutico Tossicologico, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
J Pharm Biomed Anal 35:1263-72. 2004..This indicates that accidental ingestion of a plastic material, followed by its calcification, was responsible for its formation... - A combined high-resolution mass spectrometric and in silico approach for the characterisation of small ligands of beta2-microglobulinLuca Regazzoni
Dipartimento di Scienze Farmaceutiche Pietro Pratesi, Universita degli Studi di Milano, Via Mangiagalli 25, Milan, Italy
ChemMedChem 5:1015-25. 2010..Overall, this approach can be used for predictive purposes and for a rapid screening of fibrillogenesis inhibitors... - S-nitrosation versus S-glutathionylation of protein sulfhydryl groups by S-nitrosoglutathioneDaniela Giustarini
Department of Neuroscience, Pharmacology Unit, University of Siena, Siena, Italy
Antioxid Redox Signal 7:930-9. 2005..The susceptibility of the modified proteins to denitrosation and deglutathionylation by reduced glutathione was also investigated... - Effect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokersGiovanni B Vigna
Department of Clinical and Experimental Medicine, Section of Internal Medicine II, University of Ferrara, Ferrara, Italy
Metabolism 52:1250-7. 2003..The antioxidant potential of grape seed extract polyphenols may prove effective in a model of oxidative stress (smoking); however more investigational data are needed before use in wider clinical settings...