Research Topics
| Gaetano CaramoriSummaryAffiliation: University of Ferrara Country: Italy Publications
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Detail Information
Publications
[Role of stem cells in the pathogenesis of chronic obstructive pulmonary disease and of pulmonary emphysema]Gaetano Caramori
Dipartimento di Medicina, Universita di Ferrara, Italy
Recenti Prog Med 103:31-40. 2012..Moreover, the potential side effects of the stem cell therapy are often underestimated. We should not ignore that some of the most deadly neoplasms are arising from stem cells...- New drugs targeting Th2 lymphocytes in asthmaGaetano Caramori
Dipartimento di Medicina Clinica e Sperimentale, Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Ferrara, Italy
J Occup Med Toxicol 3:S6. 2008..Some of these new Th2-oriented strategies may in the future not only control symptoms and modify the natural course of asthma, but also potentially prevent or cure the disease... - Clinical definition of COPD exacerbations and classification of their severityGaetano Caramori
Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Ferrara, Italy
South Med J 102:277-82. 2009..There is a need for greater investment in research on COPD exacerbations in order to promote a better understanding of COPD exacerbations... - [Treatment of bronchial asthma in adults. Current advances]Gaetano Caramori
Dipartimento di Medicina Clinica e Sperimentale, Centro di Ricerca su Asma e BPCO, Universita, Ferrara
Recenti Prog Med 100:171-9. 2009..Considering its efficacy and safety the current pharmacological treatment of asthma will probably remain unchanged for the next 10 years... - MUC5AC expression is increased in bronchial submucosal glands of stable COPD patientsGaetano Caramori
Centro di Ricerca su Asma e BPCO, University of Ferrara, Via Savonarola 9, Ferrara 44121, Italy
Histopathology 55:321-31. 2009..The aim was to investigate gland size and MUC5AC and MUC5B expression in bronchial rings from smokers with COPD compared with control groups... - Immune response to Mycobacterium tuberculosis infection in the parietal pleura of patients with tuberculous pleurisyGaetano Caramori
Section of Respiratory Diseases, University of Ferrara, Ferrara, Italy
PLoS ONE 6:e22637. 2011..Elevated CD3, CD4, CCR4 and Th17 cells and decreased mast cells and GATA-3+ cells in the parietal pleura distinguish patients with untreated tuberculous pleurisy from those with nonspecific pleuritis... - Mechanisms involved in lung cancer development in COPDGaetano Caramori
Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Ferrara, Italy
Int J Biochem Cell Biol 43:1030-44. 2011.... - Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancerGaetano Caramori
Centro di Ricerca su Asma e BPCO, University of Ferrara, Via Savonarola, 9, Ferrara 44100, Italy
Thorax 66:521-7. 2011..Chronic obstructive pulmonary disease (COPD) is characterised by oxidative stress and increased risk of lung carcinoma. Oxidative stress causes DNA damage which can be repaired by DNA-dependent protein kinase complex... - COPD pathology in the small airwaysG Caramori
Asthma and COPD Research Center, University of Ferrara, Ferrara, Italy
Panminerva Med 53:51-70. 2011..This review summarizes and discusses the pathology of small airways of stable COPD patients, of different severity, compared with control smokers with normal lung function... - Rescue treatment in asthma. More than as-needed bronchodilationAlberto Papi
Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Via Savonarola 9, 44100 Ferrara, Italy
Chest 135:1628-33. 2009..In the future it might even be possible to control asthma entirely with PRN combination inhalers without maintenance therapy, at least in patients with less severe disease... - A role for phosphoinositol 3-kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary diseaseJohn A Marwick
Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Ferrara, Italy
J Allergy Clin Immunol 125:1146-53. 2010..This reduction in glucocorticoid sensitivity might be due to an oxidant-mediated increase in phosphoinositol 3-kinase (PI3K) delta signaling... - Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and futureKian Fan Chung
Airway Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW36LY, UK
Eur J Clin Pharmacol 65:853-71. 2009..Other agents that could improve the efficacy of corticosteroids or reverse corticosteroid insensitivity may be added to ICS. ICS in combination with LABAs will continue to remain the main focus of treatment of airways diseases... - Fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease: 5-year follow-upMarco Contoli
Research Centre on Asthma and COPD, Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy
J Allergy Clin Immunol 125:830-7. 2010..Both smokers and patients with asthma can experience fixed airflow obstruction, which is associated with distinctive patterns of airway pathology. The influence of fixed airflow obstruction on the prognosis of these patients is unknown... - A human rhinovirus model of chronic obstructive pulmonary disease exacerbationsMarco Contoli
Department of Clinical and Experimental Medicine, Research Center on Asthma and COPD, University of Ferrara, Ferrara, Italy
Contrib Microbiol 14:101-12. 2007..In this chapter we will focus on the role of viral infections in COPD exacerbations and will discuss preliminary reports regarding the development of this human model of virus-induced COPD exacerbation... - Molecular mechanisms of respiratory virus-induced asthma and COPD exacerbations and pneumoniaGaetano Caramori
Centro di Ricerca su Asma e BPCO, University of Ferrara, Italy
Curr Med Chem 13:2267-90. 2006..Clearly this is an exciting new area of ongoing research with promising therapeutic potential... - Models of infection and exacerbations in COPDAlberto Papi
Department of Clinical and Experimental Medicine, Research Centre on Asthma and COPD, University of Ferrara, Ferrara, Italy
Curr Opin Pharmacol 7:259-65. 2007..The model will give us the opportunity to highlight key inflammatory mediators representing possible therapeutic targets for the development of novel drugs able to treat and prevent acute episodes in COPD... - Oxidative/nitrosative stress selectively altered A(2B) adenosine receptors in chronic obstructive pulmonary diseaseKatia Varani
Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Ferrara, Via Fossato di Mortara 17 19, 44100 Ferrara, Italy
FASEB J 24:1192-204. 2010..Triggiani, M., Hansel, T., Leung, E., MacLennan, S., Barnes, P. J., Fan Chung, K., Adcock, I., Papi, A., Borea, P. A. Oxidative/nitrosative stress selectively altered A(2B) adenosine receptors in chronic obstructive pulmonary disease... - Targeting Th2 cells in asthmatic airwaysGaetano Caramori
Dipartimento di Medicina Clinica e Sperimentale, Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Italy
Curr Drug Targets Inflamm Allergy 3:243-55. 2004..Some of these new Th2-oriented strategies may in the future not only control symptoms, but also potentially prevent or cure the disease... - Pathophysiology of viral-induced exacerbations of COPDAlfredo Potena
Unita Operativa di Fisiopatologia Respiratoria, Azienda Ospedaliera Universitaria Arcispedale S Anna, Ferrara, Italy
Int J Chron Obstruct Pulmon Dis 2:477-83. 2007..In this review we will focus our attention on the relationship between common respiratory viral infections and the molecular and inflammatory mechanisms that lead to COPD exacerbation... - Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammationNathan W Bartlett
Department of Respiratory Medicine, UK National Heart and Lung Institute, and Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, Norfolk Place, London W2 1PG, UK
Nat Med 14:199-204. 2008..These models have features similar to those observed in rhinovirus infection in humans, including augmentation of allergic airway inflammation, and will be useful in the development of future therapies for colds and asthma exacerbations... - New targets for drug development in asthmaIan M Adcock
Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
Lancet 372:1073-87. 2008..Although a cure is unlikely to be developed in the near future, a greater understanding of disease mechanisms could bring such a situation nearer to reality... - Chemokine receptor inhibitors as a novel option in treatment of asthmaIan M Adcock
Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College London, UK
Curr Drug Targets Inflamm Allergy 3:257-61. 2004..Furthermore, it is possible that early treatment with these agents may prevent the disease from becoming established... - Expression and activity of histone deacetylases in human asthmatic airwaysKazuhiro Ito
Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London, SW3 6LY UK
Am J Respir Crit Care Med 166:392-6. 2002..The increase in HAT activity and reduced HDAC activity in asthma may underlie the increased expression of multiple inflammatory genes, and this is reversed, at least in part, by treatment with inhaled steroids... - Decreased histone deacetylase activity in chronic obstructive pulmonary diseaseKazuhiro Ito
Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom
N Engl J Med 352:1967-76. 2005..CONCLUSIONS: Patients with COPD have a progressive reduction in total HDAC activity that reflects the severity of the disease... - Transcription factors in asthma and COPDGaetano Caramori
Dipartimento di Medicina Clinica e Sperimentale, Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Via Savonarola 9, Italy
IDrugs 7:764-70. 2004..Several new compounds based on interactions with specific transcription factors or their activation pathways are now in development for the treatment of asthma and COPD... - Is there a difference between chronic airway inflammation in chronic severe asthma and chronic obstructive pulmonary disease?Gaetano Caramori
Department of Clinical and Experimental Medicine, Centre of Research on Asthma and COPD, University of Ferrara, Ferrara, Italy
Curr Opin Allergy Clin Immunol 5:77-83. 2005..SUMMARY: These differences in chronic airway inflammation support the consensus that asthma and chronic obstructive pulmonary disease are different diseases along all their stages of severity... - New insights into the molecular mechanisms of corticosteroids actionsIan M Adcock
Cell and Molecular Biology, Airways Disease Section, National Heart and Lung Institute, Imperial College London, UK
Curr Drug Targets 7:649-60. 2006..Therapies targeting these aspects of the glucocorticoid receptor activation pathway may reverse steroid resistance in patients with chronic obstructive pulmonary disease... - Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in miceJohn A Marwick
Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
Am J Respir Crit Care Med 179:542-8. 2009..Recent studies have shown that histone deacetylase activity, which is critical to glucocorticoid function, is altered by oxidant stress and may be involved in the development of glucocorticoid insensitivity... - Pharmacology of airway inflammation in asthma and COPDGaetano Caramori
Department of Thoracic Medicine, National Heart and Lung Institute at Imperial College School of Science, Technology and Medicine, Dovehouse Street, SW3 6LY, London, UK
Pulm Pharmacol Ther 16:247-77. 2003..We review the current status of some of these new potential drugs... - Gene-environment interactions in the development of chronic obstructive pulmonary diseaseGaetano Caramori
Centro di Ricerca su Asma e BPCO, , Ferrara, Italy
Curr Opin Allergy Clin Immunol 6:323-8. 2006.... - Kinase inhibitors and airway inflammationIan M Adcock
Cell and Molecular Biology Group, Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, SW3, 6LY, United Kingdom
Eur J Pharmacol 533:118-32. 2006.... - Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory diseaseKazuhiro Ito
Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, SW3, 6LY, UK
J Pharmacol Exp Ther 321:1-8. 2007..Encouraging data from animal models, primary cells and clinical studies in other diseases suggest that inhibitors of PI3K/Akt may prove to be useful novel therapies in the treatment of asthma and chronic obstructive pulmonary disease... - Anti-inflammatory inhibitors of IkappaB kinase in asthma and COPDGaetano Caramori
Airways Disease Section, National Heart and Lung Institute, Imperal College London, Dovehouse Street, London SW3 6LY, UK
Curr Opin Investig Drugs 5:1141-7. 2004..Here, we review some of the major NFkappaB activating pathways, their role in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD), and their potential as targets in the treatment of asthma and COPD... - Effect of acute and chronic inflammatory stimuli on expression of protease-activated receptors 1 and 2 in alveolar macrophagesNicolas Roche
Department of Thoracic Medicine, Imperial College School of Medicine, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
J Allergy Clin Immunol 111:367-73. 2003..CONCLUSIONS: There is a dissociation between gene and protein expression of PAR-1 and PAR-2. PAR-1 protein overexpression in AMs from smokers might be important in the pathophysiology of chronic airways disease... - Anti-inflammatory mechanisms of glucocorticoids targeting granulocytesGaetano Caramori
Department of Thoracic Medicine, National Heart and Lung Institute at Imperial College School of Science, Technology and Medicine, Dovehouse Street, London, SW3 6LY, UK
Curr Drug Targets Inflamm Allergy 4:455-63. 2005..We summarize these known mechanisms at the end of this review... - Primary Pulmonary Epithelioid Hemangioendothelioma: A Rare Cause of PET-Negative Pulmonary NodulesRiccardo Cazzuffi
Sezione di Malattie dell Apparato Respiratorio, Dipartimento di Medicina Clinica e Sperimentale, Universita di Ferrara, Italy
Case Report Med 2011:262674. 2011..At the 18F-fluorodeoxyglucose positron emission tomography, these nodules were negative. The histopathological diagnosis was made on a pulmonary wedge resection (performed during video-thoracoscopic surgery)... - Kinase targets and inhibitors for the treatment of airway inflammatory diseases: the next generation of drugs for severe asthma and COPD?Ian M Adcock
Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
BioDrugs 18:167-80. 2004.... - Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cellsShaoping Xie
Experimental Studies, National Heart and Lung Institute, Imperial College, London, UK
Respir Res 6:148. 2005..We investigated whether human airway smooth muscle cells could express and secrete MMP-12, thereby participating in the pathogenesis of airway inflammatory diseases... - Role of nitric oxide in allergic inflammation and bronchial hyperresponsivenessPaul R Eynott
National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
Eur J Pharmacol 452:123-33. 2002..NO generated through NOS2 contributes to allergen-induced bronchial hyperresponsiveness but not to bronchial eosinophilia, indicating that these are independently expressed...