Paola Borgiani

Summary

Affiliation: University of Rome Tor Vergata
Country: Italy

Publications

  1. ncbi CYP4F2 genetic variant (rs2108622) significantly contributes to warfarin dosing variability in the Italian population
    Paola Borgiani
    Department of Biopathology and Diagnostic Imaging, School of Medicine, Tor Vergata University, Rome, Italy
    Pharmacogenomics 10:261-6. 2009
  2. ncbi Allelic variants in the CYP2C9 and VKORC1 loci and interindividual variability in the anticoagulant dose effect of warfarin in Italians
    Paola Borgiani
    Tor Vergata University, Department of Biopathology and Diagnostic Imaging, Section of Genetics, School of Medicine, Via Montpellier 1, 00133 Rome, Italy
    Pharmacogenomics 8:1545-50. 2007
  3. ncbi CARD15 mutation analysis in an Italian population: Leu1007fsinsC but neither Arg702Trp nor Gly908Arg mutations are associated with Crohn's disease
    Piero Vavassori
    Cattedra di Gastroenterologia, Centro d eccellenza per lo studio del rischio genomico in patologie complesse e multifattoriali, Universita Tor Vergata, Rome, Italy
    Inflamm Bowel Dis 10:116-21. 2004
  4. ncbi Nevirapine-induced hepatotoxicity and pharmacogenetics: a retrospective study in a population from Mozambique
    Cinzia Ciccacci
    Department of Biopathology and Diagnostic Imaging, Section of Genetics, Tor Vergata University, Rome, Italy
    Pharmacogenomics 11:23-31. 2010
  5. ncbi Psoriatic arthritis and CARD15 gene polymorphisms: no evidence for association in the Italian population
    Emiliano Giardina
    Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, School of Medicine, Tor Vergata University of Rome, Rome, Italy
    J Invest Dermatol 122:1106-7. 2004
  6. ncbi Characterization of a novel CYP2C9 gene mutation and structural bioinformatic protein analysis in a warfarin hypersensitive patient
    Cinzia Ciccacci
    Department of Biopathology and Diagnostic Imaging, Section of Genetics, School of Medicine, University of Rome Tor Vergata, Via Montpellier 1, Rome, Italy
    Pharmacogenet Genomics 21:344-6. 2011
  7. ncbi Genotyping OLR1 gene: a genomic biomarker for cardiovascular diseases
    Lucia Vecchione
    Department of Biopathology and Diagnostic Imaging, Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, School of Medicine, University of Tor Vergata, Rome, Italy
    Recent Pat Cardiovasc Drug Discov 2:147-51. 2007
  8. ncbi Pharmacogenomics in cardiovascular disease: the role of single nucleotide polymorphisms in improving drug therapy
    Ruggiero Mango
    Department of Biopathology, University of Roma Tor Vergata, Rome, Italy
    Expert Opin Pharmacother 6:2565-76. 2005
  9. ncbi Role of genetics in prevention of coronary atherosclerosis
    Giuseppe Novelli
    Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, School of Medicine, Tor Vergata University of Rome, Rome, Italy
    Curr Opin Cardiol 18:368-71. 2003
  10. ncbi Exclusion of CARD15/NOD2 as a candidate susceptibility gene to psoriasis in the Italian population
    Paola Borgiani
    Centro di Eccellenza per lo Studio del Rischio Genomico in Patologie Complesse Multifattoriali, Facolta di Medicina, Universita di Roma Tor Vergata, Via Montpellier 1, Italy
    Eur J Dermatol 12:540-2. 2002

Collaborators

Detail Information

Publications15

  1. ncbi CYP4F2 genetic variant (rs2108622) significantly contributes to warfarin dosing variability in the Italian population
    Paola Borgiani
    Department of Biopathology and Diagnostic Imaging, School of Medicine, Tor Vergata University, Rome, Italy
    Pharmacogenomics 10:261-6. 2009
    ..Numerous papers have shown the important contribution of CYP2C9 and VKORC1 genetic variants to this variability. Recently, a new SNP within the CYP4F2 gene was found associated with warfarin dose in the USA...
  2. ncbi Allelic variants in the CYP2C9 and VKORC1 loci and interindividual variability in the anticoagulant dose effect of warfarin in Italians
    Paola Borgiani
    Tor Vergata University, Department of Biopathology and Diagnostic Imaging, Section of Genetics, School of Medicine, Via Montpellier 1, 00133 Rome, Italy
    Pharmacogenomics 8:1545-50. 2007
    ....
  3. ncbi CARD15 mutation analysis in an Italian population: Leu1007fsinsC but neither Arg702Trp nor Gly908Arg mutations are associated with Crohn's disease
    Piero Vavassori
    Cattedra di Gastroenterologia, Centro d eccellenza per lo studio del rischio genomico in patologie complesse e multifattoriali, Universita Tor Vergata, Rome, Italy
    Inflamm Bowel Dis 10:116-21. 2004
    ..The purpose of this study was to evaluate the frequency of the main mutations of the CARD15 gene (Leu 1007fsinsC, Arg702Trp, and Gly908Arg) in Italian CD patients and to establish possible genotype-phenotype correlations...
  4. ncbi Nevirapine-induced hepatotoxicity and pharmacogenetics: a retrospective study in a population from Mozambique
    Cinzia Ciccacci
    Department of Biopathology and Diagnostic Imaging, Section of Genetics, Tor Vergata University, Rome, Italy
    Pharmacogenomics 11:23-31. 2010
    ..Aims: Nevirapine is widely used to treat HIV-1 infection to prevent mother-to-child transmission; unfortunately adverse drug reactions have been reported. Our aim was to identify genes/variants involved in nevirapine-induced hepatotoxicity...
  5. ncbi Psoriatic arthritis and CARD15 gene polymorphisms: no evidence for association in the Italian population
    Emiliano Giardina
    Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, School of Medicine, Tor Vergata University of Rome, Rome, Italy
    J Invest Dermatol 122:1106-7. 2004
    ....
  6. ncbi Characterization of a novel CYP2C9 gene mutation and structural bioinformatic protein analysis in a warfarin hypersensitive patient
    Cinzia Ciccacci
    Department of Biopathology and Diagnostic Imaging, Section of Genetics, School of Medicine, University of Rome Tor Vergata, Via Montpellier 1, Rome, Italy
    Pharmacogenet Genomics 21:344-6. 2011
    ..374G>T, which produces the Arg125Leu substitution. We have observed, through an electrostatic analysis, that the new mutation produces an electrostatic alteration on the cytochrome surface...
  7. ncbi Genotyping OLR1 gene: a genomic biomarker for cardiovascular diseases
    Lucia Vecchione
    Department of Biopathology and Diagnostic Imaging, Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, School of Medicine, University of Tor Vergata, Rome, Italy
    Recent Pat Cardiovasc Drug Discov 2:147-51. 2007
    ..The recent patents related to OLR1, SNPs and LOXIN are also discussed in this article...
  8. ncbi Pharmacogenomics in cardiovascular disease: the role of single nucleotide polymorphisms in improving drug therapy
    Ruggiero Mango
    Department of Biopathology, University of Roma Tor Vergata, Rome, Italy
    Expert Opin Pharmacother 6:2565-76. 2005
    ..To improve this, there is a need of new technology and large prospective trials allowing for simultaneous analysis of multiple genetic variants in molecular pathways that could affect drug disposition and action...
  9. ncbi Role of genetics in prevention of coronary atherosclerosis
    Giuseppe Novelli
    Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, School of Medicine, Tor Vergata University of Rome, Rome, Italy
    Curr Opin Cardiol 18:368-71. 2003
    ..Here, we review these advances with regard to genome scan results and candidate gene analysis...
  10. ncbi Exclusion of CARD15/NOD2 as a candidate susceptibility gene to psoriasis in the Italian population
    Paola Borgiani
    Centro di Eccellenza per lo Studio del Rischio Genomico in Patologie Complesse Multifattoriali, Facolta di Medicina, Universita di Roma Tor Vergata, Via Montpellier 1, Italy
    Eur J Dermatol 12:540-2. 2002
    ..We failed to observe any significant difference between patients and controls, thereby excluding the presence of a strong genetic association between CARD15 gene polymorphisms and psoriasis, in the Italian population...
  11. ncbi Folic acid and methionine in the prevention of teratogen-induced congenital defects in mice
    Daria Cipollone
    Department of Biopathology and Diagnostic Imaging, University Tor Vergata, Rome, Italy
    Cardiovasc Pathol 18:100-9. 2009
    ..Hereby, we analyzed the effects of nutritive therapy involving folic acid and methionine on teratogen-induced congenital defects in mice...
  12. ncbi ATG16L1 Ala197Thr is not associated with susceptibility to Crohn's disease or with phenotype in an Italian population
    Carlo Perricone
    Gastroenterology 134:368-70. 2008
  13. ncbi Neonatal screening, clinical features and genetic testing for galactosemia
    Marco Zaffanello
    Genet Med 7:211-2. 2005
  14. ncbi Association of the ACP1 genotype with metabolic parameters upon initial diagnosis of type 1 diabetes
    Gianfranco Meloni
    Department of Pediatrics, University of Sassari, Italy
    Med Sci Monit 9:CR105-8. 2003
    ..The purpose of our research was to determine the relationship of ACP1 with glycemic level, ketoacidosis and HbA1C in children with Type 1 diabetes...
  15. ncbi OLR1 gene and coronary artery disease/acute myocardial infarction: replication in an independently collected sample
    Giuseppe Novelli
    Eur J Hum Genet 14:894-5; author reply 895. 2006