Velio Alvaro Bocci

Summary

Affiliation: University of Siena
Country: Italy

Publications

  1. ncbi Why orthodox medicine has not yet taken advantage of ozone therapy
    Velio Alvaro Bocci
    Arch Med Res 39:259-60. 2008
  2. ncbi The case for oxygen-ozonetherapy
    V Bocci
    Department of Physiology, University of Siena, via Moro 2, 53100, Siena, Italy
    Br J Biomed Sci 64:44-9. 2007
  3. ncbi Potentiality of oxygen-ozonetherapy to improve the health of aging people
    Velio Bocci
    Department of Physiology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
    Curr Aging Sci 3:177-87. 2010
  4. ncbi Effect of 4-hydroxynonenal on antioxidant capacity and apoptosis induction in Jurkat T cells
    A Larini
    Department of Physiology, University of Siena, Via A. Moro, 53100 Siena, Italy
    Free Radic Res 38:509-16. 2004
  5. ncbi Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress?
    Masaru Sagai
    Department of Physiology, Viale A, Moro 2, 53100, University of Siena, Italy
    Med Gas Res 1:29. 2011
  6. ncbi Biochemical modifications induced in human blood by oxygenation-ozonation
    Velio Bocci
    Department of Physiology, University of Siena, 53100 Siena, Italy
    J Biochem Mol Toxicol 20:133-8. 2006
  7. ncbi Is it true that ozone is always toxic? The end of a dogma
    Velio Bocci
    Department of Physiology, University of Siena, Via A Moro 2, Siena 53100, Italy
    Toxicol Appl Pharmacol 216:493-504. 2006
  8. ncbi Tropospheric ozone toxicity vs. usefulness of ozone therapy
    Velio Alvaro Bocci
    Department of Physiology, University of Siena, Siena, Italy
    Arch Med Res 38:265-7. 2007
  9. ncbi Oxygenation-ozonation of blood during extracorporeal circulation: in vitro efficiency of a new gas exchange device
    Velio Bocci
    Department of Physiology, University of Siena, Siena, Italy
    Artif Organs 31:743-8. 2007
  10. ncbi Ozonation of human blood induces a remarkable upregulation of heme oxygenase-1 and heat stress protein-70
    Velio Bocci
    Department of Physiology, University of Siena, 53100 Siena, Italy
    Mediators Inflamm 2007:26785. 2007

Collaborators

Detail Information

Publications36

  1. ncbi Why orthodox medicine has not yet taken advantage of ozone therapy
    Velio Alvaro Bocci
    Arch Med Res 39:259-60. 2008
  2. ncbi The case for oxygen-ozonetherapy
    V Bocci
    Department of Physiology, University of Siena, via Moro 2, 53100, Siena, Italy
    Br J Biomed Sci 64:44-9. 2007
    ....
  3. ncbi Potentiality of oxygen-ozonetherapy to improve the health of aging people
    Velio Bocci
    Department of Physiology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
    Curr Aging Sci 3:177-87. 2010
    ..The rational exposure to a minimal amount of ozone acting as a mild stressor induces a striking improvement of crucial metabolic activities capable of preserving a good health for several years...
  4. ncbi Effect of 4-hydroxynonenal on antioxidant capacity and apoptosis induction in Jurkat T cells
    A Larini
    Department of Physiology, University of Siena, Via A. Moro, 53100 Siena, Italy
    Free Radic Res 38:509-16. 2004
    ..Furthermore, the protective effect of doubling the foetal calf serum still points out the risk that cultured cells undergo oxidative stress during incubation...
  5. ncbi Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress?
    Masaru Sagai
    Department of Physiology, Viale A, Moro 2, 53100, University of Siena, Italy
    Med Gas Res 1:29. 2011
    ..Further researches able to elucidate whether the mechanisms of action of ozone therapy involve nuclear transcription factors, such as Nrf2, NFAT, AP-1, and HIF-1? are warranted...
  6. ncbi Biochemical modifications induced in human blood by oxygenation-ozonation
    Velio Bocci
    Department of Physiology, University of Siena, 53100 Siena, Italy
    J Biochem Mol Toxicol 20:133-8. 2006
    ..3) Similarly, intraerythrocytic reduced glutathione after ozonation decreased from the initial value of 5.71 to 4.56 micromol/g Hb. (4) Both hemolysis and methemoglobin showed a negligible increase...
  7. ncbi Is it true that ozone is always toxic? The end of a dogma
    Velio Bocci
    Department of Physiology, University of Siena, Via A Moro 2, Siena 53100, Italy
    Toxicol Appl Pharmacol 216:493-504. 2006
    ..The aim of this paper is to objectively evaluate this controversial issue...
  8. ncbi Tropospheric ozone toxicity vs. usefulness of ozone therapy
    Velio Alvaro Bocci
    Department of Physiology, University of Siena, Siena, Italy
    Arch Med Res 38:265-7. 2007
    ..These activate several biochemical pathways in blood cells, which after reinfusion are responsible for therapeutic activities lasting several days. Neither acute nor chronic toxicity has been registered...
  9. ncbi Oxygenation-ozonation of blood during extracorporeal circulation: in vitro efficiency of a new gas exchange device
    Velio Bocci
    Department of Physiology, University of Siena, Siena, Italy
    Artif Organs 31:743-8. 2007
    ..This device appears to be a practical, nontoxic, and rather inexpensive tool for performing ozonation of blood for already defined human diseases...
  10. ncbi Ozonation of human blood induces a remarkable upregulation of heme oxygenase-1 and heat stress protein-70
    Velio Bocci
    Department of Physiology, University of Siena, 53100 Siena, Italy
    Mediators Inflamm 2007:26785. 2007
    ..At this concentration, there is also induction of Hsp-70. The results clarify another positive effect achievable by the use of ozone therapy...
  11. ncbi The failure of HIV vaccines: a new autovaccine may overcome some problems
    Velio Bocci
    Department of Physiology, University of Siena, Via Aldo Moro 2, Siena, Italy
    Med Hypotheses 72:662-4. 2009
    ..The preparation of the autovaccine is described as well as the administration schedule but only a clinical study will define its validity...
  12. ncbi The ozone paradox: ozone is a strong oxidant as well as a medical drug
    Velio Bocci
    Department of Physiology, University of Siena, Siena, Italy
    Med Res Rev 29:646-82. 2009
    ..Moreover, the versatility and amplitude of beneficial effect of ozone applications have become evident in orthopedics, cutaneous, and mucosal infections as well as in dentistry...
  13. ncbi May oxygen-ozone therapy improves cardiovascular disorders?
    Velio Bocci
    Department of Physiology, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
    Cardiovasc Hematol Disord Drug Targets 9:78-85. 2009
    ..Here it is proposed to associate the approach of ozonated autohemotherapy as a modifier of the biological response capable to block the pathological progress...
  14. ncbi Oxygen-ozone therapy in medicine: an update
    Velio Bocci
    Department of Physiology, University of Siena, Siena, Italy
    Blood Purif 28:373-6. 2009
    ..Recently, its use has been successfully extended to the herniated disk pathology and therapy of primary caries in children...
  15. ncbi Ozone: a new therapeutic agent in vascular diseases
    Velis Bocci
    Department of Physiology, University of Siena, Siena, Italy
    Am J Cardiovasc Drugs 11:73-82. 2011
    ..Accordingly, we propose the need for a well designed, multicenter, clinical trial to be conducted...
  16. ncbi Ozone acting on human blood yields a hormetic dose-response relationship
    Velio A Bocci
    Dipartimento di Fisiologia, Universita degli Studi di Siena, Viale Aldo Moro, 2, 53100, Siena, Italy
    J Transl Med 9:66. 2011
    ..Finally, the elucidation of the mechanisms of action of ozone as well as the obtained results in PAD may encourage clinical scientists to evaluate ozone therapy in vascular diseases in comparison to the current therapies...
  17. ncbi Oxygen/ozone as a medical gas mixture. A critical evaluation of the various methods clarifies positive and negative aspects
    Velio Bocci
    Dipartimento di Fisiologia, Universita degli Studi di Siena, Viale Aldo Moro, 2 53100 Siena, Italy
    Med Gas Res 1:6. 2011
    ..Hence, the aim of this article is to emphasize the need to objectively assess the pros and cons of oxygen/ozone as a medical gas mixture in the hope that ozone therapy will be accepted by orthodox medicine in the near future...
  18. ncbi Scientific and medical aspects of ozone therapy. State of the art
    Velio Alvaro Bocci
    Department of Physiology, University of Siena, Siena, Italy
    Arch Med Res 37:425-35. 2006
    ..It is hoped that this report will open a dialogue among clinical scientists and will inform physicians about the beneficial effects of ozone therapy...
  19. ncbi Restoration of normoxia by ozone therapy may control neoplastic growth: a review and a working hypothesis
    Velio Bocci
    Department of Physiology, University of Siena, Italy
    J Altern Complement Med 11:257-65. 2005
    ..Moreover, it may re-equilibrate the chronic oxidative stress and reduce fatigue...
  20. ncbi Rational bases for using oxygen-ozonetherapy as a biological response modifier in sickle cell anemia and beta-thalassemia: a therapeutic perspective
    V Bocci
    Department of Physiology, Ozonetherapy Centre, University of Siena, Siena, Italy
    J Biol Regul Homeost Agents 18:38-44. 2004
    ..Ozone, as any other drug, has an intrinsic toxicity that, in the proposed application, is fully tamed by the blood antioxidant system...
  21. ncbi How a physiologist viewed and lived with the interferon problem
    V Bocci
    Department of Physiology, University of Siena, Siena, Italy
    J Biol Regul Homeost Agents 17:289-94. 2003
  22. ncbi Effects of ozone on isolated peripheral blood mononuclear cells
    A Larini
    Department of Physiology, University of Siena, Via A. Moro 2, 53100 Siena, Italy
    Toxicol In Vitro 19:55-61. 2005
    ..These data show that there is a significant relationship between cytokine production and ozone concentrations and that PBMC are very sensitive to oxidation particularly in presence of serum with low antioxidant capacity...
  23. ncbi Ozonation of blood during extracorporeal circulation. I. Rationale, methodology and preliminary studies
    V Bocci
    Institute of General Physiology, University of Siena, Italy
    Int J Artif Organs 22:645-51. 1999
    ..The sheep showed no adverse effects even after 50 min of extracorporeal circulation at higher O3 concentrations (20 to 40 microg/ml) but the exchanger became less effective (low pO2 values) due to progressive clogging with cells...
  24. ncbi Ozone and ozonated oils in skin diseases: a review
    V Travagli
    Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Viale Aldo Moro 2, 53100 Siena, Italy
    Mediators Inflamm 2010:610418. 2010
    ....
  25. ncbi The oropharyngeal delivery of interferons: where are we and where do we need to go?
    V Bocci
    Institute of General Physiology, University of Siena, Italy
    J Interferon Cytokine Res 19:859-61. 1999
    ..Owing to a minimal cost and lack of toxicity, the oral as well as other unconventional routes of IFN delivery deserve to be evaluated because they may become useful...
  26. ncbi Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin-8 production
    V Bocci
    Institute of General Physiology, University of Siena, Italy
    Mediators Inflamm 7:313-7. 1998
    ..This is in line with the current idea that hydrogen peroxide, as a byproduct of O3 decomposition, acts as a messenger for the cytokine induction...
  27. ncbi Quasi-total-body exposure to an oxygen-ozone mixture in a sauna cabin
    V Bocci
    Institute of General Physiology, University of Siena, Via Laterina 8, I 53100 Siena, Italy
    Eur J Appl Physiol Occup Physiol 80:549-54. 1999
    ..However, in the present study no adverse effects were noted after one session...
  28. ncbi Thrombin receptor expression and responsiveness of human monocytic cells to thrombin is linked to interferon-induced cellular differentiation
    A Naldini
    University of Siena, Institute of General Physiology, Italy
    J Cell Physiol 177:76-84. 1998
    ..That thrombin stimulates cytokine production and proliferation in populations of differentiated monocytes suggests that thrombin may be an important regulator of inflammation and wound healing...
  29. ncbi Hypoxia affects cytokine production and proliferative responses by human peripheral mononuclear cells
    A Naldini
    Institute of General Physiology, University of Siena, Italy
    J Cell Physiol 173:335-42. 1997
    ..Furthermore, these results suggest a differential pattern of cytokine production in vivo in hypoxic tissues...
  30. ncbi Ozonation of blood during extracorporeal circulation. II. Comparative analysis of several oxygenator-ozonators and selection of one type
    V Bocci
    Institute of General Physiology, University of Siena, Italy
    Int J Artif Organs 24:890-7. 2001
    ....
  31. ncbi The ozone tolerance: I) Enhancement of antioxidant enzymes is ozone dose-dependent in Jurkat cells
    A Larini
    Department of Physiology, University of Siena, Via A. Moro, 53100 Siena, Italy
    Free Radic Res 37:1163-8. 2003
    ..Thus, as we have observed in blood, the biological response is linked to the ozone dose that must reach a threshold to be effective...
  32. ncbi The dual action of ozone on the skin
    G Valacchi
    Department of Physiology, University of Siena, Siena 53100, Italy
    Br J Dermatol 153:1096-100. 2005
    ....
  33. ncbi Effects of dietary yoghurt on immunological and clinical parameters of rhinopathic patients
    C Aldinucci
    Institute of General Physiology, University of Siena, Siena, Italy
    Eur J Clin Nutr 56:1155-61. 2002
    ..Muco-ciliary transport time (MCTt) and symptomatological score showed a definitive improvement after yoghurt feeding. CONCLUSION: Yoghurt feeding appears to improve or prevent allergic recurrences in rhinopatic patients...
  34. ncbi Necrotizing fasciitis successfully treated with extracorporeal blood oxygenation and ozonization (EBOO)
    N Di Paolo
    Department of Nephrology, Azienda Ospedaliera Senese, University of Siena, Siena, Italy
    Int J Artif Organs 25:1194-8. 2002
    ..This technique is no longer in the experimental stage and is used routinely in our hospital. Patient condition improved radically after EBOO...
  35. ncbi The physiological interferon response. IX. Interferon activity in rabbit lymph after intraduodenal administration of alimentary lectins
    V Bocci
    Institute of General Physiology, University of Siena, Italy
    Lymphokine Res 7:49-59. 1988
    ..Preliminary characterization of the IFN activity has shown it to be trypsin-sensitive acid- and heat-stable and species-specific...
  36. ncbi Can ozonetherapy be performed if the biochemistry of the process cannot be controlled?
    Velio Alvaro Bocci
    Arch Med Res 38:584-5. 2007