S Bettuzzi

Summary

Affiliation: University of Parma
Country: Italy

Publications

  1. ncbi Clusterin (SGP-2) transient overexpression decreases proliferation rate of SV40-immortalized human prostate epithelial cells by slowing down cell cycle progression
    Saverio Bettuzzi
    Dipartimento di Medicina Sperimentale, Universita di Parma, Via Volturno, 39 43100 Parma, Italy
    Oncogene 21:4328-34. 2002
  2. ncbi Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study
    Saverio Bettuzzi
    Department of Medicina Sperimentale, Sezione di Biochimica, University of Parma, Via Volturno 39, 43100 Parma, Italy
    Cancer Res 66:1234-40. 2006
  3. ncbi Successful prediction of prostate cancer recurrence by gene profiling in combination with clinical data: a 5-year follow-up study
    Saverio Bettuzzi
    Dipartimento di Medicina Sperimentale, Plesso Biotecnologico Integrato, Universita di Parma, Via Volturno 39 43100 Parma, Italy
    Cancer Res 63:3469-72. 2003
  4. ncbi The new anti-oncogene clusterin and the molecular profiling of prostate cancer progression and prognosis
    Saverio Bettuzzi
    Dipartimento di Medicina Sperimentale, Sezione di Biochimica, Biochimica Cinica e Biochimica dell'Esercizio Fisico, , Via Volturno 39, 43100 Parma, Italy
    Acta Biomed 74:101-4. 2003
  5. ncbi Clinical relevance of the inhibitory effect of green tea catechins (GtCs) on prostate cancer progression in combination with molecular profiling of catechin-resistant tumors: an integrated view
    S Bettuzzi
    Department of Experimental Medicine, University of Parma, Via Volturno 39, 43 100 Parma, Italy
    Pol J Vet Sci 10:57-60. 2007
  6. ncbi Genetic inactivation of ApoJ/clusterin: effects on prostate tumourigenesis and metastatic spread
    S Bettuzzi
    Department of Experimental Medicine, University of Parma, Via Volturno 39, 43100 Parma, Italy
    Oncogene 28:4344-52. 2009
  7. ncbi Nuclear translocation of a clusterin isoform is associated with induction of anoikis in SV40-immortalized human prostate epithelial cells
    A E Caccamo
    Department of Medicina Sperimentale, University of Parma, 43100 Parma, Italy
    Ann N Y Acad Sci 1010:514-9. 2003
  8. ncbi Targeting Clusterin in prostate cancer
    F Rizzi
    Department of Experimental Medicine, University of Parma, Parma, Italy
    J Physiol Pharmacol 59:265-74. 2008
  9. ncbi Cell detachment and apoptosis induction of immortalized human prostate epithelial cells are associated with early accumulation of a 45 kDa nuclear isoform of clusterin
    Alessandro E Caccamo
    Dipartimento di Medicina Sperimentale, University of Parma, Via Volturno 39, 43100 Parma, Italy
    Biochem J 382:157-68. 2004
  10. ncbi Molecular targets of (-)-epigallocatechin-3-gallate (EGCG): specificity and interaction with membrane lipid rafts
    S K Patra
    Department of Experimental Medicine, University of Parma, Parma, Italy
    J Physiol Pharmacol 59:217-35. 2008

Collaborators

  • Maurizio A Brausi
  • R Baffa
  • A Sala
  • Samir Kumar Patra
  • Stefania Ferretti
  • Anna Cariboni
  • T J Yeatman
  • Cesare Selli
  • John Anderson
  • Federica Rizzi
  • Maurizio Scaltriti
  • Andrea Caporali
  • Serenella Astancolle
  • Lucia Belloni
  • Arnaldo Corti
  • Alessandro E Caccamo
  • F Rizzi
  • Daniel Remondini
  • Sandra Papini
  • Rebekka Schwab
  • Roberta M Moretti
  • Pierpaola Davalli
  • Domenico D'Arca
  • Tingan Chen
  • Gaetano Marverti
  • A E Caccamo
  • Sandra Filippi
  • Mariangela Coletta
  • Alessandro Emanuele Caccamo
  • Piero Cortellini
  • Pellegrino Crafa
  • Mirca Lazzaretti
  • Patrizia Limonta
  • Stefania Mai
  • Anna De Matteis
  • Roberto P Revoltella
  • Daniela Campani
  • Marina Montagnani Marelli
  • Alessandro Caccamo
  • Alfredo Rosellini
  • Angelo F Borghetti
  • Silvia Desenzani
  • Maria Stella Moruzzi
  • Francesca Scorcioni
  • Andrea Amorosi
  • Susan McCarthy
  • Anna Santamaria
  • Maria Giuseppina Monti
  • Joel Turner
  • Rosanna Paciucci
  • Massimo Mangiola
  • G Candiano
  • F Scorcioni
  • A Caporali
  • M Scaltriti
  • D D'Arca
  • M Mangiola
  • Michaela Luconi
  • Simone Granchi
  • Paola Tozzi
  • Fabrizio Ledda
  • Mario Maggi
  • Linda Vignozzi
  • Gianni Forti

Detail Information

Publications30

  1. ncbi Clusterin (SGP-2) transient overexpression decreases proliferation rate of SV40-immortalized human prostate epithelial cells by slowing down cell cycle progression
    Saverio Bettuzzi
    Dipartimento di Medicina Sperimentale, Universita di Parma, Via Volturno, 39 43100 Parma, Italy
    Oncogene 21:4328-34. 2002
    ....
  2. ncbi Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study
    Saverio Bettuzzi
    Department of Medicina Sperimentale, Sezione di Biochimica, University of Parma, Via Volturno 39, 43100 Parma, Italy
    Cancer Res 66:1234-40. 2006
    ..As a secondary observation, administration of GTCs also reduced lower urinary tract symptoms, suggesting that these compounds might also be of help for treating the symptoms of benign prostate hyperplasia...
  3. ncbi Successful prediction of prostate cancer recurrence by gene profiling in combination with clinical data: a 5-year follow-up study
    Saverio Bettuzzi
    Dipartimento di Medicina Sperimentale, Plesso Biotecnologico Integrato, Universita di Parma, Via Volturno 39 43100 Parma, Italy
    Cancer Res 63:3469-72. 2003
    ..The best result was obtained with a selected combination of gene profiling and clinical/pathological parameters, which resulted in prediction of recurrence in 95.7% of patients...
  4. ncbi The new anti-oncogene clusterin and the molecular profiling of prostate cancer progression and prognosis
    Saverio Bettuzzi
    Dipartimento di Medicina Sperimentale, Sezione di Biochimica, Biochimica Cinica e Biochimica dell'Esercizio Fisico, , Via Volturno 39, 43100 Parma, Italy
    Acta Biomed 74:101-4. 2003
  5. ncbi Clinical relevance of the inhibitory effect of green tea catechins (GtCs) on prostate cancer progression in combination with molecular profiling of catechin-resistant tumors: an integrated view
    S Bettuzzi
    Department of Experimental Medicine, University of Parma, Via Volturno 39, 43 100 Parma, Italy
    Pol J Vet Sci 10:57-60. 2007
    ....
  6. ncbi Genetic inactivation of ApoJ/clusterin: effects on prostate tumourigenesis and metastatic spread
    S Bettuzzi
    Department of Experimental Medicine, University of Parma, Via Volturno 39, 43100 Parma, Italy
    Oncogene 28:4344-52. 2009
    ..Mechanistically, deletion of CLU induces activation of nuclear factor-kB, a potentially oncogenic transcription factor important for the proliferation and survival of prostate cells...
  7. ncbi Nuclear translocation of a clusterin isoform is associated with induction of anoikis in SV40-immortalized human prostate epithelial cells
    A E Caccamo
    Department of Medicina Sperimentale, University of Parma, 43100 Parma, Italy
    Ann N Y Acad Sci 1010:514-9. 2003
    ....
  8. ncbi Targeting Clusterin in prostate cancer
    F Rizzi
    Department of Experimental Medicine, University of Parma, Parma, Italy
    J Physiol Pharmacol 59:265-74. 2008
    ....
  9. ncbi Cell detachment and apoptosis induction of immortalized human prostate epithelial cells are associated with early accumulation of a 45 kDa nuclear isoform of clusterin
    Alessandro E Caccamo
    Dipartimento di Medicina Sperimentale, University of Parma, Via Volturno 39, 43100 Parma, Italy
    Biochem J 382:157-68. 2004
    ....
  10. ncbi Molecular targets of (-)-epigallocatechin-3-gallate (EGCG): specificity and interaction with membrane lipid rafts
    S K Patra
    Department of Experimental Medicine, University of Parma, Parma, Italy
    J Physiol Pharmacol 59:217-35. 2008
    ..We suggest here that the anticancer activity of Green Tea Catechins against different kind of cancers may find an explanation in direct targeting of lipid rafts by EGCG...
  11. ncbi Clusterin (CLU) and prostate cancer
    Federica Rizzi
    Dipartimento di Medicina Sperimentale, Sezione di Biochimica, Biochimica Clinica e Biochimica dell Esercizio Fisico, Universita di Parma, Via Volturno 39 43100 Parma, Italy
    Adv Cancer Res 105:1-19. 2009
    ..This data suggest the importance of epigenetic events in the regulation of CLU in prostate cancer, supporting the idea that prostate cell transformation at early stages requires CLU silencing through chromatin remodeling...
  12. ncbi Nuclear clusterin accumulation during heat shock response: implications for cell survival and thermo-tolerance induction in immortalized and prostate cancer cells
    Alessandro E Caccamo
    Dipartimento di Medicina Sperimentale, Sezione di Biochimica, Biochimica Clinica e Biochimica dell Esercizio Fisico, Universita di Parma, Via Volturno Parma, Italy
    J Cell Physiol 207:208-19. 2006
    ....
  13. ncbi Molecular classification of green tea catechin-sensitive and green tea catechin-resistant prostate cancer in the TRAMP mice model by quantitative real-time PCR gene profiling
    Maurizio Scaltriti
    Dipartimento di Medicina Sperimentale, Plesso Biotecnologico Integrato, Universita' di Parma, Via Volturno 39-43100 Parma, Italy
    Carcinogenesis 27:1047-53. 2006
    ....
  14. ncbi The chemopreventive action of catechins in the TRAMP mouse model of prostate carcinogenesis is accompanied by clusterin over-expression
    Andrea Caporali
    Dipartimento di Medicina Sperimentale, Plesso Biotecnologico Integrato, Universita di Parma, Via Volturno, 39 43100 Parma, Italy
    Carcinogenesis 25:2217-24. 2004
    ..A possible role for CLU as a novel tumor-suppressor gene in the prostate is thus suggested...
  15. ncbi Epigenetic DNA-(cytosine-5-carbon) modifications: 5-aza-2'-deoxycytidine and DNA-demethylation
    S K Patra
    Division of Biochemistry, Department of Experimental Medicine, University of Parma, Parma, Italy
    Biochemistry (Mosc) 74:613-9. 2009
    ..Finally, we would like to suggest that terming/designating AzadC as DNA-demethylating agent is a serious misuse of chemistry and chemical terminology...
  16. ncbi Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells
    Federica Rizzi
    Dipartimento di Medicina Sperimentale, Sezione di Biochimica, Biochimica Clinica e Biochimica dell Esercizio Fisico, Parma, Italy
    J Cell Physiol 219:314-23. 2009
    ..In conclusion, proteasome inhibition may induce prostate cancer cell death through accumulation of nCLU, a potential tumor suppressor factor...
  17. ncbi Chapter 2: Clusterin (CLU): From one gene and two transcripts to many proteins
    Federica Rizzi
    Dipartimento di Medicina Sperimentale, Sezione di Biochimica, Biochimica Clinica e Biochimica dell Esercizio Fisico, Parma, Italy
    Adv Cancer Res 104:9-23. 2009
    ....
  18. ncbi A novel gene signature for molecular diagnosis of human prostate cancer by RT-qPCR
    Federica Rizzi
    Department of Medicina Sperimentale, University of Parma, Parma, Italy
    PLoS ONE 3:e3617. 2008
    ....
  19. ncbi Epigenetic DNA-methylation regulation of genes coding for lipid raft-associated components: a role for raft proteins in cell transformation and cancer progression (review)
    Samir K Patra
    Department of Medicina Sperimentale, University of Parma, I 43100 Parma, Italy
    Oncol Rep 17:1279-90. 2007
    ..The recent research acquisitions on lipid rafts have tremendous implications in understanding the genetic and biochemical bases of metastatic diffusion of cancer...
  20. ncbi The clusterin paradigm in prostate and breast carcinogenesis
    Federica Rizzi
    Dipartimento di Medicina Sperimentale, Sezione di Biochimica, Biochimica Clinica e Biochimica dell Esercizio Fisico, Universita di Parma, Parma, Italy
    Endocr Relat Cancer 17:R1-17. 2010
    ..High expression of secreted or cytoplasmic CLU may represent a pro-survival stimulus because it confers increased resistance to killing by anti-cancer drugs or enhances tumour cell survival in specific niches...
  21. ncbi Conclusions and perspectives
    Saverio Bettuzzi
    Dipartimento di Medicina Sperimentale, Sezione di Biochimica, Biochimica Clinica e Biochimica dell Esercizio Fisico, Universita di Parma, Via Volturno 39 43100 Parma, Italy
    Adv Cancer Res 105:133-50. 2009
    ..Finally, we will address how this novel knowledge about CLU may possibly result in important implementations, from basic science all the way to the clinical setting, in the fight against cancer...
  22. ncbi Intracellular clusterin induces G2-M phase arrest and cell death in PC-3 prostate cancer cells1
    Maurizio Scaltriti
    Unitat de Recerca Biomedica, Hospital Vall d'Hebron, Barcelona, Spain
    Cancer Res 64:6174-82. 2004
    ....
  23. ncbi Estrogens, but not androgens, regulate expression and functional activity of oxytocin receptor in rabbit epididymis
    Sandra Filippi
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence 50139, Italy
    Endocrinology 143:4271-80. 2002
    ..Blocking aromatase activity almost completely abolished OT sensitivity. These findings suggest a new function of estrogens in the male: regulation of OT responsiveness in epididymis...
  24. ncbi Clusterin-mediated apoptosis is regulated by adenomatous polyposis coli and is p21 dependent but p53 independent
    Tingan Chen
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
    Cancer Res 64:7412-9. 2004
    ..These data support a potential therapeutic role for clusterin in enhancing chemotherapy-induced apoptosis and in promoting apoptosis in cells deficient in p21...
  25. ncbi Clusterin (SGP-2, ApoJ) expression is downregulated in low- and high-grade human prostate cancer
    Maurizio Scaltriti
    Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, Modena, Italy
    Int J Cancer 108:23-30. 2004
    ..In advanced CaP, the staining of the remnants of the extracellular matrix suggests a role for clusterin in the process of dismantling the stromal organization caused by cancer progression...
  26. ncbi Cisplatin-resistance modulates the effect of protein synthesis inhibitors on spermidine/spermine N(1)-acetyltransferase expression
    Gaetano Marverti
    Dipartimento di Scienze Biomediche, Sezione di Chimica Biologica, Universita di Modena e Reggio Emilia, Via Campi 287, 41100, Modena, Italy
    Int J Biochem Cell Biol 36:123-37. 2004
    ....
  27. ncbi Clusterin isoforms differentially affect growth and motility of prostate cells: possible implications in prostate tumorigenesis
    Roberta M Moretti
    Institute of Endocrinology, University of Milan, Milan, Italy
    Cancer Res 67:10325-33. 2007
    ..Thus, the antimotility activity of nCLU and its ability to cause dismantling of the actin cytoskeleton seem to be mediated by its binding to alpha-actinin...
  28. ncbi B-MYB is hypophosphorylated and resistant to degradation in neuroblastoma: implications for cell survival
    Rebekka Schwab
    Molecular Haematology and Cancer Biology Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Blood Cells Mol Dis 39:263-71. 2007
    ..Thus, expression of stable, hypophosphorylated B-MYB in neuroblastoma may promote cell survival and induce aggressive tumour growth...
  29. ncbi Demethylation of (Cytosine-5-C-methyl) DNA and regulation of transcription in the epigenetic pathways of cancer development
    Samir Kumar Patra
    Cancer Epigenetics Research, Kalyani B 7 183, Nadia, West Bengal, India
    Cancer Metastasis Rev 27:315-34. 2008
    ..The importance of truly chemically defined direct demethylation of intact DNA in regulation of gene expression, development, cell differentiation and transformation are discussed in this contribution...
  30. ncbi Establishment of an organotypic in vitro culture system and its relevance to the characterization of human prostate epithelial cancer cells and their stromal interactions
    Sandra Papini
    Institute of Biomedical Technologies, National Research Council of Italy, Pisa, Italy
    Pathol Res Pract 203:209-16. 2007
    ..The 3D-culture provides a promising approach for studying the development and phenotype of prostate epithelial tumor progenitor cells and their stromal interactions...