Research Topics
Genomes and GenesSpecies | G BelloneSummaryAffiliation: University of Turin Country: Italy Publications
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Publications
Transforming growth factor-beta binding receptor endoglin (CD105) expression in esophageal cancer and in adjacent nontumorous esophagus as prognostic predictor of recurrenceGraziella Bellone
Division of Internal Medicine, Department of Clinical Physiopathology, University of Turin, Turin, Italy
Ann Surg Oncol 14:3232-42. 2007....- Osteo-promoting activity of OSTEOPLANT ANGIOSTAD in vitroG Bellone
Department of Clinical Physiopathology, University of Turin, Italy
Minerva Stomatol 57:189-98. 2008..The in vitro study examines the effects of OSTEOPLANT ANGIOSTAD, a product developed to increase osteoinductivity... - Cytokine expression profile in human pancreatic carcinoma cells and in surgical specimens: implications for survivalGraziella Bellone
Department of Clinical Physiopathology, Universita di Torino, Via Genova, 3, 10126 Torino, Italy
Cancer Immunol Immunother 55:684-98. 2006..Patients with low circulating levels of IL-6, IL-18 and TGF-beta2 survived longer. Pancreatic cancer is characterized by peculiar cytokine expression patterns, associated with different survival probabilities... - Cooperative induction of a tolerogenic dendritic cell phenotype by cytokines secreted by pancreatic carcinoma cellsGraziella Bellone
Department of Clinical Physiopathology, University of Turin, Italy
J Immunol 177:3448-60. 2006..In summary, we have identified an array of pancreatic carcinoma-derived cytokines that cooperatively affect iMo-DC activation in a manner consistent with ineffective antitumor immune responses... - Antagonistic interactions between gemcitabine and 5-fluorouracil in the human pancreatic carcinoma cell line Capan-2Graziella Bellone
Department of Clinical Physiopathology, University of Turin, and Department of Gastroenterology, San Giovanni Battista Hospital, Turin, Italy
Cancer Biol Ther 5:1294-303. 2006.... - KIT/stem cell factor expression in premalignant and malignant lesions of the colon mucosa in relationship to disease progression and outcomesGraziella Bellone
Department of Clinical Physiopathology, University of Turin, I 10126 Torino, Italy
Int J Oncol 29:851-9. 2006..Therefore, in the subset of CRC patients with concomitant KIT/SCF expression, the activity of Imatinib mesylate, a selective inhibitor of specific tyrosine kinases including KIT, may be exploited in combination with standard therapy... - Inhibition of cell survival and invasive potential of colorectal carcinoma cells by the tyrosine kinase inhibitor STI571Graziella Bellone
Department of Clinical Physiopathology, University of Torino, Torino, Italy
Cancer Biol Ther 3:385-92. 2004..Finally, STI571 acted as a chemosensitizing agent in DLD-1 cells when used in combination with 5-fluorouracil... - Circulating vascular endothelial growth factor and interferon-gamma-inducible protein-10 levels in pancreatic cancer during chemotherapyGraziella Bellone
Department of Clinical Physiopathology, University of Turin, Italy
Anticancer Res 25:3287-91. 2005..Chemotherapeutic anticancer properties are thought to derive from apoptosis pathway activation and/or cell division arrest, but animal models have also evidenced anti-angiogenic activity in some agents... - Impact of surgery and chemotherapy on cellular immunity in pancreatic carcinoma patients in view of an integration of standard cancer treatment with immunotherapyGraziella Bellone
Department of Clinical Physiopathology, University of Turin, Turin, Italy
Int J Oncol 34:1701-15. 2009.... - Aberrant activation of c-kit protects colon carcinoma cells against apoptosis and enhances their invasive potentialG Bellone
Department of Clinical Physiopathology University of Torino, Italy
Cancer Res 61:2200-6. 2001..These results suggest multiple roles of c-kit activation in support of the malignant phenotype of DLD-1 cells related to growth, survival, migration, and invasive potential... - Differential expression of transforming growth factors-beta1, -beta2 and -beta3 in human colon carcinomaG Bellone
Department of Clinical Physiopathology, University of Torino, Via Genova, 3, 10126, Turin, Italy
Eur J Cancer 37:224-33. 2001..Taken together, our results indicate distinct expression patterns of the three TGF-beta isoforms in colon carcinoma cells and possible systemic effects of TGF-beta1 and TGF-beta2 in tumour patients... - Abnormal expression of Endoglin and its receptor complex (TGF-?1 and TGF-? receptor II) as early angiogenic switch indicator in premalignant lesions of the colon mucosaGraziella Bellone
Department of Clinical Physiopathology, University of Turin, I 10126 Torino, Italy
Int J Oncol 37:1153-65. 2010..These findings suggest active angiogenesis occurs in many pre-malignant colon cases and supports more careful evaluation of different chemopreventive agents... - Tumor-associated transforming growth factor-beta and interleukin-10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patientsG Bellone
Department of Clinical Physiopathology, University of Torino, Torino, Italy
Am J Pathol 155:537-47. 1999..Taken together, these results suggest that aberrant production of TGF-beta and IL-10 in pancreatic tumor patients skews T-cell cytokine production patterns in favor of a Th2 immunophenotype... - Growth stimulation of colorectal carcinoma cells via the c-kit receptor is inhibited by TGF-beta 1G Bellone
Department of Clinical Physiopathology, University of Torino, Italy
J Cell Physiol 172:1-11. 1997..In summary, expression of the potential autocrine SCF/ c-kit axis is a tumor-associated phenomenon in colorectal cancer that can be suppressed by TGF-beta 1 in TGF-beta-responsive CRC cells... - Production and pro-apoptotic activity of soluble CD95 ligand in pancreatic carcinomaG Bellone
Department of Clinical Physiopathology, University of Torino, Italy
Clin Cancer Res 6:2448-55. 2000..In addition, because it is released at high levels into the bloodstream, soluble CD95L may have systemic effects in tumor patients that reach beyond the microenvironment of the tumor site... - [The c-kit/Stem Cell Factor in the cancerogenetic process of colon-rectal carcinoma. Biological and clinical aspects]G Bellone
, Torino, Dipartimento di Fisiopatologia Clinica, Italy
Minerva Chir 58:875-80. 2003 - Oxaliplatin, 5-fluorouracil, and leucovorin as second-line treatment for advanced pancreatic cancerAnna Novarino
Dipartimento di Oncologia, Torino, Italy
Am J Clin Oncol 32:44-8. 2009.... - In vitro effect of transforming growth factor-beta on adhesion molecule expression by human gingival fibroblasts cultured in the presence of a titanium abutmentG Schierano
Department of Prosthetic Dentistry, University of Turin, Italy
J Periodontol 72:1658-65. 2001..CONCLUSIONS: TGF-beta not only seems to affect the orientation of the cultured gingival fibroblasts, but also to induce a clear-cut modification of their adhesion molecule expression... - Pilot study to relate clinical outcome in pancreatic carcinoma and angiogenic plasma factors/circulating mature/progenitor endothelial cells: Preliminary resultsBarbara Vizio
Department of Clinical Physiopathology, University of Turin, Turin, Italy
Cancer Sci 101:2448-54. 2010..The study provides insights into angiogenesis mechanisms in pancreatic carcinoma, for which anti-angiogenic targeting of VEGF-A and ECP could be of interest... - Human pancreatic carcinoma cells secrete bioactive interleukin-18 after treatment with 5-fluorouracil: implications for anti-tumor immune responseAnna Carbone
Department of Gastroenterology and Clinical Nutrition, Azienda Ospedaliera San Giovanni Battista, Molinette, Turin, Italy
Cancer Biol Ther 4:231-41. 2005..These findings delineate a novel mechanism by which chemotherapeutic agents may modulate local anti-tumor cell-mediated immune responses... - Phase II study of cisplatin, gemcitabine and 5-fluorouracil in advanced pancreatic cancerA Novarino
Oncologia Medica, Centro Oncologico Ematologico Subalpino, Azienda Ospedaliera Molinette, Torino, Italy
Ann Oncol 15:474-7. 2004..CONCLUSION: This schedule seems well tolerated and active in pancreatic cancer and worthwhile of further evaluation... - Association between elevated prolactin levels and circulating erythroid precursors in dialyzed patientsG Bellone
Department of Clinical Physiopathology, Nephrology Institute, and Department of Internal Medicine, University of Turin, 10126 Turin, Italy
Proc Soc Exp Biol Med 223:367-71. 2000..Since hyperprolactinemia associates in these patients with depressed EPO production, it may be regarded as a compensatory mechanism for the reduced availability of the hemopoietic factor... - IL-18 paradox in pancreatic carcinoma: elevated serum levels of free IL-18 are correlated with poor survivalAnna Carbone
Department of Clinical Physiopathology and Research Center on Experimental Medicine CeRMS, University of Turin, Turin, Italy
J Immunother 32:920-31. 2009.... - [Biological aspects of pancreatic cancer]E Tonel
Dipartimento di Fisiopatologia Clinica, , Torino, Italy
Minerva Med 96:87-94. 2005..This review will present recent emerging questions on the biology of pancreatic cancer with particular emphasis on the cell origin and tumour microenvironment... - Increased intrathecal TGF-beta1, but not IL-12, IFN-gamma and IL-10 levels in Alzheimer's disease patientsE Rota
Department of Neuroscience, University of Turin, Via Cherasco 15, I 10126 Torino, Italy
Neurol Sci 27:33-9. 2006..NPH and PD. Our results support the pathophysiological role of TGF-beta1 system in AD... - Exhaled nitric oxide and nitric oxide synthase expression in Hodgkin's diseaseG Guida
Department of Biomedical Sciences and Human Oncology, University of Torino, Torino, Italy
Int J Immunopathol Pharmacol 22:1027-34. 2009..4-17.8, p=0.011). In conclusion, high FENO and NOS expression in lymph-nodes indicate that NO is a component of the inflammatory network of HD. FENO may be proposed for the assessment and follow up of bulky mediastinal HD patients... - [The pro-apoptotic factors Fas Ligand and Trail. Molecular mechanisms, physiopathological role and therapeutic potential]V Busso
Dipartimento di Fisiopatologia Clinica, , Turin, Italy
Minerva Med 92:99-111. 2001.... - Decreased expression of stem cell factor in esophageal and gastric mucosa after esophagogastric anastomosis for cancer: potential relevance to motilityMario Nano
General Surgery Section, University of Torino, Italy
Ann Surg Oncol 10:801-9. 2003..SCF expression is here correlated with changes in mucosal morphology, acid and biliary reflux, and motility in the residual esophagus and gastric tube... - Prognostic relevance of CD105+ microvessel density in HNSCC patient outcomeTiziana Martone
Division of Otorhinolaryngology, Department of Clinical Physiopathology, University of Turin, Italy
Oral Oncol 41:147-55. 2005..Our data suggest that CD105+ MVD may represent an additional prognostic factor in HNSCC patients providing more accurate data for the determination of prognosis and management in the subset of lymph node negative patients... - Constitutive expression of interleukin-18 in head and neck squamous carcinoma cellsTiziana Martone
Division of Otorhinolaryngology, Department of Clinical Pgysiopathology, University of Torino, Via Genova 3, 10126 Torino, Italy
Head Neck 26:494-503. 2004..The aim of this study was to investigate the production of IL-18 by squamous cell carcinoma of the head and neck (HNSCC)... - Transforming growth factor-beta and interleukin 10 in oral implant sites in humansG Schierano
Department of Prosthetic Dentistry, University of Turin, Italy
J Dent Res 82:428-32. 2003..These findings suggest that newly classified TGF-beta and/or IL-10 secreting T regulatory (r)/T helper (h)-3 cells may populate implant insertion sites... - Expression of transforming growth factor-beta isoforms in the skin, kidney, pancreas and bladder in a German shepherd dog affected by renal cystadenocarcinoma and nodular dermatofibrosisA Vercelli
Department of Animal Pathology, Faculty of Veterinary Medicine, University of Torino, Via Leonardo da Vinci 44, Grugliasco, Torino, Italy
J Vet Med A Physiol Pathol Clin Med 50:506-10. 2003.... - Bone marrow stroma-derived prolactin is involved in basal and platelet-activating factor-stimulated in vitro erythropoiesisG Bellone
Department of Clinical Physiopathology, University of Turin, Italy
Blood 90:21-7. 1997..Lastly, responsiveness of BMSC to PAF was substantiated by the presence of the PAF-R mRNA on these cells... - Loss of interstitial cells of Cajal network in severe idiopathic gastroparesisEdda Battaglia
Department of Gastroenterology and Clinical Nutrition, University of Torino, Italy
World J Gastroenterol 12:6172-7. 2006..No signs of cell death were observed in the pacemaker region. CONCLUSION: These results are consistent with the hypothesis that a lack of Kit expression may lead to impaired functioning of ICC. Total gastrectomy proves to be curative... - Ski/SnoN expression in the sequence metaplasia-dysplasia-adenocarcinoma of Barrett's esophagusVincenzo Villanacci
Department of Pathology, Spedali Civili, 25100 Brescia, Italy
Hum Pathol 39:403-9. 2008..These observations might help to elucidate the molecular mechanisms involved in the BE tumorigenesis process... - Receptor-type protein tyrosine phosphatase gamma (PTPgamma), a new identifier for myeloid dendritic cells and specialized macrophagesDaniele Lissandrini
Department of Pathology, University of Verona, Verona, Italy
Blood 108:4223-31. 2006..Taken together, these results indicate that PTPgamma is a finely regulated protein in DC and macrophage subsets in vitro and in vivo...