Lorenzo Bello

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi Intraoperative mapping and monitoring of brain functions for the resection of low-grade gliomas: technical considerations
    Giulio Bertani
    Division of Neurosurgery, Department of Neurological Sciences, Universita degli Studi di Milano, 20122 Milan, Italy
    Neurosurg Focus 27:E4. 2009
  2. ncbi Suppression of malignant glioma recurrence in a newly developed animal model by endogenous inhibitors
    Lorenzo Bello
    Neurosurgery, Department of Neurological Sciences, University of Milano, Ospedale Maggiore Policlinico, Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
    Clin Cancer Res 8:3539-48. 2002
  3. ncbi Motor and language DTI Fiber Tracking combined with intraoperative subcortical mapping for surgical removal of gliomas
    Lorenzo Bello
    Neurosurgery, Department of Neurological Sciences, University of Milano, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via Francesco Sforza 35, 20122, Milan, Italy
    Neuroimage 39:369-82. 2008
  4. ncbi Intraoperative subcortical language tract mapping guides surgical removal of gliomas involving speech areas
    Lorenzo Bello
    Department of Neurological Sciences, University of Milan, Milan, Italy
    Neurosurgery 60:67-80; discussion 80-2. 2007
  5. ncbi Intraoperative language localization in multilingual patients with gliomas
    Lorenzo Bello
    Department of Neurological Sciences, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Neurosurgery 59:115-25; discussion 115-25. 2006
  6. ncbi Intraoperative mapping for tumor resection
    Lorenzo Bello
    Department of Neurological Sciences, Universita degli Studi di Milano, 20122 Milano, Italy
    Neuroimaging Clin N Am 19:597-614. 2009
  7. ncbi Combinatorial administration of molecules that simultaneously inhibit angiogenesis and invasion leads to increased therapeutic efficacy in mouse models of malignant glioma
    Lorenzo Bello
    Neurosurgery, Department of Neurological Sciences, University of Milano, Ospedale Maggiore di Milano, Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
    Clin Cancer Res 10:4527-37. 2004
  8. ncbi IS20I, a specific alphavbeta3 integrin inhibitor, reduces glioma growth in vivo
    Lorenzo Bello
    Division of Neurosurgery, Department of Neurological Sciences, University of Milan, Italy
    Neurosurgery 52:177-85; discussion 185-6. 2003
  9. ncbi Intraoperative use of diffusion tensor imaging fiber tractography and subcortical mapping for resection of gliomas: technical considerations
    Lorenzo Bello
    Division of Neurosurgery, Department of Neurological Sciences, Universita degli Studi di Milano, 20122 Milan, Italy
    Neurosurg Focus 28:E6. 2010
  10. ncbi Local intracerebral delivery of endogenous inhibitors by osmotic minipumps effectively suppresses glioma growth in vivo
    Carlo Giussani
    Neurosurgery, Department of Neurological Sciences, University of Milano, Ospedale Maggiore Policlinico, Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
    Cancer Res 63:2499-505. 2003

Collaborators

Detail Information

Publications29

  1. ncbi Intraoperative mapping and monitoring of brain functions for the resection of low-grade gliomas: technical considerations
    Giulio Bertani
    Division of Neurosurgery, Department of Neurological Sciences, Universita degli Studi di Milano, 20122 Milan, Italy
    Neurosurg Focus 27:E4. 2009
    ..They briefly discuss the results that have been obtained at their institution since 2005 as well as the main critical points they have encountered when using this approach...
  2. ncbi Suppression of malignant glioma recurrence in a newly developed animal model by endogenous inhibitors
    Lorenzo Bello
    Neurosurgery, Department of Neurological Sciences, University of Milano, Ospedale Maggiore Policlinico, Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
    Clin Cancer Res 8:3539-48. 2002
    ..Tumors treated with PEX or PF-4/CTF were small and well delineated, with few vessels. Postsurgical administration of PEX or PF-4/CTF significantly reduces the incidence human malignant glioma recurrences for a long period of time...
  3. ncbi Motor and language DTI Fiber Tracking combined with intraoperative subcortical mapping for surgical removal of gliomas
    Lorenzo Bello
    Neurosurgery, Department of Neurological Sciences, University of Milano, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via Francesco Sforza 35, 20122, Milan, Italy
    Neuroimage 39:369-82. 2008
    ..Combination of DTI-FT and ISM allows accurate identification of eloquent fiber tracts and enhances surgical performance and safety maintaining a high rate of functional preservation...
  4. ncbi Intraoperative subcortical language tract mapping guides surgical removal of gliomas involving speech areas
    Lorenzo Bello
    Department of Neurological Sciences, University of Milan, Milan, Italy
    Neurosurgery 60:67-80; discussion 80-2. 2007
    ....
  5. ncbi Intraoperative language localization in multilingual patients with gliomas
    Lorenzo Bello
    Department of Neurological Sciences, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Neurosurgery 59:115-25; discussion 115-25. 2006
    ....
  6. ncbi Intraoperative mapping for tumor resection
    Lorenzo Bello
    Department of Neurological Sciences, Universita degli Studi di Milano, 20122 Milano, Italy
    Neuroimaging Clin N Am 19:597-614. 2009
    ..This article describes the rationale, indications, and modality for intraoperative brain mapping for safe and effective surgical removal of tumors located within functional brain areas...
  7. ncbi Combinatorial administration of molecules that simultaneously inhibit angiogenesis and invasion leads to increased therapeutic efficacy in mouse models of malignant glioma
    Lorenzo Bello
    Neurosurgery, Department of Neurological Sciences, University of Milano, Ospedale Maggiore di Milano, Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
    Clin Cancer Res 10:4527-37. 2004
    ..We investigated the ability of the combinatorial administration of different inhibitors with activities on glioma angiogenesis, migration, and proliferation to produce a prolonged inhibition of glioma growth...
  8. ncbi IS20I, a specific alphavbeta3 integrin inhibitor, reduces glioma growth in vivo
    Lorenzo Bello
    Division of Neurosurgery, Department of Neurological Sciences, University of Milan, Italy
    Neurosurgery 52:177-85; discussion 185-6. 2003
    ..This article investigates the in vitro and in vivo effects of a synthetic alphavbeta3 integrin inhibitor called IS20I on human malignant gliomas...
  9. ncbi Intraoperative use of diffusion tensor imaging fiber tractography and subcortical mapping for resection of gliomas: technical considerations
    Lorenzo Bello
    Division of Neurosurgery, Department of Neurological Sciences, Universita degli Studi di Milano, 20122 Milan, Italy
    Neurosurg Focus 28:E6. 2010
    ..In this paper the authors report the results of their experience, describing the findings for each tract and discussing technical aspects of the combined use as well as the pitfalls...
  10. ncbi Local intracerebral delivery of endogenous inhibitors by osmotic minipumps effectively suppresses glioma growth in vivo
    Carlo Giussani
    Neurosurgery, Department of Neurological Sciences, University of Milano, Ospedale Maggiore Policlinico, Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
    Cancer Res 63:2499-505. 2003
    ..Our data demonstrate that local intracerebral delivery of endogenous inhibitors effectively inhibits malignant glioma growth and reduces the amount of protein needed to reach a therapeutical response...
  11. ncbi Effect of human skin-derived stem cells on vessel architecture, tumor growth, and tumor invasion in brain tumor animal models
    Federica Pisati
    Stem Cell Laboratory, Department of Neurological Science, Centro Dino Ferrari, University of Milan, Milan, Italy
    Cancer Res 67:3054-63. 2007
    ..Taken together, these data validate the use of hSDSCs for targeting human brain tumors. They may represent therapeutically effective cells for the treatment of intracranial tumors after autologous transplantation...
  12. ncbi Angiogenesis and invasion in gliomas
    Lorenzo Bello
    Neurosurgery, Department of Neurological Sciences, University of Milano, Ospedale Maggiore di Milano, IRCCS, Italy
    Cancer Treat Res 117:263-84. 2004
    ..The most widely used in vitro and in vivo models to study angiogenesis and invasion are also discussed...
  13. ncbi Effect of PEX, a noncatalytic metalloproteinase fragment with integrin-binding activity, on experimental Chlamydophila pneumoniae infection
    Dario Caronzolo
    Department of Pharmacology, Chemotherapy, and Toxicology, University of Milan, Milan, Italy
    Antimicrob Agents Chemother 50:3277-82. 2006
    ..These results offer new perspectives on the treatment of C. pneumoniae infection and indicate that alpha(v)beta(3) could be a promising target for new agents developed for activity against this pathogen...
  14. ncbi Analysis of propofol/remifentanil infusion protocol for tumor surgery with intraoperative brain mapping
    Valeria Conte
    Neuroscience Intensive Care Unit, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena IRCCS, Milan University, Italy
    J Neurosurg Anesthesiol 22:119-27. 2010
    ..Objective of this study was to prospectively collect and evaluate data about a large series of consecutive asleep-awake and asleep-asleep craniotomies...
  15. ncbi Transient inhibition of motor function induced by the Cavitron ultrasonic surgical aspirator during brain mapping
    Giorgio Carrabba
    Department of Neurosurgery, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Neurosurgery 63:E178-9; discussion E179. 2008
    ..We report, for the first time, the occurrence of interference between a Cavitron ultrasonic surgical aspirator (CUSA) and intraoperative brain mapping performed by direct electrical stimulation (DES)...
  16. ncbi Spectral analysis of heart rate variability during asleep-awake craniotomy for tumor resection
    Valeria Conte
    Neuroscience ICU, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena IRCCS, Milan University, Milan, Italy
    J Neurosurg Anesthesiol 21:242-7. 2009
    ..This information might help in tailoring the protocol and the duration of awake phase according to the individual autonomic response...
  17. ncbi Anti-angiogenic therapy induces integrin-linked kinase 1 up-regulation in a mouse model of glioblastoma
    Chiara Verpelli
    European Laboratory for Angiogenesis and Translational Research, University of Milan, Milan, Italy
    PLoS ONE 5:e13710. 2010
    ....
  18. ncbi Impact of cerebrovascular disease on the surgical treatment of idiopathic normal pressure hydrocephalus
    Diego Spagnoli
    Department of Neurological Sciences, University of Milan, Mangiagalli, Regina Elena, I R C C S, Ospedale Maggiore Policlinico, Milan, Italy
    Neurosurgery 59:545-52; discussion 545-52. 2006
    ..The influence of cerebrovascular disease (CVD) on the short- and long-term results of surgery was evaluated in a series of consecutive patients with idiopathic normal-pressure hydrocephalus (iNPH)...
  19. ncbi Multiple localization of endogenous MARK4L protein in human glioma
    Ivana Magnani
    Dipartimento di Medicina, Chirurgia e Odontoiatria, Sezione di Genetica Medica, Universita di Milano, Milan, Italy
    Cell Oncol 31:357-70. 2009
    ....
  20. ncbi Human glioma tumors express high levels of the chemokine receptor CX3CR1
    Marco Locatelli
    Neurosurgery, Fondazione IRCCS, Ca Granda Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, Milan, Italy
    Eur Cytokine Netw 21:27-33. 2010
    ..Thus, CX3CR1 expression is a frequent event in gliomas, irrespective of tumor classification and clinical severity. The molecular basis underlying CX3CR1 up-regulation and its functional biological significance remain to be determined...
  21. ncbi Processing of syntactically complex sentences relies on verbal short-term memory: evidence from a short-term memory patient
    Costanza Papagno
    Dipartimento di Psicologia, Universita di Milano Bicocca, Milan, Italy
    Cogn Neuropsychol 24:292-311. 2007
    ....
  22. ncbi Differential signature of the centrosomal MARK4 isoforms in glioma
    Ivana Magnani
    Department of Medicine, Surgery and Dentistry, Ospedale San Paolo, Medical Genetics, Universita degli Studi di Milano, Italy
    Anal Cell Pathol (Amst) 34:319-38. 2011
    ..MAP/microtubule affinity-regulating kinase 4 (MARK4) is a serine-threonine kinase expressed in two spliced isoforms, MARK4L and MARK4S, of which MARK4L is a candidate for a role in neoplastic transformation...
  23. ncbi Experimental anti-angiogenesis causes upregulation of genes associated with poor survival in glioblastoma
    Ahlame Saidi
    ELAT European Laboratory for Angiogenesis and Translational Research, INSERM U920 ex E0113, Talence, F 33405, France
    Int J Cancer 122:2187-98. 2008
    ..In particular, CHI3L1 and PI3/elafin may be useful as new prognostic markers and new therapeutic targets...
  24. ncbi Continuous delivery of endogenous inhibitors from poly(lactic-co-glycolic acid) polymeric microspheres inhibits glioma tumor growth
    Ofra Benny
    Laboratory of Cancer Drug Therapeutics and Mammalian Cell Technology, Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Haifa, Israel
    Clin Cancer Res 11:768-76. 2005
    ..CONCLUSION: Our findings show that polymeric microspheres are a very promising approach to locally and efficiently deliver endogenous inhibitors to the tumor site leading to a significant inhibition of the tumor...
  25. ncbi Inhibition of FGF receptor activity in glioma implanted into the mouse brain using the tetracyclin-regulated expression system
    Sylvain Miraux
    Magnetic Resonance Center, CNRS-University Victor Segalen Bordeaux 2, Bordeaux, France
    Angiogenesis 7:105-13. 2004
    ....
  26. ncbi Antiangiogenic therapy by local intracerebral microinfusion improves treatment efficiency and survival in an orthotopic human glioblastoma model
    Nils Ole Schmidt
    Department of Neurosurgery, Brigham and Women's Hospital and Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Cancer Res 10:1255-62. 2004
    ..Our results indicate that the local intracerebral microinfusion of antiangiogenic compounds is an effective way to overcome the logistical problems of inhibiting glioma-induced angiogenesis...
  27. ncbi Structure and inhibitory effects on angiogenesis and tumor development of a new vascular endothelial growth inhibitor
    Lior Zilberberg
    Molecular Angiogenesis Laboratory, INSERM E 0113, , 33405 Talence, France
    J Biol Chem 278:35564-73. 2003
    ..Taken together, these results suggest that cyclo-VEGI is an attractive candidate for the development of novel angiogenesis inhibitor molecules useful for the treatment of cancer and other angiogenesis-related diseases...
  28. ncbi Domain swapping in a COOH-terminal fragment of platelet factor 4 generates potent angiogenesis inhibitors
    Martin Hagedorn
    , , 33405 Talence, France
    Cancer Res 62:6884-90. 2002
    ..Tailored PF-4 peptides represent a new class of antiangiogenic agents with a defined mode of action and a strong in vivo activity...
  29. ncbi Continuous intracranial administration of suberoylanilide hydroxamic acid (SAHA) inhibits tumor growth in an orthotopic glioma model
    Hasan C Ugur
    Department of Neurosurgery, Ankara University, School of Medicine, Sihhiye, Ankara, Turkey
    J Neurooncol 83:267-75. 2007
    ..Nevertheless, very few studies have investigated the effects of SAHA on glial tumors. The present study was designed to investigate the therapeutic effects of the intracranial local delivery of SAHA in an orthotopic glioma model...