Research Topics
Genomes and GenesSpecies | Laura BazzichiSummaryAffiliation: University of Pisa Country: Italy Publications
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Detail Information
Publications
A model of anti-angiogenesis: differential transcriptosome profiling of microvascular endothelial cells from diffuse systemic sclerosis patientsBetti Giusti
Department of Medical and Surgical Critical Care DENOTHE, University of Florence, Florence, Italy
Arthritis Res Ther 8:R115. 2006..These observations indicate that microvascular endothelial cells of patients with SSc show abnormalities in a variety of genes that are able to account for defective angiogenesis...- A2B adenosine receptor activity is reduced in neutrophils from patients with systemic sclerosisLaura Bazzichi
Department of Internal Medicine, Division of Rheumatology, University of Pisa, Pisa, Italy
Arthritis Res Ther 7:R189-95. 2005..Moreover, a decrease in A2B AR mediated adenylyl cyclase activity was observed in patients with SSc. Our findings demonstrate the occurrence of selective alterations in A2B AR density and signalling in SSc... - Osteopontin is associated with increased arterial stiffness in rheumatoid arthritisLaura Bazzichi
Department of Internal Medicine, Division of Rheumatology, University of Pisa, Pisa, Italy
Mol Med 15:402-6. 2009.... - Cytokine patterns in fibromyalgia and their correlation with clinical manifestationsL Bazzichi
Department of Internal Medicine, Division of Rheumatology, University of Pisa, Pisa, Italy
Clin Exp Rheumatol 25:225-30. 2007..To examine the possible role of the soluble factor in fibromyalgia (FM) by studying the correlation of cytokine levels with the patients' clinical and psychiatric profile... - Partial remission of refractory RA after Adacolumn cytapheresis: a case reportL Bazzichi
Department of Internal Medicine, Division of Rheumatology, S Chiara Hospital, Pisa, Italy
Rheumatol Int 28:295-7. 2008..This improvement was maintained for over 2 months. At week 38, the patient was re-treated achieving again an ACR response >20... - Antipolymer antibody in Italian fibromyalgic patientsLaura Bazzichi
Department of Internal Medicine, Division of Rheumatology, University of Pisa, Pisa, Italy
Arthritis Res Ther 9:R86. 2007..The presence of APA, however, might permit the identification of a subset of FM patients with more severe symptoms and of patients who may respond differently to different therapeutic strategies... - Thyroid autoimmunity may represent a predisposition for the development of fibromyalgia?L Bazzichi
Division of Rheumatology, Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
Rheumatol Int 32:335-41. 2012.... - Quality of life in rheumatoid arthritis: impact of disability and lifetime depressive spectrum symptomatologyL Bazzichi
Department of Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy
Clin Exp Rheumatol 23:783-8. 2005..The aim of this study was to investigate the impact of disability and lifetime subthreshold depressive symptoms on Health-Related Quality of Life (HRQoL) among patients with rheumatoid arthritis (RA)... - A proposal of simple calculation (ERI calculator) to predict the early response to TNF-? blockers therapy in rheumatoid arthritisLaura Bazzichi
Department of Internal Medicine, Division of Rheumatology, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
Rheumatol Int 32:349-56. 2012..ERI could be a useful tool to early differentiate the responder from the non-responder patients... - Muscle modifications in fibromyalgic patients revealed by surface electromyography (SEMG) analysisLaura Bazzichi
Department of Internal Medicine, Division of Rheumatology, S Chiara Hospital, Pisa, Italy
BMC Musculoskelet Disord 10:36. 2009..The aims of this study were to evaluate muscle modifications by SEMG analysis in FM women with respect to a sample of healthy controls and to investigate the relationships between SEMG parameters and the clinical aspects of the disease... - Clinical improvement in systemic sclerosis resulting from urokinase therapy explained by light and electron microscopy skin examinationL Bazzichi
Rheumatic Diseases Unit, Medica Santa Chiara Hospital, Pisa, Italy
Scand J Rheumatol 32:261-7. 2003..In this study we used microscopy to document ultrastructural alterations occurring in sclerodermic skin from SSc patients treated with urokinase... - Altered amino acid homeostasis in subjects affected by fibromyalgiaLaura Bazzichi
Department of Internal Medicine, Division of Rheumatology, University of Pisa, Via Roma 67, 56126 Pisa, Italy
Clin Biochem 42:1064-70. 2009..To evaluate plasma amino acid (AA) concentrations in patients affected by fibromyalgia (FM) and to study the relationships between their levels and FM clinical parameters... - Spasmophilia comorbidity in fibromyalgia syndromeL Bazzichi
Department of Internal Medicine, Division of Rheumatology, University of Pisa, Italy
Clin Exp Rheumatol 28:S94-9. 2010..To evaluate the role of spasmophilia (SP) in fibromyalgia syndrome (FM)... - Exploring the abyss of fibromyalgia biomarkersL Bazzichi
Department of Internal Medicine, Division of Rheumatology, University of Pisa, Italy
Clin Exp Rheumatol 28:S125-30. 2010..The aim of this review is a guided tour of the specific literature... - Association between thyroid autoimmunity and fibromyalgic disease severityLaura Bazzichi
Division of Rheumatology, Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100, Pisa, Italy
Clin Rheumatol 26:2115-20. 2007..In conclusion, autoimmune thyroiditis is present in an elevated percentage of FM patients, and it has been associated with the presence of typical symptoms of the disease... - Alteration of serotonin transporter density and activity in fibromyalgiaLaura Bazzichi
Department of Internal Medicine, Division of Rheumatology, University of Pisa, Via Roma 67-56126 Pisa, Italy
Arthritis Res Ther 8:R99. 2006..A change in SERT seems to occur in fibromyalgic patients, and it seems to be related to the severity of fibromyalgic symptoms... - Association of psoriasin (S100A7) with clinical manifestations of systemic sclerosis: is its presence in whole saliva a potential predictor of pulmonary involvement?Chiara Baldini
Department of Internal Medicine, University of Pisa, Pisa, Italy
J Rheumatol 35:1820-4. 2008..To evaluate psoriasin (S100A7) expression in whole saliva (WS) of patients with diffuse systemic sclerosis (dSSc) and limited SSc (lSSc), and to correlate its presence with the different clinical manifestations of the disease... - Is GRP78/BiP a potential salivary biomarker in patients with rheumatoid arthritis?Laura Giusti
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy
Proteomics Clin Appl 4:315-24. 2010..Nonetheless, to date, there have been no studies investigating salivary biomarkers in this condition. Therefore, aim of this study is to investigate the presence of potential biomarkers of RA in human whole saliva... - [3H]PK11195 binding sites in human neutrophils: effect of fMLP stimulation and modulation in rheumatic diseasesLaura Giusti
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy
Clin Biochem 37:61-6. 2004..CONCLUSIONS: Our data suggested a fMLP modulation on [3H]PK11195 binding in human neutrophils. Moreover, our results showed an up-regulation of PBR in neutrophils of PA patients... - Specific proteins identified in whole saliva from patients with diffuse systemic sclerosisLaura Giusti
Department of Psychiatry, University of Pisa, Pisa, Italy
J Rheumatol 34:2063-9. 2007..To evaluate the global changes of salivary protein profiles in patients with systemic sclerosis (SSc) using a proteomic approach... - ATP, calcium and magnesium levels in platelets of patients with primary fibromyalgiaLaura Bazzichi
Department of Internal Medicine, Division of Rheumatology, University of Pisa, Via Roma 67, 56126 Pisa, Italy
Clin Biochem 41:1084-90. 2008..To evaluate the intracellular levels of the high energy adenosine triphosphate nucleotide ATP and essential divalent cations, calcium and magnesium, in platelets of patients affected by primary fibromyalgia syndrome (FMs)... - Proteomic analysis of saliva: a unique tool to distinguish primary Sjögren's syndrome from secondary Sjögren's syndrome and other sicca syndromesChiara Baldini
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy
Arthritis Res Ther 13:R194. 2011..We also explored the pathogenetic function of the detected putative biomarkers both in the local exocrinopathy and in the systemic inflammatory processes of SS... - Diagnosis and referral of rheumatoid arthritis by primary care physician: results of a pilot study on the city of Pisa, ItalyAlessandra Della Rossa
Department of Internal Medicine, Rheumatology Unit, S Chiara Hospital, University of Pisa, Via Roma 67, 56126, Pisa, Italy
Clin Rheumatol 29:71-81. 2010..The annual cost per patient with RA was highly variable and strictly dependent on the level of disability. More than 90% of the overall cost was due to the direct burden of costs... - Proteomic analysis of the saliva: a clue for understanding primary from secondary Sjögren's syndrome?Chiara Baldini
Department of Internal Medicine, Rheumatology Unit, University of Pisa, Via Roma 67, 56126 Pisa, Italy
Autoimmun Rev 7:185-91. 2008..This review summarizes the state of the art of proteomic analysis of human saliva in the diagnosis of connective diseases focusing its advantages, limits and future perspectives... - Incident comorbidity among patients with rheumatoid arthritis treated or not with low-dose glucocorticoids: a retrospective studyMaurizio Mazzantini
Rheumatology Unit, Department of Internal Medicine, University of Pisa, Pisa, Italy
J Rheumatol 37:2232-6. 2010..To assess the prevalence of comorbidity in a cohort of patients with rheumatoid arthritis (RA), treated or not with low-dose glucocorticoids (GC) and who have been followed for at least 10 years... - Cell-free DNA in the plasma of patients with systemic sclerosisMarta Mosca
Rheumatology Unit, Department of Internal Medicine, University of Pisa, Via Roma no 67, 56126 Pisa, Italy
Clin Rheumatol 28:1437-40. 2009..05). Our data suggest that cf-DNA could provide a useful biomarker for the assessment of disease activity in SSc patients... - Detection of potential markers of primary fibromyalgia syndrome in human salivaLaura Bazzichi
Department of Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy
Proteomics Clin Appl 3:1296-304. 2009..These preliminary results demonstrated the utility of salivary proteomic analysis in the identification of salivary biomarkers in FM patients and in clarifying some of the pathogenetic aspects of the disease... - Correspondence between salivary proteomic pattern and clinical course in primary Sjögren syndrome and non-Hodgkin's lymphoma: a case reportChiara Baldini
Department of Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy
J Transl Med 9:188. 2011..In the last years human proteomic has represented a promising tool to promote the communication between basic and clinical science... - Occurrence of organ-specific and systemic autoimmune diseases among the first- and second-degree relatives of Caucasian patients with connective tissue diseases: report of data obtained through direct patient interviewsMarta Mosca
Department of Internal Medicine, University of Pisa, Via Roma 67, 56126, Pisa, Italy
Clin Rheumatol 27:1045-8. 2008..5%). In conclusion, these data confirm the high prevalence of autoimmune conditions, particularly of AT disease, among the relatives of patients... - Proteome analysis of whole saliva: a new tool for rheumatic diseases--the example of Sjögren's syndromeLaura Giusti
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy
Proteomics 7:1634-43. 2007..These findings are in line with the systemic immuno-inflammatory aspects of pSS and open the possibility for a systematic search of diagnostic biomarkers and targets for therapeutic intervention in pSS... - Proteomic diagnosis of Sjögren's syndromeLaura Giusti
University of Pisa, Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, Via Bonanno 6, 56126 Pisa, Italy
Expert Rev Proteomics 4:757-67. 2007..This review summarizes the state of the art and the potential application of proteomics in the systematic search for diagnostic biomarkers in Sjögren's syndrome... - Peripheral-type benzodiazepine receptors in human mononuclear cells of patients affected by osteoarthritis, rheumatoid arthritis or psoriasic arthritisLaura Bazzichi
Rheumatic Diseases Unit, Medica Santa Chiara Hospital, University of Pisa, Italy
Clin Biochem 36:57-60. 2003..As peripheral benzodiazepine receptors appear to be involved in the immune function, and in the protection of hematopoietic cells against oxygen radical damage, the observed decrease in B(max) might be related to cellular protection... - Clinical significance of lifetime mood and panic-agoraphobic spectrum symptoms on quality of life of patients with rheumatoid arthritisArmando Piccinni
Department of Psychiatry, Pharmacology and Biotechnology, Psychiatry II Unit, University of Pisa, 56100 Pisa, Italy
Compr Psychiatry 47:201-8. 2006.... - Clinical features of the stomatognathic involvement in fibromyalgia syndrome: a comparison with temporomandibular disorders patientsGiovanni Salvetti
Section of Prosthetic Dentistry, Department of Neuroscience, University of Pisa, Italy
Cranio 25:127-33. 2007..Results of the present study confirm the high rate of involvement of the stomatognathic system in the course of FM and support the need for a careful multidisciplinary approach to patients with TMD, including the rheumatologist... - Blunted increase of digital skin vasomotion following acetylcholine and sodium nitroprusside iontophoresis in systemic sclerosis patientsM Rossi
Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
Rheumatology (Oxford) 47:1012-7. 2008..Possible relationships between FSV abnormalities and the severity and/or activity of SSc were also investigated... - Patient preferences in the choice of anti-TNF therapies in rheumatoid arthritis. Results from a questionnaire survey (RIVIERA study)Salvatore Scarpato
Rheumatology Unit, M Scarlato Hospital, Scafati, 5, Via Passanti, 84018 Scafati SA, Italy
Rheumatology (Oxford) 49:289-94. 2010..To identify the determinants of anti-TNF-naive patients' preferences for the route of administration of anti-TNF agents... - Manic spectrum symptoms are correlated to the severity of pain and the health-related quality of life in patients with fibromyalgiaL Dell'Osso
Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy
Clin Exp Rheumatol 27:S57-61. 2009..We aimed at investigating the impact of lifetime manic spectrum symptoms on the severity of pain and the health-related quality of life (HRQoL) in patients with fibromyalgia (FM)... - Ultrasonography of the temporomandibular joint: comparison of findings in patients with rheumatic diseases and temporomandibular disorders. A preliminary reportDaniele Manfredini
Department of Neuroscience, University of Pisa, Italy
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:481-5. 2005..The objective of the study was to compare findings from ultrasonography (US) of the temporomandibular joint (TMJ) in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and temporomandibular disorders (TMD)... - The evaluation of the fibromyalgia patientsF Atzeni
Rheumatology Unit, L Sacco University Hospital, Milan, Italy
Reumatismo 60:36-49. 2008..To address the identification of core outcome domains, the Initiative on IMMPACT and OMERACT workshop convened a meeting to develop consensus recommendations for chronic pain clinical trials... - Etiopathogenetic mechanisms of fibromyalgia syndromeS Stisi
Rheumatology Unit, G Rummo Hospital, Benevento, Italy
Reumatismo 60:25-35. 2008..Understanding of pathogenetic pathways in FMS has advanced beyond observing patient responses to neurophysiologically targeted therapies and basic research... - A comparison of ultrasonography and magnetic resonance imaging in the evaluation of temporomandibular joint involvement in rheumatoid arthritis and psoriatic arthritisD Melchiorre
Department of Medical and Surgical Critical Care, Rheumatology Unit, University of Florence, Italy
Rheumatology (Oxford) 42:673-6. 2003.... - Comparison of masticatory dysfunction in temporomandibular disorders and fibromyalgiaD Manfredini
Section of Prosthetic Dentistry, Department of Neurosciences, University of Pisa, Pisa, Italy
Minerva Stomatol 53:641-50. 2004..The aim of this study was to investigate the clinical features of the involvement of the stomatognathic system in patients with fibromyalgia, and to compare signs and symptoms of masticatory dysfunction between TMD and FM patients... - Fibromyalgia syndrome: the pharmacological treatment optionsP Sarzi-Puttini
Rheumatology Unit, L Sacco University Hospital, Milan, Italy
Reumatismo 60:50-8. 2008..The nature of FM suggests that an individualized, multimodal approach that includes both pharmacologic and nonpharmacologic therapies seems to be the most appropriate treatment strategy to date... - Impaired glutathione reductase activity and levels of collagenase and elastase in synovial fluid in rheumatoid arthritisL Bazzichi
Rheumatic Diseases Unit, Medica Santa Chiara Hospital, University of Pisa, Pisa, Italy
Clin Exp Rheumatol 20:761-6. 2002..The limited increase in glutathione reductase activity during the inflammatory process might lead to an insufficient protective effect at the joint level in rheumatoid arthritis... - Peripheral benzodiazepine receptors on platelets of fibromyalgic patientsL Bazzichi
Department of Internal Medicine, U O of Rheumatology, University of Pisa, Italy
Clin Biochem 39:867-72. 2006..The aim of the present study was to analyze if alterations of peripheral-type benzodiazepine receptor (PBR) characteristics occurred in platelet membranes of patients affected by primary fibromyalgia (FM)... - Domain 1 of the urokinase-type plasminogen activator receptor is required for its morphologic and functional, beta2 integrin-mediated connection with actin cytoskeleton in human microvascular endothelial cells: failure of association in systemic sclerosisFrancesca Margheri
University of Florence, Florence, Italy
Arthritis Rheum 54:3926-38. 2006..CONCLUSION: The reduced angiogenic properties of SSc MVECs can be explained by the effects of uPAR truncation and the subsequent loss of the beta2 integrin-mediated connection of uPAR with the actin cytoskeleton in these ECs...