A Arcangeli

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. ncbi Targeting ion channels in leukemias: a new challenge for treatment
    A Arcangeli
    Department of Experimental Pathology and Oncology, University of Florence, Viale G B Morgagni, 50, 50134 Firenze, Italy
    Curr Med Chem 19:683-96. 2012
  2. ncbi Ion channels and transporters in cancer. 3. Ion channels in the tumor cell-microenvironment cross talk
    Annarosa Arcangeli
    Department of Experimental Pathology and Oncology, University of Firenze, Italy
    Am J Physiol Cell Physiol 301:C762-71. 2011
  3. ncbi Irresponsiveness of two retinoblastoma cases to conservative therapy correlates with up- regulation of hERG1 channels and of the VEGF-A pathway
    Pina Fortunato
    Department of Experimental Pathology and Oncology, University of Florence Viale G, B, Morgagni, Florence Italy
    BMC Cancer 10:504. 2010
  4. ncbi Stable GM3 lactone mimetic raises antibodies specific for the antigens expressed on melanoma cells
    Annarosa Arcangeli
    Dipartimento di Patologia e Oncologia Sperimentali, Universita di Firenze, Florence, Italy
    Bioconjug Chem 21:1432-8. 2010
  5. ncbi Targeting ion channels in cancer: a novel frontier in antineoplastic therapy
    A Arcangeli
    Department of Experimental Pathology and Oncology, University of Firenze, Italy
    Curr Med Chem 16:66-93. 2009
  6. ncbi Physical and functional interaction between integrins and hERG potassium channels
    A Arcangeli
    Department of Experimental Pathology and Oncology, University of Firenze, Italy
    Biochem Soc Trans 32:826-7. 2004
  7. ncbi HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium
    A Cherubini
    Department of Experimental Pathology and Oncology, University of Firenze, Viale G B Morgagni 50, Firenze, 50134, Italy
    Br J Cancer 83:1722-9. 2000
  8. ncbi HERG K+ channels and beta1 integrins interact through the assembly of a macromolecular complex
    A Cherubini
    Department of Experimental Pathology and Oncology, University of Florence, Florence, Italy
    Ann N Y Acad Sci 973:559-61. 2002
  9. ncbi HERG K+ channels activation during beta(1) integrin-mediated adhesion to fibronectin induces an up-regulation of alpha(v)beta(3) integrin in the preosteoclastic leukemia cell line FLG 29.1
    G Hofmann
    Department of Experimental Pathology and Oncology, University of Firenze, Viale G. B. Morgagni, 50, 50134 Florence, Italy
    J Biol Chem 276:4923-31. 2001
  10. ncbi Long-term modulation of HERG channel gating in hypoxia
    L Fontana
    Department of Experimental Pathology and Oncology, University of Florence, Viale Morgagni 50, Florence, 50134, Italy
    Biochem Biophys Res Commun 286:857-62. 2001

Collaborators

  • A Becchetti
  • L Guasti
  • G L Taddei
  • I Noci
  • P Defilippi
  • Anna M Buccoliero
  • Lucio Toma
  • L Costa
  • A Amedei
  • Olivia Crociani
  • E Wanke
  • A Cherubini
  • S Pillozzi
  • M Olivotto
  • G Hofmann
  • A Masi
  • Pina Fortunato
  • S Polvani
  • C Becchi
  • B Rosati
  • L Fontana
  • M Paglierani
  • P A Bernabei
  • B Bartolozzi
  • E Lastraioli
  • Angela Tamburini
  • Serena Pillozzi
  • Alessandro Franchi
  • Agostino La Torre
  • Liliana Pollazzi
  • S Boncinelli
  • M Al Malyan
  • L P Fabbri
  • M Masselli
  • M Nucera
  • C Della Bella
  • C Cacciapuoti
  • B Pollo
  • R Restano Cassulini
  • S Franceschetti
  • P Gallina
  • N Di Lorenzo
  • R Restano-Cassulini
  • M F Brizzi
  • M Balzi
  • L Pegoraro
  • L Gragnani
  • T Biagiotti
  • V Solazzo
  • M Solazzo
  • P Borri
  • M Giachi
  • E Borrani

Detail Information

Publications15

  1. ncbi Targeting ion channels in leukemias: a new challenge for treatment
    A Arcangeli
    Department of Experimental Pathology and Oncology, University of Florence, Viale G B Morgagni, 50, 50134 Firenze, Italy
    Curr Med Chem 19:683-96. 2012
    ..Hence, ion channel modulators could overcome chemoresistance in acute leukemias, a major hindrance to therapeutic success...
  2. ncbi Ion channels and transporters in cancer. 3. Ion channels in the tumor cell-microenvironment cross talk
    Annarosa Arcangeli
    Department of Experimental Pathology and Oncology, University of Firenze, Italy
    Am J Physiol Cell Physiol 301:C762-71. 2011
    ..On the whole, it is conceivable to prospect the targeting of ion channels for new therapeutic strategies aimed at better controlling the malignant progression of the cancer tissue...
  3. ncbi Irresponsiveness of two retinoblastoma cases to conservative therapy correlates with up- regulation of hERG1 channels and of the VEGF-A pathway
    Pina Fortunato
    Department of Experimental Pathology and Oncology, University of Florence Viale G, B, Morgagni, Florence Italy
    BMC Cancer 10:504. 2010
    ....
  4. ncbi Stable GM3 lactone mimetic raises antibodies specific for the antigens expressed on melanoma cells
    Annarosa Arcangeli
    Dipartimento di Patologia e Oncologia Sperimentali, Universita di Firenze, Florence, Italy
    Bioconjug Chem 21:1432-8. 2010
    ..Capitalizing on the stability and on the reduced structural complexity of mimetic 3, the immunostimulant 5 we report represents a new promising synthetic glycoconjugate for the immunotherapy of melanoma...
  5. ncbi Targeting ion channels in cancer: a novel frontier in antineoplastic therapy
    A Arcangeli
    Department of Experimental Pathology and Oncology, University of Firenze, Italy
    Curr Med Chem 16:66-93. 2009
    ..Finally, we propose that a novel therapeutic tactic could be developed by unlocking ion channels from multiprotein membrane signaling complexes...
  6. ncbi Physical and functional interaction between integrins and hERG potassium channels
    A Arcangeli
    Department of Experimental Pathology and Oncology, University of Firenze, Italy
    Biochem Soc Trans 32:826-7. 2004
    ..Preliminary results suggest that a macromolecular signalling complex indeed occurs between integrins and the hERG1 protein and that hERG channel activity can modulate integrin downstream signalling...
  7. ncbi HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium
    A Cherubini
    Department of Experimental Pathology and Oncology, University of Firenze, Viale G B Morgagni 50, Firenze, 50134, Italy
    Br J Cancer 83:1722-9. 2000
    ..On the whole, these data are the first demonstration of the presence of HERG channels in primary human neoplasias, and could candidate HERG as a potential tool capable of marking cancerous versus hyperplastic endometrial growth...
  8. ncbi HERG K+ channels and beta1 integrins interact through the assembly of a macromolecular complex
    A Cherubini
    Department of Experimental Pathology and Oncology, University of Florence, Florence, Italy
    Ann N Y Acad Sci 973:559-61. 2002
  9. ncbi HERG K+ channels activation during beta(1) integrin-mediated adhesion to fibronectin induces an up-regulation of alpha(v)beta(3) integrin in the preosteoclastic leukemia cell line FLG 29.1
    G Hofmann
    Department of Experimental Pathology and Oncology, University of Firenze, Viale G. B. Morgagni, 50, 50134 Florence, Italy
    J Biol Chem 276:4923-31. 2001
    ....
  10. ncbi Long-term modulation of HERG channel gating in hypoxia
    L Fontana
    Department of Experimental Pathology and Oncology, University of Florence, Viale Morgagni 50, Florence, 50134, Italy
    Biochem Biophys Res Commun 286:857-62. 2001
    ..Such a current modulation is suitable to stabilise the resting potential (V(REST)) in hypoxic environments...
  11. ncbi HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors
    S Pillozzi
    Department of Experimental Pathology and Oncology, University of Firenze, Firenze, Italy
    Leukemia 16:1791-8. 2002
    ..These results open new perspectives on the pathogenetic role of HERG K(+) channels in leukemias...
  12. ncbi hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines
    A Masi
    Department of Experimental Pathology and Oncology, University of Firenze, Italy
    Br J Cancer 93:781-92. 2005
    ..Our data provide important confirmation for studies proposing the hERG1 channel as a molecular marker of tumour progression and a possible target for novel anticancer therapies...
  13. ncbi erg gene(s) expression during development of the nervous and muscular system of quail embryos
    O Crociani
    Department of Experimental Pathology and Oncology, University of Florence, Viale G B Morgagni 50, 50134, Florence, Italy
    Mech Dev 95:239-43. 2000
    ..We report here a study showing the expression pattern of HERG K(+) currents-encoding (erg) genes in various nervous and muscular tissues at different stages of quail embryo development...
  14. ncbi Longstanding survival without cancer progression in a patient affected by endometrial carcinoma treated primarily with leuprolide
    I Noci
    Department of Gynaecology, Perinatal Medicine and Human Reproduction, University of Florence, Viale G B Morgagni 85, 50134, Firenze, Italy
    Br J Cancer 85:333-6. 2001
    ..Moreover, since this tumour was shown to express mRNA for LHRH receptors, new evidence is provided about the favourable impact of LHRH analogue treatment in patients affected by endometrial cancer...
  15. ncbi The increase of endothelial progenitor cells in the peripheral blood: a new parameter for detecting onset and severity of sepsis
    C Becchi
    Department of Medical and Surgical Critical Care, Section of Anaesthesia and Intensive Care, Florence, Italy
    Int J Immunopathol Pharmacol 21:697-705. 2008
    ..4 (p < 0.001). Our data suggest that the cEPC evaluation in peripheral blood, even at early times of diagnosis, in patients with sepsis can be envisaged as a valuable parameter to confirm diagnosis and suggest further prognosis...