S Aquaro

Summary

Affiliation: University of Rome Tor Vergata
Country: Italy

Publications

  1. ncbi Specific mutations in HIV-1 gp41 are associated with immunological success in HIV-1-infected patients receiving enfuvirtide treatment
    Stefano Aquaro
    Department of Experimental Medicine and Biochemical Sciences, University of Rome, Tor Vergata, Rome, Italy
    J Antimicrob Chemother 58:714-22. 2006
  2. ncbi Telomerase activity, hTERT expression, and phosphorylation are downregulated in CD4(+) T lymphocytes infected with human immunodeficiency virus type 1 (HIV-1)
    Ornella Franzese
    Department of Neuroscience, Section of Pharmacology and Medical Oncology, University of Rome Tor Vergata, Rome, Italy
    J Med Virol 79:639-46. 2007
  3. ncbi Profound anti-HIV-1 activity of DAPTA in monocytes/macrophages and inhibition of CCR5-mediated apoptosis in neuronal cells
    Michela Pollicita
    Department of Experimental Medicine and Biochemical Science, University of Rome Tor Vergata, Rome, Italy
    Antivir Chem Chemother 18:285-95. 2007
  4. ncbi Apoptosis and telomeres shortening related to HIV-1 induced oxidative stress in an astrocytoma cell line
    Michela Pollicita
    Department of Experimental Medicine and Biochemical Sciences, University Tor Vergata, Rome, Italy
    BMC Neurosci 10:51. 2009
  5. ncbi Primary macrophages infected by human immunodeficiency virus trigger CD95-mediated apoptosis of uninfected astrocytes
    S Aquaro
    Department of Experimental Medicine, University of Rome Tor Vergata, Italy
    J Leukoc Biol 68:429-35. 2000
  6. ncbi Macrophages and HIV infection: therapeutical approaches toward this strategic virus reservoir
    Stefano Aquaro
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier, 1, 00133, Rome, Italy
    Antiviral Res 55:209-25. 2002
  7. ncbi Long-term survival and virus production in human primary macrophages infected by human immunodeficiency virus
    Stefano Aquaro
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    J Med Virol 68:479-88. 2002
  8. ncbi Does residual virus replication during successful HAART lead to HIV-1 genetic evolution?
    Stefano Aquaro
    Department of Pharmaco-Biology, University of Carabria, Reude, Rome, Italy
    J HIV Ther 11:84-8. 2006
  9. ncbi Mechanisms underlying activity of antiretroviral drugs in HIV-1-infected macrophages: new therapeutic strategies
    Stefano Aquaro
    Department of Experimental Medicine and Biochemical Sciences, University of Rome, Rome, Italy
    J Leukoc Biol 80:1103-10. 2006
  10. ncbi Potent antiviral activity of amprenavir in primary macrophages infected by human immunodeficiency virus
    Stefano Aquaro
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellie 1, Rome 00133, Italy
    Antiviral Res 61:133-7. 2004

Detail Information

Publications44

  1. ncbi Specific mutations in HIV-1 gp41 are associated with immunological success in HIV-1-infected patients receiving enfuvirtide treatment
    Stefano Aquaro
    Department of Experimental Medicine and Biochemical Sciences, University of Rome, Tor Vergata, Rome, Italy
    J Antimicrob Chemother 58:714-22. 2006
    ..To investigate gp41 variability and correlation with viro-immunological parameters in 54 HIV-1-infected patients receiving enfuvirtide added as single active drug to a failing regimen...
  2. ncbi Telomerase activity, hTERT expression, and phosphorylation are downregulated in CD4(+) T lymphocytes infected with human immunodeficiency virus type 1 (HIV-1)
    Ornella Franzese
    Department of Neuroscience, Section of Pharmacology and Medical Oncology, University of Rome Tor Vergata, Rome, Italy
    J Med Virol 79:639-46. 2007
    ..Telomerase was found to be downregulated in both nuclear and cytoplasmic compartments, together with an impairment of human telomerase reverse transcriptase (hTERT) expression and of the cell machinery involved in hTERT phosporylation...
  3. ncbi Profound anti-HIV-1 activity of DAPTA in monocytes/macrophages and inhibition of CCR5-mediated apoptosis in neuronal cells
    Michela Pollicita
    Department of Experimental Medicine and Biochemical Science, University of Rome Tor Vergata, Rome, Italy
    Antivir Chem Chemother 18:285-95. 2007
    ....
  4. ncbi Apoptosis and telomeres shortening related to HIV-1 induced oxidative stress in an astrocytoma cell line
    Michela Pollicita
    Department of Experimental Medicine and Biochemical Sciences, University Tor Vergata, Rome, Italy
    BMC Neurosci 10:51. 2009
    ..In the present study we analyzed the potential relations occurring between free radicals formation and telomere length during HIV-1 mediated astroglial death...
  5. ncbi Primary macrophages infected by human immunodeficiency virus trigger CD95-mediated apoptosis of uninfected astrocytes
    S Aquaro
    Department of Experimental Medicine, University of Rome Tor Vergata, Italy
    J Leukoc Biol 68:429-35. 2000
    ..This phenomenon may help to explain the cellular damage found in HIV-infected patients also in areas of the brain not strictly adjacent to HIV-infected M/M...
  6. ncbi Macrophages and HIV infection: therapeutical approaches toward this strategic virus reservoir
    Stefano Aquaro
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier, 1, 00133, Rome, Italy
    Antiviral Res 55:209-25. 2002
    ..Testing new and promising antiviral compounds in such cells may provide crucial hints about their efficacy in patients infected by HIV...
  7. ncbi Long-term survival and virus production in human primary macrophages infected by human immunodeficiency virus
    Stefano Aquaro
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    J Med Virol 68:479-88. 2002
    ..In conclusion, the long-term dynamics and the high cumulative virus production that characterize HIV-1 infection of macrophages underscore the peculiar role of these cells as a persistently infected reservoir of HIV...
  8. ncbi Does residual virus replication during successful HAART lead to HIV-1 genetic evolution?
    Stefano Aquaro
    Department of Pharmaco-Biology, University of Carabria, Reude, Rome, Italy
    J HIV Ther 11:84-8. 2006
  9. ncbi Mechanisms underlying activity of antiretroviral drugs in HIV-1-infected macrophages: new therapeutic strategies
    Stefano Aquaro
    Department of Experimental Medicine and Biochemical Sciences, University of Rome, Rome, Italy
    J Leukoc Biol 80:1103-10. 2006
    ..A better understanding of the activity of the anti-HIV drugs in M/M may represent a key element for the design of effective anti-HIV chemotherapy...
  10. ncbi Potent antiviral activity of amprenavir in primary macrophages infected by human immunodeficiency virus
    Stefano Aquaro
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellie 1, Rome 00133, Italy
    Antiviral Res 61:133-7. 2004
    ..These findings suggest that amprenavir (at relatively high concentrations) has a clinically relevant antiviral effect in persistently infected reservoirs of HIV...
  11. ncbi Human immunodeficiency virus infection and acquired immunodeficiency syndrome dementia complex: role of cells of monocyte-macrophage lineage
    Stefano Aquaro
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    J Neurovirol 11:58-66. 2005
    ..A better understanding of the mechanisms involved in this process may help in a successful therapeutic approach to the neuropathogenesis of HIV infection...
  12. ncbi The contribution of peroxynitrite generation in HIV replication in human primary macrophages
    Stefano Aquaro
    Faculty of Pharmacy, University of Catanzaro Magna Graecia, Roccelletta di Borgia, Catanzaro, Italy
    Retrovirology 4:76. 2007
    ..MnTBAP (Mn(III)tetrakis(4-benzoic acid)porphrin chloride), a synthetic peroxynitrite decomposition catalyst, reduced oxidative stress subsequent to peroxynitrite generation...
  13. ncbi Limited development and progression of resistance of HIV-1 to the nucleoside analogue reverse transcriptase inhibitor lamivudine in human primary macrophages
    Stefano Aquaro
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome
    J Antimicrob Chemother 55:872-8. 2005
    ....
  14. ncbi The LD78beta isoform of MIP-1alpha is the most potent CC-chemokine in inhibiting CCR5-dependent human immunodeficiency virus type 1 replication in human macrophages
    S Aquaro
    Laboratory of Experimental Chemotherapy, Department of Microbiology and Immunology, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
    J Virol 75:4402-6. 2001
    ..LD78beta strongly downregulated CCR5 expression in M/M, thereby explaining its potent antiviral activity...
  15. ncbi Intracellular metabolism of CycloSaligenyl 3'-azido-2', 3'-dideoxythymidine monophosphate, a prodrug of 3'-azido-2', 3'-dideoxythymidine (zidovudine)
    J Balzarini
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
    Mol Pharmacol 56:1354-61. 1999
    ....
  16. ncbi Macrophages: a crucial reservoir for human immunodeficiency virus in the body
    E Balestra
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Italy
    J Biol Regul Homeost Agents 15:272-6. 2001
    ....
  17. ncbi Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus
    J Balzarini
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    FEBS Lett 410:324-8. 1997
    ..Both Cf 1001 and Cf 1093 were equally efficient as 3TC (lamivudine) in inhibiting HBV replication in hepatocytes, and rank among the most potent HIV and HBV inhibitors reported so far in cell culture...
  18. ncbi Antiviral profile of HIV inhibitors in macrophages: implications for therapy
    C F Perno
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier, 1 00133 Roma, Italy
    Curr Top Med Chem 4:1009-15. 2004
    ....
  19. ncbi Potent inhibition of human immunodeficiency virus and herpes simplex virus type 1 by 9-(2-phosphonylmethoxyethyl)adenine in primary macrophages is determined by drug metabolism, nucleotide pools, and cytokines
    C F Perno
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Italy
    Mol Pharmacol 50:359-66. 1996
    ..The dual potent activity of PMEA against HIV and HSV-1 stresses the importance of clinical trials to assess the role of this drug in the therapy of HIV-related disease...
  20. ncbi Carbohydrate-binding agents (CBAs) inhibit HIV-1 infection in human primary monocyte-derived macrophages (MDMs) and efficiently prevent MDM-directed viral capture and subsequent transmission to CD4+ T lymphocytes
    M Pollicita
    University of Rome, Tor Vergata, Italy
    Virology 370:382-91. 2008
    ....
  21. ncbi S-adenosylhomocysteine hydrolase inhibitors interfere with the replication of human immunodeficiency virus type 1 through inhibition of the LTR transactivation
    D Daelemans
    Rega Institute for Medical Research, Katholieke Universtiteit Leuven, Belgium
    Mol Pharmacol 52:1157-63. 1997
    ..Our results suggest that AdoHcy hydrolase and the associated S-adenosylmethionine-dependent methylation mechanism play a role in the process of long terminal repeat transactivation and, hence, HIV replication...
  22. ncbi Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication
    J Balzarini
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Mol Pharmacol 50:394-401. 1996
    ....
  23. ncbi Cyclosaligenyl-2',3'-didehydro-2',3'-dideoxythymidine monophosphate: efficient intracellular delivery of d4TMP
    J Balzarini
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
    Mol Pharmacol 58:928-35. 2000
    ..d4TMP is a poor substrate for the cytosolic 5'(3')-deoxyribonucleotidase (V(max)/K(m) for d4TMP: 0.08 of V(max)/K(m) for dTMP) and is only slowly hydrolyzed to d4T. This contributes to the efficient conversion of the prodrug of d4TTP...
  24. ncbi HIV/HCV co-infection: the magnitude of the problem
    E Balestra
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    J Biol Regul Homeost Agents 17:138-43. 2003
    ....
  25. ncbi Peroxynitrite decomposition catalyst prevents apoptotic cell death in a human astrocytoma cell line incubated with supernatants of HIV-infected macrophages
    Carolina Muscoli
    Faculty of Pharmacy, University of Catanzaro Magna Graecia, Roccelletta di Borgia, Catanzaro, Italy
    BMC Neurosci 3:13. 2002
    ..Here we investigated the role of peroxynitrite in apoptosis occurring in astroglial cells incubated with supernatants of HIV-infected human primary macrophages (M/M)...
  26. ncbi gp41 sequence variability in HIV type 1 non-B subtypes infected patients undergoing enfuvirtide pressure
    Roberta D'Arrigo
    Spallanzani Institute for Infectious Diseases, Rome, Italy
    AIDS Res Hum Retroviruses 23:1296-302. 2007
    ....
  27. ncbi Productive infection of primary macrophages with human herpesvirus 7
    Y Zhang
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium
    J Virol 75:10511-4. 2001
    ..Thus, macrophages become infected by HHV-7 and might play an important role as a viral reservoir, as has been demonstrated for human immunodeficiency virus type 1...
  28. ncbi Treatment with the fusion inhibitor enfuvirtide influences the appearance of mutations in the human immunodeficiency virus type 1 regulatory protein rev
    Valentina Svicher
    Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, Rome, Italy
    Antimicrob Agents Chemother 53:2816-23. 2009
    ..This highlights the multiple roles of ENF (and perhaps other entry inhibitors) in modulating the correct interplay between the different HIV-1 genes and proteins during the HIV-1 life cycle...
  29. ncbi Specific enfuvirtide-associated mutational pathways in HIV-1 Gp41 are significantly correlated with an increase in CD4(+) cell count, despite virological failure
    Valentina Svicher
    Department of Experimental Medicine, University of Tor Vergata Rome, Italy
    J Infect Dis 197:1408-18. 2008
    ..We investigated the correlation of enfuvirtide (ENF)-associated gp41 mutational clusters with viroimmunological parameters, as well as the potential underlying mechanisms...
  30. ncbi Secondary integrase resistance mutations found in HIV-1 minority quasispecies in integrase therapy-naive patients have little or no effect on susceptibility to integrase inhibitors
    Francesca Ceccherini-Silberstein
    Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Antimicrob Agents Chemother 54:3938-48. 2010
    ....
  31. ncbi Anti-nerve growth factor Ab abrogates macrophage-mediated HIV-1 infection and depletion of CD4+ T lymphocytes in hu-SCID mice
    Enrico Garaci
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    Proc Natl Acad Sci U S A 100:8927-32. 2003
    ..This may open new perspectives of experimental approaches aimed at selectively eliminating persistently infected macrophages from the bodies of HIV-infected patients...
  32. ncbi Therapeutic strategies towards HIV-1 infection in macrophages
    Carlo Federico Perno
    National Institute for Infectious Diseases L Spallanzani, Via Portuense 292, 00149 Rome, Italy
    Antiviral Res 71:293-300. 2006
    ..Moreover, testing new and promising antiviral compounds in such cells may provide crucial hints about their efficacy in patients infected by HIV...
  33. ncbi Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates
    J Balzarini
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Antimicrob Agents Chemother 46:2185-93. 2002
    ..e., DNA, RNA, or protein) synthesis. Compounds 1 and 11 should be considered attractive novel pyrimidine nucleotide phosphonate analogues to be further pursued for their potential as antiretroviral agents in the clinical setting...
  34. ncbi Novel in vivo model for the study of human immunodeficiency virus type 1 transcription inhibitors: evaluation of new 6-desfluoroquinolone derivatives
    Miguel Stevens
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, and Division of Histopathology, University Hospitals, Leuven, Belgium
    Antimicrob Agents Chemother 51:1407-13. 2007
    ..Since both quinolone derivatives were able to inhibit the reactivation of HIV-1 from this artificial viral reservoir in vivo, we provide encouraging evidence for the use of quinolones in the control of HIV-1 infections...
  35. ncbi Improved antiviral activity of the aryloxymethoxyalaninyl phosphoramidate (APA) prodrug of abacavir (ABC) is due to the formation of markedly increased carbovir 5'-triphosphate metabolite levels
    Jan Balzarini
    Rega Institute for Medical Research, K U Leuven, B 3000 Leuven, Belgium
    FEBS Lett 573:38-44. 2004
    ....
  36. ncbi HIV-1-associated dementia during HAART therapy
    Stefano Aquaro
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    Recent Pat CNS Drug Discov 3:23-33. 2008
    ..In this review, we outline the current state of knowledge regarding the pathophysiology of CNS injury in HIV-1 infection and will focus on the effects of HAART on CNS...
  37. ncbi The contribution of oxidative stress in apoptosis of human-cultured astroglial cells induced by supernatants of HIV-1-infected macrophages
    Vincenzo Mollace
    Faculty of Pharmacy, University of Catanzaro Magna Graecia, Roccelletta di Borgia, Italy
    J Leukoc Biol 71:65-72. 2002
    ....
  38. ncbi Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist
    Katrien Princen
    Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium
    J Virol 78:12996-3006. 2004
    ..AMD3451 is the first low-molecular-weight anti-HIV agent with selective HIV coreceptor, CCR5 and CXCR4, interaction...
  39. ncbi Assessing the relative efficacy of antiretroviral activity of different drugs on macrophages
    Stefano Aquaro
    Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy
    Methods Mol Biol 304:445-53. 2005
    ....
  40. ncbi Mannose-specific plant lectins from the Amaryllidaceae family qualify as efficient microbicides for prevention of human immunodeficiency virus infection
    Jan Balzarini
    Rega Institute for Medical Research, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Antimicrob Agents Chemother 48:3858-70. 2004
    ..0) for prolonged time periods and can be easily formulated in gel preparations for microbicidal use; they did not agglutinate human erythrocytes and were not toxic to mice when administered intravenously...
  41. ncbi Identification of the novel KI Polyomavirus in paranasal and lung tissues
    Muhammed Babakir-Mina
    Laboratory of Molecular Virology, University Hospital Tor Vergata, Rome, Italy
    J Med Virol 81:558-61. 2009
    ..In vitro studies are needed to investigate the transforming potential of KIV strains...
  42. ncbi Phylogenetic analysis of the surface proteins of influenza A (H5N1) viruses isolated in Asian and African populations
    Muhammed Babakir-Mina
    Laboratory of Molecular Virology, University Hospital Tor Vergata, Rome, Italy
    New Microbiol 32:397-403. 2009
    ..So, although all H5N1 viruses were derived from ancestors circulating in south-east Asia more than ten years ago, since 2003 they have evolved into geographically distinct groups within each country...
  43. ncbi Drug-loaded red blood cell-mediated clearance of HIV-1 macrophage reservoir by selective inhibition of STAT1 expression
    Mauro Magnani
    Institute of Biochemistry G Fornaini University of Urbino, Via Saffi 2, 61029, Urbino, Italy
    J Leukoc Biol 74:764-71. 2003
    ..Taken together, the evidence of HIV-1-induced increase of STAT1, and the availability of a selective drug targeting system, may prove useful in the design of new pharmacological treatments to clear the HIV-1 macrophage reservoir...
  44. ncbi Advances in macrophage and dendritic cell biology in HIV-1 infection stress key understudied areas in infection, pathogenesis, and analysis of viral reservoirs
    Luis J Montaner
    The Wistar Institute, Philadelphia, PA 19104 4268, USA
    J Leukoc Biol 80:961-4. 2006
    ....