Research Topics
| M G RoncaroloSummaryAffiliation: San Raffaele Scientific Institute Country: Italy Publications
| Collaborators
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Detail Information
Publications
The role of different subsets of T regulatory cells in controlling autoimmunityM G Roncarolo
San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, Milan 20132, Italy
Curr Opin Immunol 12:676-83. 2000..The resolution of these mechanisms will make it possible to use T regulatory cells therapeutically in human autoimmune diseases...- Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patientsManuela Battaglia
San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, 20132 Milan, Italy
J Immunol 177:8338-47. 2006.... - The role of interleukin 10 in the control of autoimmunityMaria-Grazia Roncarolo
San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET, Via Olgettina 58, Milan 20132, Italy
J Autoimmun 20:269-72. 2003 - Interleukin-10-secreting type 1 regulatory T cells in rodents and humansMaria Grazia Roncarolo
San Raffaele Telethon Institute for Gene Therapy HSR TIGET, San Raffaele Scientific Institute, Milan, Italy
Immunol Rev 212:28-50. 2006.... - Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humansMaria Grazia Roncarolo
San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, 20132 Milan, Italy
Nat Rev Immunol 7:585-98. 2007.... - Clinical tolerance in allogeneic hematopoietic stem cell transplantationMaria Grazia Roncarolo
San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Division of Regenerative Medicine, Stem Cells, Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
Immunol Rev 241:145-63. 2011..Furthermore, we summarize different cell therapy approaches with regulatory T cells, designed to facilitate tolerance induction, minimizing pharmaceutical interventions... - Type 1 T regulatory cellsM G Roncarolo
San Raffaele Telethon Institute of Gene Therapy HSR TIGET, San Raffaele Scientific Institute, Milan, Italy
Immunol Rev 182:68-79. 2001..The use of Tr1 cells to identify novel targets for the development of new therapeutic agents, and as a cellular therapy to modulate peripheral tolerance, can be foreseen... - Is FOXP3 a bona fide marker for human regulatory T cells?Maria Grazia Roncarolo
San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
Eur J Immunol 38:925-7. 2008..Furthermore, FOXP3-independent mechanisms, mediated by IL-10, contribute to the induction and suppressor functions of Tr1 cells... - IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cellsM K Levings
San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET, Milan, Italy
J Immunol 166:5530-9. 2001.... - Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of functionM K Levings
San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET, Via Olgettina 58, Milan, Italy 20132
J Exp Med 193:1295-302. 2001.... - Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cellsManuela Battaglia
San Raffaele Scientific Institute, Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, 20132 Milan, Italy
Diabetes 55:1571-80. 2006..Rapamycin plus IL-10 treatment, promoting distinct subsets of Tr cells, may constitute a novel and potent tolerance-inducing protocol for immune-mediated diseases... - The role of cytokines (and not only) in inducing and expanding T regulatory type 1 cellsManuela Battaglia
San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
Transplantation 77:S16-8. 2004..Whether this combined treatment can also be used in humans is still an open question... - Design and optimization of lentiviral vectors for transfer of GALC expression in Twitcher brainD Dolcetta
Telethon Institute for Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
J Gene Med 8:962-71. 2006..Lentiviral vectors, which are highly efficient to transfer the expression of therapeutic genes in neurons and glial cells, have not been evaluated for direct cerebral therapy in GLD mice... - Myelin deterioration in Twitcher mice: motor evoked potentials and magnetic resonance imaging as in vivo monitoring toolsD Dolcetta
Telethon Institute for Gene Therapy, San Raffaele Scientific Institute, Milano, Italy
J Neurosci Res 81:597-604. 2005.... - Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cellsManuela Battaglia
San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET, Milan, Italy
Blood 105:4743-8. 2005..Based on this new mode of action, rapamycin can be used to expand CD4(+)CD25(+)FoxP3(+) Tr cells for ex vivo cellular therapy in T-cell-mediated diseases... - IL-10-producing T regulatory type 1 cells and oral toleranceManuela Battaglia
San Raffaele Telethon Institute for Gene Therapy, Milano, Italy
Ann N Y Acad Sci 1029:142-53. 2004..Overall, these data demonstrate that IL-10-producing Tr1 cells play a central role in the induction of oral as well as systemic tolerance... - CD4+ regulatory T cells: mechanisms of induction and effector functionRosa Bacchetta
San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina, 58, Milan I 20132, Italy
Autoimmun Rev 4:491-6. 2005..A better understanding of the mechanisms underlying the induction and functions of Tr cells in controlling the immune system is critical in view of a future cellular therapy to modulate immune-mediated pathologies... - WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cellsFrancesco Marangoni
San Raffaele Telethon Institute for Gene Therapy HSR TIGET, 20132 Milan, Italy
J Exp Med 204:369-80. 2007..Thus, WASP appears to play an important role in the activation and suppressor function of nTreg cells, and a dysfunction or incorrect localization of nTreg cells may contribute to the development of autoimmunity in WAS patients... - Rapamycin and interleukin-10 treatment induces T regulatory type 1 cells that mediate antigen-specific transplantation toleranceManuela Battaglia
San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET, Via Olgettina 58, 20132 Milan, Italy
Diabetes 55:40-9. 2006..Thus rapamycin plus IL-10 not only prevented allograft rejection but also induced Tr1 cells that mediated stable antigen-specific, long-term tolerance in vivo... - Defective Th1 cytokine gene transcription in CD4+ and CD8+ T cells from Wiskott-Aldrich syndrome patientsSara Trifari
San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
J Immunol 177:7451-61. 2006..Together, our data indicate that WASP regulates the transcriptional activation of T cells and is required specifically for Th1 cytokine production... - Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cellsPaolo Monti
Telethon Juvenile Diabetes Research Foundation Center for Beta Cell Replacement, San Raffaele Scientific Institute, Milan, Italy
Diabetes 57:2341-7. 2008..Preclinical murine models have shown that rapamycin enhances nTreg proliferation and regulatory function also in vivo. Objective of this study was to assess whether rapamycin has in vivo effects on human nTregs... - Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokinesRosa Bacchetta
San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
Eur J Immunol 32:2237-45. 2002..This growth factor enables a significant in vitro expansion of Tr1 cells facilitating further biological and biochemical characterization of this unique T cell subset... - Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cellsMegan K Levings
San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, Milan 20132, Italy
J Exp Med 196:1335-46. 2002..Together these data indicate that naturally occurring human CD25(+)CD4(+) T cells are distinct from IL-10-producing Tr1 cells... - Escalating doses of donor lymphocytes for incipient graft rejection following SCT for thalassemiaI Frugnoli
Pediatric Immunohematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan 20132, Italy
Bone Marrow Transplant 45:1047-51. 2010..We suggest giving escalating doses of donor T cells to attempt a graft-versus-thalassemia as soon as level 2-3 MC is detected... - A novel human packaging cell line with hematopoietic supportive capacity increases gene transfer into early hematopoietic progenitorsJ S Dando
San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET, Milan 20132, Italy
Hum Gene Ther 12:1979-88. 2001..This novel packaging cell represents a significant advance in HSPC genetic modification technology, combining both a beneficial hematopoietic supportive effect and the gene transfer vector function in a human-based system... - Utilizing regulatory T cells to control alloreactivityE Hauben
San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET, Via Olgettina 58, 20132 Milan, Italy
Cytotherapy 7:158-65. 2005..Better understanding of the mechanisms of immune regulation mediated by Tr cells may enable fine-tuning of specific immune responses and pave the way for novel therapeutic approaches... - An anti-CD45RO/RB monoclonal antibody modulates T cell responses via induction of apoptosis and generation of regulatory T cellsSilvia Gregori
San Raffaele Telethon Institute for Gene Therapy, 20132 Milan, Italy
J Exp Med 201:1293-305. 2005.... - The immune response to lentiviral-delivered transgene is modulated in vivo by transgene-expressing antigen-presenting cells but not by CD4+CD25+ regulatory T cellsAndrea Annoni
San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
Blood 110:1788-96. 2007..These data indicate that antitransgene immune response can be modulated by transgene-expressing APCs possibly through deletion of effector T cells... - The puzzling world of murine T regulatory cellsManuela Battaglia
San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET, Via Olgettina 58, Milan 20132, Italy
Microbes Infect 4:559-66. 2002..This review describes the considerable progress made in the recent years in the characterization of the many subsets that constitute the puzzled world of murine T regulatory cells... - Molecular and functional characterization of allogantigen-specific anergic T cells suitable for cell therapyRosa Bacchetta
San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Department of Regenerative Medicine, Stem Cells, and Gene Therapy, Milan, Italy
Haematologica 95:2134-43. 2010..Several experimental protocols have been used to expand natural regulatory T cells and to generate adaptive type 1 regulatory T cells for regulatory T-cell-based therapies... - Wiskott-Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formationLoïc Dupré
San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, 20132 Milan, Italy
Immunity 17:157-66. 2002..These results demonstrate that WASP plays a central role in the movements of lipid rafts and identify a potential mechanism underlying the T cell defect affecting WAS patients... - Regulatory T cells: prospective for clinical application in hematopoietic stem cell transplantationSilvia Gregori
San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET, Milan, Italy
Curr Opin Hematol 12:451-6. 2005.... - High incidence of severe cyclosporine neurotoxicity in children affected by haemoglobinopaties undergoing myeloablative haematopoietic stem cell transplantation: early diagnosis and prompt intervention ameliorates neurological outcomeAnna Noè
Pediatric Immunohaematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy
Ital J Pediatr 36:14. 2010..Neurotoxicity is a recognized complication of cyclosporine A (CSA) treatment. The incidence of severe CSA-related neurological complications following hematopoietic stem cell transplantation (HSCT) is 4-11%... - Antigen-specific dependence of Tr1-cell therapy in preclinical models of islet transplantNicola Gagliani
San Raffaele Diabetes Research Institute HSR DRI, Milan, Italy
Diabetes 59:433-9. 2010..This study was designed to define the efficacy of Tr1-cell therapy in preclinical models of islet transplant... - Gliadin-specific type 1 regulatory T cells from the intestinal mucosa of treated celiac patients inhibit pathogenic T cellsCarmen Gianfrani
Institute of Food Science Consiglio Nazionale delle Ricerche, Avellino, Italy
J Immunol 177:4178-86. 2006..In conclusion, dietary Ag-specific Tr1 cells are present in the human intestinal mucosa, and strategies to boost their numbers and/or function may offer new therapeutic opportunities to restore gut homeostasis... - Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cellsCindy S Ma
Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
J Clin Invest 115:1049-59. 2005..Thus, insufficient IL-10 production may contribute to hypogammaglobulinemia in XLP. This finding suggests new strategies for treating this immunodeficiency... - Role of regulatory T cells and FOXP3 in human diseasesRosa Bacchetta
San Raffaele Telethon Institute for Gene Therapy, Milano, Italy
J Allergy Clin Immunol 120:227-35; quiz 236-7. 2007..Interestingly, there is increasing evidence that the individual signature of genes relevant for immune regulation definitely influences the final outcome of an immune response... - Development of lentiviral gene therapy for Wiskott Aldrich syndromeAnne Galy
Head of Immunology and Gene Therapy Group, INSERM U790, Genethon, 1 bis rue de l Internationale, 91002 Evry, France
Expert Opin Biol Ther 8:181-90. 2008..WAS is attracting growing attention not only because it highlights the rich cellular and systems biology revolving around cytoskeletal regulation but also because it is candidate for a haematopoietic stem cell gene therapy indication... - Immunological lessons learnt from patients transplanted with fully mismatched stem cellsJean Louis Touraine
Department of Transplantation and Clinical Immunology, Claude Bernard University and Edouard Herriot Hospital, Lyon, France
Immunol Res 38:201-9. 2007..Tolerance to donor antigens was acquired by clonal deletion; tolerance to host antigens existed despite the presence of many host-reactive T-cells and involved clonal anergy...