Research Topics
| S PluchinoSummaryAffiliation: San Raffaele Scientific Institute Country: Italy Publications
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Detail Information
Publications
Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosisStefano Pluchino
Neuroimmunology Unit-DIBIT, San Raffaele Hospital, Via Olgettina 58, 20132 Milano, Italy
Nature 422:688-94. 2003..Thus, adult neural precursor cells promote multifocal remyelination and functional recovery after intravenous or intrathecal injection in a chronic model of multiple sclerosis...- Transplanted neural stem/precursor cells instruct phagocytes and reduce secondary tissue damage in the injured spinal cordMelania Cusimano
Dept of Clinical Neurosciences, Cambridge Centre for Brain Repair and Cambridge Stem Cell Initiative, University of Cambridge, E D Adrian Building, Forvie Site, Robinson Way, Cambridge CB2 0PY, UK
Brain 135:447-60. 2012.... - The therapeutic plasticity of neural stem/precursor cells in multiple sclerosisStefano Pluchino
Neuroimmunology Unit DIBIT and Institute of Experimental Neurology, San Raffaele Scientific Institute, Via Olgettina 58, I 20132 Milan, Italy
J Neurol Sci 265:105-10. 2008.... - Immune regulatory neural stem/precursor cells protect from central nervous system autoimmunity by restraining dendritic cell functionStefano Pluchino
Neuroimmunology Unit, San Raffaele Scientific Institute and Università Vita Salute, Milan, Italy
PLoS ONE 4:e5959. 2009..This study was designed to identify the first candidate that exemplifies and sustains the immune modulatory capacity of transplanted NPCs... - Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primatesStefano Pluchino
Neuroimmunology Unit, San Raffaele Scientific Institute, Milan, Italy
Ann Neurol 66:343-54. 2009.... - Remodelling the injured CNS through the establishment of atypical ectopic perivascular neural stem cell nichesS Pluchino
CNS Repair Unit, Institute of Experimental Neurology INSPE, DIBIT2 and San Raffaele Scientific Institute, Milan, Italy
Arch Ital Biol 148:173-83. 2010.... - Neural stem cell-mediated immunomodulation: repairing the haemorrhagic brainStefano Pluchino
Gianvito Martino Neuroimmunology Unit-DIBIT and Institute of Experimental Neurology (InSpe)-San Raffaele Scientific Institute, Via Olgettina 58, I-20132, Milan, Italy
Brain 131:604-5. 2008 - Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanismStefano Pluchino
Neuroimmunology Unit-DIBIT, Vita-Salute University, San Raffaele Hospital, Via Olgettina 58, 20132 Milan, Italy
Nature 436:266-71. 2005..These results indicate that undifferentiated adult NPCs have relevant therapeutic potential in chronic inflammatory CNS disorders because they display immune-like functions that promote long-lasting neuroprotection... - Regeneration and repair in multiple sclerosis: the role of cell transplantationStefano Pluchino
Neuroimmunology Unit and Institute of Experimental Neurology INSpe, DIBIT San Raffaele Scientific Institute, Via Olgettina 58, 20123 Milano, Italy
Neurosci Lett 456:101-6. 2009.... - Gene therapy-mediated modulation of immune processes in the central nervous systemRoberto Furlan
Neuroimmunology Unit, Department of Neurology, San Raffaele Scientific Institute Via Olgettina, 58 20132 Milan, Italy
Curr Pharm Des 9:2002-8. 2003.... - The therapeutic potential of neural stem cellsGianvito Martino
Neuroimmunology Unit, DIBIT, and Department of Neurology and Neurophysiology, San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milano, Italy
Nat Rev Neurosci 7:395-406. 2006..We propose that it is the most challenging example of reciprocal therapeutic crosstalk between the inflamed CNS and systemically transplanted neural stem cells... - Cell-based remyelinating therapies in multiple sclerosis: evidence from experimental studiesStefano Pluchino
Neuroimmunology Unit - Department of Biotechnology (DIBIT) and Department of Neurology and Neurophysiology, San Raffaele Scientific Institute, Milan, Italy
Curr Opin Neurol 17:247-55. 2004.... - Gene therapy for autoimmune diseasesRoberto Furlan
Neuroimmunology Unit, DIBIT, Department of Neurology and Neurophysiology, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
Curr Opin Mol Ther 6:525-36. 2004..Gene therapy studies in experimental models of diabetes, rheumatoid arthritis and multiple sclerosis are reviewed... - The therapeutic use of gene therapy in inflammatory demyelinating diseases of the central nervous systemRoberto Furlan
Neuroimmunology Unit (DIBIT) and Department of Neurology and Neurophysiology, San Raffaele Scientific Institute, Milan, Italy
Curr Opin Neurol 16:385-92. 2003..Here, we summarize the most recent findings of this novel area of research... - Neural stem cells and their use as therapeutic tool in neurological disordersStefano Pluchino
Department of Neuroscience, San Raffaele Scientific Institute, Neuroimmunology Unit-DIBIT, Milano, Italy
Brain Res Brain Res Rev 48:211-9. 2005.... - IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosisE Butti
Neuroimmunology Unit, San Raffaele Scientific Institute, Milan, Italy
Gene Ther 15:504-15. 2008..CSF delivery of HD-Ad vectors expressing anti-inflammatory molecules might represent a valuable therapeutic option for CNS inflammatory disorders... - Motor evoked potentials in a mouse model of chronic multiple sclerosisStefano Amadio
Department of Neurology and Clinical Neurophysiology, San Raffaele Scientific Institute, , Milan, Italy
Muscle Nerve 33:265-73. 2006..These results demonstrate that cMEPs are a useful method for monitoring corticospinal tract function in chronic-progressive EAE, and provide insight into the pathological substrate of the condition... - The therapeutic use of stem cells for myelin repair in autoimmune demyelinating disordersStefano Pluchino
Neuroimmunology Unit--DIBIT and Department of Neurology and Neurophysiology, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
J Neurol Sci 233:117-9. 2005.... - Persistent inflammation alters the function of the endogenous brain stem cell compartmentStefano Pluchino
Neuroimmunology Unit, DIBIT, San Raffaele Scientific Institute, Milano, Italy
Brain 131:2564-78. 2008.... - Cytokine gene delivery into the central nervous system using intrathecally injected nonreplicative viral vectorsRoberto Furlan
Neuroimmunology Unit, Department of Neuroscience, San Raffaele Scientific Institute-DIBIT, Milan, Italy
Methods Mol Biol 215:279-89. 2003 - Neural stem/precursor cells for the treatment of ischemic strokeMarco Bacigaluppi
Department of Neurology, University Hospital Zurich USZ, Frauenklinikstr, 26, CH 8091 Zurich, Switzerland
J Neurol Sci 265:73-7. 2008..Here we discuss, with special emphasis on neural stem/precursor cells, potential mechanisms that may be involved in the action of cell-based therapies in stroke... - Magnetic-resonance-based tracking and quantification of intravenously injected neural stem cell accumulation in the brains of mice with experimental multiple sclerosisLetterio S Politi
Neuroradiology Unit, Centro Eccellenza Risonanza Magnetica ad Alto Campo, Italy
Stem Cells 25:2583-92. 2007..Disclosure of potential conflicts of interest is found at the end of this article... - Synergy between immune cells and adult neural stem/progenitor cells promotes functional recovery from spinal cord injuryYaniv Ziv
Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel
Proc Natl Acad Sci U S A 103:13174-9. 2006.... - Neural stem cells: guardians of the brainGianvito Martino
Nat Cell Biol 9:1031-4. 2007 - Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cellsOleg Butovsky
Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
Mol Cell Neurosci 31:149-60. 2006..It thus appears that microglial phenotype critically affects their ability to support or impair cell renewal from adult stem cell...