Davide Rossi

Summary

Country: Italy

Publications

  1. ncbi Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia
    Davide Rossi
    Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Blood 119:2854-62. 2012
  2. ncbi Molecular history of Richter syndrome: origin from a cell already present at the time of chronic lymphocytic leukemia diagnosis
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Int J Cancer 130:3006-10. 2012
  3. ncbi Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Blood 119:521-9. 2012
  4. ncbi The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors
    Davide Rossi
    Division of Haematology, Department of Clinical and Experimental Medicine and BRMA, Amedeo Avogadro University of Eastern Piedmont and Azienda Ospedaliero Universitaria Maggiore della Carità, Novara, Italy
    Br J Haematol 146:64-75. 2009
  5. ncbi Usefulness of JAK2V617F mutation in distinguishing idiopathic erythrocytosis from polycythemia vera
    Davide Rossi
    Division of Haematology, Department of Clinical and Experimental Medicine and IRCAD, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Leuk Res 31:97-101. 2007
  6. ncbi Simultaneous diagnosis of CD3+ T-cell large granular lymphocyte leukaemia and true thymic hyperplasia
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine and IRCAD, Amedeo Avogadro University of Eastern Piedmont and Ospedale Maggiore della Carità, Novara, Italy
    Leuk Res 31:1019-21. 2007
  7. ncbi Hairy cell leukaemia complicated by anti-MAG paraproteinemic demyelinating neuropathy: resolution of neurological syndrome after cladribrine treatment
    Davide Rossi
    Division of Haematology, Department of Clinical and Experimental Medicine and IRCAD, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Leuk Res 31:873-6. 2007
  8. ncbi Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine and IRCAD, Amedeo Avogadro University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy
    Haematologica 91:1405-9. 2006
  9. ncbi Prevalence and clinical characteristics of immune thrombocytopenic purpura in a cohort of monoclonal gammopathy of uncertain significance
    Davide Rossi
    Division of Haematology, Department of Clinical and Experimental Medicine and IRCAD, Amedeo Avogadro University of Eastern Piedmont and Ospedale Maggiore della Carità, Novara, Italy
    Br J Haematol 138:249-52. 2007
  10. ncbi Transient monoclonal expansion of CD8+/CD57+ T-cell large granular lymphocytes after primary cytomegalovirus infection
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine and IRCAD, Amedeo Avogadro University of Eastern Piedmont and Ospedale Maggiore della Carità, Novara, Italy
    Am J Hematol 82:1103-5. 2007

Detail Information

Publications67

  1. ncbi Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia
    Davide Rossi
    Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Blood 119:2854-62. 2012
    ..These data identify BIRC3 disruption as a recurrent genetic lesion of high-risk CLL devoid of TP53 abnormalities...
  2. ncbi Molecular history of Richter syndrome: origin from a cell already present at the time of chronic lymphocytic leukemia diagnosis
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Int J Cancer 130:3006-10. 2012
    ....
  3. ncbi Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Blood 119:521-9. 2012
    ..NOTCH1 mutations are an independent predictor of CLL OS, tend to be mutually exclusive with TP53 abnormalities, and identify cases with a dismal prognosis...
  4. ncbi The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors
    Davide Rossi
    Division of Haematology, Department of Clinical and Experimental Medicine and BRMA, Amedeo Avogadro University of Eastern Piedmont and Azienda Ospedaliero Universitaria Maggiore della Carità, Novara, Italy
    Br J Haematol 146:64-75. 2009
    ..Given that the biological profile can predict treatment requirement, stratification based on biological prognosticators may be helpful for cMBL management...
  5. ncbi Usefulness of JAK2V617F mutation in distinguishing idiopathic erythrocytosis from polycythemia vera
    Davide Rossi
    Division of Haematology, Department of Clinical and Experimental Medicine and IRCAD, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Leuk Res 31:97-101. 2007
    ..All 11 IE tested negative for JAK2V617F mutation, which, conversely, occurred in 11/15 (73.3%) PV. Our results demonstrate that JAK2V617F is absent in IE and may represent a useful molecular marker for distinguishing IE from PV...
  6. ncbi Simultaneous diagnosis of CD3+ T-cell large granular lymphocyte leukaemia and true thymic hyperplasia
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine and IRCAD, Amedeo Avogadro University of Eastern Piedmont and Ospedale Maggiore della Carità, Novara, Italy
    Leuk Res 31:1019-21. 2007
    ..The patient presented with severe symptomatic neutropenia. Complete and persistent haematological and molecular remission was induced with an association of low-dose methotrexate and cyclosporin A, followed by thymectomy...
  7. ncbi Hairy cell leukaemia complicated by anti-MAG paraproteinemic demyelinating neuropathy: resolution of neurological syndrome after cladribrine treatment
    Davide Rossi
    Division of Haematology, Department of Clinical and Experimental Medicine and IRCAD, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Leuk Res 31:873-6. 2007
    ..Purine analogs may represent a choice in IgM PDN associated with lymphoproliferative disorders...
  8. ncbi Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine and IRCAD, Amedeo Avogadro University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy
    Haematologica 91:1405-9. 2006
    ..Our findings demonstrate that acquisition of novel mutations due to aberrant somatic hypermutation was associated with DLBCL transformation in 5/9 (55.5%) cases of FL and 2/9 (22.2%) cases of B-CLL...
  9. ncbi Prevalence and clinical characteristics of immune thrombocytopenic purpura in a cohort of monoclonal gammopathy of uncertain significance
    Davide Rossi
    Division of Haematology, Department of Clinical and Experimental Medicine and IRCAD, Amedeo Avogadro University of Eastern Piedmont and Ospedale Maggiore della Carità, Novara, Italy
    Br J Haematol 138:249-52. 2007
    ..After a follow-up of 681.3 patient-years, the crude incidence of ITP in MGUS was 146.8 per 100 000 patient-year (95% CI: 3.7-817.8). Overall, these observations point to an association between MGUS and ITP...
  10. ncbi Transient monoclonal expansion of CD8+/CD57+ T-cell large granular lymphocytes after primary cytomegalovirus infection
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine and IRCAD, Amedeo Avogadro University of Eastern Piedmont and Ospedale Maggiore della Carità, Novara, Italy
    Am J Hematol 82:1103-5. 2007
    ..These observations further corroborate the need for a close follow-up before assigning the diagnosis of LGL leukemia to individuals developing monoclonal CD8+ T-cell expansions...
  11. ncbi Bone marrow necrosis complicating post-transplant lymphoproliferative disorder: resolution with rituximab
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine and IRCAD, Amedeo Avogadro University of Eastern Piedmont and Ospedale Maggiore della Carità, Via Solaroli 17, 28100 Novara, Italy
    Leuk Res 32:829-34. 2008
    ..This case report provides the first evidence of (i) bone marrow necrosis as a complication of PTLD; (ii) rapid resolution of NHL-associated bone marrow necrosis after rituximab treatment...
  12. ncbi Analysis of the host pharmacogenetic background for prediction of outcome and toxicity in diffuse large B-cell lymphoma treated with R-CHOP21
    D Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine and BRMA, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Leukemia 23:1118-26. 2009
    ..These results highlight the need to improve characterization of the host genetic background for a better prognostication of DLBCL...
  13. ncbi Biological and clinical risk factors of chronic lymphocytic leukaemia transformation to Richter syndrome
    Davide Rossi
    Division of Haematology, Department of Clinical and Experimental Medicine and BRMA, Amedeo Avogadro University of Eastern Piedmont and Ospedale Maggiore della Carità, Novara, Italy
    Br J Haematol 142:202-15. 2008
    ..Predominant nodal disease, CD38 expression, IGHV4-39 usage, and absence of del13q14 may help in predicting RS at CLL diagnosis. Close monitoring and a careful biopsy policy are needed in patients carrying transformation risk factors...
  14. ncbi CD49d expression is an independent risk factor of progressive disease in early stage chronic lymphocytic leukemia
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine and BRMA, Amedeo Avogadro University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy
    Haematologica 93:1575-9. 2008
    ..Our observations indicate CD49d >or=30% as a new marker for the initial prognostic assessment of Binet A chronic lymphocytic leukemia...
  15. ncbi Richter syndrome: molecular insights and clinical perspectives
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine and BRMA, Amedeo Avogadro University of Eastern Piedmont and Azienda Ospedaliero Universitaria Maggiore della Carità, Novara, Italy
    Hematol Oncol 27:1-10. 2009
    ..Depending on patient's age and RS score, the therapeutic options for RS may range from conventional immunochemotherapy to allogeneic bone marrow transplantation...
  16. ncbi Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome
    Davide Rossi
    Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Clin Cancer Res 15:4415-22. 2009
    ..Stereotyped B-cell receptors (BCR) may have prognostic effect in CLL progression. We tested the prognostic effect of stereotyped BCR for predicting RS transformation...
  17. ncbi The host genetic background of DNA repair mechanisms is an independent predictor of survival in diffuse large B-cell lymphoma
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine and CRIFF, Amedeo Avogadro University of Eastern Piedmont, Via Solaroli 17, Novara, Italy
    Blood 117:2405-13. 2011
    ....
  18. ncbi The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: implications for overall survival and chemorefractoriness
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine and BRMA, Amedeo Avogadro University of Eastern Piedmont and Azienda Ospedaliero Universitaria Maggiore della Carità, Novara, Italy
    Clin Cancer Res 15:995-1004. 2009
    ..Conversely, it is unknown whether TP53 mutations carry any prognostic value independent of del17p13. We tested the independent prognostic value of TP53 mutations in CLL...
  19. ncbi The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Blood 117:3391-401. 2011
    ..0%; P = .009). The molecular dissection of RS into biologically distinct categories highlights the genetic heterogeneity of this disorder and provides clinically relevant information for refining the prognostic stratification of patients...
  20. ncbi Analysis of immunoglobulin heavy and light chain variable genes in post-transplant lymphoproliferative disorders
    Daniela Capello
    Department of Clinical and Experimental Medicine and IRCAD, Division of Hematology, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Hematol Oncol 24:212-9. 2006
    ..The high frequency of IGV loci inactivation appears to be a peculiar feature of PTLD among immunodeficiency-associated lymphoproliferations...
  21. ncbi A variant of the LRP4 gene affects the risk of chronic lymphocytic leukaemia transformation to Richter syndrome
    Silvia Rasi
    Division of Haematology, Department of Clinical and Experimental Medicine and IRCAD, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Br J Haematol 152:284-94. 2011
    ..Bioinformatic analysis scored LRP4 rs2306029 as a variant with possible deleterious and damaging variant of LRP4. LRP4 genotyping may help the recognition of patients with increased risk of RS at the time of CLL diagnosis...
  22. ncbi Bortezomib-melphalan-prednisone-thalidomide followed by maintenance with bortezomib-thalidomide compared with bortezomib-melphalan-prednisone for initial treatment of multiple myeloma: a randomized controlled trial
    Antonio Palumbo
    Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero Universitaria A O U S Giovanni Battista, Torino, Italy
    J Clin Oncol 28:5101-9. 2010
    ....
  23. ncbi Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Blood 118:6904-8. 2011
    ..046). The identification of SF3B1 mutations points to splicing regulation as a novel pathogenetic mechanism of potential clinical relevance in CLL...
  24. ncbi Molecular analysis of immunoglobulin variable genes in human immunodeficiency virus-related non-Hodgkin's lymphoma reveals implications for disease pathogenesis and histogenesis
    Daniela Capello
    Division of Hematology, Department of Clinical and Experimental Medicine and BRMA, Amedeo Avogadro University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy
    Haematologica 93:1178-85. 2008
    ..Analysis of immunoglobulin variable genes (IGV) may provide insights into the pathogenesis and histogenesis of HIV-NHL...
  25. ncbi Aberrant promoter methylation of multiple genes throughout the clinico-pathologic spectrum of B-cell neoplasia
    Davide Rossi
    Hematology Unit, Dept. of Medical Sciences and IRCAD, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Haematologica 89:154-64. 2004
    ..Finally, the frequency of GSTP1 aberrant methylation in diffuse large B-cell lymphoma prompts studies aimed at verifying the prognostic impact of this epigenetic lesion in these lymphomas...
  26. ncbi Molecular characterization of post-transplant lymphoproliferative disorders of donor origin occurring in liver transplant recipients
    Daniela Capello
    Division of Hematology, Department of Clinical and Experimental Medicine and BRMA, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    J Pathol 218:478-86. 2009
    ....
  27. ncbi Frequent aberrant promoter hypermethylation of O6-methylguanine-DNA methyltransferase and death-associated protein kinase genes in immunodeficiency-related lymphomas
    Davide Rossi
    Department of Medical Sciences and IRCAD, Haematology Unit, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Br J Haematol 123:475-8. 2003
    ..In particular, promoter hypermethylation of DAP-K represents the most frequent molecular alteration yet identified in immunodeficiency-related lymphomas...
  28. ncbi Epigenetic inactivation of suppressors of cytokine signalling in Philadelphia-negative chronic myeloproliferative disorders
    Daniela Capello
    Division of Haematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Br J Haematol 141:504-11. 2008
    ..The frequent inactivation of SOCS3 is a novel finding in CMPD with potential implications for the molecular pathology of these disorders...
  29. ncbi Genome wide DNA-profiling of HIV-related B-cell lymphomas
    Daniela Capello
    Department of Clinical and Experimental Medicine and BRMA, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Br J Haematol 148:245-55. 2010
    ..The same genes involved by fragile site deletions were also frequently affected by aberrant methylation of regulative regions...
  30. ncbi Molecular histogenesis of posttransplantation lymphoproliferative disorders
    Daniela Capello
    Hematology Unit, Department of Medical Sciences and Interdisciplinary Research Center on Autoimmune Diseases, Amedeo Avogadro University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy
    Blood 102:3775-85. 2003
    ..Overall, the histogenetic diversity of monoclonal B-cell PTLDs may help define biologically homogeneous categories of the disease...
  31. ncbi Molecular heterogeneity of diffuse large B-cell lymphoma: implications for disease management and prognosis
    Davide Rossi
    Hematology Unit, Division of Internal Medicine, Department of Medical Sciences and IRCAD, Amedeo Avogadro University of Eastern Piedmont, Via Solaroli 17, I-28100, Novara, Italy
    Hematology 7:239-52. 2002
    ..Overall the molecular features of DLBCL may identify prognostic categories of the disease and may represent a powerful tool for therapeutic stratification...
  32. ncbi Beta-2-microglobulin is an independent predictor of progression in asymptomatic multiple myeloma
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Eastern Piedmont and Maggiore della Carita Hospital, Novara, Italy
    Cancer 116:2188-200. 2010
    ..Although serum beta-2 microglobulin (B2M) represents a key variable for symptomatic multiple myeloma (MM) prognostication, its role in predicting the risk of progression of asymptomatic MM to symptomatic disease has not been explored...
  33. ncbi Saliva is a reliable and practical source of germline DNA for genome-wide studies in chronic lymphocytic leukemia
    Silvia Rasi
    Division of Hematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Leuk Res 35:1419-22. 2011
    ..Saliva DNA was successfully run on SNP 6.0 arrays, and passed quality control call rate thresholds. On these bases, saliva represents a useful source of germline DNA for high-throughput genomic studies of hematologic neoplasia...
  34. ncbi Extramedullary intracranial localization of multiple myeloma and treatment with novel agents: a retrospective survey of 50 patients
    Alessandro Gozzetti
    Division of Hematology, Azienda Ospedaliera Universitaria Senese, Policlinico Santa Maria alle Scotte, Siena, Italy
    Cancer 118:1574-84. 2012
    ..Intracranial involvement in multiple myeloma is extremely rare. The effect of new drugs (eg, thalidomide, bortezomib, lenalidomide) with respect to old drugs (eg, alkylators, steroids) has not been reported...
  35. ncbi Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma
    Silvia Zibellini
    Division of Hematology, Department of Oncohematology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Viale Golgi 19, Pavia, Italy
    Haematologica 95:1792-6. 2010
    ..Overall, data suggest that the pathogenesis of splenic marginal zone lymphoma may involve also HCV-unrelated epitopes or an antigenic trigger common to other indolent lymphomas...
  36. ncbi Molecular histogenesis of plasmablastic lymphoma of the oral cavity
    Gianluca Gaidano
    Hematology Unit, Division of Internal Medicine, Department of Medical Sciences, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Br J Haematol 119:622-8. 2002
    ..Conversely, another fraction of these lymphomas were devoid of somatic IgVH mutations and appeared to originate from naive B cells that have undergone preterminal differentiation independent of GC transit...
  37. ncbi NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLL
    Ilaria del Giudice
    Division of Hematology, Department of Cellular Biotechnologies and Haematology University, Sapienza Via Benevento 6, 00161 Rome, Italy
    Haematologica 97:437-41. 2012
    ..NOTCH1 mutations refine the intermediate prognosis of +12 CLL...
  38. ncbi Complete response correlates with long-term progression-free and overall survival in elderly myeloma treated with novel agents: analysis of 1175 patients
    Francesca Gay
    Myeloma Unit, Division of Hematology, University of Torino, AOU S Giovanni Battista, Torino, Italy
    Blood 117:3025-31. 2011
    ..This trial was registered at www.clinicaltrials.gov as #NCT00232934, #ISRCTN 90692740, and #NCT01063179...
  39. ncbi Alteration of BIRC3 and multiple other NF-?B pathway genes in splenic marginal zone lymphoma
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Blood 118:4930-4. 2011
    ..Genetic lesions of NF-?B provide a molecular basis for the pathogenesis of more than 30% of SMZLs and offer a suitable target for NF-?B therapeutic approaches in this lymphoma...
  40. ncbi Post-transplant lymphoproliferative disorders: molecular basis of disease histogenesis and pathogenesis
    Daniela Capello
    Division of Hematology, Department of Medical Sciences and IRCAD, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Hematol Oncol 23:61-7. 2005
    ..Apart from microsatellite instability, molecular alterations of cellular genes recognized in PTLD include alterations of c-MYC, BCL-6, p53, DNA hypermethylation, and aberrant somatic hypermutation of proto-oncogenes...
  41. ncbi Predictive markers and driving factors behind Richter syndrome development
    Marco Fangazio
    Division of Hematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy
    Expert Rev Anticancer Ther 11:433-42. 2011
    ..Genome-wide studies that are currently ongoing are important for identifying novel molecular lesions implicated in RS that might represent a suitable target for future therapeutic strategies...
  42. ncbi Efficacy and safety of once-weekly bortezomib in multiple myeloma patients
    Sara Bringhen
    Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero Universitaria S Giovanni Battista, Torino, Italy
    Blood 116:4745-53. 2010
    ..001). This improvement in safety did not appear to affect efficacy. This study is registered at http://www.clinicaltrials.gov as NCT01063179...
  43. ncbi Hepatitis B virus and lymphomagenesis: Novel insights into an occult relationship
    David J Pinato
    Imperial College London, Division of Experimental Medicine, Hammersmith Hospital, Du Cane Road, London, UK Internal Medicine, Universita degli Studi del Piemonte Orientale, Department of Clinical and Experimental Medicine, Novara, Italy
    Dig Liver Dis 44:235-8. 2012
    ..It remains unclear (a) whether this association is restricted to discrete subtypes of B-cell neoplasms and (b) if occult hepatitis B virus infection can impact on the risk of B-cell malignancy...
  44. ncbi Renal outcome and monoclonal immunoglobulin deposition disease in 289 old patients with blood cell dyscrasias: a single center experience
    Piero Stratta
    Department of Clinical and Experimental Medicine, Units Nephrology and Transplantation, Department of Nephro urology, and Interdisciplinary Research Center Autoimmune Disease IRCAD, Amedeo Avogadro University, Novara, Italy
    Crit Rev Oncol Hematol 79:31-42. 2011
    ....
  45. ncbi Derivative (1)t(1;16)(p11;p11.1) in myelodysplastic syndrome: a case report and review of the literature
    Monia Lunghi
    Division of Hematology, Amedeo Avogadro University of Eastern Piedmont and Ospedale Maggiore della Carità, Via Solaroli 17, 28100 Novara, Italy
    Cancer Genet Cytogenet 196:89-92. 2010
    ..The unbalanced nature of the t(1;16)(p11;p11.1) indicates that gain of 1q and/or loss of 16q might be relevant for neoplastic transformation in a subset of MDS patients...
  46. ncbi Occult hepatitis B virus infection of peripheral blood mononuclear cells among treatment-naive patients with chronic lymphocytic leukemia
    Davide Rossi
    Department of Clinical and Experimental Medicine, University of Eastern Piedmont A Avogadro, Novara, Italy
    Leuk Lymphoma 50:604-11. 2009
    ....
  47. ncbi Messengers of cell death: apoptotic signaling in health and disease
    Davide Rossi
    Hematology Unit, Department of Medical Sciences and IRCAD, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Haematologica 88:212-8. 2003
    ..PERSPECTIVES: Tumor-specific alterations in the apoptotic machinery may represent new potential targets for molecular therapy of lymphoma...
  48. ncbi High density genome-wide DNA profiling reveals a remarkably stable profile in hairy cell leukaemia
    Francesco Forconi
    Sezione Ematologia e Trapianti, Universita di Siena, Italy
    Br J Haematol 141:622-30. 2008
    ..As a whole, however, HCL showed a remarkably stable genome. This finding adds to several other features that are unique to HCL among mature B-cell tumours...
  49. ncbi Alternative translocation breakpoint cluster region 5' to BCL-6 in B-cell non-Hodgkin's lymphoma
    Marion P Butler
    Institute for Cancer Genetics, and the Department of Pathology, Columbia University, New York, NY 10032, USA
    Cancer Res 62:4089-94. 2002
    ..The identification of BCL-6 ABR provides new tools for the diagnosis of lymphomas carrying aberrations at 3q27 and deregulated BCL-6 genes...
  50. ncbi Primary cutaneous large B-cell lymphoma of the leg: histogenetic analysis of a controversial clinicopathologic entity
    Marco Paulli
    Department of Pathology, IRCCS Policlinico S.Matteo/University of Pavia, Italy
    Hum Pathol 33:937-43. 2002
    ..Our results indicate that PCLBCL-leg are similar both under the morphofunctional and molecular profiles to most DLBCL of other sites. Thus, caution seems justified before definitely considering PCLBCL of the leg as a distinct entity...
  51. ncbi Anaplastic large cell lymphoma and acquired angioedema: a novel association?
    Davide Rossi
    Ann Ital Med Int 17:143-5. 2002
  52. ncbi Incidence of novel N-glycosylation sites in the B-cell receptor of lymphomas associated with immunodeficiency
    Francesco Forconi
    Divisione di Ematologia e Trapianti, Dipartimento di Medicina Clinica e Scienze Immunologiche Applicate, Universita di Siena, Siena, Italy
    Br J Haematol 124:604-9. 2004
    ....
  53. ncbi Aberrant somatic hypermutation in multiple subtypes of AIDS-associated non-Hodgkin lymphoma
    Gianluca Gaidano
    Institute for Cancer Genetics, Columbia University, Russ Berrie Science Pavilion, 1150 St Nicholas Ave, Rm 303B, New York, NY 10032, USA
    Blood 102:1833-41. 2003
    ..These data indicate that aberrant hypermutation is associated with various subtypes of AIDS-NHL and may represent a major contributor to their pathogenesis...
  54. ncbi Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma
    Manel Esteller
    Division of Cancer Biology, The Johns Hopkins Oncology Center, Baltimore, MD 21231, USA
    J Natl Cancer Inst 94:26-32. 2002
    ..CONCLUSION: MGMT promoter hypermethylation appears to be a useful marker for predicting survival in patients with B-DLCL treated with multidrug regimens including cyclophosphamide...
  55. ncbi B-cell posttransplant lymphoproliferative disorders in heart and/or lungs recipients: clinical and molecular-histogenetic study of 17 cases from a single institution
    Marco Lucioni
    Anatomic Pathology Section, Department of Human Pathology, University of Pavia, IRCCS Policlinico San Matteo, Pavia, Italy
    Transplantation 82:1013-23. 2006
    ..The EBV-negative cases with GC histogenetic phenotype showed a slightly better outcome; however, such less aggressive prognostic trend was not confirmed by statistical analysis...
  56. ncbi CD38 gene polymorphism and chronic lymphocytic leukemia: a role in transformation to Richter syndrome?
    Semra Aydin
    Department of Genetics, Biology, and Biochemistry, University of Torino Medical School, Turin, Italy
    Blood 111:5646-53. 2008
    ..Multivariate analysis on a total of 30 RS patients confirmed that the probability of transformation is strongly associated with G allele, likely representing an independent risk factor for RS development...
  57. ncbi Comparative genome-wide profiling of post-transplant lymphoproliferative disorders and diffuse large B-cell lymphomas
    Andrea Rinaldi
    Laboratory of Experimental Oncology and Lymphoma Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Br J Haematol 134:27-36. 2006
    ..The combination of DNA copy number and LOH assessment lead to the hypothesis that uniparental disomy may be a potential mechanism in B-cell lymphomagenesis...
  58. ncbi JAK2 V617F mutation in leukaemic transformation of philadelphia-negative chronic myeloproliferative disorders
    Davide Rossi
    Br J Haematol 135:267-8. 2006
  59. ncbi Selective influences in the expressed immunoglobulin heavy and light chain gene repertoire in hairy cell leukemia
    Francesco Forconi
    DM, Sezione di Ematologia e Trapianti, Dipartimento di Medicina Clinica e Scienze Immunologiche, Universita di Siena, AOUS, Viale Bracci, 53100 Siena, Italy
    Haematologica 93:697-705. 2008
    ..Those analyses raised questions on the incidence and type of selective influences occurring on the tumor B-cell receptor of hairy cell leukemia...
  60. ncbi Human herpesvirus type 8-associated primary lymphomatous effusion in an elderly HIV-negative patient: clinical and molecular characterization
    Daniela Buonaiuto
    Centro per lo Studio e la Cura delle Malattie del Sangue, Clinica Medica Generale, Universita degli Studi del Piemonte Orientale Amedeo Avogadro
    Ann Ital Med Int 17:54-9. 2002
    ..Overall, this case report illustrates the need for an integrated diagnostic approach based on clinical features, morphology, immunophenotype, and molecular genetics to primary lymphomatous effusions...
  61. ncbi Early stage chronic lymphocytic leukaemia carrying unmutated IGHV genes is at risk of recurrent infections during watch and wait
    Davide Rossi
    Br J Haematol 141:734-6. 2008
  62. ncbi Simian virus 40 infection in lymphoproliferative disorders
    Daniela Capello
    Baylor Coll Med, Houston, TX
    Lancet 361:88-9. 2003
  63. ncbi POEMS and calciphylaxis: a novel association?
    Davide Rossi
    Ann Ital Med Int 19:235-7. 2004
  64. ncbi CCL19 and CXCL12 trigger in vitro chemotaxis of human mantle cell lymphoma B cells
    Anna Corcione
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genoa, Italy
    Clin Cancer Res 10:964-71. 2004
    ..Information on these issues may allow us to identify novel mechanisms of chemokine-driven tumor cell migration...
  65. ncbi Downregulation of the major histocompatibility complex class I molecules by human herpesvirus type 8 and impaired natural killer cell activity in primary effusion lymphoma development
    Maria Caterina Sirianni
    Clinical Immunology, Department of Clinical Medicine, University of Roma La Sapienza, Italy
    Br J Haematol 130:92-5. 2005
    ..Intriguingly, analysis of MHC-I non-restricted cytotoxicity in two PEL patients indicated a reduced NK cell activity when compared with healthy individuals. These data suggest that PEL outgrowth may require an impaired NK cell function...
  66. ncbi Aberrant somatic hypermutation in post-transplant lymphoproliferative disorders
    Michaela Cerri
    Br J Haematol 127:362-4. 2004
  67. ncbi Aberrant methylation in the promoter region of the reduced folate carrier gene is a potential mechanism of resistance to methotrexate in primary central nervous system lymphomas
    Andres J M Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Br J Haematol 126:657-64. 2004
    ..If confirmed in prospective trials on PCNSL treated with HD-MTX alone, these data may suggest the necessity for alternative strategies in M-PCNSL considering the increased risk of MTX resistance by tumour cells...