Luca Pani

Summary

Country: Italy

Publications

  1. ncbi Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid
    Anna Porcella
    CNR Institute of Neurogenetics and Neuropharmacology, Cagliari, Monserrato, Italy
    Eur J Endocrinol 147:255-61. 2002
  2. ncbi Synthesis and biological evaluation of 1,8-naphthyridin-4(1H)-on-3-carboxamide derivatives as new ligands of cannabinoid receptors
    Pier Luigi Ferrarini
    Dipartimento di Scienze Farmaceutiche, Via Bonanno 6, 56126 Pisa, Italy
    Bioorg Med Chem 12:1921-33. 2004
  3. ncbi Synthesis and characterization of NESS 0327: a novel putative antagonist of the CB1 cannabinoid receptor
    Stefania Ruiu
    Institute of Neurogenetic and Neuropharmacology, Via Boccaccio 8, 09047 Selargius, Italy
    J Pharmacol Exp Ther 306:363-70. 2003
  4. ncbi Differential distribution of functional cannabinoid CB1 receptors in the mouse gastroenteric tract
    Maria Antonietta Casu
    Neuroscienze Scarl, Via Palabanda, 9 09124-I, Cagliari, Italy
    Eur J Pharmacol 459:97-105. 2003
  5. ncbi Tricyclic pyrazoles. 3. Synthesis, biological evaluation, and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide
    Gabriele Murineddu
    Dipartimento Farmaco Chimico Tossicologico, , via F. Muroni 23/A, 07100 Sassari, Italy
    J Med Chem 48:7351-62. 2005
  6. ncbi Tricyclic pyrazoles. Part 2: Synthesis and biological evaluation of novel 4,5-dihydro-1H-benzo[g]indazole-based ligands for cannabinoid receptors
    Gabriele Murineddu
    Dipartimento Farmaco Chimico Tossicologico, , via F. Muroni 23/A, 07100 Sassari, Italy
    Bioorg Med Chem 13:3309-20. 2005
  7. ncbi Carmoxirole is able to reduce amisulpride-induced hyperprolactinemia without affecting its central effect
    Giorgio Marchese
    Neuroscienze S.c.a.r.l, Cagliari, Italy
    Eur J Pharmacol 447:109-14. 2002
  8. ncbi Modulation of ATP-mediated contractions of the rat vas deferens through presynaptic cannabinoid receptors
    Simone Tambaro
    Neuroscienze PharmaNess S c ar l, Via Palabanda 9, 09124 Cagliari, Italy
    Eur J Pharmacol 525:150-3. 2005
  9. ncbi Effect of delta9-tetrahydrocannabinol on phosphorylated CREB in rat cerebellum: an immunohistochemical study
    Maria Antonietta Casu
    Neuroscienze PharmaNess SCARL, Via Palabanda, 9 09125 Cagliari, Italy
    Brain Res 1048:41-7. 2005
  10. ncbi Blockade of neurotensin receptors affects differently hypo-locomotion and catalepsy induced by haloperidol in mice
    Paola Casti
    Neuroscienze S.c.a r.l, Cagliari, Italy
    Neuropharmacology 47:128-35. 2004

Collaborators

  • Anna Porcella
  • Giorgio Marchese
  • G L Gessa
  • Mauro A M Carai
  • Stefania Ruiu
  • Gabriele Murineddu
  • Simone Tambaro
  • Maria Antonietta Casu
  • Paolo Lazzari
  • Giovanni Loriga
  • Paola Casti
  • Angela Sanna
  • Ilaria Manca
  • Raymond Mongeau
  • Pier Luigi Ferrarini
  • Roberta Reali
  • Jean-Mario Mussinu
  • Pierluigi Saba
  • Giorgio Chelucci
  • Matteo Falzoi
  • Maria M Curzu
  • Gabriele Pinna Spada
  • Christian Dessi
  • Carla Pisu
  • Giuseppe E Grella
  • Lucio Toma
  • Clementina Manera
  • Vincenzo Calderone
  • Tiziana Cavallini
  • Giuseppe Saccomanni
  • Gianluca Casu
  • Gerard A Pinna
  • Romina Vargiu
  • Jean Mario Mussinu

Detail Information

Publications11

  1. ncbi Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid
    Anna Porcella
    CNR Institute of Neurogenetics and Neuropharmacology, Cagliari, Monserrato, Italy
    Eur J Endocrinol 147:255-61. 2002
    ..The aim of this study was to characterize the CB1 functional expression in the rat thyroid by a multi-methods approach...
  2. ncbi Synthesis and biological evaluation of 1,8-naphthyridin-4(1H)-on-3-carboxamide derivatives as new ligands of cannabinoid receptors
    Pier Luigi Ferrarini
    Dipartimento di Scienze Farmaceutiche, Via Bonanno 6, 56126 Pisa, Italy
    Bioorg Med Chem 12:1921-33. 2004
    ..5 and 8.0 nM respectively; also compounds 4a, 5a and 8a exhibit a good CB(2) affinity, with K(i) values in the range of 10-44 nM. Furthermore, compounds 3g-i and 18 revealed a good CB(2) selectivity, with a CB(1)/CB(2) ratio >20...
  3. ncbi Synthesis and characterization of NESS 0327: a novel putative antagonist of the CB1 cannabinoid receptor
    Stefania Ruiu
    Institute of Neurogenetic and Neuropharmacology, Via Boccaccio 8, 09047 Selargius, Italy
    J Pharmacol Exp Ther 306:363-70. 2003
    ..042 +/- 0.01 mg/kg i.p.) and hot-plate test (ID50 = 0.018 +/- 0.006 mg/kg i.p.). These results indicated that NESS 0327 is a novel cannabinoid antagonist with high selectivity for the cannabinoid CB1 receptor...
  4. ncbi Differential distribution of functional cannabinoid CB1 receptors in the mouse gastroenteric tract
    Maria Antonietta Casu
    Neuroscienze Scarl, Via Palabanda, 9 09124-I, Cagliari, Italy
    Eur J Pharmacol 459:97-105. 2003
    ..Moreover, the dose of 0.3 microg/kg of HU 210, devoid per se of any activity on mouse intestinal propulsion, blocked the increased gastroenteric transit induced by the cannabinoid CB(1) antagonist SR 141716A...
  5. ncbi Tricyclic pyrazoles. 3. Synthesis, biological evaluation, and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide
    Gabriele Murineddu
    Dipartimento Farmaco Chimico Tossicologico, , via F. Muroni 23/A, 07100 Sassari, Italy
    J Med Chem 48:7351-62. 2005
    ....
  6. ncbi Tricyclic pyrazoles. Part 2: Synthesis and biological evaluation of novel 4,5-dihydro-1H-benzo[g]indazole-based ligands for cannabinoid receptors
    Gabriele Murineddu
    Dipartimento Farmaco Chimico Tossicologico, , via F. Muroni 23/A, 07100 Sassari, Italy
    Bioorg Med Chem 13:3309-20. 2005
    ..Compounds 2a and c increased intestinal propulsion in mouse. Their pro-kinetic effects were reversed by the reference CB agonist CP-55,940. Consequently, in vivo CB(1) antagonistic activity was highlighted for these compounds...
  7. ncbi Carmoxirole is able to reduce amisulpride-induced hyperprolactinemia without affecting its central effect
    Giorgio Marchese
    Neuroscienze S.c.a.r.l, Cagliari, Italy
    Eur J Pharmacol 447:109-14. 2002
    ..These results suggested that a peripheral dopamine D(2) receptor agonists could be a useful tool in alleviating amisulpride-induced hyperprolactinemia without possibly affecting its central effect...
  8. ncbi Modulation of ATP-mediated contractions of the rat vas deferens through presynaptic cannabinoid receptors
    Simone Tambaro
    Neuroscienze PharmaNess S c ar l, Via Palabanda 9, 09124 Cagliari, Italy
    Eur J Pharmacol 525:150-3. 2005
    ..It is suggested that activation of pre-junctional cannabinoid receptors on sympathetic nerves of the vas deferens modulates ATP neurotransmission...
  9. ncbi Effect of delta9-tetrahydrocannabinol on phosphorylated CREB in rat cerebellum: an immunohistochemical study
    Maria Antonietta Casu
    Neuroscienze PharmaNess SCARL, Via Palabanda, 9 09125 Cagliari, Italy
    Brain Res 1048:41-7. 2005
    ..This might be a mechanism by which delta9-THC interferes with motor and cognitive functions...
  10. ncbi Blockade of neurotensin receptors affects differently hypo-locomotion and catalepsy induced by haloperidol in mice
    Paola Casti
    Neuroscienze S.c.a r.l, Cagliari, Italy
    Neuropharmacology 47:128-35. 2004
    ....
  11. ncbi Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide
    Gabriele Murineddu
    Dipartimento Farmaco Chimico Tossicologico, , via F. Muroni 23/A, 07100 Sassari, Italy
    J Med Chem 49:7502-12. 2006
    ..Furthermore, compounds 2a and 2b, as well as lead structures 1a,b, were also shown to be agonist in an in vitro model based on human promyelocytic leukemia HL-60 cells...