Marta Balietti

Summary

Affiliation: Neurobiology of Aging Laboratory
Country: Italy

Publications

  1. ncbi Ketogenic diets: an historical antiepileptic therapy with promising potentialities for the aging brain
    Marta Balietti
    Neurobiology of Aging Laboratory, INRCA, Via Birarelli 8, 60121 Ancona, Italy
    Ageing Res Rev 9:273-9. 2010
  2. ncbi Effect of two medium chain triglycerides-supplemented diets on synaptic morphology in the cerebellar cortex of late-adult rats
    Marta Balietti
    Neurobiology of Aging Laboratory, INRCA, 60121 Ancona, Italy
    Microsc Res Tech 72:933-8. 2009
  3. ncbi A ketogenic diet increases succinic dehydrogenase activity in aging cardiomyocytes
    Marta Balietti
    Neurobiology of Aging Laboratory, Italian National Research Centers on Aging, Ancona, Italy
    Ann N Y Acad Sci 1171:377-84. 2009
  4. ncbi Ketogenic diets cause opposing changes in synaptic morphology in CA1 hippocampus and dentate gyrus of late-adult rats
    Marta Balietti
    Neurobiology of Aging Laboratory, INRCA Research Department, Ancona, Italy
    Rejuvenation Res 11:631-40. 2008
  5. ncbi A ketogenic diet increases succinic dehydrogenase (SDH) activity and recovers age-related decrease in numeric density of SDH-positive mitochondria in cerebellar Purkinje cells of late-adult rats
    Marta Balietti
    Neurobiology of Aging Laboratory, INRCA, Via Birarelli 8, 60121 Ancona, Italy
    Micron 41:143-8. 2010
  6. ncbi Chronic aluminum administration to old rats results in increased levels of brain metal ions and enlarged hippocampal mossy fibers
    Patrizia Fattoretti
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1019:44-7. 2004
  7. ncbi Testing mitochondrial metabolic competence by cytochrome oxidase preferential cytochemistry versus immunoreactivity of subunits I and IV
    Patrizia Fattoretti
    Neurobiology of Aging Laboratory, INRCA Research Department, Ancona, Italy
    Rejuvenation Res 9:215-8. 2006
  8. ncbi Cytochrome oxidase activity in hippocampal synaptic mitochondria during aging: a quantitative cytochemical investigation
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1019:33-6. 2004
  9. ncbi Alterations of synaptic turnover rate in aging may trigger senile plaque formation and neurodegeneration
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1096:128-37. 2007
  10. ncbi Preservation of mitochondrial volume homeostasis at the early stages of age-related synaptic deterioration
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1096:138-46. 2007

Collaborators

Detail Information

Publications34

  1. ncbi Ketogenic diets: an historical antiepileptic therapy with promising potentialities for the aging brain
    Marta Balietti
    Neurobiology of Aging Laboratory, INRCA, Via Birarelli 8, 60121 Ancona, Italy
    Ageing Res Rev 9:273-9. 2010
    ..Here we review clinical and experimental data on KDs treatments, focusing on their possible use during pathological aging. Proposed mechanisms of action are also reported and discussed...
  2. ncbi Effect of two medium chain triglycerides-supplemented diets on synaptic morphology in the cerebellar cortex of late-adult rats
    Marta Balietti
    Neurobiology of Aging Laboratory, INRCA, 60121 Ancona, Italy
    Microsc Res Tech 72:933-8. 2009
    ..Since GCL-CCx is more vulnerable to age than OML DG but less than SM CA1, present and previous results suggest that the effects of MCT-SDs in the aging brain critically depend on neuronal vulnerability to age, besides MCT percentage...
  3. ncbi A ketogenic diet increases succinic dehydrogenase activity in aging cardiomyocytes
    Marta Balietti
    Neurobiology of Aging Laboratory, Italian National Research Centers on Aging, Ancona, Italy
    Ann N Y Acad Sci 1171:377-84. 2009
    ..These effects might counteract metabolic alterations leading to apoptosis-induced myocardial atrophy and failure during aging...
  4. ncbi Ketogenic diets cause opposing changes in synaptic morphology in CA1 hippocampus and dentate gyrus of late-adult rats
    Marta Balietti
    Neurobiology of Aging Laboratory, INRCA Research Department, Ancona, Italy
    Rejuvenation Res 11:631-40. 2008
    ..This implies risks but also promising potentialities for their therapeutic use during aging...
  5. ncbi A ketogenic diet increases succinic dehydrogenase (SDH) activity and recovers age-related decrease in numeric density of SDH-positive mitochondria in cerebellar Purkinje cells of late-adult rats
    Marta Balietti
    Neurobiology of Aging Laboratory, INRCA, Via Birarelli 8, 60121 Ancona, Italy
    Micron 41:143-8. 2010
    ..Given the central role of mitochondrial impairment in age-related physio-pathological changes of the brain, these findings may represent a starting point to examine novel potentialities for KDs...
  6. ncbi Chronic aluminum administration to old rats results in increased levels of brain metal ions and enlarged hippocampal mossy fibers
    Patrizia Fattoretti
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1019:44-7. 2004
    ..This may contribute, as an aggravating factor, to the development of neurodegenerative events, as observed in Alzheimer disease...
  7. ncbi Testing mitochondrial metabolic competence by cytochrome oxidase preferential cytochemistry versus immunoreactivity of subunits I and IV
    Patrizia Fattoretti
    Neurobiology of Aging Laboratory, INRCA Research Department, Ancona, Italy
    Rejuvenation Res 9:215-8. 2006
    ....
  8. ncbi Cytochrome oxidase activity in hippocampal synaptic mitochondria during aging: a quantitative cytochemical investigation
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1019:33-6. 2004
    ....
  9. ncbi Alterations of synaptic turnover rate in aging may trigger senile plaque formation and neurodegeneration
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1096:128-37. 2007
    ..According to current literature data on synaptic structural dynamics, this decay may represent an early and subtle alteration able to trigger the development of senile plaques and neurodegenerative events...
  10. ncbi Preservation of mitochondrial volume homeostasis at the early stages of age-related synaptic deterioration
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1096:138-46. 2007
    ..However, the clear age-related preservation of the mitochondrial potential for structural dynamics may be interpreted as a reactive response to early signs of synaptic deterioration...
  11. ncbi Synaptic and mitochondrial morphometry provides structural correlates of successful brain aging
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1097:51-3. 2007
    ..Considering the functional significance of the above parameters, their substantial age-related constancy suggests that they may reasonably represent structural correlates of successful brain aging...
  12. ncbi Selective decline of the metabolic competence of oversized synaptic mitochondria in the old monkey cerebellum
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Ancona, Italy
    Rejuvenation Res 11:387-91. 2008
    ....
  13. ncbi Brain aging: The zinc connection
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli, 60121 Ancona, Italy
    Exp Gerontol 43:389-93. 2008
    ....
  14. ncbi Neuronal apoptosis in Alzheimer's disease: the role of age-related mitochondrial metabolic competence
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, Italian National Research Center on Aging, Ancona, Italy
    Ann N Y Acad Sci 1171:18-24. 2009
    ....
  15. ncbi Differences in gene expression in the hippocampus of aged rats are associated with better long-term memory performance in a passive avoidance test
    Giuseppina Di Stefano
    Neurobiology of Aging Laboratory, INRCA, Ancona, Italy
    Rejuvenation Res 13:224-8. 2010
    ..The differential expression of 14 of these genes was confirmed by real-time polymerase chain reaction...
  16. ncbi Platelet as a physiological model to investigate apoptotic mechanisms in Alzheimer beta-amyloid peptide production
    Tiziana Casoli
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Mech Ageing Dev 129:154-62. 2008
    ..As a result, Abeta40 might be dangerous even before it becomes secreted rendering neurons highly vulnerable...
  17. ncbi Decay of mitochondrial metabolic competence in the aging cerebellum
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, 60121 Ancona, Italy
    Ann N Y Acad Sci 1019:29-32. 2004
    ..0%). The present findings support that a marked dysfunction of small and medium-sized mitochondria contributes to the significant decay of energy metabolism currently reported in physiological aging...
  18. ncbi Level and distribution of microtubule-associated protein-2 (MAP2) as an index of dendritic structural dynamics
    Giuseppina Di Stefano
    INRCA Research Department, Neurobiology of Aging Laboratory, Ancona, Italy
    Rejuvenation Res 9:94-8. 2006
    ..These findings lend support to the many converging results on the higher vulnerability to aging of the CNS areas featuring higher plasticity...
  19. ncbi Age-related decline in metabolic competence of small and medium-sized synaptic mitochondria
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Naturwissenschaften 92:82-5. 2005
    ....
  20. ncbi Experimental apoptosis provides clues about the role of mitochondrial changes in neuronal death
    Patrizia Fattoretti
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1090:79-88. 2006
    ..A better understanding of the mitochondrial role in neuronal apoptosis may suggest potential interventions to prevent the extensive nerve cell death typical of neurodegenerative diseases...
  21. ncbi Cytochemical estimation of cytochrome oxidase activity as a morphofunctional mitochondrial check-up
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Ancona, Italy
    Rejuvenation Res 9:202-6. 2006
    ....
  22. ncbi Decreased presence of perforated synapses in a triple-transgenic mouse model of Alzheimer's disease
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Ancona, Italy
    Rejuvenation Res 11:309-13. 2008
    ....
  23. ncbi Release of beta-amyloid from high-density platelets: implications for Alzheimer's disease pathology
    Tiziana Casoli
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1096:170-8. 2007
    ..Investigating the biochemical pathways triggering Abeta secretion in platelets might provide important information for developing tools to modulate this phenomenon in AD brains...
  24. ncbi Synaptic pathology in the brain cortex of old monkeys as an early alteration in senile plaque formation
    Carlo Bertoni-Freddari
    INRCA Research Department, Neurobiology of Aging Laboratory, Ancona, Italy
    Rejuvenation Res 9:85-8. 2006
    ..6%). The present data support the hypothesis of an increased sensitivity to deterioration of TC synapses in aged monkeys, which might constitute a predisposing condition to the development of senile plaques...
  25. ncbi The effect of chronic physical exercise on succinic dehydrogenase activity in the heart muscle of old rats
    Marta Balietti
    INRCA Research Department, Neurobiology of Aging Laboratory, Ancona, Italy
    Biogerontology 6:95-100. 2005
    ..Considering that myocardial function highly relies on mitochondrial metabolism, our results support a beneficial effect of chronic physical exercise on the old heart muscle...
  26. ncbi Peripheral inflammatory biomarkers of Alzheimer's disease: the role of platelets
    Tiziana Casoli
    Neurobiology of Aging Centre, Scientific Technological Area, INRCA, 60121 Ancona, Italy
    Biogerontology 11:627-33. 2010
    ....
  27. ncbi Dynamin binding protein gene expression and memory performance in aged rats
    Tiziana Casoli
    Neurobiology of Aging Laboratory, INRCA Scientific Technological Area, Ancona, Italy
    Neurobiol Aging 33:618.e15-9. 2012
    ....
  28. ncbi Increased mitochondrial and nuclear gene expression of cytochrome oxidase subunits I and IV in neuronal aging
    Patrizia Fattoretti
    Neurobiology of Aging Laboratory, National Institute of Research and Care on Aging Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1030:303-9. 2004
    ....
  29. ncbi Role of mitochondrial deterioration in physiological and pathological brain aging
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Ancona, Italy
    Gerontology 50:187-92. 2004
    ..In addition to providing the energy for the myriad of cellular performances, mitochondria are involved in regulating thermogenesis, calcium buffering, integration of pro- and anti-apoptotic signals...
  30. ncbi Impairments of synaptic plasticity in aged animals and in animal models of Alzheimer's disease
    Marta Balietti
    1 Neurobiology of Aging Laboratory, INRCA Scientific Technological Area, Ancona, Italy
    Rejuvenation Res 15:235-8. 2012
    ..We briefly review recent experimental evidence here...
  31. ncbi The effect of chronic aluminum(III) administration on the nervous system of aged rats: clues to understand its suggested role in Alzheimer's disease
    Patrizia Fattoretti
    Neurobiology of Aging Laboratory, INRCA Research Department, Ancona, Italy
    J Alzheimers Dis 5:437-44. 2003
    ....
  32. ncbi Synaptic remodeling in hippocampal CA1 region of aged rats correlates with better memory performance in passive avoidance test
    Daniela Platano
    Department of Human and General Physiology, University of Bologna, Bologna, Italy
    Rejuvenation Res 11:341-8. 2008
    ..Present findings indicate that maintenance of synaptic plastic reactivity during aging is a critical requirement for preserving long-term memory consolidation...
  33. ncbi Effects of ageing on the fine distribution of the circadian CLOCK protein in reticular formation neurons
    Manuela Malatesta
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Anatomia e Istologia, Strada Le Grazie, 8, 37134, Verona, Italy
    Histochem Cell Biol 127:641-7. 2007
    ....
  34. ncbi Long-term visual object recognition memory in aged rats
    Daniela Platano
    Department of Human and General Physiology, University of Bologna, Italy
    Rejuvenation Res 11:333-9. 2008
    ....