Fabio Virgili

Summary

Affiliation: National Institute for Food and Nutrition Research
Country: Italy

Publications

  1. ncbi Red wine metabolites modulate NF-kappaB, activator protein-1 and cAMP response element-binding proteins in human endothelial cells
    Raffaella Canali
    National Research Institute for Food and Nutrition, Rome, Italy
    Br J Nutr 103:807-14. 2010
  2. ncbi How does Nutrigenomics impact human health?
    Fabio Virgili
    National Research Institute on Food and Nutrition, Rome, Italy
    IUBMB Life 60:341-4. 2008
  3. ncbi Regulation of cellular signals from nutritional molecules: a specific role for phytochemicals, beyond antioxidant activity
    Fabio Virgili
    National Institute for Food and Nutrition Research, Via Ardeatina, 546, I 00178 Roma, Italy
    Free Radic Biol Med 45:1205-16. 2008
  4. ncbi The anti-inflammatory pharmacology of Pycnogenol in humans involves COX-2 and 5-LOX mRNA expression in leukocytes
    Raffaella Canali
    National Research Institute for Food and Nutrition, Rome, Italy
    Int Immunopharmacol 9:1145-9. 2009
  5. ncbi A novel mechanism of natural vitamin E tocotrienol activity: involvement of ERbeta signal transduction
    Raffaella Comitato
    National Research Institute for Food and Nutrition, 00178 Rome, Italy
    Am J Physiol Endocrinol Metab 297:E427-37. 2009
  6. ncbi Modulation of kinase activity by polyphenols
    Mirella Nardini
    National Institute for Food and Nutrition Research, 00178 Rome, Italy
    Ann N Y Acad Sci 973:368-70. 2002
  7. ncbi A novel model to study the biological effects of red wine at the molecular level
    Raffaella Canali
    National Research Institute for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy
    Br J Nutr 97:1053-8. 2007
  8. ncbi Characterization of the hsp70 response in lymphoblasts from aged and centenarian subjects and differential effects of in vitro zinc supplementation
    Roberto Ambra
    National Institute for Food and Nutrition Research INRAN, Free radicals Res Group, 546 Via Ardeatina, I00178 Rome, Italy
    Exp Gerontol 39:1475-84. 2004
  9. ncbi Tocotrienols activity in MCF-7 breast cancer cells: involvement of ERbeta signal transduction
    Raffaella Comitato
    National Research Institute for Food and Nutrition, Rome, Italy
    Mol Nutr Food Res 54:669-78. 2010
  10. ncbi Daidzein-sulfate metabolites affect transcriptional and antiproliferative activities of estrogen receptor-beta in cultured human cancer cells
    Pierangela Totta
    Department of Biology, University Roma Tre, I-00146 Rome, Italy
    J Nutr 135:2687-93. 2005

Collaborators

Detail Information

Publications12

  1. ncbi Red wine metabolites modulate NF-kappaB, activator protein-1 and cAMP response element-binding proteins in human endothelial cells
    Raffaella Canali
    National Research Institute for Food and Nutrition, Rome, Italy
    Br J Nutr 103:807-14. 2010
    ..This is the first report on the effects of a complex food matrix, on the molecular mechanisms associated with inflammatory response in HUVEC cultured in condition that reproduces the physiological environment occurring in vivo...
  2. ncbi How does Nutrigenomics impact human health?
    Fabio Virgili
    National Research Institute on Food and Nutrition, Rome, Italy
    IUBMB Life 60:341-4. 2008
  3. ncbi Regulation of cellular signals from nutritional molecules: a specific role for phytochemicals, beyond antioxidant activity
    Fabio Virgili
    National Institute for Food and Nutrition Research, Via Ardeatina, 546, I 00178 Roma, Italy
    Free Radic Biol Med 45:1205-16. 2008
    ..In particular, their direct interaction with nuclear receptors and their ability to modulate the activity of key enzymes involved in cell signaling and antioxidant responses are presented and discussed...
  4. ncbi The anti-inflammatory pharmacology of Pycnogenol in humans involves COX-2 and 5-LOX mRNA expression in leukocytes
    Raffaella Canali
    National Research Institute for Food and Nutrition, Rome, Italy
    Int Immunopharmacol 9:1145-9. 2009
    ..Here we show for the first time that Pycnogenol supplementation simultaneously inhibits COX-2 and 5-LOX gene expression and reduces leukotriene biosynthesis in human PMNL upon pro-inflammatory stimulation ex vivo...
  5. ncbi A novel mechanism of natural vitamin E tocotrienol activity: involvement of ERbeta signal transduction
    Raffaella Comitato
    National Research Institute for Food and Nutrition, 00178 Rome, Italy
    Am J Physiol Endocrinol Metab 297:E427-37. 2009
    ..Finally, we observed that TT treatment is associated with alteration of cell morphology, DNA fragmentation, and caspase-3 activation. Altogether, these experiments elucidated the molecular mechanism underling gamma- and delta-TT effects...
  6. ncbi Modulation of kinase activity by polyphenols
    Mirella Nardini
    National Institute for Food and Nutrition Research, 00178 Rome, Italy
    Ann N Y Acad Sci 973:368-70. 2002
  7. ncbi A novel model to study the biological effects of red wine at the molecular level
    Raffaella Canali
    National Research Institute for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy
    Br J Nutr 97:1053-8. 2007
    ..Data obtained by this approach indicate the importance of taking into account the complex metabolic transformation of polyphenols that occurs during absorption when studying their effect on human health...
  8. ncbi Characterization of the hsp70 response in lymphoblasts from aged and centenarian subjects and differential effects of in vitro zinc supplementation
    Roberto Ambra
    National Institute for Food and Nutrition Research INRAN, Free radicals Res Group, 546 Via Ardeatina, I00178 Rome, Italy
    Exp Gerontol 39:1475-84. 2004
    ..Moreover, in vitro zinc supplementation had an age-dependent effect on hsp70 expression, indicating a role for this nutritionally important molecule and suggesting its involvement in cellular stress responses...
  9. ncbi Tocotrienols activity in MCF-7 breast cancer cells: involvement of ERbeta signal transduction
    Raffaella Comitato
    National Research Institute for Food and Nutrition, Rome, Italy
    Mol Nutr Food Res 54:669-78. 2010
    ..Finally, cDNA-array experiments suggest that the activation of specific pathways in cells treated with gamma-TT with respect to alpha-TT. Our data suggest a novel potential molecular mechanism for TTs activity...
  10. ncbi Daidzein-sulfate metabolites affect transcriptional and antiproliferative activities of estrogen receptor-beta in cultured human cancer cells
    Pierangela Totta
    Department of Biology, University Roma Tre, I-00146 Rome, Italy
    J Nutr 135:2687-93. 2005
    ....
  11. ncbi Proteome analysis for identification of target proteins of genistein in primary human endothelial cells stressed with oxidized LDL or homocysteine
    Dagmar Fuchs
    Dept. of Food and Nutrition, Molecular Nutrition Unit Technical University of Munich, Hochfeldweg 2, 85350, Freising, Germany
    Eur J Nutr 44:95-104. 2005
    ..CONCLUSION: Proteome analysis allows the identification of potential interactions of dietary components in the molecular process of atherosclerosis and consequently provides a powerful tool to define biomarkers of response...
  12. ncbi Effect of oxidized low-density lipoprotein on differential gene expression in primary human endothelial cells
    Fabio Virgili
    Antioxid Redox Signal 5:237-47. 2003
    ....