Research Topics
| Alessandra SacchiSummaryAffiliation: National Institute for Infectious Diseases Country: Italy Publications
| Collaborators
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Detail Information
Publications
The basal activation state of DC subsets correlates with anti-HCV treatment outcome in HCV/HIV co-infected patientsAlessandra Sacchi
Laboratory of Cellular Immunology, National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy
Clin Immunol 138:178-86. 2011..These findings could be helpful to better understand the mediators of IFN-? action in HCV+/HIV+ patients and to explore possible exploitation of this knowledge to improve therapeutic response...- Differentiation of monocytes into CD1a- dendritic cells correlates with disease progression in HIV-infected patientsAlessandra Sacchi
National Institute for Infectious Disease L Spallanzani IRCCS, Rome, Italy
J Acquir Immune Defic Syndr 46:519-28. 2007..These results suggest that the differentiation of monocytes into CD1a* DCs may be a phenotypic marker associated with progression of the disease... - Zoledronic acid and interleukin-2 treatment improves immunocompetence in HIV-infected persons by activating Vgamma9Vdelta2 T cellsFabrizio Poccia
Laboratory of Cellular Immunology, National Institute for Infectious Diseases, LazzaroSpallanzani I R C C S, Rome 00149, Italy
AIDS 23:555-65. 2009.... - Activated V gamma 9V delta 2 T cells trigger granulocyte functions via MCP-2 releaseChiara Agrati
National Institute for Infectious Diseases Lazzaro Spallanzani Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
J Immunol 182:522-9. 2009.... - Innate gamma/delta T-cells during HIV infection: Terra relatively Incognita in novel vaccination strategies?Chiara Agrati
Laboratory of Cellular Immunology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy
AIDS Rev 13:3-12. 2011..In particular, strategies enhancing gamma/delta T-cell functions may open the possibility to formulate new immunotherapeutic regimens, which could impact the improvement of immune control of HIV disease... - CD3zeta down-modulation may explain Vgamma9Vdelta2 T lymphocyte anergy in HIV-infected patientsAlessandra Sacchi
Laboratory of Cellular Immunology, National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
J Infect Dis 199:432-6. 2009..Our findings may contribute to clarification of the molecular mechanisms of Vgamma9Vdelta2 T cell anergy found in HIV-positive patients... - Cutting edge: TGF-beta1 and IL-15 Induce FOXP3+ gammadelta regulatory T cells in the presence of antigen stimulationRita Casetti
Laboratory of Cellular Immunology, National Institute for Infectious Diseases Lazzaro Spallanzani Instituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
J Immunol 183:3574-7. 2009..Phenotypic and functional analyses of Vdelta2 Tregs will very likely improve our understanding about the role of gammadelta T cells in the pathogenesis of autoimmune, infectious, and neoplastic diseases... - Characterization of transglutaminase type II role in dendritic cell differentiation and functionIvana Matic
Department of Biology, University of Rome Tor Vergata, Rome, Italy
J Leukoc Biol 88:181-8. 2010..Taken together, these data suggest that TG2 plays an important role in regulating the response of DCs to LPS and could be a candidate target for treating endotoxin-induced sepsis... - GB-virus type C effect on HIV infection, interferon system, and dendritric cellsAlessandra Sacchi
National Institute for Infectious Diseases L. Spallanzani, Rome, Italy
Arch Med Res 39:362-3. 2008 - Central memory Vgamma9Vdelta2 T lymphocytes primed and expanded by bacillus Calmette-Guérin-infected dendritic cells kill mycobacterial-infected monocytesAngelo Martino
Unit of Cellular Immunology Fabrizio Poccia, National Institute for Infectious Diseases Lazzaro Spallanzani, Instituto di Ricovero e Cura a Carattere Scientifico, Via Portuense 292, Rome, Italy
J Immunol 179:3057-64. 2007..This study provides further evidences about the complex relationship between important players of innate immunity and suggests an immunoregulatory role of Vgamma9Vdelta2 T cells in the control of mycobacterial infection... - Mycobacteria and dendritic cell differentiation: escape or control of immunityAngelo Martino
Unit of Cellular Immunology, Padiglione Del Vecchio, National Institute for Infectious Diseases, Lazzaro Spallanzani, IRCCS, Via Portuense 292, 00149 Rome, Italy
Immunol Lett 102:115-7. 2006..However, it could represents a new mechanism of immune escape by persistent pathogens or a control mechanism of immune system to preserve the life of the organ against persistent infections... - Complementary function of gamma delta T-lymphocytes and dendritic cells in the response to isopentenyl-pyrophosphate and lipopolysaccharide antigensAngelo Martino
Unit of Cellular Immunology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy
J Clin Immunol 25:230-7. 2005..Altogether, dendritic cells and gamma delta T-cells exert a complementary function promoting an optimal immune response to non peptidic microbial antigens... - Dendritic cells derived from BCG-infected precursors induce Th2-like immune responseAngelo Martino
National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy
J Leukoc Biol 76:827-34. 2004..The induction of IL-4 production by DCs generated by BCG-infected monocytes could explain the failure of the BCG vaccine to prevent pulmonary tuberculosis... - Inhibition of T cell proliferation by cholera toxin involves the modulation of costimulatory molecules CTLA-4 and CD28Silvia Vendetti
Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, Rome, Italy
Immunol Lett 115:59-69. 2008..These findings show that the inhibition of T cell proliferation by CT affects early stages of the T cell activation and involves the modulation of costimulatory molecules CTLA-4 and CD28 on resting T cells... - Non-pathogenic Mycobacterium smegmatis induces the differentiation of human monocytes directly into fully mature dendritic cellsAngelo Martino
National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
J Clin Immunol 25:365-75. 2005..This could explain one of the mechanisms by which environmental mycobacteria can influence the immune response to pathogenic species... - Cyclic adenosine 5'-monophosphate and calcium induce CD152 (CTLA-4) up-regulation in resting CD4+ T lymphocytesSilvia Vendetti
Laboratory of Bacteriology and Medical Micology, Istituto Superiore di Sanita, Rome, Italy
J Immunol 169:6231-5. 2002..These findings demonstrate that at least two novel signal pathways regulate CTLA-4 gene expression and CD152 molecule up-regulation in human CD4(+) T lymphocytes, in the absence of full T cell activation...