Research Topics
Genomes and Genes | S FaisSummaryAffiliation: Istituto Superiore di Sanit Country: Italy Publications
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Publications
Cannibalism: a way to feed on metastatic tumorsStefano Fais
Department of Drug Research and Evaluation, Section of Pharmacogenetic, Drug Resistance and Experimental Therapeutic, Istituto Superiore di Sanita, Rome, Italy
Cancer Lett 258:155-64. 2007..Each of the components of the cannibal framework may represent specific tumor targets for future new strategies against cancer...- Leukocyte uropod formation and membrane/cytoskeleton linkage in immune interactionsStefano Fais
Laboratory of Immunology, Istituto Superiore di Sanita, Rome, Italy
J Leukoc Biol 73:556-63. 2003..This review is focused on the mechanisms underlying the formation of the leukocyte uropod, the role of cytoskeleton in defining its structure and function, and the involvement of the uropod in the complex interplay between immune cells... - A role for ezrin in a neglected metastatic tumor functionStefano Fais
Department of Drug Research and Evaluation, Pharmacogenetic, Drug Resistance and Experimental Therapeutic Section, Istituto Superiore di Sanita, 00161 Rome, Italy
Trends Mol Med 10:249-50. 2004 - Linkage between cell membrane proteins and actin-based cytoskeleton: the cytoskeletal-driven cellular functionsS Fais
Laboratory of Immunology, Istituto Superiore di Sanita, Rome, Italy
Histol Histopathol 15:539-49. 2000..We provide evidence that membrane/cytoskeleton interaction is the key to regulation of the vast majority of cellular functions... - The role of FAS to ezrin association in FAS-mediated apoptosisS Fais
Department of Drug Research and Evaluation, Pharmacogenetic, Drug Resistance and Experimental Therapeutic Section, Istituto Superiore di Sanita, Rome 00161, Italy
Apoptosis 10:941-7. 2005.... - CD95/phosphorylated ezrin association underlies HIV-1 GP120/IL-2-induced susceptibility to CD95(APO-1/Fas)-mediated apoptosis of human resting CD4(+)T lymphocytesF Luciani
Laboratories of Immunology, Istituto Superiore di Sanita, 00161 Rome, Italy
Cell Death Differ 11:574-82. 2004.... - Activation of rho GTPases by cytotoxic necrotizing factor 1 induces macropinocytosis and scavenging activity in epithelial cellsC Fiorentini
Department of Ultrastructures, Istituto Superiore di Sanita, 00161, Rome, Italy
Mol Biol Cell 12:2061-73. 2001..The activation of such activity in epithelial cells may be relevant, in mucosal tissues, in supporting or integrating the scavenging activity of resident macrophages... - CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathwayS Parlato
Laboratories of Virology, Istituto Superiore di Sanità Viale Regina Elena 299, 00161 Rome, Italy
EMBO J 19:5123-34. 2000.... - Expression of CCR-7, MIP-3beta, and Th-1 chemokines in type I IFN-induced monocyte-derived dendritic cells: importance for the rapid acquisition of potent migratory and functional activitiesS Parlato
Laboratory of Virology, Laboratory of Ultrastructures, , Rome, Italy
Blood 98:3022-9. 2001.... - Coordinate induction of interferon alpha and gamma by recombinant HIV-1 glycoprotein 120M R Capobianchi
Institute of Virology, University La Sapienza, Rome, Italy
AIDS Res Hum Retroviruses 9:957-62. 1993..Our data suggest that the HIV envelope glycoprotein could be responsible for the induction of endogenous IFN-alpha and -gamma observed in AIDS patients... - GD3 glycosphingolipid contributes to Fas-mediated apoptosis via association with ezrin cytoskeletal proteinA M Giammarioli
Department of Ultrastructures, , Rome, Italy
FEBS Lett 506:45-50. 2001..Altogether, these results are suggestive for a role of GD3 in Fas/ezrin-mediated apoptosis, supporting the view that uropods contain a multimolecular signaling complex involved in Fas-mediated apoptosis... - Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cellsM L Marino
Department of Therapeutic Research and Medicines Evaluation, Unit of Antitumor Drugs, Istituto Superiore di Sanita, Rome, Italy
Cell Death Dis 1:e87. 2010..The data presented suggest that autophagy represents an adaptive survival mechanism to overcome drug-induced cellular stress and cytotoxicity, including alteration of pH homeostasis mediated by proton pump inhibition... - Interferon-gamma up-regulates expression and activity of P-glycoprotein in human peripheral blood monocyte-derived macrophagesP Puddu
Laboratory of Immunology, Istituto Superiore di Sanita, Rome, Italy
Lab Invest 79:1299-309. 1999..These results indicate that Pgp expression and activity can be up-regulated in human MDM in response to IFN-gamma. We suggest that IFN-gamma may be involved in the induction of multidrug resistance in macrophages... - Epithelial cells and expression of the phagocytic marker CD68: scavenging of apoptotic bodies following Rho activationS Travaglione
Department of Ultrastructures, Istituto Superiore di Sanit, Viale Regina Elena 299, 00161 Rome, Italy
Toxicol In Vitro 16:405-11. 2002..Together with the capability of digesting apoptotic cells following their internalization, our findings indicate that Rho-activated epithelial cells behave in most respects as professional phagocytes... - Proton pump inhibitor-induced tumour cell death by inhibition of a detoxification mechanismS Fais
Anti Tumour Drugs Section, Department of Therapeutic Research and Medicines Evaluation, Istituo Superiore di Sanità National Institute of Health, Rome, Italy
J Intern Med 267:515-25. 2010..Clinical data will provide the proof of concept on the use of PPIs as a new class of antitumour agent with a very low level of systemic toxicity as compared with standard chemotherapeutic agents... - Unidirectional budding of HIV-1 at the site of cell-to-cell contact is associated with co-polarization of intercellular adhesion molecules and HIV-1 viral matrix proteinS Fais
Institute of Virology, La Sapienza University, Rome, Italy
AIDS 9:329-35. 1995..To explore the possibility that HIV-1 budding and cellular adhesion molecules co-polarize at cell-to-cell contact sites. To investigate the incorporation of host-cell-derived adhesion molecules into HIV-1... - Potent phagocytic activity discriminates metastatic and primary human malignant melanomas: a key role of ezrinLuana Lugini
Laboratory of Immunology, Istituto Superiore di Sanit, Rome, Italy
Lab Invest 83:1555-67. 2003..Moreover, our data suggest that gene therapy or drug treatments aimed at inhibiting actin assembly to the phagosomal membranes may be proposed as a new strategy for the control of tumor aggressiveness... - Tumor acidity, chemoresistance and proton pump inhibitorsAngelo De Milito
Department of Drug Research and Evaluation, Pharmacogenetic, Drug Resistance and Experimental Therapeutic Section, Istituto Superiore di Sanita, Rome, Italy
Future Oncol 1:779-86. 2005..These data suggest that tumor alkalinization may represent a key target of future antitumor strategies... - Proton pump inhibitors may reduce tumour resistanceAngelo De Milito
Expert Opin Pharmacother 6:1049-54. 2005..In vivo experiments showed that oral pretreatment with omeprazole induced a sensitivity of the human solid tumours to anticancer drugs... - Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen speciesAngelo De Milito
Department of Drug Research and Evaluation, Pharmacogenetic, Drug Resistance, and Experimental Therapeutic Section, Istituto Superiore di Sanita, Rome, Italy
Cancer Res 67:5408-17. 2007..This study further supports the importance of acidity and pH gradients in tumor cell homeostasis and suggests new therapeutic approaches for human B-cell tumors based on PPI... - Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugsFrancesca Luciani
Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Nazionale dei Tumori, Milan, Italy
J Natl Cancer Inst 96:1702-13. 2004..CONCLUSION: Our results open new possibilities for the treatment of drug-resistant tumors through combination strategies based on the use of well-tolerated pH modulators such as PPIs... - Targeting vacuolar H+-ATPases as a new strategy against cancerStefano Fais
Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Rome, Italy
Cancer Res 67:10627-30. 2007..These results propose V-ATPases as a key target for new strategies in cancer treatment... - P-glycoprotein-actin association through ERM family proteins: a role in P-glycoprotein function in human cells of lymphoid originFrancesca Luciani
Laboratory of Immunology and Ultrastructures, Istituto Superiore di Sanit, Rome, Italy
Blood 99:641-8. 2002..Strategies aimed at inhibiting P-glycoprotein-actin association may be helpful in increasing the efficiency of both antitumor and antiviral therapies... - Identification and relevance of the CD95-binding domain in the N-terminal region of ezrinFrancesco Lozupone
Laboratory of Immunology and Ultrastructures, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome 00161, Italy
J Biol Chem 279:9199-207. 2004..Moreover, this study suggests that a major role of ezrin is to connect CD95 to actin, thus allowing the CD95 polarization on the cells and the occurrence of the following multiple cascades of the CD95 pathway... - Differential expression and distribution of ezrin, radixin and moesin in human natural killer cellsCarlo Ramoni
Laboratory of Immunology, Istituto Superiore di Sanita, Rome, Italy
Eur J Immunol 32:3059-65. 2002..Moreover, our data suggest that radixin may represent an additional biological marker of human NK cells and that this protein may hold a specific role in NK cell function... - Immunity to cancer: attack and escape in T lymphocyte-tumor cell interactionLicia Rivoltini
Units of Human Tumor Immunotherapy and Immunobiology, Istituto Nazionale Tumori, Milan, Italy
Immunol Rev 188:97-113. 2002..Finally, we discuss the role of inducible nitric oxide synthases in determining the inhibition of apoptosis in melanoma cells, which can make such tumor cells resistant to the T-cell attack... - Cannibalism of live lymphocytes by human metastatic but not primary melanoma cellsLuana Lugini
Department of Drug Research and Evaluation, Istituto Superiore di Sanit, Viale Regina Elena 299, 00161 Rome, Italy
Cancer Res 66:3629-38. 2006..Moreover, our data suggest that cannibalism may represent a sort of "feeding" activity aimed at sustaining survival and progression of malignant tumor cells in an unfavorable microenvironment... - Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infectionCaroline Fluur
Department of Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
J Immunol 178:5340-50. 2007..Elevated IL-7 levels associated with lymphopenic conditions, including HIV-infection, might participate in the increased sensitivity of T cells for activation-induced apoptosis... - Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-beta-mediated suppressive activity on T lymphocytesRoberta Valenti
Unit of Immunotherapy of Human Tumors, Istituto Nazionale Tumori, Milan, Italy
Cancer Res 66:9290-8. 2006..Therapeutic interventions on the crucial steps of this pathway may contribute to restore tumor/immune system interactions favoring T-cell-mediated control of tumor growth in cancer patients... - Importance of the state of activation and/or differentiation of CD4+ T cells in AIDS pathogenesisStefano Fais
Trends Immunol 23:128-9. 2002 - Escape strategies and reasons for failure in the interaction between tumour cells and the immune system: how can we tilt the balance towards immune-mediated cancer control?Licia Rivoltini
Istituto Nazionale Tumori, ViaVenezian 1, 20133 Milan, Italy
Expert Opin Biol Ther 5:463-76. 2005.... - Rho-activating Escherichia coli cytotoxic necrotizing factor 1: macropinocytosis of apoptotic bodies in human epithelial cellsAlessia Fabbri
Department of Ultrastructures, Istituto Superiore di Sanit, Rome, Italy
Int J Med Microbiol 291:551-4. 2002..By exerting this activity, CNF1-activated epithelial cells might support the scavenging activity of macrophages during bacterial overgrowth... - Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesiclesGiovanna Andreola
Unit of Immunotherapy of Human Tumors, Istituto Nazionale dei Tumori, Milan 20133, Italy
J Exp Med 195:1303-16. 2002..Such vesicles may form a sort of front line hindering lymphocytes and other immunocompetent cells from entering neoplastic lesions and exert their antitumor activity... - Effect of human natural killer and gammadelta T cells on the growth of human autologous melanoma xenografts in SCID miceFrancesco Lozupone
Laboratories of Immunology and Virology, Istituto Superiore di Sanit, Rome, Italy
Cancer Res 64:378-85. 2004..Moreover, our study emphasizes the usefulness of human tumor/SCID mouse models for preclinical evaluation of immunotherapy protocols against human tumors... - Adoptive transfer of an anti-MART-1(27-35)-specific CD8+ T cell clone leads to immunoselection of human melanoma antigen-loss variants in SCID miceFrancesco Lozupone
Laboratory of Immunology, Istituto Superiore di Sanit, Rome, Italy
Eur J Immunol 33:556-66. 2003..Furthermore, this work shows that human tumors/SCID mouse models may be useful in evaluating the in vivo efficacy of adoptive immunotherapies...