Research Topics
Species | Massimo Di NicolaSummaryAffiliation: Istituto Nazionale Tumori Country: Italy Publications
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Detail Information
Publications
Vaccination with autologous tumor-loaded dendritic cells induces clinical and immunologic responses in indolent B-cell lymphoma patients with relapsed and measurable disease: a pilot studyMassimo Di Nicola
C Gandini Medical Oncology, Bone Marrow Transplantation Unit, Fondazione Istituti di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, Milan, Italy
Blood 113:18-27. 2009..This study is registered with the Istituto Superiore di Sanità : http://www.iss.it with protocol number 7578-PRE 21-801...- Boosting T cell-mediated immunity to tyrosinase by vaccinia virus-transduced, CD34(+)-derived dendritic cell vaccination: a phase I trial in metastatic melanomaMassimo Di Nicola
Cristina Gandini Bone Marrow Transplantation Unit, Istituto Nazionale Tumori, Milan, Italy
Clin Cancer Res 10:5381-90. 2004.... - Skewed T-cell differentiation in patients with indolent non-Hodgkin lymphoma reversed by ex vivo T-cell culture with gammac cytokinesAndrea Anichini
Human Tumor Immunobiology Unit, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
Blood 107:602-9. 2006.... - High-dose yttrium-90-ibritumomab tiuxetan with tandem stem-cell reinfusion: an outpatient preparative regimen for autologous hematopoietic cell transplantationLiliana Devizzi
Cristina Gandini Medical Oncology and Department of Nuclear Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy
J Clin Oncol 26:5175-82. 2008..To develop high-dose myeloablative therapy for CD20(+) non-Hodgkin's lymphoma (NHL) as a safe and widely applicable regimen... - IFN-gamma enhances the antimyeloma activity of the fully human anti-human leukocyte antigen-DR monoclonal antibody 1D09C3Carmelo Carlo Stella
Cristina Gandini Medical Oncology Unit, Medical Oncology, University of Milano, Milan, Italy
Cancer Res 67:3269-75. 2007..Our data show that (a) one fourth of MM patients express HLA-DR on CD138(+) cells and (b) IFN-gamma-induced up-regulation of HLA-DR results in a potent enhancement of the in vivo antimyeloma activity of 1D09C3... - Long-term results of high-dose chemotherapy with autologous bone marrow or peripheral stem cell transplant as first salvage treatment for relapsed or refractory Hodgkin lymphoma: a single institution experienceSimonetta Viviani
Division of Medical Oncology 3, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
Leuk Lymphoma 51:1251-9. 2010..Therefore, this therapeutic strategy may represent an active salvage approach even in the unfavorable group of patients with induction failure... - Tumor-reactive CD8+ early effector T cells identified at tumor site in primary and metastatic melanomaAndrea Anichini
Human Tumors Immunobiology Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
Cancer Res 70:8378-87. 2010..These results suggest development of early phases of antitumor immunity even in advanced melanoma. Moreover, the CD8(+) FOXP3(+) "early effector" subset may be an invaluable tool for monitoring immunity at tumor site... - The effect of artificial antigen-presenting cells with preclustered anti-CD28/-CD3/-LFA-1 monoclonal antibodies on the induction of ex vivo expansion of functional human antitumor T cellsRoberta Zappasodi
C Gandini Medical Oncology, Bone Marrow Transplantation Unit, Fondazione IRCCS Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
Haematologica 93:1523-34. 2008.... - Dendritic cell viability is decreased after phagocytosis of apoptotic tumor cells induced by staurosporine or vaccinia virus infectionMassimo Di Nicola
C Gandini Bone Marrow Transplantation Unit, Department of Medical Oncology, Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy
Haematologica 88:1396-404. 2003..However, the clinical use of killed tumor cells as a source of antigens will require an optimal methodology to induce effective tumor cell apoptosis... - Use of recombinant human growth hormone (rhGH) plus recombinant human granulocyte colony-stimulating factor (rhG-CSF) for the mobilization and collection of CD34+ cells in poor mobilizersCarmelo Carlo-Stella
Cristina Gandini Oncology Unit, Istituto Nazionale Tumori, and Department of Hematology and Medical Oncology, University of Milano, Milan, Italy
Blood 103:3287-95. 2004..In conclusion, our data demonstrate that in poor mobilizers addition of rhGH to rhG-CSF allows the patients to efficiently mobilize and collect CD34(+) cells with maintained functional properties... - High response rate and manageable toxicity with an intensive, short-term chemotherapy programme for Burkitt's lymphoma in adultsMassimo Di Nicola
Cristina Gandini Bone Marrow Transplantation Unit, Istituto Nazionale Tumori, Milan, Italy
Br J Haematol 126:815-20. 2004..Confirmation of these excellent efficacy and feasibility results by larger, multicentre and prospective studies is warranted... - Improved clinical outcome in indolent B-cell lymphoma patients vaccinated with autologous tumor cells experiencing immunogenic deathRoberta Zappasodi
C Gandini Medical Oncology, Bone Marrow Transplantation Unit, Department of Experimental Oncology, Fondazione Istituti di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale per lo Studio e la Cura dei Tumori, Italy
Cancer Res 70:9062-72. 2010..Therapeutic improvements may thus be accomplished by circumventing the tumor-impaired ability to undergo immunogenic death and prime the antitumor immune response... - The anti-human leukocyte antigen-DR monoclonal antibody 1D09C3 activates the mitochondrial cell death pathway and exerts a potent antitumor activity in lymphoma-bearing nonobese diabetic/severe combined immunodeficient miceCarmelo Carlo-Stella
Cristina Gandini Medical Oncology Unit, Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy
Cancer Res 66:1799-808. 2006.... - Clinical protocol. Immunization of patients with malignant melanoma with autologous CD34(+) cell-derived dendritic cells transduced ex vivo with a recombinant replication-deficient vaccinia vector encoding the human tyrosinase gene: a phase I trialMassimo Di Nicola
Cristina Gandini Bone Marrow Transplantation Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan I-20133, Italy
Hum Gene Ther 14:1347-60. 2003 - Serological identification of HSP105 as a novel non-Hodgkin lymphoma therapeutic targetRoberta Zappasodi
C Gandini Medical Oncology, Bone Marrow Transplantation Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
Blood 118:4421-30. 2011..Our study adds HSP105 to the list of nononcogenes that can be exploited as antilymphoma targets... - In vivo T-cell immune response against anaplastic lymphoma kinase in patients with anaplastic large cell lymphomasLorena Passoni
Oncogenic Fusion Protein Unit, Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy
Haematologica 91:48-55. 2006..One of the promising ALK-targeted therapeutic options is cancer vaccination. In this study, we investigate whether ALK is a tumor-associated antigen suitable for immune interventions... - Long-term remission in mantle cell lymphoma following high-dose sequential chemotherapy and in vivo rituximab-purged stem cell autografting (R-HDS regimen)Alessandro M Gianni
Division of Medical Oncology C Donazione Cristina Gandini, Istituto Nazionale Tumori, Milan, Italy
Blood 102:749-55. 2003..The R-HDS regimen can be safely applied in a multicenter hematology setting and leads to long-term EFS and OS in the majority of patients with an otherwise incurable disease... - Topical prophylaxis of conjunctivitis induced by high-dose cytosine arabinosidePaola Matteucci
Cristina Gandini Medical Oncology Unit, Istituto Nazionale Tumori, Via Venezian, 1 20133 Milano, Italy
Haematologica 91:255-7. 2006..The incidence and severity of HD Ara-C-induced conjunctivitis are significantly reduced by combined dexamethasone/ diclofenac prophylaxis... - Mutation-independent anaplastic lymphoma kinase overexpression in poor prognosis neuroblastoma patientsLorena Passoni
Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
Cancer Res 69:7338-46. 2009..Alternative mechanisms other than direct mutations and/or gene amplification regulate the ALK level of expression in NBL cells. Wild-type ALK is a potential therapeutic target for advanced/metastatic NBLs... - Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuliMassimo Di Nicola
Cristina Gandini Bone Marrow Transplantation Unit, Istituto Nazionale Tumori, Milano, Italy
Blood 99:3838-43. 2002.... - Dendritic cellsMassimo Di Nicola
C Gandini Bone Marrow Transplantation Unit, Division of Medical Oncology, National Cancer Institute, Milan, Italy
Suppl Tumori 1:S29-31. 2002 - Identical rearrangement of immunoglobulin heavy chain gene in neoplastic Langerhans cells and B-lymphocytes: evidence for a common precursorMichele Magni
Division of Medical Oncology C, Cristina Gandini Bone Marrow Transplantation Unit, Istituto Nazionale Tumori, Milan, Italy
Leuk Res 26:1131-3. 2002 - Myeloablative doses of yttrium-90-ibritumomab tiuxetan and the risk of secondary myelodysplasia/acute myelogenous leukemiaAnna Guidetti
Medical Oncology 3, National Cancer Institute, Milan, Italy
Cancer 117:5074-84. 2011....