Silvia Baroncelli

Summary

Affiliation: Istituto Superiore di Sanit
Country: Italy

Publications

  1. ncbi Macaca mulatta, fascicularis and nemestrina in AIDS vaccine development
    Silvia Baroncelli
    Pharmacology and Therapy of Viral Diseases Unit, Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Viale Regina Elena, 299, Rome, 00161 Italy
    Expert Rev Vaccines 7:1419-34. 2008
  2. ncbi Hematological effects of zidovudine prophylaxis in newborn infants with and without prenatal exposure to zidovudine
    Silvia Baroncelli
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità ISS, Rome, Italy
    J Med Virol 83:551-6. 2011
  3. ncbi Single-nucleotide polymorphisms in human beta-defensin-1 gene in Mozambican HIV-1-infected women and correlation with virologic parameters
    Silvia Baroncelli
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    AIDS 22:1515-7. 2008
  4. ncbi Long-term protection against SHIV89.6P replication in HIV-1 Tat vaccinated cynomolgus monkeys
    Maria Teresa Maggiorella
    Laboratory of Virology, Istituto Superiore di Sanit, Viale Regina Elena, 299, 00161 Rome, Italy
    Vaccine 22:3258-69. 2004
  5. ncbi Containment of infection in tat vaccinated monkeys after rechallenge with a higher dose of SHIV89.6P(cy243)
    Alessandra Borsetti
    National AIDS Center, Istituto Superiore di Sanita, Rome, Italy
    Viral Immunol 22:117-24. 2009
  6. ncbi Development and use of SIV-based Integrase defective lentiviral vector for immunization
    Zuleika Michelini
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    Vaccine 27:4622-9. 2009
  7. ncbi T cell receptor excision circles (TRECs) analysis during acute intrarectal infection of cynomolgus monkeys with pathogenic chimeric simian human immunodeficiency virus
    Roberta Bona
    National AIDS Center, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Virus Res 126:86-95. 2007
  8. ncbi Pregnancy outcomes in women with advanced HIV infection in Italy
    Silvia Baroncelli
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    AIDS Patient Care STDS 25:639-45. 2011
  9. ncbi T-cell-mediated protective efficacy of a systemic vaccine approach in cynomolgus monkeys after SIV mucosal challenge
    Zuleika Michelini
    Laboratory of Virology, Istituto Superiore Sanit, Rome, Italy
    J Med Primatol 33:251-61. 2004
  10. ncbi Characterization of alpha-defensins plasma levels in Macaca fascicularis and correlations with virological parameters during SHIV89.6Pcy11 experimental infection
    Silvia Baroncelli
    Department of Drug Research and Evaluation, National AIDS Center, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    AIDS Res Hum Retroviruses 23:287-96. 2007

Collaborators

Detail Information

Publications23

  1. ncbi Macaca mulatta, fascicularis and nemestrina in AIDS vaccine development
    Silvia Baroncelli
    Pharmacology and Therapy of Viral Diseases Unit, Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Viale Regina Elena, 299, Rome, 00161 Italy
    Expert Rev Vaccines 7:1419-34. 2008
    ..This article aims at summarizing the main characteristics of the three macaque species used in vaccine trials...
  2. ncbi Hematological effects of zidovudine prophylaxis in newborn infants with and without prenatal exposure to zidovudine
    Silvia Baroncelli
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità ISS, Rome, Italy
    J Med Virol 83:551-6. 2011
    ..The distinct effects of these two pathways should be considered...
  3. ncbi Single-nucleotide polymorphisms in human beta-defensin-1 gene in Mozambican HIV-1-infected women and correlation with virologic parameters
    Silvia Baroncelli
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    AIDS 22:1515-7. 2008
    ....
  4. ncbi Long-term protection against SHIV89.6P replication in HIV-1 Tat vaccinated cynomolgus monkeys
    Maria Teresa Maggiorella
    Laboratory of Virology, Istituto Superiore di Sanit, Viale Regina Elena, 299, 00161 Rome, Italy
    Vaccine 22:3258-69. 2004
    ....
  5. ncbi Containment of infection in tat vaccinated monkeys after rechallenge with a higher dose of SHIV89.6P(cy243)
    Alessandra Borsetti
    National AIDS Center, Istituto Superiore di Sanita, Rome, Italy
    Viral Immunol 22:117-24. 2009
    ..This effect was associated with a strong anamnestic response to Tat, while responses to Gag and Env were nearly undetectable. Taken together, these data provide further evidence for the usefulness of Tat-based vaccines...
  6. ncbi Development and use of SIV-based Integrase defective lentiviral vector for immunization
    Zuleika Michelini
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    Vaccine 27:4622-9. 2009
    ....
  7. ncbi T cell receptor excision circles (TRECs) analysis during acute intrarectal infection of cynomolgus monkeys with pathogenic chimeric simian human immunodeficiency virus
    Roberta Bona
    National AIDS Center, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Virus Res 126:86-95. 2007
    ..These data suggest that SHIV89.6P(cy11) intrarectal infection of cynomolgus monkeys differently affects TRECs content in CD3+ CD4+ and CD3+ CD8+ T cell subsets...
  8. ncbi Pregnancy outcomes in women with advanced HIV infection in Italy
    Silvia Baroncelli
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    AIDS Patient Care STDS 25:639-45. 2011
    ..During postpartum care, women with more advanced HIV infection should receive particular care to prevent loss of virologic suppression...
  9. ncbi T-cell-mediated protective efficacy of a systemic vaccine approach in cynomolgus monkeys after SIV mucosal challenge
    Zuleika Michelini
    Laboratory of Virology, Istituto Superiore Sanit, Rome, Italy
    J Med Primatol 33:251-61. 2004
    ..These results underline the efficacy of a multiprotein approach in combination with a triple vector system of antigen delivery...
  10. ncbi Characterization of alpha-defensins plasma levels in Macaca fascicularis and correlations with virological parameters during SHIV89.6Pcy11 experimental infection
    Silvia Baroncelli
    Department of Drug Research and Evaluation, National AIDS Center, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    AIDS Res Hum Retroviruses 23:287-96. 2007
    ....
  11. ncbi Microbial translocation is associated with residual viral replication in HAART-treated HIV+ subjects with <50copies/ml HIV-1 RNA
    Silvia Baroncelli
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    J Clin Virol 46:367-70. 2009
    ..Recent data have shown that plasma levels of lipopolysaccharide (LPS) are a quantitative indicator of microbial translocation in HIV infected individuals...
  12. ncbi Nonintegrating Lentiviral Vector-Based Vaccine Efficiently Induces Functional and Persistent CD8+ T Cell Responses in Mice
    Donatella R M Negri
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Biomed Biotechnol 2010:534501. 2010
    ..In addition, IDLV immunization induced high frequency of polyfunctional CD8+ T cells able to simultaneously produce IFNgamma, TNFalpha, and IL2...
  13. ncbi Trough concentrations of lopinavir, nelfinavir, and nevirapine with standard dosing in human immunodeficiency virus-infected pregnant women receiving 3-drug combination regimens
    Silvia Baroncelli
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome, Italy
    Ther Drug Monit 30:604-10. 2008
    ..Subtherapeutic predose concentrations among HIV-infected pregnant women were more commonly found with NVP than with protease inhibitors. LPV administration was associated with the best viral load suppression...
  14. ncbi Common occurrence of anaemia at the end of pregnancy following exposure to zidovudine-free regimens
    Carmela Pinnetti
    Department of Infectious Diseases, Catholic University, Rome, Italy
    J Infect 63:144-50. 2011
    ..Although zidovudine-free regimens are increasingly used in pregnancy, their haematological effects in mothers and newborns are incompletely defined...
  15. ncbi Successful immunization with a single injection of non-integrating lentiviral vector
    Donatella R M Negri
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Mol Ther 15:1716-23. 2007
    ..These data provide evidence that a single administration of an IN-defective sinLV elicits a significant immune response in the absence of vector integration and may be a safe and useful strategy for vaccine development...
  16. ncbi Factors influencing gestational age-adjusted birthweight in a national series of 600 newborns from mothers with HIV
    Marco Floridia
    Department of Drug Research and Evaluation, Istituto Superiore di Sanità ISS, Rome, Italy
    HIV Clin Trials 9:287-97. 2008
    ..Few studies have assessed the determinants of birthweight in newborns from HIV-positive mothers in analyses that adjusted for different gestational age at delivery...
  17. ncbi Antiretroviral treatment in pregnancy: a six-year perspective on recent trends in prescription patterns, viral load suppression, and pregnancy outcomes
    Silvia Baroncelli
    Department of Drug Research and Evaluation, Istituto Superiore di Sanità ISS, Rome, Italy
    AIDS Patient Care STDS 23:513-20. 2009
    ..Constant improvements in the rates of HIV suppression were observed, probably driven by the adoption of stronger and more effective regimens and by the increasing options available for combination treatment...
  18. ncbi Raltegravir plasma concentrations in treatment-experienced patients receiving salvage regimens based on raltegravir with and without maraviroc coadministration
    Silvia Baroncelli
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    Ann Pharmacother 44:838-43. 2010
    ..The safety and efficacy of both drugs have been investigated, but there is no information on possible pharmacokinetic interactions between these 2 drugs in clinical practice...
  19. ncbi HIV-1 Tat-based vaccines: from basic science to clinical trials
    Emanuele Fanales-Belasio
    Laboratory of Virology, Istituto Superiore di Sanit, Rome, Italy
    DNA Cell Biol 21:599-610. 2002
    ..Based on these results and on data of Tat conservation and immune cross-recognition in field isolates from different clades, phase I clinical trials are being initiated in Italy for both preventive and therapeutic vaccination...
  20. ncbi Circular viral DNA detection and junction sequence analysis from PBMC of SHIV-infected cynomolgus monkeys with undetectable virus plasma RNA
    Andrea Cara
    Laboratory of Virology, Istituto Superiore di Sanit, Viale Regina Elena 299, 00161 Rome, Italy
    Virology 324:531-9. 2004
    ..Persistence of unintegrated viral DNA in monkeys with undetectable plasma RNA could indicate either stability in non-dividing cells or ongoing low levels of viral replication in dividing cells...
  21. ncbi Protective efficacy of a multicomponent vector vaccine in cynomolgus monkeys after intrarectal simian immunodeficiency virus challenge
    Donatella R M Negri
    Laboratory of Virology, Istituto Superiore di Sanit, Viale R. Elena 299, 00161 Rome, Italy
    J Gen Virol 85:1191-201. 2004
    ..These results, reminiscent of the efficacy of live attenuated virus vaccines, suggest that vaccination with a combination of many viral antigens can induce a robust and stable vaccine-induced immunity able to abrogate virus replication...
  22. ncbi Tumor necrosis factor-alpha, Interleukin-10, and alpha-defensins in plasma and breast milk of HIV-infected highly active antiretroviral therapy-treated and untreated pregnant women in Mozambique
    Silvia Baroncelli
    J Acquir Immune Defic Syndr 47:647-9. 2008
  23. ncbi Identification of a cytotoxic T-lymphocyte (CTL) epitope recognized by Gag-specific CTLs in cynomolgus monkeys infected with simian/human immunodeficiency virus
    Donatella R M Negri
    Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanit, Viale Regina Elena 299, 00161 Rome, Italy
    J Gen Virol 87:3385-92. 2006
    ..This newly identified SIV Gag CTL epitope in SHIV-infected cynomolgus monkeys will be a useful tool for monitoring and evaluating Gag-specific immune responses during vaccination and infection in the cynomolgus monkey model of AIDS...