Giuliano Avanzini

Summary

Affiliation: Istituto Nazionale Neurologico Carlo Besta
Country: Italy

Publications

  1. ncbi The role of the thalamus in vigilance and epileptogenic mechanisms
    G Avanzini
    Istituto Nazionale Neurologico C Besta, Via Celoria 11, 20133, Milan, Italy
    Clin Neurophysiol 111:S19-26. 2000
  2. ncbi Suppressive efficacy by a commercially available blue lens on PPR in 610 photosensitive epilepsy patients
    Giuseppe Capovilla
    Epilepsy Center, Department of Child Neuropsychiatry, C Poma Hospital, Mantova, Italy
    Epilepsia 47:529-33. 2006
  3. ncbi Musicogenic seizures
    Giuliano Avanzini
    Istituto Nazionale Neurologico C Besta, Milan, Italy
    Ann N Y Acad Sci 999:95-102. 2003
  4. ncbi Epileptogenic channelopathies: experimental models of human pathologies
    Giuliano Avanzini
    Department ofNeurophysiopathology, Istituto Neurologico C Besta, Milan, Italy
    Epilepsia 48:51-64. 2007
  5. ncbi Cellular biology of epileptogenesis
    Giuliano Avanzini
    Istituto Nazionale Neurologico C Besta, Milan, Italy
    Lancet Neurol 2:33-42. 2003
  6. ncbi Prospects for novel antiepileptic drugs
    Giuliano Avanzini
    Istituto Nazionale Neurologico C Besta, Via Celoria 11, I 20133, Milano, Italy
    Curr Opin Investig Drugs 4:805-14. 2003
  7. ncbi Molecular biology of channelopathies: impact on diagnosis and treatment
    Giuliano Avanzini
    Istituto Nazionale Neurologico C Besta, Via Celoria 11, 20133 Milan, Italy
    Expert Rev Neurother 4:519-39. 2004
  8. ncbi Temporal lobe epilepsy: neuropathological and clinical correlations in 243 surgically treated patients
    Laura Tassi
    Epilepsy Surgery Centre C Munari, Milan, Italy
    Epileptic Disord 11:281-92. 2009
  9. ncbi Potentially epileptogenic dysfunction of cortical NMDA- and GABA-mediated neurotransmission in Otx1-/- mice
    G Sancini
    Istituto Nazionale Neurologico C Besta, Via Celoria 11, 20133 Milan, Italy
    Eur J Neurosci 14:1065-74. 2001
  10. ncbi Focal epilepsies in adult patients attending two epilepsy centers: Classification of drug-resistance, assessment of risk factors, and usefulness of "new" antiepileptic drugs
    Isabella Gilioli
    C Besta Foundation Neurological Institute, Epilepsy Center, Milan, Italy S Paolo Hospital, Neurological Unit and Epilepsy Center, Milan, Italy Department of Medicine, Surgery and Dentistry, University of Milan, Milan, Italy
    Epilepsia 53:733-40. 2012

Detail Information

Publications56

  1. ncbi The role of the thalamus in vigilance and epileptogenic mechanisms
    G Avanzini
    Istituto Nazionale Neurologico C Besta, Via Celoria 11, 20133, Milan, Italy
    Clin Neurophysiol 111:S19-26. 2000
    ..The most relevant results of studies on the anatomo-physiological substrate of the thalamic rhythmogenic mechanisms responsible for sleep spindles and spike-wave discharges are reviewed...
  2. ncbi Suppressive efficacy by a commercially available blue lens on PPR in 610 photosensitive epilepsy patients
    Giuseppe Capovilla
    Epilepsy Center, Department of Child Neuropsychiatry, C Poma Hospital, Mantova, Italy
    Epilepsia 47:529-33. 2006
    ..Nonpharmacologic treatment using blue sunglasses is effective and safe in controlling photosensitivity, but large series of patients have never been studied...
  3. ncbi Musicogenic seizures
    Giuliano Avanzini
    Istituto Nazionale Neurologico C Besta, Milan, Italy
    Ann N Y Acad Sci 999:95-102. 2003
    ..The implementations of the results of ongoing investigations on brain processing of musical information will advance our understanding of the mechanisms responsible for the transition from interictal to ictal phases of epilepsy...
  4. ncbi Epileptogenic channelopathies: experimental models of human pathologies
    Giuliano Avanzini
    Department ofNeurophysiopathology, Istituto Neurologico C Besta, Milan, Italy
    Epilepsia 48:51-64. 2007
    ..These findings underscore the need for further studies to address the mechanisms involved in mutated-channel dysfunctions...
  5. ncbi Cellular biology of epileptogenesis
    Giuliano Avanzini
    Istituto Nazionale Neurologico C Besta, Milan, Italy
    Lancet Neurol 2:33-42. 2003
    ..better understanding of the role of these epileptogenic mechanisms will promote new advances in the development of selective and targeted antiepileptic drugs...
  6. ncbi Prospects for novel antiepileptic drugs
    Giuliano Avanzini
    Istituto Nazionale Neurologico C Besta, Via Celoria 11, I 20133, Milano, Italy
    Curr Opin Investig Drugs 4:805-14. 2003
    ....
  7. ncbi Molecular biology of channelopathies: impact on diagnosis and treatment
    Giuliano Avanzini
    Istituto Nazionale Neurologico C Besta, Via Celoria 11, 20133 Milan, Italy
    Expert Rev Neurother 4:519-39. 2004
    ....
  8. ncbi Temporal lobe epilepsy: neuropathological and clinical correlations in 243 surgically treated patients
    Laura Tassi
    Epilepsy Surgery Centre C Munari, Milan, Italy
    Epileptic Disord 11:281-92. 2009
    ..FS are particularly relevant in patients with focal cortical dysplasia and HS...
  9. ncbi Potentially epileptogenic dysfunction of cortical NMDA- and GABA-mediated neurotransmission in Otx1-/- mice
    G Sancini
    Istituto Nazionale Neurologico C Besta, Via Celoria 11, 20133 Milan, Italy
    Eur J Neurosci 14:1065-74. 2001
    ..Prominent postsynaptic inhibitory potentials may also act as a further pro-epileptogenic event by synchronizing abnormal excitatory potentials...
  10. ncbi Focal epilepsies in adult patients attending two epilepsy centers: Classification of drug-resistance, assessment of risk factors, and usefulness of "new" antiepileptic drugs
    Isabella Gilioli
    C Besta Foundation Neurological Institute, Epilepsy Center, Milan, Italy S Paolo Hospital, Neurological Unit and Epilepsy Center, Milan, Italy Department of Medicine, Surgery and Dentistry, University of Milan, Milan, Italy
    Epilepsia 53:733-40. 2012
    ..Actually, a small but not negligible percentage of patients reached seizure freedom after trying several AEDs (including "new" AEDs), suggesting repeated trials may be necessary for seizure control...
  11. ncbi Enhanced frontocentral EEG connectivity in photosensitive generalized epilepsies: a partial directed coherence study
    Giulia Varotto
    Department of Neurophysiology, Epilepsy Centre, C Besta Neurological Institute IRCCS Foundation, Milan, Italy
    Epilepsia 53:359-67. 2012
    ....
  12. ncbi Third conference on epileptogenesis. S Servolo Island, Venice, Italy, July 27-30, 2005
    Marco de Curtis
    Istituto Nazionale Neurologico Carlo Besta, Milano, Itlay
    Epilepsia 47:1243-6. 2006
  13. ncbi Vagal nerve stimulation: relationship between outcome and electroclinical seizure pattern
    Marina Casazza
    Division of Neurophysiopathology, Istituto Nazionale Neurologico C Besta, Via Celoria 11, 20133 Milano, Italy
    Seizure 15:198-207. 2006
    ..These results of this small series of patients suggest that VNS might be more suitable in patients with temporal rather than frontal or central seizure onset. Further studies are required to support this hypothesis...
  14. ncbi Epileptic and imaging findings in perinatal hypoxic-ischemic encephalopathy with ulegyria
    Flavio Villani
    Istituto Nazionale Neurologico, Via Celoria 11, Milan, Italy
    Epilepsy Res 55:235-43. 2003
    ..Drug refractoriness was an almost constant correlate of this form of symptomatic epilepsy...
  15. ncbi Na+-activated K+ current contributes to postexcitatory hyperpolarization in neocortical intrinsically bursting neurons
    Silvana Franceschetti
    National Neurological Institute C Besta, 20133 Milan and Department of Physiological and Pharmacological Sciences, University of Pavia, 27100 Pavia, Italy
    J Neurophysiol 89:2101-11. 2003
    ....
  16. ncbi Subcortical nodular heterotopia: a functional MRI and somatosensory evoked potentials study
    F Villani
    Division of Clinical Neurophysiology and Epilepsy Centre, Istituto Nazionale Neurologico C Besta, Via Celoria 11, I 20133 Milan, Italy
    Neurol Sci 25:225-9. 2004
    ....
  17. ncbi Unilateral frontal lobe epilepsy affects executive functions in children
    D Riva
    Developmental Neurology Division, Istituto Nazionale Neurologico C Besta, Via Celoria 11, I 20133 Milan, Italy
    Neurol Sci 26:263-70. 2005
    ..No side-specific deficits were detected, while an earlier onset of epilepsy and the duration of the disorder, but not the seizures frequency, were found to correspond with more severe deficits in some specific frontal lobe functions...
  18. ncbi Interictal spikes in focal epileptogenesis
    M De Curtis
    Department of Experimental Neurophysiology, Istituto Nazionale Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy
    Prog Neurobiol 63:541-67. 2001
    ....
  19. ncbi Preserved memory in temporal lobe epilepsy patients after surgery for low-grade tumour. A pilot study
    A R Giovagnoli
    Department of Clinical Neuroscience, C Besta National Neurological Institute, Via Celoria 11, I 20133, Milan, Italy
    Neurol Sci 28:251-8. 2007
    ..In patients with TLE and low-grade tumour, temporal lobe surgery does not necessarily induce memory deficits. Improvement of memory abilities subserved by the unoperated temporal lobe may be expected...
  20. ncbi Positive response to immunomodulatory therapy in an adult patient with Rasmussen's encephalitis
    F Villani
    Division of Clinical Neurophysiology and Epileptology, Istituto Nazionale Neurologico C Besta, Milan, Italy
    Neurology 56:248-50. 2001
    ..High-dose corticosteroids and plasmapheresis were not effective. She improved with high-dose therapy with human IV immunoglobulin...
  21. ncbi Event-related potential (ERP) markers of melodic processing: The N2 component is modulated by structural complexity, not by melodic 'meaningfulness'
    L Minati
    Scientific Department, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
    Brain Res Bull 83:23-8. 2010
    ..04) elevated for random notes as compared to tonal melodies. This may be related to attentional modulation, or more specifically to associative components of auditory processing...
  22. ncbi Effects in neocortical neurons of mutations of the Na(v)1.2 Na+ channel causing benign familial neonatal-infantile seizures
    Paolo Scalmani
    Department of Neurophysiopathology, Istituto Neurologico C Besta, 20133 Milan, Italy
    J Neurosci 26:10100-9. 2006
    ..Thus, the pathogenic mechanism of BFNIS mutations is neuronal hyperexcitability caused by increased Na+ current...
  23. ncbi The chicken with four legs: a case of semantic amnesia and cryptogenic epilepsy
    Anna R Giovagnoli
    Neuropsychology Laboratory, C Besta National Neurological Institute, Department of Clinical Neuroscience, Milan, Italy
    Epilepsy Behav 14:261-8. 2009
    ....
  24. ncbi A pathogenetic hypothesis of Unverricht-Lundborg disease onset and progression
    Silvana Franceschetti
    Division of Neurophysiology and Epileptology, Neurological Institute C Besta via Caloria 11, 20133 Milan, Milan, Italy
    Neurobiol Dis 25:675-85. 2007
    ..Furthermore, a greater degree of neuronal damage was observed in CSTB-deficient than in WT mice after seizures of identical grade, indicating increased susceptibility to seizure-induced cell death...
  25. ncbi Movement-related desynchronization-synchronization (ERD/ERS) in patients with Unverricht-Lundborg disease
    E Visani
    Department of Neurophysiology; C. Besta National Neurological Institute, Milan, Italy
    Neuroimage 33:161-8. 2006
    ..The changes involving beta-ERS had a significant relationship with the functional disability in individual patients and might play a pathogenic role in the motor dysfunction...
  26. ncbi Sensorimotor cortex excitability in Unverricht-Lundborg disease and Lafora body disease
    L Canafoglia
    Department of Clinical Neurophysiology, IRCCS National Neurological Institute C. Besta, Milano, Italy
    Neurology 63:2309-15. 2004
    ..The LBD findings highlight sustained hyperexcitability of the sensorimotor cortex in response to afferent stimuli, which fit with a more severe impairment of inhibitory mechanisms...
  27. ncbi Immunocytochemical investigation on dysplastic human tissue from epileptic patients
    R Spreafico
    Department of Neurophysiology, National Neurological Institute C Besta, Milano, Italy
    Epilepsy Res 32:34-48. 1998
    ....
  28. ncbi Photosensitive epilepsy: spectral and coherence analyses of EEG using 14Hz intermittent photic stimulation
    E Visani
    Unit of Neurophysiopathology Epilepsy Centre, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, Milano, Italy
    Clin Neurophysiol 121:318-24. 2010
    ..To evaluate the EEG recorded in photosensitive idiopathic generalised epilepsy (IGE) patients at rest and during 14Hz IPS, frequency capable of inducing photoparoxysmal responses (PPRs)...
  29. ncbi Morphological organization of somatosensory cortex in Otx1(-/-) mice
    B Cipelletti
    Dipartimento Neurofisiologia Sperimentale, Istituto Nazionale Neurologico C Besta, Via Celoria 11, 20133, Milano, Italy
    Neuroscience 115:657-67. 2002
    ..The defects found in the cortical GABAergic system of the Otx1(-/-) mouse can plausibly explain the cortical hyperexcitability that produces seizures in these animals...
  30. ncbi Layer-specific properties of the persistent sodium current in sensorimotor cortex
    P Aracri
    C. Besta National Neurological Institute, Via Celoria 11, 20133 Milan, Italy
    J Neurophysiol 95:3460-8. 2006
    ....
  31. ncbi Dealing with drug dependency: a commentary on ILAE's partnership with the pharmaceutical industry
    Giuliano Avanzini
    Istituto Neurologico Carlo Besta, Milano, Italy
    Epilepsia 48:1821-4. 2007
  32. ncbi Immune-mediated epilepsies
    Tiziana Granata
    Department of Child Neurology, Carlo Besta Neurological Institute, Milan, Italy
    Epilepsia 52:5-11. 2011
    ..We highlight future directions for preclinical and clinical research that are required for improved diagnosis and treatment of immune-mediated epilepsies...
  33. ncbi ICTAL EEG fast activity in West syndrome: from onset to outcome
    Ferruccio Panzica
    C Besta Foundation Neurological Institute, Via Celoria 11, Milan, Italy
    Epilepsia 48:2101-10. 2007
    ..To characterize the fast EEG activities associated with infantile spasms in West syndrome, and their value in predicting the recurrence and localization of late seizures...
  34. ncbi Rhythmic cortical myoclonus in Niemann-Pick disease type C
    Laura Canafoglia
    Department of Neurophysiology and Epileptology, Carlo Besta National Neurological Institute, Milan, Italy
    Mov Disord 21:1453-6. 2006
    ..EEG-EMG frequency analysis (better than jerk-locked back-averaging) demonstrated the cortical origin of the myoclonus. Our observations indicate that cortical myoclonus may occur as the main symptom of NPC...
  35. ncbi Semantic memory in partial epilepsy: verbal and non-verbal deficits and neuroanatomical relationships
    Anna Rita Giovagnoli
    Laboratory of Neuropsychology, Department of Neurology and Neuropathology, Carlo Besta National Neurological Institute, Via Celoria 11, 20133 Milan, Italy
    Neuropsychologia 43:1482-92. 2005
    ..The semantic memory impairment may reflect damage in the lateral and mesial temporal lobe regions that impair neocortical functions in storing and retrieving information or hippocampal functions in processing meaningful stimuli...
  36. ncbi Rhythmic cortical myoclonus in a case of HIV-related encephalopathy
    Laura Canafoglia
    Department of Clinical Neurophysiology; Istituto Nazionale Neurologico Carlo Besta, Milan, Italy
    Mov Disord 18:1533-8. 2003
    ....
  37. ncbi The use of immunoglobulins in the treatment of human epilepsy
    F Villani
    Division of Clinical Neurophysiology and Epilepsy Center, C. Besta National Neurological Institute, Via Celoria 11, I-20123 Milan, Italy
    Neurol Sci 23:S33-7. 2002
    ....
  38. ncbi Epileptic phenotypes associated with mitochondrial disorders
    L Canafoglia
    Department of Clinical Neurophysiology, Epilepsy Center, Istituto Nazionale Neurologico C. Besta, Milan, Italy
    Neurology 56:1340-6. 2001
    ..Except for those with an A8344G mitochondrial DNA point mutation, most of our patients had partial seizures or EEG signs indicating a focal origin...
  39. ncbi Protein-kinase C-dependent phosphorylation inhibits the effect of the antiepileptic drug topiramate on the persistent fraction of sodium currents
    G Curia
    Department of Neurophysiology, Laboratory of Experimental Epileptology, C. Besta National Neurological Institute, Via Celoria 11, 20133 Milan, Italy
    Neuroscience 127:63-8. 2004
    ..The channel phosphorylation that may occur in cortical neurons as a result of physiological or pathological (e.g. epileptic) events can modulate the action of TPM on Na(+) currents...
  40. ncbi Is tolerance to antiepileptic drugs clinically relevant?
    Giuliano Avanzini
    Istituto Nazionale Neurologico C. Besta, Milan, Italy
    Epilepsia 47:1285-7. 2006
  41. ncbi Part I: Cerebral organization of music-related functions. Introduction
    Giuliano Avanzini
    Department of Experimental Research and Diagnostics, National Neurologic Institute C. Besta, Milan, Italy
    Ann N Y Acad Sci 999:1-3. 2003
  42. ncbi AlphaCaMKII and NMDA-receptor subunit expression in epileptogenic cortex from human periventricular nodular heterotopia
    Giorgio Battaglia
    Molecular Neuroanatomy Laboratory, Department of Experimental Neurophysiology, C Besta Neurological Institute, Via Celoria 11, 20133 Milan, Italy
    Epilepsia 43:209-16. 2002
    ..To understand the cellular mechanisms underlying its intrinsic hyperexcitability, we investigated the expression of glutamate-receptor subunits and related proteins in four human patients affected by PNH...
  43. ncbi Spectral properties of EEG fast activity ictal discharges associated with infantile spasms
    F Panzica
    Department of Neurophysiology, C Besta Neurological Institute, Milan, Italy
    Clin Neurophysiol 110:593-603. 1999
    ..The aim of this study was to evaluate the characteristics of the ictal EEG event accompanying infantile spasms...
  44. ncbi Progressive myoclonus epilepsies: an electroclinical, biochemical, morphological and molecular genetic study of 17 cases
    S Franceschetti
    Neurological Institute C Besta, Milan, Italy
    Acta Neurol Scand 87:219-23. 1993
    ..Molecular genetical investigation of mtDNA demonstrated the reported heteroplasmic point mutation at nt 8344 of mtDNA in the two MERRF patients, while it was negative in all of the others...
  45. ncbi Neurophysiological features in relation to clinical signs in clinically diagnosed corticobasal degeneration
    D Monza
    Department of Neurology I, C. Besta National Neurological Institute, Via Celoria 11, I-20133 Milan, Italy
    Neurol Sci 24:16-23. 2003
    ..Patients with evident parkinsonism had greater SEP N30 (frontal) abnormalities, while most patients with marked paresis had slower MEP times...
  46. ncbi Phosphorylation of sodium channels mediated by protein kinase-C modulates inhibition by topiramate of tetrodotoxin-sensitive transient sodium current
    G Curia
    Department of Neurophysiology, Laboratory of Experimental Epileptology, C Besta National Neurological Institute, Milano, Italy
    Br J Pharmacol 150:792-7. 2007
    ..We investigated the consequences of phosphorylation of the sodium channel on the effect of topiramate on tetrodotoxin (TTX)-sensitive transient Na(+) current (I(NaT))...
  47. ncbi Clinical and genetic findings in 26 Italian patients with Lafora disease
    Silvana Franceschetti
    Department of Clinical Neurophysiology, Istituto Nazionale Neurologico C. Besta, Milan, Italy
    Epilepsia 47:640-3. 2006
    ..Additional clinical and functional studies will clarify whether specific mutations may influence the course of the disease in LD patients...
  48. ncbi Cortical myoclonus in Janz syndrome
    F Panzica
    Department of Neurophysiology, C. Besta Neurological Institute, Via Celoria 11, 20133, Milan, Italy
    Clin Neurophysiol 112:1803-9. 2001
    ....
  49. ncbi Movement-activated myoclonus in genetically defined progressive myoclonic epilepsies: EEG-EMG relationship estimated using autoregressive models
    F Panzica
    National Neurological Institute C. Besta, Via Celoria 11, 20133, Milan, Italy
    Clin Neurophysiol 114:1041-52. 2003
    ..Moreover, they could detect the uneven spectral profiles characterising the different forms of PME...
  50. ncbi FVEPs in Creutzfeldt-Jacob disease: waveforms and interaction with the periodic EEG pattern assessed by single sweep analysis
    E Visani
    Department of Neurophysiology, C. Besta National Neurological Institute, Via Celoria 11, 20133 Milan, Italy
    Clin Neurophysiol 116:895-904. 2005
    ..SIGNIFICANCE: Our data contribute to clarifying the debated problem of the occurrence of giant FVEPs in CJD and their relationships with the spontaneous periodic EEG pattern...
  51. ncbi Intrauterine growth in the offspring of epileptic women: a prospective multicenter study
    D Battino
    Carlo Besta Neurological Institute, Milan, Italy
    Epilepsy Res 36:53-60. 1999
    ....
  52. ncbi Anemone toxin (ATX II)-induced increase in persistent sodium current: effects on the firing properties of rat neocortical pyramidal neurones
    M Mantegazza
    Laboratorio di Neurofisiologia Sperimentale, Istituto Nazionale Neurologico Carlo Besta, Milano, Italy
    J Physiol 507:105-16. 1998
    ..We suggest that IB and, to a lesser extent, RSNA neurones are endowed with a relatively large fraction of INa,p which, in physiological conditions, is sufficient to sustain bursting in IB but not in RSNA neurones...
  53. ncbi Sensorimotor organization in double cortex syndrome
    Jeffrey D Jirsch
    Montreal Neurological Institute and Hospital, Department of Neurology, McGill University, Quebec, Canada
    Hum Brain Mapp 27:535-43. 2006
    ..The recruitment of bilateral primary areas and higher-order association normotopic cortices indicates the need for a widespread network to perform simple tasks...
  54. ncbi Is refractory epilepsy preventable?
    Santiago Arroyo
    Epilepsy Unit, Hospital Clinic i Provincial, Barcelona, Spain
    Epilepsia 43:437-44. 2002
    ..The early initiation of aggressive therapy may improve outcome and overall quality of life...
  55. ncbi Are epilepsy classifications based on epileptic syndromes and seizure types outdated?
    Jerome Engel
    Epileptic Disord 8:159-60. 2006
  56. ncbi Fourth conference on epileptogenesis, May 23-26, 2007, Pisa, Italy
    Yuri Bozzi
    Istituto di Neuroscienze, Consiglio Nazionale delle Ricerche, Pisa, Italy
    Epilepsia 49:929-34. 2008