Research Topics
Species | P BossuSummaryAffiliation: Fondazione Santa Lucia Country: Italy Publications
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Detail Information
Publications
Interleukin-18 produced by peripheral blood cells is increased in Alzheimer's disease and correlates with cognitive impairmentPaola Bossù
IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Via Ardeatina 306, 00179 Rome, Italy
Brain Behav Immun 22:487-92. 2008....- Mucosal delivery of anti-inflammatory IL-1Ra by sporulating recombinant bacteriaStefano Porzio
Inpharzam Ricerche SA, Zambon Group, Via Ai Soi, CH 6807 Taverne, Switzerland
BMC Biotechnol 4:27. 2004..However, the possible systemic effects of mucosally delivered recombinant bacteria have not been investigated... - Interleukin-18, from neuroinflammation to Alzheimer's diseaseP Bossu
IRCCS Fondazione Santa Lucia, Department of Clinical and Behavioral Neurology, Experimental Neuro psychobiology Lab Via Ardeatina, 306, I 00179 Roma, Italy
Curr Pharm Des 16:4213-24. 2010.... - Disease outcome, alexithymia and depression are differently associated with serum IL-18 levels in acute strokePaola Bossù
Department of Clinical and Behavioral Neurology, Santa Lucia Foundation, Rome, Italy
Curr Neurovasc Res 6:163-70. 2009..These results suggest that IL-18 might be specifically implicated in the pathogenesis of post-stroke alexithymia, ultimately contributing to impaired recovery from stroke... - Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patientsPaola Bossù
IRCCS Santa Lucia Foundation, Rome, Italy
J Neuroinflammation 8:65. 2011..Thus, our findings point to IL-6 as a possible specific mediator and a potential therapeutic target in this monogenic disease, suggesting that an enhanced inflammatory response might be indeed involved in its progression... - Interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer's diseasePaola Bossù
IRCCS Santa Lucia Foundation, Rome, Italy
J Neurol Neurosurg Psychiatry 78:807-11. 2007..The aim of this study was to investigate the impact of two polymorphisms of the human IL-18 gene promoter at positions -607 (C/A) and -137 (G/C) on both susceptibility to and progression of AD... - Glutathione S-transferase P1 *C allelic variant increases susceptibility for late-onset Alzheimer disease: association study and relationship with apolipoprotein E epsilon4 alleleSergio Bernardini
Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
Clin Chem 51:944-51. 2005.... - Increased pro-inflammatory response by dendritic cells from patients with Alzheimer's diseaseAntonio Ciaramella
Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
J Alzheimers Dis 19:559-72. 2010.... - Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) patients are characterized by increased BDNF serum levelsFrancesco Angelucci
Department of Clinical and Behavioural Neurology, 00179, Rome, Italy
Curr Alzheimer Res 7:15-20. 2010..Other studies are necessary to establish a direct link between BDNF peripheral levels and AD longitudinal course, as well as the role of other factors, such as blood cell activation, in determining these events... - Increased concentrations of nerve growth factor and brain-derived neurotrophic factor in the rat cerebellum after exposure to environmental enrichmentFrancesco Angelucci
Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 304, Rome, Italy
Cerebellum 8:499-506. 2009.... - Delusion symptoms and response to antipsychotic treatment are associated with the 5-HT2A receptor polymorphism (102T/C) in Alzheimer's disease: a 3-year follow-up longitudinal studyFrancesco Angelucci
IRCCS Santa Lucia Foundation, Rome, Italy
J Alzheimers Dis 17:203-11. 2009.... - Glutathione S-transferase P1 and T1 gene polymorphisms predict longitudinal course and age at onset of Alzheimer diseaseGianfranco Spalletta
Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy
Am J Geriatr Psychiatry 15:879-87. 2007..Therefore, the authors studied the effect of glutathione S-transferase (GST) P1-M1-T1 gene polymorphisms and their interactions with the apolipoprotein E (ApoE) epsilon4 allelic variant on the three-year longitudinal course of AD... - Amyloid beta peptide promotes differentiation of pro-inflammatory human myeloid dendritic cellsAntonio Ciaramella
Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 306, 00179 Rome, Italy
Neurobiol Aging 30:210-21. 2009..These results demonstrate that A beta 42 can modulate the immune system by inducing pro-inflammatory DC differentiation, thus gaining new insights into AD pathogenesis and immune-based therapeutic intervention... - A multimodal MRI investigation of the subventricular zone in mild cognitive impairment and Alzheimer's disease patientsAndrea Cherubini
Department of Clinical and Behavioral Neurology, Santa Lucia Foundation, Rome, Italy
Neurosci Lett 469:214-8. 2010..Multimodal MRI, being able to highlight structural changes of microscopic tissue in humans in vivo, could represent a precious tool to complement histological studies of neurogenesis... - Combined volumetry and DTI in subcortical structures of mild cognitive impairment and Alzheimer's disease patientsAndrea Cherubini
IRCCS Santa Lucia Foundation, Rome, Italy
J Alzheimers Dis 19:1273-82. 2010..Combining different MRI modalities can allow identifying sensitive indicators of the subtle pathogenic mechanisms that occur in subcortical areas of AD patients... - Depression and cancer: an unexplored and unresolved emergent issue in elderly patientsIlaria Spoletini
IRCCS Santa Lucia Foundation, Rome, Italy
Crit Rev Oncol Hematol 65:143-55. 2008..In the near future, we need to develop validated mood disorder diagnoses and verify antidepressant treatment efficacy for elderly cancer patients with depression in order to improve their clinical outcome and quality of life...