Felice Femiano

Summary

Country: Italy

Publications

  1. ncbi [Statistical survey of afferent pathologies during a 5-year study in the oral pathology Department at the Second University of Naples]
    F Femiano
    Oral Immunopathology, School of Dentistry, II University of Medicine and Surgery, Naples, Italy
    Minerva Stomatol 51:73-8. 2002
  2. ncbi Recurrent aphthous stomatitis unresponsive to topical corticosteroids: a study of the comparative therapeutic effects of systemic prednisone and systemic sulodexide
    Felice Femiano
    Stomatology Clinic, II University of Medicines and Surgery, Naples, Italy
    Int J Dermatol 42:394-7. 2003
  3. ncbi Burning mouth syndrome (BMS): evaluation of thyroid and taste
    F Femiano
    Med Oral Patol Oral Cir Bucal 11:E22-5. 2006
  4. ncbi [Mucocutaneous bullous pemphigoid induced by valsartan. A clinical case]
    F Femiano
    Reparto di Patologia Orale, Prima Clinica Odontostomatologica, Facolta di Medicina e Chirurgia, Seconda Universita degli Studi di Napoli, Napoli, Italy
    Minerva Stomatol 52:187-90. 2003
  5. ncbi Recurrent herpes labialis: a pilot study of the efficacy of zinc therapy
    F Femiano
    Stomatology Clinic, II University of Medicines and Surgery, Naples, Italy
    J Oral Pathol Med 34:423-5. 2005
  6. ncbi Pilot study on recurrent aphthous stomatitis (RAS): a randomized placebo-controlled trial for the comparative therapeutic effects of systemic prednisone and systemic montelukast in subjects unresponsive to topical therapy
    F Femiano
    Department of Odontostomatology, School of Medicine and Surgery, II University of Naples, Naples, Italy
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:402-7. 2010
  7. ncbi Damage to taste system and oral pain: burning mouth syndrome
    F Femiano
    Department of Dentistry, Second University of Naples, Naples, Italy
    Minerva Stomatol 53:471-8. 2004
  8. ncbi Functions of the cytokines in relation oral lichen planus-hepatitis C
    Felice Femiano
    Department of Odontostomatological, Orthodontic and Surgical Science, II University of Medicineand Surgery, Naples, Italy
    Med Oral Patol Oral Cir Bucal 10:E40-4. 2005
  9. ncbi DNA cytometry of oral leukoplakia and oral lichen planus
    Felice Femiano
    Department of Odontostomatological, Orthodontic and Surgical Science, II University of Medicineand Surgery, Naples, Italy
    Med Oral Patol Oral Cir Bucal 10:E9-14. 2005
  10. ncbi Pemphigus mimicking aphthous stomatitis
    Felice Femiano
    Stomatology Clinic, Second University of Medicines and Surgery, Via Francseco Girardi 2, S Antimo, Naples 80029, Italy
    J Oral Pathol Med 34:508-10. 2005

Detail Information

Publications49

  1. ncbi [Statistical survey of afferent pathologies during a 5-year study in the oral pathology Department at the Second University of Naples]
    F Femiano
    Oral Immunopathology, School of Dentistry, II University of Medicine and Surgery, Naples, Italy
    Minerva Stomatol 51:73-8. 2002
    ..The purpose of this study was to carry out a statistical and epidemiological survey of the afferent pathologies in the department of oral pathology at the Second University of Naples from December 1995 to December 2000...
  2. ncbi Recurrent aphthous stomatitis unresponsive to topical corticosteroids: a study of the comparative therapeutic effects of systemic prednisone and systemic sulodexide
    Felice Femiano
    Stomatology Clinic, II University of Medicines and Surgery, Naples, Italy
    Int J Dermatol 42:394-7. 2003
    ..Numerous therapeutic protocols have been tried. Apart from immunomodulators, no therapy is unequivocally effective, and many systemic therapies have potential adverse effects...
  3. ncbi Burning mouth syndrome (BMS): evaluation of thyroid and taste
    F Femiano
    Med Oral Patol Oral Cir Bucal 11:E22-5. 2006
    ..The latter can have a range of causes, including hormonal...
  4. ncbi [Mucocutaneous bullous pemphigoid induced by valsartan. A clinical case]
    F Femiano
    Reparto di Patologia Orale, Prima Clinica Odontostomatologica, Facolta di Medicina e Chirurgia, Seconda Universita degli Studi di Napoli, Napoli, Italy
    Minerva Stomatol 52:187-90. 2003
    ..Substances considered innocuous are often to blame. We present a case of mucous-cutaneous bullous pemphigoid induced by an anti-hypertensive of the sartan group, valsartan...
  5. ncbi Recurrent herpes labialis: a pilot study of the efficacy of zinc therapy
    F Femiano
    Stomatology Clinic, II University of Medicines and Surgery, Naples, Italy
    J Oral Pathol Med 34:423-5. 2005
    ..The objective of this study was to investigate the effect of zinc on recurrent herpes labialis...
  6. ncbi Pilot study on recurrent aphthous stomatitis (RAS): a randomized placebo-controlled trial for the comparative therapeutic effects of systemic prednisone and systemic montelukast in subjects unresponsive to topical therapy
    F Femiano
    Department of Odontostomatology, School of Medicine and Surgery, II University of Naples, Naples, Italy
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:402-7. 2010
    ..Recurrent aphthous stomatitis (RAS) is characterized by recurrent painful oral ulcers whose etiology remains largely unknown. Numerous therapeutic protocols have been tried so far, but effectiveness remains an issue...
  7. ncbi Damage to taste system and oral pain: burning mouth syndrome
    F Femiano
    Department of Dentistry, Second University of Naples, Naples, Italy
    Minerva Stomatol 53:471-8. 2004
    ..This suggests that individuals who suffer from BMS are likely to be supertasters...
  8. ncbi Functions of the cytokines in relation oral lichen planus-hepatitis C
    Felice Femiano
    Department of Odontostomatological, Orthodontic and Surgical Science, II University of Medicineand Surgery, Naples, Italy
    Med Oral Patol Oral Cir Bucal 10:E40-4. 2005
    ..Recent studies using in situ hybridization suggest that HCV may replicate in the oral mucosa...
  9. ncbi DNA cytometry of oral leukoplakia and oral lichen planus
    Felice Femiano
    Department of Odontostomatological, Orthodontic and Surgical Science, II University of Medicineand Surgery, Naples, Italy
    Med Oral Patol Oral Cir Bucal 10:E9-14. 2005
    ..DNA cytometry is a technique that allows densitometric analysis of nuclear DNA of cells and in this way the evaluation of DNA ploidy...
  10. ncbi Pemphigus mimicking aphthous stomatitis
    Felice Femiano
    Stomatology Clinic, Second University of Medicines and Surgery, Via Francseco Girardi 2, S Antimo, Naples 80029, Italy
    J Oral Pathol Med 34:508-10. 2005
    ..The aim of this report is to highlight the case that pemphigus vulgaris (PV) may mimic aphthous stomatitis. Pemphigus classically causes persistent oral ulceration...
  11. ncbi Guidelines for diagnosis and management of aphthous stomatitis
    Felice Femiano
    Stomatology Department, II University of Medicines and Surgery, Naples, Italy
    Pediatr Infect Dis J 26:728-32. 2007
    ..Systemic medications can be tried if topical therapy is ineffective...
  12. ncbi Burning mouth syndrome and burning mouth in hypothyroidism: proposal for a diagnostic and therapeutic protocol
    Felice Femiano
    Stomatology Department, University of Medicine and Surgery, Naples, Italy
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:e22-7. 2008
    ..It is characterized by oral burning, mainly involving the tongue, lip, and anterior palate, but without oral lesions or alteration showing in blood tests and/or instrumental findings...
  13. ncbi Oral aphthous-like lesions, PFAPA syndrome: a review
    Felice Femiano
    II University of Medicines and Surgery, Naples, Italy
    J Oral Pathol Med 37:319-23. 2008
    ..Children diagnosed with this condition require systematic oral follow-up to monitor for signs of ulceration...
  14. ncbi Oral malignant melanoma: a review of the literature
    Felice Femiano
    Stomatology Clinic, School of Medicine and Surgery, University of Naples 11, Naples, Italy
    J Oral Pathol Med 37:383-8. 2008
    ..The prognosis is extremely poor, especially in advanced stages. Therefore, pigmented lesions of undetermined origin should be routinely subjected to a biopsy examination. In this study, we aimed to present a review on primary malignancy...
  15. ncbi Oral manifestations of adverse drug reactions: guidelines
    F Femiano
    Stomatology Clinic, School of Medicine and Surgery, University of Naples 11, Naples, Italy
    J Eur Acad Dermatol Venereol 22:681-91. 2008
    ..Their pathogenesis, especially of the mucosal reactions, is largely unknown and appears to involve complex interactions between the drug in question, other medications, the patient's underlying disease, genetics and lifestyle factors...
  16. ncbi A comparison of salivary substitutes versus a natural sialogogue (citric acid) in patients complaining of dry mouth as an adverse drug reaction: a clinical, randomized controlled study
    Felice Femiano
    Department of Stomatology, Second University of Medicine and Surgery, Naples, Italy
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112:e15-20. 2011
    ..We aimed to compare the efficacy of saliva substitutes and citric acid long-term therapy for oral dryness relief and unstimulated salivary flow in patients reporting drug-induced xerostomia...
  17. ncbi Burning mouth disorder (BMD) and taste: a hypothesis
    Felice Femiano
    Department of Internal Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto Brazil
    Med Oral Patol Oral Cir Bucal 13:E470-4. 2008
    ..Often BMD patients report, in association, change in taste. In this regards, it is relevant that in central nervous system connections exist between taste and oral pain and that taste normally inhibits oral pain...
  18. ncbi Pyostomatitis vegetans: a review of the literature
    Felice Femiano
    Department of Odontostomatology, II University of Naples, 80138 Naples, Italy
    Med Oral Patol Oral Cir Bucal 14:E114-7. 2009
    ..The underlying connective tissue exhibits neutrophil and eosinophil infiltration, with miliary abscesses in some cases. Treatment of PV focuses on control of the underlying disease...
  19. ncbi Burning mouth syndrome: the efficacy of lipoic acid on subgroups
    F Femiano
    Stomatology Clinic, II University of Medicine and Surgery, Naples, Italy
    J Eur Acad Dermatol Venereol 18:676-8. 2004
    ..We have examined the effect of alpha-lipoic acid (ALA, tioctic acid; Tiobec), a free radical scavenger, on the discomfort of burning mouth syndrome (BMS) in patients who had used tranquillizers previously, compared with those who had not...
  20. ncbi Burning mouth syndrome (BMS): double blind controlled study of alpha-lipoic acid (thioctic acid) therapy
    F Femiano
    Stomatology Clinic II, University of Medicine and Surgery, Napoli, Italy
    J Oral Pathol Med 31:267-9. 2002
    ..Alpha-lipoic acid is an antioxidant able to increase the levels of intracellular glutathione and eliminate free radicals. This study aimed to examine the effectiveness of alpha-lipoic acid in the therapy of BMS...
  21. ncbi Linear IgA dermatosis induced by a new angiotensin-converting enzyme inhibitor
    Felice Femiano
    University of Medicine and Surgery, Eastman Dental Institute, London, United Kingdom
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95:169-73. 2003
    ..The histologic results supported the clinical diagnosis of drug-induced linear IgA disease. The substitution of benazepril with a beta blocker resulted in complete resolution of all mucocutaneous lesions...
  22. ncbi Benign fibrous histiocytoma (BHF) of the cheek: CD 68-KP1 positivity
    F Femiano
    Stomatology Clinic II, University of Medicine and Surgery, Napoli, Italy
    Oral Oncol 37:673-5. 2001
    ..In this study the diagnosis was confirmed using immunostaining with the antibody CD 68-KP1 that is positive in any lesion containing lysosomal granules or phagolysosomes...
  23. ncbi Geographic tongue (migrant glossitis) and psoriasis
    F Femiano
    Oral Immunopathology Stomatology Clinic, II University of Medicine and Surgery, Naples, Italy
    Minerva Stomatol 50:213-7. 2001
    ..The aim of this study was to examine the relationship of geographic tongue to psoriasis...
  24. ncbi Oral proliferative verrucous leukoplakia (PVL); open trial of surgery compared with combined therapy using surgery and methisoprinol in papillomavirus-related PVL
    F Femiano
    Stomatology Clinic, II University of Medicine and Surgery, Napoli, Italy
    Int J Oral Maxillofac Surg 30:318-22. 2001
    ..The use of this antiviral agent appeared to offer a significant enhancement to the surgical management of PVL...
  25. ncbi [HLA (Human Leukocyte Antigens) and oral immunological diseases]
    F Femiano
    Facolta di Medicina e Chirurgia, Corso di Laurea in Odontoiatria e Protesi Dentaria, Seconda Universita degli Studi, Naples, Italy
    Minerva Stomatol 50:21-30. 2001
    ..The HLA typing is useful for an early diagnosis because it allows to single out the subjects at risk in a particular studied family...
  26. ncbi Pemphigus vulgaris with oral involvement: evaluation of two different systemic corticosteroid therapeutic protocols
    F Femiano
    Stomatology Clinic, II University of Medicine and Surgery, Naples, Italy
    J Eur Acad Dermatol Venereol 16:353-6. 2002
    ..Nevertheless, oral lesions are often recalcitrant and corticosteroid therapy can provoke adverse effects...
  27. ncbi Recurrent herpes labialis: efficacy of topical therapy with penciclovir compared with acyclovir (aciclovir)
    F Femiano
    Stomatology Clinic, II, University of Medicine and Surgery, Napoli, Italy
    Oral Dis 7:31-3. 2001
    ..The results not only confirmed that aciclovir is ineffective, but confirmed that penciclovir is effective, and that penciclovir is superior to aciclovir...
  28. ncbi Idiopathic dysgeusia; an open trial of alpha lipoic acid (ALA) therapy
    F Femiano
    Stomatology Clinic II, University of Medicine and Surgery, Napoli, Italy
    Int J Oral Maxillofac Surg 31:625-8. 2002
    ....
  29. ncbi Burning mouth syndrome (BMS): controlled open trial of the efficacy of alpha-lipoic acid (thioctic acid) on symptomatology
    F Femiano
    Stomatology Clinic II, University of Medicine and Surgery, Napoli, Italy
    Oral Dis 6:274-7. 2000
    ..This study examined the effect of ALA on the symptomatology of Burning mouth syndrome (BMS)...
  30. ncbi Sweet's syndrome: recurrent oral ulceration, pyrexia, thrombophlebitis, and cutaneous lesions
    Felice Femiano
    II University of Medicine and Surgery, Naples, Italy
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95:324-7. 2003
    ....
  31. ncbi Oral erosive/ulcerative lichen planus: preliminary findings in an open trial of sulodexide compared with cyclosporine (ciclosporin) therapy
    Felice Femiano
    Stomatology Clinic, University of Medicine and Surgery, Naples, Italy
    Int J Dermatol 42:308-11. 2003
    ..To study the effect of the heparinoid sulodexide systemically, compared with topical cyclosporine (ciclosporin), on chronic oral erosive/ulcerative lichen planus...
  32. ncbi If pemphigus vulgaris IgG are the cause of acantholysis, new IgG-independent mechanisms are the concause
    Nicola Cirillo
    Regional Center on Craniofacial Malformations MRI, 1st School of Medicine and Surgery, II University of Naples, Naples, Italy
    J Cell Physiol 212:563-7. 2007
    ..Thus, researchers are well advised that PV pathophysiology cannot be faithfully reproduced by leaving non-IgG serum factors out of consideration...
  33. ncbi A novel method to investigate pemphigus-induced keratinocyte dysmorphisms through living cell immunofluorescence microscopy
    Nicola Cirillo
    Regional Center on Craniofacial Malformations MRI, First School of Medicine and Surgery, II University of Naples, 80138 Naples, Italy
    Virchows Arch 450:683-90. 2007
    ..Furthermore, images displayed clear and sharp contours because living cell microscopy allows to avoid antigen distortion due to cell manipulation, which usually precedes the immunolabelling...
  34. ncbi Cleavage of desmoglein 3 can explain its depletion from keratinocytes in pemphigus vulgaris
    Nicola Cirillo
    Regional Center on Craniofacial Malformations MRI, First School of Medicine and Surgery, Second University of Naples, Naples, Italy
    Exp Dermatol 17:858-63. 2008
    ..Total amounts of full-length plakoglobin and Dsg1 were apparently unchanged. Taken together, our findings provide evidence that proteolytic processing of Dsg3 can lead to depletion of Dsg3 from the cell...
  35. ncbi How does acantholysis occur in pemphigus vulgaris: a critical review
    Alessandro Lanza
    Regional Center on Craniofacial Malformations, School of Medicine, II University of Naples, 80100 Naples, Italy
    J Cutan Pathol 33:401-12. 2006
    ....
  36. ncbi An unusual case of oral hirsutism in a patient with polycystic ovarian syndrome
    Felice Femiano
    Stomatology Department, Second University of Naples, Naples, Italy
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108:e13-6. 2009
    ..The hypothesis proposed for this unusual condition could be correlated to the high rate of circulating testosterone that may have influenced and led to the development and appearance of the hair follicles in the oral mucosa...
  37. ncbi Serum from pemphigus vulgaris reduces desmoglein 3 half-life and perturbs its de novo assembly to desmosomal sites in cultured keratinocytes
    Nicola Cirillo
    Regional Center on Craniofacial Malformations MRI, Department of Odontostomatology 1st School of Medicine and Surgery, Second University of Naples, Via Luigi De Crecchio 7, 80138 Naples, Italy
    FEBS Lett 580:3276-81. 2006
    ..Conversely, incorporation of PV IgG-Dsg3 complexes into new forming desmosomes appears perturbed. With our study, the basic biochemical changes of Dsg3 in an in vitro model of PV have been defined...
  38. ncbi Evidence of key role of Cdk2 overexpression in pemphigus vulgaris
    Alessandro Lanza
    Regional Center on Craniofacial Malformations, Clinical Odontostomatology, and Human Pathology, 1st School of Medicine and Surgery, II University of Naples, Naples, Italy
    J Biol Chem 283:8736-45. 2008
    ..Our data indicate that major Cdk2-dependent multiple gene regulatory events are present in PV. This alteration may influence the evolution of PV and its therapy...
  39. ncbi High-dose pemphigus antibodies against linear epitopes of desmoglein 3 (Dsg3) can induce acantholysis and depletion of Dsg3 from keratinocytes
    Nicola Cirillo
    Regional Center on Craniofacial Malformations MRI, Italy
    Immunol Lett 122:208-13. 2009
    ..Collectively, the data presented here demonstrate that PV IgG recognizing non-conformational epitopes of Dsg3 are pathogenic when administered on doses largely exceeding those found in PV sera...
  40. ncbi The N-terminal fraction of desmoglein 3 encompassing its immunodominant domain is present in human serum: implications for pemphigus vulgaris autoimmunity
    A Lanza
    Department of Odontostomatology, Division of Oral Medicine and Regional Center on Craniofacial Malformations MRI, Second University of Naples, Via Luigi di Crecchio 7, 80138 Naples, Italy
    Int J Immunopathol Pharmacol 19:399-407. 2006
    ....
  41. ncbi At least three phosphorylation events induced by pemphigus vulgaris sera are pathogenically involved in keratinocyte acantholysis
    N Cirillo
    Regional Center on Craniofacial Malformations MRI, II University of Naples, Naples, Italy
    Int J Immunopathol Pharmacol 21:189-95. 2008
    ..Thus, at least three phosphorylation events are pathogenically involved in pemphigus acantholysis...
  42. ncbi Burning mouth syndrome (BMS): an open trial of comparative efficacy of alpha-lipoic acid (thioctic acid) with other therapies
    F Femiano
    Stomatology Clinic II, University of Medicine and Surgery, Naples, Italy
    Minerva Stomatol 51:405-9. 2002
    ..CONCLUSIONS: These results suggest that double-blind randomized controlled multicenter studies of ALA are indicated...
  43. ncbi Pemphigus vulgaris: recent advances in our understanding of its pathogenesis
    F Femiano
    Department of Odontostomatology, Orthodontics and Oral Surgery, Faculty of Medicine and Surgery, Second University of Naples, Naples, Italy
    Minerva Stomatol 56:215-23. 2007
    ..Cholinergic agonists can protect keratinocyte monolayers against anti-Dsg antibody-induced acantholysis and reverse acantholysis produced by PV IgGs...
  44. ncbi Oral leukoplakia: open trial of topical therapy with calcipotriol compared with tretinoin
    F Femiano
    Clinic II, University of Medicine and Surgery, Napoli, Italy
    Int J Oral Maxillofac Surg 30:402-6. 2001
    ..Tretinoin however, potentially can induce erythema, angular cheilitis and xerostomia. The study suggests that topical calcipotriol is as effective in the therapy of oral leukoplakia as is topical tretinoin...
  45. ncbi Metalloproteinase 9 is the outer executioner of desmoglein 3 in apoptotic keratinocytes
    N Cirillo
    Regional Center on Craniofacial Malformations MRI, Department of Odontostomatology, 1st School of Medicine and Surgery, II University of Naples, Naples, Italy
    Oral Dis 13:341-5. 2007
    ..To investigate the specific matrix metalloproteinases (MMPs) targeting desmoglein 3 (Dsg3) in apoptotic keratinocytes...
  46. ncbi Internalization of non-clustered desmoglein 1 without depletion of desmoglein 1 from adhesion complexes in an experimental model of the autoimmune disease pemphigus foliaceus
    A Lanza
    Center of Craniofacial Malformations MRI, 1st School of Medicine and Surgery, II University of Naples, Italy
    Int J Immunopathol Pharmacol 20:355-61. 2007
    ....
  47. ncbi Matrix metalloproteinase gene expression in oral lichen planus: erosive vs. reticular forms
    N Mazzarella
    Department of Odontostomatological, Medical School II, University of Naples, Via L. De Crecchio 7, 80128 Naples, Italy
    J Eur Acad Dermatol Venereol 20:953-7. 2006
    ..The expression of specific tissue inhibitors of metalloproteinases (TIMPs) was also evaluated. CONCLUSIONS: The different clinical appearances of OLP are associated with significant differences in MMP mRNA levels...
  48. ncbi Burning Mouth Syndrome: open trial of psychotherapy alone, medication with alpha-lipoic acid (thioctic acid), and combination therapy
    Felice Femiano
    , Eastman Dental Institute, Londres
    Med Oral 9:8-13. 2004
    ..0005). CONCLUSION: The present results suggest that alpha lipoic acid may complement psychotherapy and can be an acceptable alternative to psychoactive agents, but trials to compare the two approaches are now warranted...
  49. ncbi Oral lichen planus: clinical and histological evaluation in an open trial using a low molecular weight heparinoid (sulodexide)
    Felice Femiano
    Int J Dermatol 45:986-9. 2006