Research Topics
Genomes and Genes | T RussoSummaryAffiliation: Federico II University Country: Italy Publications
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Detail Information
Publications
Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor proteinT Russo
Dipartimento di Biochimica e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, Naples, Italy
FEBS Lett 434:1-7. 1998..In this short review the possible functional roles of this complex protein network and its involvement in the generation of Alzheimer's phenotype are discussed...
Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteinsN Zambrano
Dipartimento di Biochimica e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, CEINGE Biotecnologie Avanzate s c r l, Via S Pansini 5, 80131 Naples, Italy
J Biol Chem 272:6399-405. 1997..A role for Fe65 in the pathogenesis of familial Alzheimer's disease is suggested by the finding that mutant APP, responsible for some cases of familial Alzheimer's disease, shows an altered in vivo interaction with Fe65...
The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocationG Minopoli
Dipartimento di Biochimica e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, I 80131 Naples, Italy
J Biol Chem 276:6545-50. 2001....
Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor proteinA Duilio
Dipartimento di Biochimica e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, CEINGE, Biotecnologie Avanzate s c r l, Via S Pansini 5, I 80131 Napoli, Italy
Biochem J 330:513-9. 1998....
The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1N Zambrano
Dipartimento di Biochimica e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, Via S Pansini 5, 80131 Napoli, Italy
J Biol Chem 273:20128-33. 1998..This analysis allowed us to observe that a small region N-terminal to the WW domain is phosphorylated and is necessary for the presence of Fe65 in the nuclear fraction...
The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogeneN Zambrano
Dipartimento di Biochimica e Biotecnologie Mediche, Universita di Napoli Federico II, I 80131 Napoli, Italy
J Biol Chem 276:19787-92. 2001..These results suggest that Abl, Mena, and mDab1 are involved in a common molecular machinery and that APP can play a role in tyrosine kinase-mediated signaling...
Retinoblastoma protein dephosphorylation is an early event of cellular response to prooxidant conditionsF Esposito
Dipartimento di Biochimica e Biotecnologie Mediche, Universita di Napoli Federico II, Via S Pansini 5, 80131, Naples, Italy
FEBS Lett 470:211-5. 2000..Finally, pRb dephosphorylation is catalyzed by phosphatases activated by DEM treatment...
The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor proteinF Fiore
Dipartimento di Biochimica e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, Napoli, Italy
J Biol Chem 270:30853-6. 1995....
Regulation of p21waf1/cip1 expression by intracellular redox conditionsF Esposito
Dipartimento di Biochimica e Biotecnologie Mediche, Universita di Napoli Federico II, Naples, Italy
IUBMB Life 52:67-70. 2001..Accordingly, DEM treatment strongly activates ERK2. On the other hand, redox perturbations provoked by DEM induce several early phenomena, including p21waf1/cip1 and Rb dephosphorylation...
Transcription factor NF-Y regulates differentiation of CaCo-2 cellsM A Bevilacqua
Dipartimento di Biochimica e Biotecnologie Mediche, Universita di Napoli Federico II, Via Sergio Pansini 5, Napoli, Italy
Arch Biochem Biophys 407:39-44. 2002....
The DNA sequence encompassing the transcription start site of a TATA-less promoter contains enough information to drive neuron-specific transcriptionR Faraonio
Dipartimento di Biochimica e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, Italy
Nucleic Acids Res 22:4876-83. 1994..The analysis of point mutations in this region indicates that the proteins that bind to this cis-element interact with both overlapping and distinct nucleotide sequences...
Isolation and structural characterization of the rat gene encoding the brain specific snRNP-associated polypeptide "N"F Esposito
Dipartimento di Biochimica e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, Italy
Biochem Biophys Res Commun 195:317-26. 1993..We isolated and characterized two of these regions. They contain sequences very similar to the cDNA, not interrupted by introns and flanked by a polyA tail at their 3'-ends; hence they are considered two different pseudogenes...
Novel autocrine and paracrine loops of the stem cell factor/chymase networkA de Paulis
Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
Int Arch Allergy Immunol 118:422-5. 1999..We also addressed the question whether mast cell chymase, a chymotrypsin-like protease, also present in the secretory granules of human mast cells cleaves SCF at the peptide bound between Phe 158 and Met159...
The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabledK S Ermekova
Department of Biochemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 272:32869-77. 1997....
Functions of WW domains in the nucleusM Sudol
Department of Medicine, Mount Sinai Medical Center, New York, NY 10029, USA
FEBS Lett 490:190-5. 2001..It is expected that by understanding the details of the WW domain-mediated protein-protein interactions, we will be able to illuminate numerous signaling pathways which control certain aspects of transcription and cell cycle...
Expression of the neuron-specific FE65 gene marks the development of embryo ganglionic derivativesA Simeone
Istituto Internazionale di Genetica e Biofisica, CNR, Napoli, Italia
Dev Neurosci 16:53-60. 1994..Thus FE65 gene expression can be considered a marker of the development of embryo ganglionic derivatives...
Nerve growth factor inhibits apoptosis in memory B lymphocytes via inactivation of p38 MAPK, prevention of Bcl-2 phosphorylation, and cytochrome c releaseM Torcia
Department of Experimental Medicine and Internal Medicine, University of Rome Tor Vergata, Via di Tor Vergata 135, Rome I 00133, Italy
J Biol Chem 276:39027-36. 2001..These data demonstrate that the molecular mechanisms underlying the survival factor function of NGF critically rely upon the continuous inactivation of p38 MAPK, a Bcl-2-modifying enzyme...
Isolation of cDNA fragments hybridizing to rat brain-specific mRNAsF Esposito
Dipartimento di Biochimica e Biotecnologie Mediche, Universita di Napoli, Italia
Dev Neurosci 12:373-81. 1990..A very recent comparison with the EMBL nucleotide sequence data bank showed that this mRNA codes for a brain-specific snRNP-associated protein...
