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Species | Claudio De FeliceSummaryCountry: Italy Publications
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Publications
Predictive value of skin color for illness severity in the high-risk newbornClaudio De Felice
Department of Pediatrics, Obstetrics and Reproduction, University of Siena, Italy
Pediatr Res 51:100-5. 2002..7; 95% confidence interval, 6.4 to 33.8). Our findings indicate that skin color reflects clinical severity in the newborn and that skin colorimetry can accurately identify higher risk infants...- Oral mucosal microvascular abnormalities: an early marker of bronchopulmonary dysplasiaClaudio De Felice
Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, University of Siena, I 53100 Siena, Italy
Pediatr Res 56:927-31. 2004..0001). Our findings provide a new early clinical sign in BPD and stress the importance of an early disorder in the oral mucosal vascularization process in the disease pathogenesis... - Histologic chorioamnionitis and severity of illness in very low birth weight newbornsClaudio De Felice
Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte, Viale M Bracci 16, I 53100 Siena, Italy
Pediatr Crit Care Med 6:298-302. 2005..In this study, the relationships among HCA, initial illness severity, and neonatal outcomes were analyzed in very low birth weight (VLBW) newborns admitted to the neonatal intensive care unit... - Fordyce granules and hereditary non-polyposis colorectal cancer syndromeC De Felice
Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte, Viale M Bracci, 16 I 53100 Siena, Italy
Gut 54:1279-82. 2005..Early identification of gene carriers is essential to reduce cancer incidence and overall mortality... - Skin reflectance changes in preterm infants with patent ductus arteriosusClaudio De Felice
Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte, Viale M Bracci 16, Siena I 53100, Italy
Early Hum Dev 78:45-51. 2004..Patent ductus arteriosus (PDA) is a common complication in preterm infants. While two-dimensional echocardiography is the method of choice for diagnosing a PDA, clinical signs are known to be of limited value... - A new phenotypical variant of intrauterine growth restriction?Claudio DeFelice
Neonatal Intensive Care Unit, Division of Neonatology, Azienda Ospedaliera Universitaria Senese Le Scotte Hospital, Viale M Bracci 16, 53100 Siena, Italy
Pediatrics 119:e983-90. 2007..A link between intrauterine growth restriction and major adult-onset diseases has been reported. In this study we observed a series of hitherto-unrecognized clinical features in a population of children with intrauterine growth restriction... - Early activation of the hypothalamic-pituitary-adrenal-axis in very-low-birth-weight infants with small thymus at birthC De Felice
Neonatal Intensive Care Unit, Italy
J Matern Fetal Neonatal Med 21:251-4. 2008..However, the mechanisms of thymic involution remain to be clarified. Here, we tested the hypothesis that an activation of the hypothalamic-pituitary-adrenal (HPA) axis occurs in VLBW infants with acute thymic involution at birth... - Abnormal vascular network complexity: a new phenotypic marker in hereditary non-polyposis colorectal cancer syndromeC De Felice
Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy
Gut 52:1764-7. 2003..HNPCC results from dominantly inherited germline mutations in mismatch repair (MMR) genes, leading to genomic instability and cancer. No predictive physical signs of HNPCC are available to date... - Maternal pulse oximetry perfusion index as a predictor of early adverse respiratory neonatal outcome after elective cesarean deliveryClaudio De Felice
Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte, Siena, Italy
Pediatr Crit Care Med 9:203-8. 2008..Here, we prospectively tested the hypothesis that a low maternal perfusion index at the baseline phase (i.e., preanesthesia) of the elective cesarean section is a predictor of early adverse neonatal respiratory outcome... - Abnormal oral mucosal light reflectance: a new clinical marker of high risk for colorectal cancerC De Felice
Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte, Viale M Bracci, 16 I 53100 Siena, Italy
Gut 55:1436-9. 2006..In the present study, the value of oral mucosal light reflectance in identifying hereditary non-polyposis colorectal cancer (HNPCC) carriers was investigated... - Small thymus at birth: a predictive radiographic sign of bronchopulmonary dysplasiaClaudio De Felice
Department of Pediatrics, Obstetrics and Reproduction, University of Siena, Italy
Pediatrics 110:386-8. 2002..We tested the hypothesis that a small thymus detected at birth on the routine chest radiograph is a predictor of BPD in VLBW infants... - Subclinical chorioamnionitis: an unrecognised risk factor for severe pulmonary haemorrhage in extremely low birth weight infantsClaudio De Felice
Division of Neonatology, Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Le Scotte General Hospital, Viale M. Bracci 16, 53100 Siena, Italy
Eur J Pediatr 164:111-2. 2005 - The pulse oximeter perfusion index as a predictor for high illness severity in neonatesClaudio De Felice
Dipartimento di Pediatria Ostetricia e Medicina della Riproduzione, Azienda Ospedaliera Senese, Viale M Bracci 16, 53100 Siena, Italy
Eur J Pediatr 161:561-2. 2002 - Recurrent otitis media with effusion in preterm infants with histologic chorioamnionitis--a 3 years follow-up studyClaudio De Felice
Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese Siena, Italy
Early Hum Dev 84:667-71. 2008..Here, we tested the hypothesis of an association between recurrent OME during the first 3 years of life and HCA in very low birth weight (VLBW) infants... - Abnormal oral mucosal light reflectance in bronchopulmonary dysplasiaClaudio De Felice
Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy
Early Hum Dev 82:273-8. 2006..56%; 690 nm: < or = 48.95%; 700 nm: < or = 50.81%). CONCLUSIONS: These findings indicate the presence of previously unrecognised, early abnormalities in the average optical properties of the oral mucosa from infants developing BPD... - Abnormal oral mucosal light reflectance in achondroplasiaClaudio De Felice
Hospital-based Neonatologist and Clinical Researcher, Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Italy
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:748-52. 2006..4% specificity. These findings indicate the presence of previously unrecognized oral mucosal reflectance abnormalities in unaffected ACH parents of ACH children... - F?-neuroprostanes mediate neurological severity in Rett syndromeCinzia Signorini
Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Siena, Italy
Clin Chim Acta 412:1399-406. 2011..In addition, we investigate on the impact of ?-3 polyunsaturated fatty acids (?-3 PUFAs) supplementation on F?-NeuroPs levels... - Oxidative stress in Rett syndrome: natural history, genotype, and variantsSilvia Leoncini
Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, and Neonatal Intensive Care Unit, University Hospital, Azienda Ospedaliera Senese, Siena, Italy
Redox Rep 16:145-53. 2011.... - Early dynamic changes in pulse oximetry signals in preterm newborns with histologic chorioamnionitisClaudio De Felice
Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte, Siena, Italy
Pediatr Crit Care Med 7:138-42. 2006..CONCLUSIONS: Our findings indicate that early autonomic tone balance abnormalities are present in newborns with HCA and suggest that early dynamic analysis of pulse oximetry signals could be useful in identifying affected infants... - Unrecognized lung disease in classic Rett syndrome: a physiologic and high-resolution CT imaging studyClaudio De Felice
Neonatal Intensive Care Unit, University Hospital, Azienda Ospedaliera Universitaria Senese of Siena, Siena, Italy
Chest 138:386-92. 2010..The aim of the present study was to determine if there are RS-associated pulmonary abnormalities... - Abnormal oral mucosal light reflectance in infantile hypertrophic pyloric stenosisStefano Parrini
Department of Odontostomatologic Sciences, University of Siena, Siena, Italy
J Pediatr Gastroenterol Nutr 39:53-5. 2004..CONCLUSIONS: This study reports a previously unrecognized mucosal reflectance abnormality of the oral mucosa in IHPS, thus offering a new, accurate, and noninvasive phenotypic marker for the condition... - Oral mucosa spectrophotometric changes in healthy parents of patients with Down syndromeGiuseppe Latini
Division of Neonatology, Ospedale Perrino, Brindisi, Italy
Prenat Diagn 24:685-7. 2004..To date, no phenotypical markers in the parents of DS offspring are known. Here, we tested the value of oral mucosal reflectance spectrophotometry in identifying unaffected parents of DS patients (free trisomy 21)... - F2-dihomo-isoprostanes as potential early biomarkers of lipid oxidative damage in Rett syndromeClaudio De Felice
Neonatal Intensive Care Unit, University Hospital, Azienda Ospedaliera Universitaria Senese, Siena, Italy
J Lipid Res 52:2287-97. 2011.... - Universal neonatal hearing screening: the Siena (Italy) experience on 19,700 newbornsBruno De Capua
U O S Audiologia Clinica, Neonatal Intensive Care Unit, D A I Materno Infantile, Azienda Ospedaliera Universitaria Senese, Policlinico Santa Maria alle Scotte, Viale M Bracci 16, I 53100 Siena, Italy
Early Hum Dev 83:601-6. 2007..As 33-50% of all congenital HLs cannot be detected in a selective hearing risk, use of universal neonatal hearing screening (UNHS) programs is expanding... - Abnormal oral vascular network pattern geometry: a new clinical sign of down syndromeGiuseppe Latini
Division of Neonatology, Perrino Hospital, Brindisi, Clinical Physiology Institute, National Research Council of Italy IFC CNR, Lecce Section, Italy
J Pediatr 148:132-7. 2006..0006) for the oral vascular networks of patients (n = 14) and their unaffected parents. This newly recognized sign may provide a useful phenotypical marker for identifying couples potentially at risk for offspring with Down syndrome... - Early postnatal skin colour changes in term newborns with subclinical histological chorioamnionitisClaudio De Felice
Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy
Eur J Pediatr 163:550-4. 2004..CONCLUSION: These findings, compatible with early peripheral microcirculatory changes, indicate skin vasoconstriction as an early neonatal manifestation of subclinical chorioamnionitis... - Prolonged fetal bradycardia as the presenting clinical sign in Streptococcus agalactiae chorioamnionitisGiuseppe Presta
Division of Neonatology, Perrino Hospital, Brindisi, Italy
J Perinat Med 32:535-7. 2004..We report a case of a 37 weeks' gestation infant with severe birth asphyxia, status epilepticus and GBS chorioamnionitis, in which a prolonged fetal bradycardia was the only prenatal clinical sign... - Subclinical myocardial dysfunction in Rett syndromeClaudio De Felice
Neonatal Intensive Care Unit, University General Hospital, Azienda Ospedaliera Universitaria Senese AOUS, Viale M Bracci, 16, I 53100 Siena, Italy
Eur Heart J Cardiovasc Imaging 13:339-45. 2012..Besides, increased oxidative stress markers (OS) have been found in RTT. We hypothesized that (i) RTT patients present a subclinical biventricular dysfunction and (ii) the myocardial dysfunction correlate with OS... - Morphological changes and oxidative damage in Rett Syndrome erythrocytesLucia Ciccoli
Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Siena, Italy
Biochim Biophys Acta 1820:511-20. 2012..Here, RBCs shape was evaluated in RTT patients and healthy subjects as a function of OS markers, blood oxygenation, pulmonary gas exchange, and cardio-respiratory parameters... - Di-(2-ethylhexyl)phthalate leakage and color changes in endotracheal tubes after application in high-risk newbornsGiuseppe Latini
Division of Neonatology, A Perrino Hospital, Brindisi, Italy
Neonatology 95:317-23. 2009..Polyvinylchloride (PVC) is often adopted for making medical devices... - Transient hypothyroxinemia of prematurity and histological chorioamnionitisClaudio De Felice
Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Italy
J Perinat Med 33:514-8. 2005..CONCLUSION: Our findings indicate a previously un-recognized relationship between HCA and THOP, hence suggesting a predominant role for a fetal systemic inflammatory response syndrome in the pathogenesis of THOP... - Abnormal oral vascular network geometric complexity in Ehlers-Danlos syndromeClaudio De Felice
Hospital-based Neonatologist and Clinical Researcher, Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98:429-34. 2004..0001) than controls. These findings indicate the presence of a previously unrecognized microvascular network abnormality on the oral mucosa in EDS patients, and provide an additional phenotypical marker for the condition... - Abnormal oral mucosal light reflectance: a new clinical sign of Ehlers-Danlos syndromeStefano Parrini
Department of Odontostomatological Sciences, University of Siena, Italy
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:335-8. 2004..51% at the 400 nm wavelength identified the EDS patients with 100% sensitivity and 100% specificity. These findings indicate that an abnormal oral mucosal reflectance is a previously unrecognized clinical marker of EDS... - Increased levels of 4HNE-protein plasma adducts in Rett syndromeAlessandra Pecorelli
Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Siena, Via Aldo Moro 2, 53100 Siena, Italy
Clin Biochem 44:368-71. 2011..Increased oxidative stress (OS) has been documented in MeCP2-RTT patients. Here, we evaluated the levels of 4-hydroxynonenal plasma protein adducts (4HNE-PAs) in MeCP2-, CDKL5-, and FOXG1-RTT and in their clinical variants... - Lactational exposure to phthalates in Southern ItalyGiuseppe Latini
Division of Neonatology, Perrino Hospital, Brindisi, Italy
Environ Int 35:236-9. 2009..Infants are considered to represent a population at increased risk, as they are exposed early in life to several different sources of exposure to phthalates... - Systematic underestimation of oxygen delivery in ventilated preterm infantsClaudio De Felice
Neonatal Intensive Care Unit, Policlinico S Maria alle Scotte, Azienda Ospedaliera Universitaria Senese, Siena, Italy claudiodefelix hotmail it
Neonatology 98:18-22. 2010..To date, the equivalence between set and delivered oxygen (O(2)) in ventilated preterm infants has not been rigorously studied... - Persistent pulmonary hypertension of the newborn: therapeutical approachGiuseppe Latini
Division of Neonatology, Perrino Hospital, s s 7 per Mesagne, 72100 Brindisi, Italy
Mini Rev Med Chem 8:1507-13. 2008..In particular, recent studies seem to show that sildenafil, a phosphodiesterase inhibitor type 5 that selectively reduces pulmonary vascular resistance may be a useful therapeutic adjunct to critically ill neonates with PPHN... - Evaluating illness severity for very low birth weight infants: CRIB or CRIB-II?Claudio De Felice
Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy
J Matern Fetal Neonatal Med 17:257-60. 2005.... - Determinants of nosocomial infection in 6 neonatal intensive care units: an Italian multicenter prospective cohort studyCinzia Auriti
Neonatal Intensive Care Unit, Bambino Gesu Children s Hospital, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Rome, Italy
Infect Control Hosp Epidemiol 31:926-33. 2010..Nosocomial infections are still a major cause of morbidity and mortality among neonates admitted to neonatal intensive care units (NICUs)... - Plasticizers, infant nutrition and reproductive healthGiuseppe Latini
Division of Neonatology, Ospedale A Perrino, s s 7 per Mesagne, 72100 Brindisi, Italy
Reprod Toxicol 19:27-33. 2004..Here, we report a review on dietary phthalate exposure in babies... - In utero exposure to phthalates and fetal developmentGiuseppe Latini
Division of Neonatology, Ospedale A Perrino, s s 7 per Mesagne, 72100 Brindisi, Italy
Curr Med Chem 13:2527-34. 2006..Here, we analyze the existing evidence on the link between antenatal phthalate exposure and abnormal fetal development, as well as on possible therapeutic tools to fight the adverse effect of this exposure... - Indications and limitations for a neonatal pulse oximetry screening of critical congenital heart diseaseEnrico Rosati
Division of Neonatology, Perrino Hospital, Brindisi, Italy
J Perinat Med 33:455-7. 2005..145) (95% CI: 0.823 to 0.843) in identifying CCVMs. CONCLUSIONS: Our findings indicate that pulse oximetry is a non-invasive and specific screening tool for an early detection of CCVMs, and is easily applicable to a small size nursery... - Low serum concentrations of di-(2-ethylhexyl)phthalate in women with uterine fibromatosisStefano Luisi
Obstetrics and Gynecology, Department of Pediatrics, Obstetrics, and Reproductive Medicine, University of Siena, Siena, Italy
Gynecol Endocrinol 22:92-5. 2006..In conclusion, the present findings indicate for the first time that serum DEHP and MEHP concentration are lower in women with uterine fibromatosis, suggesting a possible correlation between phthalate esters and fibromatosis pathology... - Phthalate exposure and male infertilityGiuseppe Latini
Division of Neonatology, A Perrino Hospital, s s 7 per Mesagne, 72100 Brindisi, Italy
Toxicology 226:90-8. 2006..Here we review the data that support or discounts the evidence existing to date linking phthalate exposure and the decline of human male fertility, especially in developed countries... - Silent increase of urinary ethylmalonic acid is an indicator of nonspecific brain dysfunctionRaffaella Zannolli
Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte, Siena, Italy
NMR Biomed 23:353-8. 2010..6% sensitivity). These observations are of importance, as we found that subtle increases in urinary EMA levels are frequent in patients with non-specific CNS impairment. The reasons for this association remain unknown... - Congenital oral mucosal abnormalities in true umbilical cord knotsClaudio De Felice
Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy
Biol Neonate 86:34-8. 2004.... - Placental stress factors and maternal-fetal adaptive response: the corticotropin-releasing factor familyPasquale Florio
Chair of Obstetrics and Gynecology, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy
Endocrine 19:91-102. 2002.... - Inhaled nitric oxide and oral nifedipine in a preterm infant with bronchopulmonary dysplasia and pulmonary hypertensionEnrico Rosati
Division of Neonatology, Perrino Hospital, S.S. 7 per Mesagne, 72100 Brindisi, Italy
Eur J Pediatr 166:737-8. 2007 - In utero exposure to di-(2-ethylhexyl)phthalate and duration of human pregnancyGiuseppe Latini
Neonatal Intensive Care Unit, Division of Paediatrics, Perrino Hospital, Brindisi, Italy
Environ Health Perspect 111:1783-5. 2003..50, 95% CI, 1.013-2.21; p = 0.043). These findings confirm that human exposure to DEHP can begin in utero and suggest that phthalate exposure is significantly associated with a shorter pregnancy duration... - Systemic oxidative stress in classic Rett syndromeClaudio De Felice
Neonatal Intensive Care Unit, University Hospital AOUS of Siena, I 53100 Siena, Italy
Free Radic Biol Med 47:440-8. 2009..These data identify hypoxia-induced oxidative stress as a key factor in the pathogenesis of classic RS and suggest new therapeutic approaches based on oxidative stress modulation... - Peroxisome proliferator-activated receptors as mediators of phthalate-induced effects in the male and female reproductive tract: epidemiological and experimental evidenceGiuseppe Latini
Division of Neonatology, Perrino Hospital, 72100 Brindisi, Italy
PPAR Res 2008:359267. 2008..Here, we analyze the epidemiological and experimental evidence linking phthalate exposure to both PPAR activation and adverse effects on male and female reproductive health... - DI-2-ethylhexyl phthalate and endocrine disruption: a reviewGiuseppe Latini
Division of Pediatrics, Ospedale Perrino, Brindisi, University of Chieti, and 4Neonatal Intensive Care Unit, Azienda Ospedaliera Senese, Siena, Italy
Curr Drug Targets Immune Endocr Metabol Disord 4:37-40. 2004..In particular, certain members of this chemical class, such as di-[2-ethylhexyl]-phthalate (DEHP), have been shown to cause reproductive and developmental toxicity and are suspected to be endocrine disruptors... - First day of life reference values for pleth variability index in spontaneously breathing term newbornsGiuseppe Latini
Division of Neonatology, A Perrino Hospital, Brindisi, Italy
Neonatology 101:179-82. 2012..The plethysmographic variability index (PVI) is a measure of the dynamic change in PI occurring during a complete respiratory cycle... - EEG features and epilepsy in MECP2-mutated patients with the Zappella variant of Rett syndromeSabrina Buoni
Department of Pediatrics, Obstetrics and Reproductive Medicine, Section of Child Neurology and Psychiatry Pediatrics, Azienda Ospedaliera Universitaria Senese, S Maria alle Scotte Hospital, Siena, Italy
Clin Neurophysiol 121:652-7. 2010..To assess the presence/absence of peculiar EEG features and epilepsy in MECP2-mutated Rett patients with the Zappella-Rett variant (Z-RTT) also known as preserved speech variant... - Spleen depletion in neonatal sepsis and chorioamnionitisPaolo Toti
Department of Human Pathology and Oncology, Siena University Hospital, University of Siena, Siena, Italy
Am J Clin Pathol 122:765-71. 2004.... - Identification of activin A and follistatin in human milkStefano Luisi
Chair of Obstetrics and Gynecology, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy
Growth Factors 20:147-50. 2002..01). Activin A and follistatin are present in human milk in high concentrations in the first week of lactation, while decrease after a month suggesting a possible role as growth factors in human milk... - Small thymus at birth and gestational ageClaudio De Felice
Eur J Pediatr 161:362-3. 2002 - Small thymus at birth and neonatal outcome in very-low-birth-weight infantsClaudio De Felice
Eur J Pediatr 162:204-6. 2003 - Polyhydramnios: a predictor of severe growth impairment in achondroplasiaGiuseppe Latini
Division of Pediatrics, Perrino Hospital, Azienda Ospedaliera A. Di Summa, Clinical Physiology Institute (IFC-CNR, National Research Council of Italy, Lecce Section, Brindisi, Italy
J Pediatr 141:274-6. 2002..A history of polyhydramnios (9 of 20 cases) was associated with a lower height (SD) (P <.05), more severe shortening of the lower segment and upper limbs (P =.0001), and higher frequency of left-handedness (P =.0081)... - Nephrogenic rests: their frequency and their fateVito Antonio Caiulo
Division of Pediatrics, Perrino Hospital, Brindisi, and The Italian Study Group on Neonatal Nephrology of the Italian Society of Neonatology, Pediatric Department, School of Medicine, Catholic University of Roma, Italy
J Pediatr Hematol Oncol 29:361-3. 2007..Our observations indicate that our policy of "wait and see" is appropriate when NRs are identified incidentally during ultrasonographic screening done for whatever purpose... - Cerebro-fronto-facial syndrome (Dandy-Walker Variant and frontofacial dysmorphisms): report of the first case identified by increased nuchal translucency beyond 13(+6) weeksGabriele Tonni
Division of Obstetrics and Gynecology, Guastalla Provincial Hospital, AUSL Reggio Emilia, Italy
Congenit Anom (Kyoto) 47:68-71. 2007..Careful ultrasonographic follow-up is mandatory in all cases of increased first trimester nuchal translucency with normal karyotype in order to identify associated anomalies... - Birth characteristics and hepatoblastoma risk in young childrenGiuseppe Latini
Cancer 101:210. 2004