Research Topics
Species | Diana CrivellariSummaryAffiliation: Centro di Riferimento Oncologico Country: Italy Publications
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Publications
IdarubicinDiana Crivellari
Centro di Riferimento Oncologico, Aviano (PN
Tumori 88:S73-4. 2002- Letrozole compared with tamoxifen for elderly patients with endocrine-responsive early breast cancer: the BIG 1-98 trialDiana Crivellari
IBCSG Coordinating Center, Effingerstrasse 40, CH 3008 Bern, Switzerland
J Clin Oncol 26:1972-9. 2008..To explore potential differences in efficacy, treatment completion, and adverse events (AEs) in elderly women receiving adjuvant tamoxifen or letrozole for five years in the Breast International Group (BIG) 1-98 trial... - Innovative schedule of oral idarubicin in elderly patients with metastatic breast cancer: comprehensive results of a phase II multi-institutional study with pharmacokinetic drug monitoringD Crivellari
Division of Medical Oncology C, Centro di Riferimento Oncologico, Aviano, Italy
Ann Oncol 17:807-12. 2006..To determine if protracted low-dose oral idarubicin (IDA), feasible in a previous dose-finding study, would result in similar activity and a better toxicity profile in patients with metastatic breast cancer... - Adjuvant endocrine therapy compared with no systemic therapy for elderly women with early breast cancer: 21-year results of International Breast Cancer Study Group Trial IVDiana Crivellari
Centro di Riferimento Oncologico, Via Pedemontana Occidentale 12, I 33081 Aviano, Italy
J Clin Oncol 21:4517-23. 2003..The role of adjuvant therapy for this population is still a matter of debate. We reviewed the long-term outcome of a mature trial comparing endocrine treatment versus no adjuvant therapy in older women with node-positive breast cancer... - Breast cancer in the elderlyDiana Crivellari
Division of Medical Oncology C, Centro di Riferimento Oncologico National Cancer Institute, Aviano, PN Italy
J Clin Oncol 25:1882-90. 2007.... - Treatment of older breast cancer patients with high recurrence riskD Crivellari
Division of Medical Oncology C, Centro di Riferimento Oncologico, 33081, Aviano, Italy
Crit Rev Oncol Hematol 46:241-6. 2003.... - Breast cancer and pregnancyDiana Crivellari
Division of Medical Oncology C, Centro di Riferimento Oncologico, 33081 Aviano, PN, Italy
Tumori 88:187-92. 2002..The decision should be evaluated for each single patient, taking into account the prognosis of the patient and her desire of pregnancy... - New oral drugs in older patients: a review of idarubicin in elderly patientsDiana Crivellari
Medical Oncology Department, Centro di Riferimento Oncologico, Via Pedemontana Occ, 12, 33081 Aviano, PN, Italy
Crit Rev Oncol Hematol 49:153-63. 2004..The pharmacokinetics, activity, adverse effects and new modalities of oral administration are reviewed... - Late tamoxifen in patients previously operated for breast cancer without postoperative tamoxifen: 5-year results of a single institution randomised studyAndrea Veronesi
Division of Medical Oncology C, National Cancer Institute, Via Franco Gallini 2, 33081 Aviano, Italy
BMC Cancer 10:205. 2010..A population of breast cancer patients exists who, for various reasons, never received adjuvant post-operative tamoxifen (TAM). This study was aimed to evaluate the role of late TAM in these patients... - Long-term, weekly one-hour infusion of paclitaxel in patients with metastatic breast cancer: a phase II monoinstitutional studyDavide Lombardi
Division of Medical Oncology C, Centro di Riferimento Oncologico, Aviano, Italy
Tumori 90:285-8. 2004..We performed a monoinstitutional phase II trial in order to confirm these interesting results... - Acceptance of external infusion pumps in patients with advanced breast cancer receiving continuous infusion fluorouracilDavide Lombardi
Division of Medical Oncology C, Centro di Riferimento Oncologico, Aviano, Italy
Tumori 89:488-91. 2003.... - Trastuzumab and vinorelbine as highly effective and safe therapy for HER-2-overexpressing metastatic breast cancer. A single institution experienceVincenzo Di Lauro
Division of Medical Oncology C, Centro di Riferimento Oncologico, Aviano, Italy
Tumori 94:464-8. 2008..Trastuzumab-based therapy has improved survival of women with human epidermal growth factor receptor 2 (HER2)-overexpressing metastatic breast cancer... - Therapeutic management of breast cancer in the elderlySimon Spazzapan
Centro di Riferimento Oncologico, CRO IRCCS Medical Oncology C, Via F Gallini 2, Aviano Pordenone 33081, Italy
Expert Opin Pharmacother 12:945-60. 2011..Whatever the direction, the management of elderly breast-cancer patients is inherently multidisciplinary: the contribution of medical and allied health professionals is essential to the provision of optimal care... - Familial breast cancer: characteristics and outcome of BRCA 1-2 positive and negative casesAndrea Veronesi
Division of Medical Oncology C, Centro di Riferimento Oncologico, Aviano, Italy
BMC Cancer 5:70. 2005..The clinical and pathological characteristics and the clinical course of patients with breast cancer and BRCA 1-2 mutation are poorly known... - Epirubicin and docetaxel as neoadjuvant treatment of locally advanced breast cancer: a phase II studyDavide Lombardi
Division of Medical Oncology C, Centro di Riferimento Oncologico, Aviano, Italy
Tumori 96:229-33. 2010..We report here the overall results of a phase II study of epirubicin and docetaxel as neoadjuvant chemotherapy in advanced breast cancer... - Hormone therapy in elderly breast cancer patients with comorbiditiesDiana Crivellari
Division of Medical Oncology C, Centro di Riferimento Oncologico National Cancer Institute, Aviano 33081, Italy
Crit Rev Oncol Hematol 73:92-8. 2010..The hormonal therapeutic armamentarium of the medical oncologist is now open to different options that may best be tailored to different clinical situations, particularly in elderly women... - Comparison of ultrasonography, hysteroscopy, and biopsy in the diagnosis of endometrial lesions in postmenopausal tamoxifen-treated patientsGiorgio Giorda
Division of Gynecologic Oncology, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy
Acta Obstet Gynecol Scand 81:975-80. 2002..At present, no proven recommendations can be made for the surveillance of tamoxifen-treated women. The aim of the present study was to evaluate ultrasonography and hysteroscopy in this setting... - A different immunologic profile characterizes patients with HER-2-overexpressing and HER-2-negative locally advanced breast cancer: implications for immune-based therapiesElena Muraro
Cancer Bio Immunotherapy Unit, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Via Franco Gallini 2, Aviano PN, 33081, Italy
Breast Cancer Res 13:R117. 2011..On these grounds, a careful analysis of basal immune profile may be capital to dissect the heterogeneity of clinical responses to these drugs in patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy... - Oral etoposide in elderly patients with advanced non small cell lung cancer: a clinical and pharmacological studyR Sorio
Medical Department, Centro di Riferimento Oncologico, Aviano, Italy
J Chemother 18:188-91. 2006..The easy self-management, favorable toxicity profile and synergy with other compounds makes oral etoposide suitable for further clinical-pharmacological studies in elderly patients... - Long-term survival in patients with metastatic renal cell carcinoma treated with continuous intravenous infusion of recombinant interleukin-2: the experience of a single institutionMassimo Libra
Division of Medical Oncology, Centro di Riferimento Oncologico, IRCCS, Aviano, PN, Italy
Tumori 89:400-4. 2003..Moreover, ECOG performance status, clinical response, hypotension and oliguria toxicity resulted as independent survival prognostic factors... - Capecitabine cardiac toxicity presenting as effort angina: a case reportChiara Lestuzzi
Cardiologia, Centro di Riferimento Oncologico, IRCCS, Via F Gallini 2, 33081 Aviano, Pordenone, Italy
J Cardiovasc Med (Hagerstown) 11:700-3. 2010..The most (even if not fully) effective strategy was reducing capecitabine dosage together with nitrates, calcium-channel blockers and trimetazidine therapy... - High-dose epirubicin in locally advanced operable noninflammatory breast cancer: a feasibility trialD Crivellari
Division of Medical Oncology, Centro di Riferimento Oncologico, Aviano, Italy
Tumori 83:656-60. 1997..In this era of cost containment, the use of this short-term, high-dose induction course instead of repetitive courses of conventional dose regimens merits further evaluation, possibly in a large randomized trial... - Quantifying trade-offs: quality of life and quality-adjusted survival in a randomised trial of chemotherapy in postmenopausal patients with lymph node-negative breast cancerJ Bernhard
IBCSG Coordinating Center, Bern, Switzerland
Br J Cancer 91:1893-901. 2004..Q-TWiST analysis based on patient ratings is feasible in large-scale cross-cultural clinical trials... - Adjuvant therapy for primary breast cancer in a female patient affected by autoimmune liver disease: does it cure breast cancer and primary biliary cirrhosis?D Crivellari
Divisione di Oncologia Medica, IRCCS, Aviano, Italy
Tumori 78:395-6. 1992..In conclusion, we suggest that the CMF regimen is potentially useful in patients with breast cancer and primary biliary cirrhosis... - Burdens and benefits of adjuvant cyclophosphamide, methotrexate, and fluorouracil and tamoxifen for elderly patients with breast cancer: the International Breast Cancer Study Group Trial VIID Crivellari
Centro di Riferimento Oncologico, Aviano, Italy
J Clin Oncol 18:1412-22. 2000..Information on the tolerability and efficacy of adjuvant chemoendocrine therapy for older women is limited. We studied these issues using the data collected as part of the International Breast Cancer Study Group Trial VII... - High incidence of central nervous system involvement in patients with metastatic or locally advanced breast cancer treated with epirubicin and docetaxelD Crivellari
Divisione di Oncologia Medica, Istituto Nazionale Tumori, Aviano, Italy
Ann Oncol 12:353-6. 2001..Clinically overt central nervous system (CNS) involvement occurs in 10%-15% of patients with advanced breast cancer... - Cisplatin and mitomycin C in advanced chemotherapy-refractory breast cancerD Crivellari
Medical Oncology Department, Centro di Riferimento Oncologico, Aviano, Pordenone, Italy
Tumori 76:234-7. 1990..We conclude that at these doses and schedule, the cisplatin and mitomycin C combination has a limited efficacy in advanced breast cancer patients, and its use is not recommended in pretreated patients... - Fourteen-day infusion of ifosfamide in the management of advanced breast cancer refractory to protracted continuous infusion of 5-fluorouracilV D Lauro
Division of Medical Oncology C, Centro di Riferimento Oncologico, Aviano, Italy
Tumori 87:27-9. 2001..Hair lost or alopecia was universal. CONCLUSIONS: The regimen yielded some clinically useful re sponses with acceptable toxicity. Its evaluation in less ad vanced cases appears to be warranted... - Tamoxifen as adjuvant after surgery for breast cancer and tamoxifen or placebo as chemoprevention in healthy women: different compliance with treatmentA Veronesi
Division of Preventive Oncology, Centro di Riferimento Oncologico, Aviano, Italy
Tumori 84:372-5. 1998..Due to the double-blind nature of the chemoprevention study, the impact of the toxicity of tamoxifen upon compliance in the chemopreventive setting cannot be ascertained... - Retrospective analysis of the CYVADIC regimen in advanced soft tissue sarcomasS Frustaci
Division of Medical Oncology, Centro di Riferimento Oncologico, Aviano, Pordenone, Italy
Tumori 75:152-5. 1989.... - Ovarian cancer: ten-year experience in a community hospitalG Franchin
Division of Radiotherapy, Centro di Riferimento Oncologico, Aviano Pordenone, Italy
Tumori 73:381-8. 1987..Patients with advanced disease, considering the lack of established efficacious treatments, should be referred to specialized centers, where new drugs or experimental strategies can be tested... - Continuous infusion fluorouracil in the management of advanced breast cancer: a phase II studyD Crivellari
Division of Medical Oncology C, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy
Tumori 86:42-5. 2000..In order to improve on these results further studies are needed in a less advanced stage of the disease and together with other active drugs... - Gastric cancer with bone marrow invasion at presentation: case-report and review of the literatureD Crivellari
Division of Medical Oncology, Centro di Riferimento Oncologico, Aviano, Italy
Tumori 81:74-6. 1995..Due to the disappearance of bone marrow infiltration, the patient was considered for curative resection of the primary gastric cancer. After 27 months the patient is alive and in clinical complete remission... - Determination of tamoxifen and its metabolites in the endometrial tissue of long-term treated womenG Giorda
Gynecological Oncology Department, Centro di Riferimento Oncologico, Via Pedemontana Occidentale, I 33081, Aviano, Italy
Eur J Cancer 36:S88-9. 2000..Endometrial polyps of an additional 9 women showed a trend to a lesser concentration of compounds. Increased concentration of tamoxifen compounds could possibly be explained by the avidity of these compounds for oestrogen receptors (ER)... - Treatment patterns in elderly patients (greater than or equal to 70 years) with breast carcinoma. A retrospective study of the Gruppo Oncologico Clinico Cooperativo del nord-Est (GOCCNE)D Crivellari
Division of Medical Oncology, Centro di Riferimento Oncologico, Aviano, Italy
Tumori 77:136-40. 1991..Comorbid conditions are of particular concern in therapy planning, considering that more stage III patients died of competing causes than for disease progression. The role of chemotherapy was very marginal... - Treatment of breast cancer in older womenDaniele Bernardi
Division of Medical Oncology, Ospedale Civile, Vittorio Veneto, TV, Italy
Acta Oncol 47:187-198. 2008.... - Anemia during adjuvant non-taxane chemotherapy for early breast cancer: Incidence and risk factors from two trials of the International Breast Cancer Study GroupLorenzo Gianni
Divisione di Oncologia e di Ematologia, Ospedale degli Infermi, and Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Azienda USL Rimini Via Settembrini 2, Rimini, Italy
Support Care Cancer 16:67-74. 2008..The objective of this study was to evaluate the incidence of anemia and risk factors for anemia occurrence in patients with early breast cancer who received adjuvant chemotherapy... - Nail toxicity related to weekly taxanes: an important issue requiring a change in common toxicity criteria grading?Simon Spazzapan
J Clin Oncol 20:4404-5; author reply 4405. 2002 - The role of the number of uninvolved lymph nodes in predicting locoregional recurrence in breast cancerPer Karlsson
Department of Oncology, University of Goteborg, Sahlgrenska University Hospital, Goteborg, Sweden
J Clin Oncol 25:2019-26. 2007..To identify groups of early breast cancer patients with substantial risk (10-year risk > 20%) for locoregional failure (LRF) who might benefit from postmastectomy radiotherapy (RT)... - Results of adjuvant treatments in breast cancer patients over 70 years old: the IBCSG experience. International Breast Cancer Study GroupDiana Crivellari
Centro di Riferimento Oncologico, Aviano (PN
Tumori 88:S81-2. 2002 - Hormonal treatment duration in elderly patients: an open questionDiana Crivellari
J Clin Oncol 22:1164-5; author reply 1165. 2004 - Adjuvant therapy in elderly patients with breast cancerLaura Biganzoli
Sandro Pitigliani Medical Oncology Unit, Hospital of Prato, Italy
Clin Breast Cancer 5:188-95; discussion 196-7. 2004..Therefore, specific clinical trials are needed to investigate adjuvant treatments tailored for the heterogeneous older population... - Site of primary tumor has a prognostic role in operable breast cancer: the international breast cancer study group experienceMarco Colleoni
Division of Medical Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
J Clin Oncol 23:1390-400. 2005..For medial tumors, axillary lymph node staging may not accurately reflect the metastatic potential of the disease... - Prognostic value of extracapsular tumor spread for locoregional control in premenopausal patients with node-positive breast cancer treated with classical cyclophosphamide, methotrexate, and fluorouracil: long-term observations from International Breast CaGünther Gruber
Department of Radiation Oncology, and the Institute of Medical Oncology, Inselspital, Switzerland
J Clin Oncol 23:7089-97. 2005..We sought to determine retrospectively whether extracapsular spread (ECS) might identify a subgroup that could benefit from radiotherapy after mastectomy, especially patients with 1 to 3 positive lymph nodes (LN1-3+)... - Breast carcinoma during pregnancy. International recommendations from an expert meetingSibylle Loibl
Department of Obstetrics and Gynaecology, J W Goethe University, Frankfurt am Main, Germany
Cancer 106:237-46. 2006..Breast carcinoma during pregnancy (BCP) is a difficult clinical situation, as it appears to put the health of the mother in conflict with that of the fetus... - Randomized trial comparing axillary clearance versus no axillary clearance in older patients with breast cancer: first results of International Breast Cancer Study Group Trial 10-93Carl Magnus Rudenstam
West Swedish Breast Cancer Study Group, Sahlgrenska University Hospital Molndal, Göteborgsvägen 31, 431 80 Mölndal, Sweden
J Clin Oncol 24:337-44. 2006..We therefore investigated whether avoiding axillary surgery in older women would result in improved quality of life (QL) with similar disease-free survival (DFS) and overall survival (OS)... - Ocular toxicity during adjuvant chemoendocrine therapy for early breast cancer: results from International Breast Cancer Study Group trialsLorenzo Gianni
Division of Oncology and Hematology, Hospital degli Infermi, Rimini, Italy
Cancer 106:505-13. 2006..Others have reported ocular toxicity after adjuvant chemoendocrine therapy, but this study looked at ocular toxicity in similarly treated patients from large randomized clinical trials... - Randomized Phase II Trial of weekly paclitaxel alone versus trastuzumab plus weekly paclitaxel as first-line therapy of patients with Her-2 positive advanced breast cancerGiampietro Gasparini
Medical Oncology Division, San Filippo Neri Hospital, Unità Operativa Complessa di Oncologia Medica, Azienda Complesso Ospedaliero di Rilevanza Nazionale S Filippo Neri, Via G Martinotti, 20 00135 Rome, Italy
Breast Cancer Res Treat 101:355-65. 2007..A randomized Phase II study evaluated the activity of weekly paclitaxel versus its combination with trastuzumab for treatment of patients with advanced breast cancer overexpressing HER-2...